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1. 发明授权

US07709529B2 Treatment of cancer with glutamine 有权
标题翻译：用谷氨酰胺治疗癌症
公开(公告)号：US07709529B2
公开(公告)日：2010-05-04
申请号：US10633402
申请日：2003-08-01
申请人： V. Suzanne Klimberg , Robert G. Petit, II , Edward C. Shinal
发明人： V. Suzanne Klimberg , Robert G. Petit, II , Edward C. Shinal
IPC分类号： A61K31/195
CPC分类号： A61K9/0095 , A61K9/0014 , A61K31/198 , A61K31/70 , A61K45/06 , A61K47/26 , A61K2300/00
摘要： Provided are methods of treating cancer, and/or the side effects of cancer therapy, involving the administration of glutamine, optionally in combination with a carbohydrate carrier that enhances the absorption of glutamine.
摘要翻译：提供了治疗癌症的方法和/或癌症治疗的副作用，其涉及施用谷氨酰胺，任选地与增强谷氨酰胺吸收的碳水化合物载体组合。

2. 发明申请

US20100152130A1 TREATMENT OF CANCER WITH GLUTAMINE 审中-公开
标题翻译：用谷氨酰胺治疗癌症
公开(公告)号：US20100152130A1
公开(公告)日：2010-06-17
申请号：US12631895
申请日：2009-12-07
申请人： V. Suzanne Klimberg , Robert G. Petit, II , Edward C. Shinal
发明人： V. Suzanne Klimberg , Robert G. Petit, II , Edward C. Shinal
IPC分类号： A61K31/70 , A61K31/7016 , A61K31/7004 , A61P35/00
CPC分类号： A61K9/0095 , A61K9/0014 , A61K31/198 , A61K31/70 , A61K45/06 , A61K47/26 , A61K2300/00
摘要： Provided are methods of treating cancer, and/or the side effects of cancer therapy, involving the administration of glutamine, optionally in combination with a carbohydrate carrier that enhances the absorption of glutamine.
摘要翻译：提供了治疗癌症和/或癌症治疗的副作用的方法，其涉及施用谷氨酰胺，任选地与增强谷氨酰胺吸收的碳水化合物载体组合。

3. 发明授权

US07601800B2 Compositions and methods for monitoring breast cancer treatment 有权
标题翻译：用于监测乳腺癌治疗的组成和方法
公开(公告)号：US07601800B2
公开(公告)日：2009-10-13
申请号：US11615123
申请日：2006-12-22
申请人： Larry J. Suva , V. Suzanne Klimberg
发明人： Larry J. Suva , V. Suzanne Klimberg
IPC分类号： C07K14/00 , A61K38/00
CPC分类号： G01N33/57415 , C07K14/47 , G01N2333/976
摘要： The present invention provides compositions and processes for preparing the same wherein the compositions are useful for monitoring breast cancer treatment.
摘要翻译：本发明提供了组合物及其制备方法，其中组合物可用于监测乳腺癌治疗。

4. 发明授权

US08268573B2 Compositions and methods for monitoring breast cancer treatment 有权
标题翻译：用于监测乳腺癌治疗的组成和方法
公开(公告)号：US08268573B2
公开(公告)日：2012-09-18
申请号：US12538987
申请日：2009-08-11
申请人： Larry J. Suva , V. Suzanne Klimberg
发明人： Larry J. Suva , V. Suzanne Klimberg
IPC分类号： G01N33/483
CPC分类号： G01N33/57415 , C07K14/47 , G01N2333/976
摘要： The present invention provides compositions and processes for preparing the same wherein the compositions are useful for monitoring breast cancer treatment.
摘要翻译：本发明提供了组合物及其制备方法，其中组合物可用于监测乳腺癌治疗。

5. 发明申请

US20100129918A1 COMPOSITIONS AND METHODS FOR MONITORING BREAST CANCER TREATMENT 有权
标题翻译：用于监测乳腺癌治疗的组合物和方法
公开(公告)号：US20100129918A1
公开(公告)日：2010-05-27
申请号：US12538987
申请日：2009-08-11
申请人： Larry J. Suva , V. Suzanne Klimberg
发明人： Larry J. Suva , V. Suzanne Klimberg
IPC分类号： G01N33/50
CPC分类号： G01N33/57415 , C07K14/47 , G01N2333/976
摘要： The present invention provides compositions and processes for preparing the same wherein the compositions are useful for monitoring breast cancer treatment.
摘要翻译：本发明提供了组合物及其制备方法，其中组合物可用于监测乳腺癌治疗。

6. 发明授权

US07186517B2 Compositions and methods for monitoring breast cancer treatment 有权
标题翻译：用于监测乳腺癌治疗的组成和方法
公开(公告)号：US07186517B2
公开(公告)日：2007-03-06
申请号：US10903500
申请日：2004-07-30
申请人： Larry J. Suva , V. Suzanne Klimberg
发明人： Larry J. Suva , V. Suzanne Klimberg
IPC分类号： G01N33/483
CPC分类号： G01N33/57415 , C07K14/47 , G01N2333/976
摘要： The present invention provides compositions and a method for monitoring breast cancer treatment.
摘要翻译：本发明提供了用于监测乳腺癌治疗的组合物和方法。

7. 发明授权

US06714808B2 Method for detecting and excising nonpalpable lesions 失效
标题翻译：检测和切除不可触及的病变的方法
公开(公告)号：US06714808B2
公开(公告)日：2004-03-30
申请号：US09970456
申请日：2001-10-03
申请人： V. Suzanne Klimberg , Steven E. Harms , Sohelia Korourian
发明人： V. Suzanne Klimberg , Steven E. Harms , Sohelia Korourian
IPC分类号： A61B5055
CPC分类号： A61B90/39 , A61B10/0233 , A61B2090/374 , A61B2090/378 , A61B2090/3908
摘要： A novel method of hematoma-directed ultrasound guided excisional breast biopsy is disclosed. In one aspect of the inventon, the hematoma is produced by an injection of the patient's own blood into a pre-selected area to target a lesion. Detection of the targeted lesion and hematoma is achieved with MRI. In a second aspect of the invention, the hematoma is produced by stereotactic core needle breast biopsy in a pre-selected area, and the targeted lesion and hematoma are detected using intraoperative ultrasound. The method avoids many of the disadvantages associated with traditional needle localized breast biopsy. The method can also be used to guide the excision of lesions visualized by MRI, ultrasound, mammography, PET scanning, and scintimammography. The method may be used in any organ and, in particular, the breast.
摘要翻译：公开了一种血肿导向超声引导切除乳腺活检的新方法。在本发明的一个方面，血肿是通过将患者自己的血液注射到预选区域来靶向病变而产生的。用MRI检测目标病变和血肿。在本发明的第二方面中，通过在预选区域中的立体定向核心针乳房活检产生血肿，并且使用术中超声检测靶向病变和血肿。该方法避免了与传统针定位乳腺活检相关的许多缺点。该方法还可用于指导通过MRI，超声，乳房X线照相术，PET扫描和闪烁扫描显像的病变切除。该方法可用于任何器官，特别是乳房。

8. 发明授权

US06978788B2 Minimally invasive treatment for breast cancer 有权
标题翻译：微创治疗乳腺癌
公开(公告)号：US06978788B2
公开(公告)日：2005-12-27
申请号：US10306117
申请日：2002-11-27
申请人： V. Suzanne Klimberg , Steven Harms , Soheila Korourian
发明人： V. Suzanne Klimberg , Steven Harms , Soheila Korourian
IPC分类号： A61B10/00 , A61B10/02 , A61B17/00 , A61B18/24 , A61B19/00
CPC分类号： A61B10/0233 , A61B10/0041 , A61B10/0283 , A61B2017/008 , A61B2018/2005 , A61B2090/374
摘要： The present invention provides a minimally invasive, comprehensive same-day diagnosis and treatment method to remove tumor and ablate margins in breast cancer patients, comprising disease diagnosis by MRI and touch preparation cytology, followed by tumor removal and ablation of tumor margins.
摘要翻译：本发明提供了一种微创，全面的同期诊断和治疗方法，用于消除乳腺癌患者的肿瘤和消融边缘，包括通过MRI和触摸准备细胞学检查的疾病诊断，随后肿瘤切除和肿瘤边缘消融。

9. 发明授权

US07769432B2 Minimally invasive diagnosis and treatment for breast cancer 有权
标题翻译：乳腺癌的微创诊断和治疗
公开(公告)号：US07769432B2
公开(公告)日：2010-08-03
申请号：US10866913
申请日：2004-06-14
申请人： V. Suzanne Klimberg , Sohelia Korourian , Steven Harms , Gal Shafirstein
发明人： V. Suzanne Klimberg , Sohelia Korourian , Steven Harms , Gal Shafirstein
IPC分类号： A61B6/00 , A61B8/00
CPC分类号： A61B10/0233 , A61B10/0041 , A61B10/0283 , A61B2017/008 , A61B2018/2005 , A61B2090/374
摘要： The present invention provides a treatment method to excise a cancerous lesion, such as in the breast, with subsequent ablation of the margin. The method provides for location and excision with ablation under open guidance or guided imaging and for diagnosis by cytology. The method may be a minimally, invasive same day method with diagnosis before or immediately after excision. Also provided is a method of treating close or positive margins of an excisional site of a cancerous lesion in a breast by ablating the margin while monitoring the fluorescence of a fluorophor at the site to determine when ablation of the close or positive margin has occurred.
摘要翻译：本发明提供了一种治疗方法，用于消除诸如乳房中的癌性病变，随后消融边缘。该方法提供了在开放引导或引导成像下进行消融的定位和切除，并通过细胞学诊断。该方法可以是在切除之前或之后具有诊断的最小侵入性同一天方法。还提供了一种通过在监测位点处的荧光体的荧光的同时消除边缘来处理乳房中的癌性病变的切除部位的接近或正边缘的方法，以确定何时发生接近或正边缘的消融。

10. 发明授权

US06884605B2 Compositions, methods and products comprising human papillomavirus for detecting and treating a cancer 失效
标题翻译：包含用于检测和治疗癌症的人乳头瘤病毒的组合物，方法和产品
公开(公告)号：US06884605B2
公开(公告)日：2005-04-26
申请号：US09927585
申请日：2001-08-09
申请人： Paul L. Hermonat , V. Suzanne Klimberg , Yong Liu
发明人： Paul L. Hermonat , V. Suzanne Klimberg , Yong Liu
IPC分类号： A61B10/00 , C12P19/34
CPC分类号： A61B10/0041 , G01N2333/025
摘要： Methods for screening a patient for a cancer wherein the methods comprise detecting an HPV in a biopsy from a patient are disclosed. Also disclosed are compositions and products for screening and for treating cancer in a patient, as well as methods of treating a patient afflicted with a cancer.
摘要翻译：公开了筛选患者癌症的方法，其中所述方法包括从患者的活组织检查中检测HPV。还公开了用于筛选和治疗患者中的癌症的组合物和产品，以及治疗患有癌症的患者的方法。

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