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1. 发明申请

US20210153949A1 Intervention Device with Electrodes 有权
公开(公告)号：US20210153949A1
公开(公告)日：2021-05-27
申请号：US16627725
申请日：2018-06-29
申请人： Universitat Bern , EMPA Eidgenossische Forschungsanstalt
发明人： Juan Anso Romeo , Stefan Weber , Kate Gerber , Kerstin Thorwarth , Aarati Chacko , Jorg Patscheider
IPC分类号： A61B34/20 , A61B17/16 , A61N1/05
摘要： The present invention relates to an intervention device (20) for surgically intervening a target tissue of a human or animal body, comprising a penetrating body (100) arranged to be advanced into the target tissue along an advancing axis (Z+). The penetrating body (100) has an outer surface with a plurality of electrodes (e1, e2, e3, e4, . . . , eN) insulated from each other. More particularly, the penetrating body comprises a substrate base (5), a number N>1 of electrically conducting coatings (cce1, cce2, cce3, cce4, . . . , cceN) and a number M=N−1 electrically insulating coatings (ici1, ici2, ici3, . . . , iciM). A 1st electrically conducting coating (cce1) at least partially covers the substrate base (5), whereas each mth electrically insulating coating of the M electrically insulating coatings ici1, ici2, ici3, ici4, . . . , iciM) partially covers the mth electrically conducting coating of the N electrically conducting coatings (cce1, cce2, cce3, cce4, . . . ) and each nth electrically conducting coating of the N electrically conducting coatings (cce2, cce3, cce4) partially covers the (n−1)th electrically insulating coating (ici1, ici2, ici3). Thus, the outer surface of the penetrating body (100) comprises at least L=N+M sections (e1, i1, e2, i2, e3, i3, e4) alternatingly formed by the N electrically conducting coatings (cce1, cce2, cce3, cce4, . . . , cceN) and the M electrically insulating coatings (ici1, ici2, ici3, . . . , iciM). The present invention also relates to a an intervention system comprising a power supply unit and an intervention device (20; 200) as above described, wherein at least one (cce1) of the N electrically conducting coatings (cce1, cce2, cce3, cce4, . . . , cceN) of the intervention device (20; 200) is connected to the power supply unit such that it forms a cathode and at least another one (cce2, cce3, cce4) of the N electrically conducting coatings is an anode.

2. 发明申请

US20200166721A1 MODULAR SYSTEM FOR SECURE AND CONTROLLED ARRANGEMENT OF OPTICAL FIBRES AND COMPONENTS OF AN OPTICAL SYSTEM 审中-公开
公开(公告)号：US20200166721A1
公开(公告)日：2020-05-28
申请号：US16631612
申请日：2018-07-06
申请人： UNIVERSITAT BERN
发明人： Philippe Richard RAISIN , Christoph BACHER , Andres LUDER SCHAIBLE , Manuel Alain RYSER , Adrian JENK
IPC分类号： G02B6/44
摘要： The invention relates to a modular and stackable system (1) for arranging an optical fibre of an optical system in a controlled and secure manner, comprising at least the following components: a modular frame (30) comprising a plurality of upright posts (31), wherein the posts (31) are arranged such on the frame (30) that a next-neighbour distance of the posts (31) is identical, wherein each post (31) comprises a recess (31a) on the upper end; at least one module (20) for receiving an optical fibre, wherein the module (20) comprises at least four corners (21); wherein the posts (31) are arranged such that four modules (20) can be arranged with their corners (21) non-overlapping on a single post (31); wherein each module's corner (21) can be fixed with a fixing means on the post (31), wherein the fixing means is designed to engage in the recess (31a) on the upper end of the post (31) and wherein the corners (21) of each module (20) and the fixing means are designed such that the fixing means can simultaneously fix four non-overlappingly arranged modules (20) on a single post (31) of the frame (30). The invention furthermore relates to a fibre laser comprising a modular system (1).

3. 发明授权

US10271819B2 Computed ultrasound tomography in echo mode (CUTE) for imaging speed of sound using pulse-echo sonography 有权
公开(公告)号：US10271819B2
公开(公告)日：2019-04-30
申请号：US15104992
申请日：2014-12-16
申请人： UNIVERSITAT BERN
发明人： Martin Frenz , Michael Jaeger
IPC分类号： A61B8/14 , A61B8/08 , G01S7/52 , G01S15/89 , G01H5/00
摘要： The invention relates to a method for determining and particularly imaging sound speed in an object by means of pulse-echo ultrasound, comprising the steps of: transmitting by means of an ultrasound probe (1) at least a first ultrasound pulse (10) in a first direction (φ0) and a second ultrasound pulse (20) in a different second direction (φ) into an object (O) to be imaged, so that said first ultrasound pulse (10) is backscattered in said object towards said ultrasound probe in the form of first ultrasound pulse echoes (11), and so that said second ultrasound pulse (20) is backscattered in said object towards said ultrasound probe in the form of second ultrasound pulse echoes (21), detecting said backscattered first ultrasound pulse echoes (11) and said backscattered second ultrasound pulse echoes (21) with said ultrasound probe (1), reconstructing from said detected backscattered first ultrasound pulse echoes (11) a first image of first local echoes (5) and from said detected backscattered second ultrasound pulse echoes (21) a second image of second local echoes (7), wherein said images lie in an image plane spanned by said directions (φ0, φ), determining from said reconstructed images the respective resulting local echo phase shift Δτ(x, z, φ, φ0) corresponding to the difference in echo time (t) between the respective first local echo and the corresponding second local echo relative to the case of an assumed constant sound speed, and determining the local sound speed c(x, z) in said object for at least a region of said image plane in said object from said local echo phase shift Δτ(x, z, φ, φ0). Further, the invention relates to a corresponding computer program and a system.

4. 发明申请

US20170260524A1 TRICYCLO-DNA ANTISENSE OLIGONUCLEOTIDES, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF DISEASE 审中-公开
公开(公告)号：US20170260524A1
公开(公告)日：2017-09-14
申请号：US15428385
申请日：2017-02-09
申请人： ASSOCIATION INSTITUT DE MYOLOGIE , UNIVERSITE PIERRE ET MARIE CURIE , UNIVERSITAT BERN , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA SANTE DE LA RECHERCHE MEDICALE
发明人： Daniel SCHUMPERLI , Christian LEUMANN , Denis FURLING , Luis GARCIA , Thomas VOIT
IPC分类号： C12N15/113 , C12N15/11 , A61K31/711 , A61K31/712
CPC分类号： C12N15/113 , A61K31/711 , A61K31/712 , C12N15/111 , C12N2310/11 , C12N2310/3231 , C12N2320/33
摘要： Provided are tricyclo-DNA (tc-DNA) AON and methods employing tc-DNA AON for modifying splicing events that occur during pre-mRNA processing. Tricyclo-DNA (tc-DNA) AON are described that may be used to facilitate exon skipping or to mask intronic silencer sequences and/or terminal stein-loop sequences during pre-mRNA processing and to target RNase-mediated destruction of processed mRNA. Tc-DNA AON described herein may be used in methods for the treatment of Duchenne Muscular Dystrophy by skipping a mutated exon 23 or exon 51 within a dystrophin gene to restore functionality of a dystrophin protein; in methods for the treatment of Spinal Muscular Atrophy by masking an intronic silencing sequence and/or a terminal stem-loop sequence within an SMN2 gene to yield modified functional SMN2 protein, including an amino acid sequence encoded by exon 7, which is capable of at least partially complementing a non-functional SMN1 protein; and in methods for the treatment of Steinert's Myotonic Dystrophy by targeting the destruction of a mutated DM1 mRNA comprising 3′-terminal CUG repeats.

5. 发明申请

US20160122372A1 TRICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM 审中-公开
公开(公告)号：US20160122372A1
公开(公告)日：2016-05-05
申请号：US14987937
申请日：2016-01-05
申请人： UNIVERSITAT BERN
发明人： Christian Leumann , Branislav Dugovic , Jory Lietard
IPC分类号： C07F9/655 , C12N15/113
CPC分类号： C07F9/65517 , C07H19/02 , C07H19/04 , C07H19/06 , C07H19/16 , C07H21/00 , C12N15/113 , C12N2310/11
摘要： The present invention provides novel tricyclic nucleosides and oligomeric compounds prepared therefrom. Incorporation of one or more of the tricyclic nucleosides into an oligomeric compound is expected to enhance one or more properties of the oligomeric compound. Such oligomeric compounds can also be included in double stranded compositions. In certain embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.

6. 发明授权

US12076331B2 Inositol derivatives for use in pathological crystallization 有权
公开(公告)号：US12076331B2
公开(公告)日：2024-09-03
申请号：US18332849
申请日：2023-06-12
申请人： ETH Zurich , Universitat Bern
发明人： Anna Kletzmayr , Makoto Kuro-o , Hirosaka Hayashi , Mattias Ivarsson , Jean-Christophe Leroux
IPC分类号： A61K31/6615 , A61P13/04
CPC分类号： A61K31/6615 , A61P13/04
摘要： Provided herein is an inositol polyphosphate oligo alkyl ether compound, or its pharmaceutically acceptable salt, for use in treatment or prevention of a disease associated with formation of calcium salt crystals.

7. 发明授权

US11707470B2 Inositol derivatives for use in pathological crystallization 有权
公开(公告)号：US11707470B2
公开(公告)日：2023-07-25
申请号：US17340163
申请日：2021-06-07
申请人： ETH Zurich , UNIVERSITAT BERN
发明人： Anna Kletzmayr , Makoto Kuro-o , Hirosaka Hayashi , Mattias E. Ivarsson , Jean-Christophe Leroux
IPC分类号： A61K31/6615 , A61P13/04
CPC分类号： A61K31/6615 , A61P13/04
摘要： The invention is related to an inositol polyphosphate oligo alkyl ether compound, or its pharmaceutically acceptable salt, for use in treatment or prevention of a disease associated with formation of calcium salt crystals.

8. 发明申请

US20190382397A1 THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION 审中-公开
公开(公告)号：US20190382397A1
公开(公告)日：2019-12-19
申请号：US16546328
申请日：2019-08-21
申请人： UNIVERSITAT BERN
发明人： Jean-Louis REYMOND , Simon NICOLUSSI , Jurg GERTSCH
IPC分类号： C07D417/06 , C07D277/54
摘要： The invention relates to a compound comprising the following general formula (1): and said compound for use as a medicament, in particular for use in the treatment psychiatric or neurological disorders and inflammation, in particular neuroinflammation: (formula 1) wherein each of R1, R2 and R3 are selected independently from each other from alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, aryl, heterocycle, or heteroaryl.

9. 发明申请

US20190352297A1 SELECTIVE AURORA A KINASE INHIBITORS 审中-公开
公开(公告)号：US20190352297A1
公开(公告)日：2019-11-21
申请号：US16476295
申请日：2017-01-06
申请人： UNIVERSITAT BERN
发明人： Jean-Louis REYMOND , Falco KILCHMANN
IPC分类号： C07D417/06 , C07D417/14
摘要： The invention relates to a compound wherein R1 is selected from —I, —Br, —Cl, —F, C1-C6-alkyl, —O(CH2)mCH3, —(CH2)mOCH3, C1-C6-haloalkyl, a cycloalkyl, a heterocycle, a aryl or heteroaryl, wherein R2 is selected from H, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6-cycloalkyl, —CH2—(C3-C6-cycloalkyl), or —(CH2)rOCH3, wherein R3 is —NH2, —NH—R4, —NHC(═O)—R4, —NHC(═O)NH—R4, —NHC(═S)—R4 or —NHC(═S)NH—R4, wherein R4 is selected from a cycloalkyl, a heterocycle, a aryl or a heteroaryl, or -L-R5, wherein L is selected from C1-C5-alkyl, a cycloalkyl, a heterocycle, a aryl, or a heteroaryl, and R5 is selected from —OH, —CH2OH, —NH2, —COOH, —CONH2, —CONH—R6 or carboxylic acid isosteres, wherein R6 is selected from C1-C4-alkyl, with n, m and r being 0, 1, 2, 3, 4 or 5 and their use.

10. 发明授权

US10300048B2 Thiazolidinones as cellular anandamide uptake inhibitors and their use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation 有权
公开(公告)号：US10300048B2
公开(公告)日：2019-05-28
申请号：US15314105
申请日：2015-05-28
申请人： UNIVERSITAT BERN
发明人： Jean-Louis Reymond , Jurg Gertsch , Simon Nicolussi
IPC分类号： A61K31/426 , A61K31/427
摘要： The invention relates to a compound comprising the following general formula (1) for use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation: (1) wherein each of R1, R2 and R3 are selected independently from each other from alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, aryl, heterocycle or heteroaryl.

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