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1. 发明授权

US08389958B2 Up and down conversion systems for production of emitted light from various energy sources 有权
标题翻译：用于生产来自各种能源的发射光的上下转换系统
公开(公告)号：US08389958B2
公开(公告)日：2013-03-05
申请号：US12725108
申请日：2010-03-16
申请人： Tuan Vo-Dinh , Jonathan P. Scaffidi , Venkata Gopal Reddy Chada , Benoit Lauly , Yan Zhang , Molly K. Gregas , Ian Nicholas Stanton , Joshua T. Stecher , Michael J. Therien , Frederic A. Bourke, Jr. , Zak Fathi , Jennifer Ann Ayres , Zhenyuan Zhang , Joseph H. Simmons , Stephen John Norton
发明人： Tuan Vo-Dinh , Jonathan P. Scaffidi , Venkata Gopal Reddy Chada , Benoit Lauly , Yan Zhang , Molly K. Gregas , Ian Nicholas Stanton , Joshua T. Stecher , Michael J. Therien , Frederic A. Bourke, Jr. , Zak Fathi , Jennifer Ann Ayres , Zhenyuan Zhang , Joseph H. Simmons , Stephen John Norton
IPC分类号： G01J1/58
CPC分类号： F21K2/00 , A61L2/08 , A61L2202/22 , A61N5/062 , B82Y20/00 , B82Y30/00 , G01N21/63 , G02B5/003 , G02F2/02 , Y10T428/25 , Y10T428/256
摘要： A system for energy upconversion and/or down conversion and a system for producing a photostimulated reaction in a medium. These systems include 1) a nanoparticle configured, upon exposure to a first wavelength λ1 of radiation, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1 and 2) a metallic structure disposed in relation to the nanoparticle. A physical characteristic of the metallic structure is set to a value where a surface plasmon resonance in the metallic structure resonates at a frequency which provides a spectral overlap with either the first wavelength λ1 or the second wavelength λ2, or with both λ1 and λ2. The system for producing a photostimulated reaction in a medium includes a receptor disposed in the medium in proximity to the nanoparticle which, upon activation by the second wavelength λ2, generates the photostimulated reaction.
摘要翻译：一种用于能量上转换和/或下转换的系统和用于在介质中产生光刺激反应的系统。这些系统包括1）在暴露于辐射的第一波长λ1时配置的纳米颗粒，以产生具有比第一波长λ1更高的能量的辐射的第二波长λ2，和2）相对于纳米颗粒设置的金属结构。金属结构的物理特性被设定为金属结构中的表面等离子体共振在以与第一波长λ1或第二波长λ2或与λ1和λ2两者提供光谱重叠的频率谐振的值。用于在培养基中产生光刺激反应的系统包括设置在接近纳米颗粒的培养基中的受体，其在第二波长λ2激活时产生光刺激反应。

2. 发明申请

US20100016783A1 NON-INVASIVE SYSTEMS AND METHODS FOR IN-SITU PHOTOBIOMODULATION 审中-公开
标题翻译：非入侵系统和用于现场光电转换的方法
公开(公告)号：US20100016783A1
公开(公告)日：2010-01-21
申请号：US12417779
申请日：2009-04-03
申请人： Frederic J. BOURKE, JR. , Tuan Vo-Dinh , Harold Walder
发明人： Frederic J. BOURKE, JR. , Tuan Vo-Dinh , Harold Walder
IPC分类号： A61M37/00 , A61B18/18 , A61B18/04 , A61P35/00 , A61P25/00 , A61P37/00 , A61P17/02 , A61P19/08 , A61P31/00 , A61K33/38 , A61K33/24 , A61N5/10 , A61N5/06
CPC分类号： A61N5/062 , A61K41/0057 , A61K41/0061 , A61K47/6923 , A61N5/022 , A61N5/0618 , A61N5/0622 , A61N5/10 , A61N2005/0642 , A61N2005/0659 , A61N2005/0661 , A61N2005/0662 , A61N2005/1098
摘要： Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
摘要翻译：用于修饰介导或与生物活性相关的靶结构的产物，组合物，系统和方法，包括治疗由病毒，细胞，亚细胞结构介导或与靶结构相关的疾病，病症或疾病或胞外结构。所述方法可以通过向受试者施加起始能量以非侵入性方式原位进行，从而直接或经由调节剂产生对靶结构的作用或改变。所述方法还可以通过向受试者原位施加引发能量来直接或经由能量调节剂活化药剂，任选地在一种或多种等离子体激活剂活性剂的存在下进行，从而产生对其的作用或改变目标结构。包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。

3. 发明授权

US06422998B1 Fractal analysis of time varying data 失效
标题翻译：时变数据的分形分析
公开(公告)号：US06422998B1
公开(公告)日：2002-07-23
申请号：US09398703
申请日：1999-09-20
申请人： Tuan Vo-Dinh , Ajit Sadana
发明人： Tuan Vo-Dinh , Ajit Sadana
IPC分类号： A61B500
CPC分类号： G06F17/17
摘要： Characteristics of time varying data, such as an electrical signal, are analyzed by converting the data from a temporal domain into a spatial domain pattern. Fractal analysis is performed on the spatial domain pattern, thereby producing a fractal dimension DF. The fractal dimension indicates the regularity of the time varying data.
摘要翻译：通过将来自时域的数据转换为空间域模式来分析诸如电信号的时变数据的特性。对空间域图案进行分形分析，从而产生分形维数DF。分形维数表示时变数据的规律性。

4. 发明授权

US06219137B1 Nanoprobe for surface-enhanced Raman spectroscopy in medical diagnostic and drug screening 失效
标题翻译：用于医学诊断和药物筛选的表面增强拉曼光谱的纳米探针
公开(公告)号：US06219137B1
公开(公告)日：2001-04-17
申请号：US09205773
申请日：1998-12-03
申请人： Tuan Vo-Dinh
发明人： Tuan Vo-Dinh
IPC分类号： G01J344
CPC分类号： G01N21/658 , A61B5/0075 , A61B5/0084 , A61B5/0086 , G01J3/44 , Y10S436/801 , Y10S436/805
摘要： A probe for a surface-enhanced Raman scattering spectrometer is provided for injection into a cell in order to detect trace amounts of a compound within that cell. The probe has a spherical shape with a diameter less than one micrometer and preferably in the 10-500 nanometer range. The nanoprobes can have a receptor coating related to the specific compound to be detected by the probe. A process for producing, injecting and utilizing the nanoprobes are described.
摘要翻译：提供了用于表面增强拉曼散射光谱仪的探针，用于注入细胞，以便检测该细胞内微量的化合物。探针具有直径小于1微米，优选在10-500纳米范围内的球形形状。纳米探针可以具有与要由探针检测的特定化合物相关的受体涂层。描述了制备，注入和利用纳米探针的方法。

5. 发明授权

US5938617A Advanced synchronous luminescence system for the detection of biological agents and infectious pathogens 失效
标题翻译：先进的同步发光系统，用于检测生物制剂和感染性病原体
公开(公告)号：US5938617A
公开(公告)日：1999-08-17
申请号：US760165
申请日：1996-12-03
申请人： Tuan Vo-Dinh
发明人： Tuan Vo-Dinh
IPC分类号： A61B5/00 , G01J3/12 , G01N21/64 , A61B6/00
CPC分类号： G01N21/6402 , A61B5/0059 , G01J3/1256 , G01N21/6456 , G01N21/6486
摘要： A method and apparatus for detecting and identifying biological pathogens in a sample includes exposing the sample to an excitation radiation and thereby generating an emission radiation, synchronously scanning the wavelength of the excitation radiation and the wavelength of the emission radiation to produce a spectrum, and correlating the spectrum to a biological pathogen in the sample. In another aspect, a method and apparatus for imaging chemical and biological agents in a sample includes exposing the sample to an excitation radiation and thereby generating an emission radiation and synchronously imaging the wavelength of the excitation radiation and the wavelength of the emission radiation to produce an imaged spectrum.
摘要翻译：用于检测和识别样品中生物病原体的方法和装置包括将样品暴露于激发辐射，从而产生发射辐射，同步扫描激发辐射的波长和发射辐射的波长以产生光谱，并且将相关样品中生物病原体的光谱。在另一方面，用于对样品中的化学和生物试剂进行成像的方法和装置包括将样品暴露于激发辐射，从而产生发射辐射并同步成像激发辐射的波长和发射辐射的波长，以产生成像光谱。

6. 发明授权

US5599717A Advanced synchronous luminescence system 失效
标题翻译：先进的同步发光系统
公开(公告)号：US5599717A
公开(公告)日：1997-02-04
申请号：US300202
申请日：1994-09-02
申请人： Tuan Vo-Dinh
发明人： Tuan Vo-Dinh
IPC分类号： A61B5/00 , G01J3/12 , G01N21/64
CPC分类号： G01N21/6402 , A61B5/0059 , G01J3/1256 , G01N21/6456 , G01N21/6486
摘要： A method and apparatus for determining the condition of tissue or otherwise making chemical identifications includes exposing the sample to a light source, and using a synchronous luminescence system to produce a spectrum that can be analyzed for tissue condition.
摘要翻译：用于确定组织状况或以其他方式进行化学鉴定的方法和装置包括将样品暴露于光源，并使用同步发光系统产生可分析组织状况的光谱。

7. 发明授权

US5579773A Laser-induced differential normalized fluorescence method for cancer diagnosis 失效
标题翻译：激光诱导的差异归一化荧光法用于癌症诊断
公开(公告)号：US5579773A
公开(公告)日：1996-12-03
申请号：US316132
申请日：1994-09-30
申请人： Tuan Vo-Dinh , Masoud Panjehpour , Bergein F. Overholt
发明人： Tuan Vo-Dinh , Masoud Panjehpour , Bergein F. Overholt
IPC分类号： A61B10/00 , A61B1/00 , A61B5/00 , A61B6/00
CPC分类号： A61B5/0084 , A61B5/0071 , A61B5/4233 , A61B5/0075 , A61B5/7239
摘要： An apparatus and method for cancer diagnosis are disclosed. The diagnostic method includes the steps of irradiating a tissue sample with monochromatic excitation light, producing a laser-induced fluorescence spectrum from emission radiation generated by interaction of the excitation light with the tissue sample, and dividing the intensity at each wavelength of the laser-induced fluorescence spectrum by the integrated area under the laser-induced fluorescence spectrum to produce a normalized spectrum. A mathematical difference between the normalized spectrum and an average value of a reference set of normalized spectra which correspond to normal tissues is calculated, which provides for amplifying small changes in weak signals from malignant tissues for improved analysis. The calculated differential normalized spectrum is correlated to a specific condition of a tissue sample.
摘要翻译：公开了一种用于癌症诊断的装置和方法。诊断方法包括以下步骤：用单色激发光照射组织样本，通过激发光与组织样本的相互作用产生的发射辐射产生激光诱导荧光光谱，并将激光诱导的每个波长的强度除以荧光光谱由激光诱导荧光光谱下的积分面积产生归一化光谱。计算归一化光谱与对应于正常组织的归一化光谱参考组的平均值之间的数学差异，其提供用于扩增来自恶性组织的弱信号的小变化以进行改进的分析。所计算的差分归一化光谱与组织样品的特定条件相关。

8. 发明授权

US5176881A Fiber optic-based regenerable biosensor 失效
标题翻译：基于光纤的可再生生物传感器
公开(公告)号：US5176881A
公开(公告)日：1993-01-05
申请号：US765579
申请日：1991-09-25
申请人： Michael J. Sepaniak , Tuan Vo-Dinh
发明人： Michael J. Sepaniak , Tuan Vo-Dinh
IPC分类号： A61B5/00 , G01N21/77 , G01N21/85 , G01N33/543
CPC分类号： A61B5/0084 , G01N21/7703 , G01N21/8507 , G01N33/54373 , A61B5/0071 , G01N2021/6434 , G01N2021/7733
摘要： A fiber optic-based regenerable biosensor. The biosensor is particularly suitable for use in microscale work in situ. In one embodiment, the biosensor comprises a reaction chamber disposed adjacent the distal end of a waveguide and adapted to receive therein a quantity of a sample containing an analyte. Leading into the chamber is a plurality of capillary conduits suitable for introducing into the chamber antibodies or other reagents suitable for selective interaction with a predetermined analyte. Following such interaction, the contents of the chamber may be subjected to an incident energy signal for developing fluorescence within the chamber that is detectable via the optical fiber and which is representative of the presence, i.e. concentration, of the selected analyte. Regeneration of the biosensor is accomplished by replacement of the reagents and/or the analyte, or a combination of these, at least in part via one or more of the capillary conduits. The capillary conduits extend from their respective terminal ends that are in fluid communication with the chamber, away from the chamber to respective location(s) remote from the chamber thereby permitting in situ location of the chamber and remote manipulation and/or analysis of the activity with the chamber.
摘要翻译：一种基于光纤的可再生生物传感器。生物传感器特别适用于原位微量工作。在一个实施例中，生物传感器包括邻近波导的远端设置的反应室，并适于在其中接收一定量的含有分析物的样品。进入腔室的是多个毛细管道，其适于将腔室内的抗体或适于与预定分析物的选择性相互作用的其它试剂引入。在这种相互作用之后，腔室的内容物可以经受入射能量信号，用于在室内发展可通过光纤检测的荧光，并且其代表所选分析物的存在即浓度。生物传感器的再生是通过至少部分地经由一个或多个毛细管道替换试剂和/或分析物或它们的组合而实现的。毛细导管从其相应的终端延伸，其与腔室流体连通，远离腔室到远离腔室的相应位置，从而允许腔室的原位位置，并且对活动进行远程操作和/或分析与房间。

9. 发明授权

US4999810A Surface-enhanced raman optical data storage system 失效
标题翻译：表面增强型拉曼光学数据存储系统
公开(公告)号：US4999810A
公开(公告)日：1991-03-12
申请号：US423995
申请日：1989-10-19
申请人： Tuan Vo-Dinh
发明人： Tuan Vo-Dinh
IPC分类号： G11B7/004
CPC分类号： G11B7/004
摘要： A method and apparatus for a Surface-Enhanced Raman Optical Data Storage (SERODS) System is disclosed. A medium which exhibits the Surface Enhanced Raman Scattering (SERS) phenomenon has data written onto its surface of microenvironment by means of a write-on procedure which disturbs the surface or microenvironment of the medium and results in the medium having a changed SERS emission when excited. The write-on procedure is controlled by a signal that corresponds to the data to be stored so that the disturbed regions on the storage device (e.g., disk) represent the data. After the data is written onto the storage device it is read by exciting the surface of the storage device with an appropriate radiation source and detecting changes in the SERS emission to produce a detection signal. The data is then reproduced from the detection signal.
摘要翻译：公开了一种用于表面增强拉曼光数据存储（SERODS）系统的方法和装置。表现出表面增强拉曼散射（SERS）现象的介质通过写入过程写入微环境表面的数据，该写入程序干扰介质的表面或微环境，并导致当激发时具有改变的SERS发射的介质。写入过程由对应于要存储的数据的信号控制，使得存储设备（例如，盘）上的干扰区域表示数据。在将数据写入存储装置之后，通过用适当的辐射源激励存储装置的表面并检测SERS发射的变化以产生检测信号来读取。然后从检测信号再现数据。

10. 发明授权

US09302116B2 Non-invasive energy upconversion methods and systems for in-situ photobiomodulation 有权
标题翻译：用于原位光生物调节的非侵入性能量上转换方法和系统
公开(公告)号：US09302116B2
公开(公告)日：2016-04-05
申请号：US12764184
申请日：2010-04-21
申请人： Tuan Vo-Dinh , Jonathan P. Scaffidi , Venkata Gopal Reddy Chada , Benoit Lauly , Yan Zhang , Molly K. Gregas , Ian N. Stanton , Joshua T. Stecher , Michael J. Therien , Frederic A. Bourke, Jr. , Harold Walder , Zak Fathi , Jennifer A. Ayres , Zhenyuan Zhang , Joseph H. Simmons , Stephen John Norton
发明人： Tuan Vo-Dinh , Jonathan P. Scaffidi , Venkata Gopal Reddy Chada , Benoit Lauly , Yan Zhang , Molly K. Gregas , Ian N. Stanton , Joshua T. Stecher , Michael J. Therien , Frederic A. Bourke, Jr. , Harold Walder , Zak Fathi , Jennifer A. Ayres , Zhenyuan Zhang , Joseph H. Simmons , Stephen John Norton
IPC分类号： A61N5/06 , A61K49/00 , A61L2/08 , A61N1/40 , A61N5/02
CPC分类号： A61N5/062 , A61B5/0059 , A61B5/0071 , A61B5/055 , A61B5/4848 , A61B6/481 , A61K41/0042 , A61K41/0052 , A61K41/0061 , A61K49/0039 , A61L2/0047 , A61L2/08 , A61L2202/21 , A61L2202/22 , A61M5/007 , A61N1/406 , A61N5/02 , A61N5/0601 , A61N5/0618 , A61N5/0622 , A61N5/0624 , A61N5/10 , A61N2005/063 , A61N2005/0656 , A61N2005/0659 , A61N2005/0662 , A61N2005/067 , A61N2005/1098
摘要： Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
摘要翻译：用于修饰介导或与生物活性相关的靶结构的产物，组合物，系统和方法，包括治疗由病毒，细胞，亚细胞结构介导或与靶结构相关的疾病，病症或疾病或胞外结构。所述方法可以以非侵入性方式在原位进行，通过将具有金属壳的纳米颗粒放置在受试者的靶结构附近的表面的至少一部分上，并向受试者施加引发能量，从而产生直接或通过调制剂对目标结构的影响或改变。纳米颗粒在暴露于第一波长λ1时被配置为产生具有比第一波长λ1更高的能量的辐射的第二波长λ2。所述方法还可以通过向受试者原位施加引发能量来直接或经由能量调节剂活化药剂，任选地在一种或多种等离子体激活剂活性剂的存在下进行，从而产生对其的作用或改变目标结构。包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。

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