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1. 发明授权

US09278944B2 Nitrogen-containing saturated heterocyclic compound 有权
标题翻译：含氮饱和杂环化合物
公开(公告)号：US09278944B2
公开(公告)日：2016-03-08
申请号：US14005512
申请日：2012-03-15
申请人： Toru Iijima , Hiroshi Sugama , Takayuki Kawaguchi , Jingkang Shen , Guangxin Xia , Jianshu Xie , Miki Hirai
发明人： Toru Iijima , Hiroshi Sugama , Takayuki Kawaguchi , Jingkang Shen , Guangxin Xia , Jianshu Xie , Miki Hirai
IPC分类号： C07D241/36 , C07D265/30 , C07D403/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D471/04 , C07D231/56
CPC分类号： C07D265/30 , C07D231/56 , C07D403/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D471/04
摘要： The present invention provides a nitrogen-containing saturated heterocyclic compound of the formula [I]: wherein R1 is a cycloalkyl group and the like, R22 is an optionally substituted aryl and the like, R is a lower alkyl and the like, T is a carbonyl group, Z is —O— and the like, and R3 to R6 are the same or different and a hydrogen atom and the like; or a pharmaceutically acceptable salt, that is useful as a renin inhibitor.
摘要翻译：本发明提供式[I]的含氮饱和杂环化合物：其中R 1为环烷基等，R 22为任意取代的芳基等，R为低级烷基等，T为羰基，Z为-O-等，R3〜R6相同或不同，为氢原子等; 或药学上可接受的盐，其可用作肾素抑制剂。

2. 发明授权

US08762514B2 Load-testing device and load-testing method 有权
标题翻译：负载测试装置和负载测试方法
公开(公告)号：US08762514B2
公开(公告)日：2014-06-24
申请号：US12047512
申请日：2008-03-13
申请人： Toru Iijima
发明人： Toru Iijima
IPC分类号： G06F15/173 , G06F11/00
CPC分类号： G06F11/3414 , G06F11/3419 , G06F11/3433
摘要： The performances of computers having various configurations are compared by putting a common load on the computers. Servers (2-1 to 2-n) provide a simulator (4) with a common interface for accepting a processing request. The simulator (4) sequentially sends a processing request in which the contents of the processing is specified to each of the servers (2-1 to 2-n). According to the processing requests, the servers (2-1 to 2-n) perform the processings and send processing responses to the simulator (4). The simulator (4) receives the processing responses, compiles the processing times each from the sending of a processing request to the reception of the processing responses corresponding to the processing request, the usage rates of various resources in the servers (2), etc., and displays the compiled results to the user.
摘要翻译：通过在计算机上放置共同的负载来比较具有各种配置的计算机的性能。服务器（2-1至2-n）提供具有用于接受处理请求的公共接口的模拟器（4）。模拟器（4）顺序地发送处理请求，其中处理的内容被指定给每个服务器（2-1至2-n）。根据处理请求，服务器（2-1至2-n）执行处理并向模拟器（4）发送处理响应。模拟器（4）接收处理响应，从处理请求的发送到对应于处理请求的处理响应的接收，服务器（2）中的各种资源的使用率等编译处理时间。，并将编译结果显示给用户。

3. 发明申请

US20100240644A1 MORPHOLINE DERIVATIVE 有权
标题翻译：吗啉衍生物
公开(公告)号：US20100240644A1
公开(公告)日：2010-09-23
申请号：US12664637
申请日：2008-06-16
申请人： Hidenori Akatsuka , Hiroshi Sugama , Nobumasa Awai , Takayuki Kawaguchi , Yoichi Takahashi , Toru Iijima , Jingkang Shen , Guangxin Xia , Jianshu Xie
发明人： Hidenori Akatsuka , Hiroshi Sugama , Nobumasa Awai , Takayuki Kawaguchi , Yoichi Takahashi , Toru Iijima , Jingkang Shen , Guangxin Xia , Jianshu Xie
IPC分类号： A61K31/538 , C07D265/30 , A61K31/5375 , C07D265/36 , C07D413/12 , A61K31/5377 , C07D409/12 , A61K31/5355 , A61P9/12
CPC分类号： C07D265/30 , C07D209/08 , C07D209/14 , C07D209/30 , C07D209/34 , C07D209/42 , C07D231/56 , C07D265/36 , C07D403/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present invention provides a morpholine derivative of the formula [I]; wherein R1 is a substituted alkyl group, an optionally substituted aryl group, an optionally substituted heterocyclo group, a cycloalkyl group or an alkyl group; R2 is a substituted alkyl group, an optionally substituted aryl group, an optionally substituted heterocyclo group, an optionally substituted alkylcarbonyl group, an optionally substituted arylcarbonyl group, an optionally substituted heterocyclo-substituted carbonyl group or a cycloalkylcarbonyl group; T is a methylene group or a carbonyl group; R3, R4, R5 and R6 are the same or different and a hydrogen atom, an optionally substituted carbamoyl group or an optionally substituted alkyl group; or pharmaceutically acceptable salts thereof. These compounds are useful as a renin inhibitor.
摘要翻译：本发明提供式[I]的吗啉衍生物。其中R1是取代的烷基，任选取代的芳基，任选取代的杂环基，环烷基或烷基; R 2是取代的烷基，任选取代的芳基，任选取代的杂环基，任选取代的烷基羰基，任选取代的芳基羰基，任选取代的杂环取代的羰基或环烷基羰基; T是亚甲基或羰基; R3，R4，R5和R6相同或不同，氢原子，任选取代的氨基甲酰基或任选取代的烷基; 或其药学上可接受的盐。这些化合物可用作肾素抑制剂。

4. 发明授权

US07514449B2 Fused furan compound 失效
标题翻译：稠化呋喃化合物
公开(公告)号：US07514449B2
公开(公告)日：2009-04-07
申请号：US10540878
申请日：2004-01-08
申请人： Takayuki Kawaguchi , Hidenori Akatsuka , Toru Iijima , Tatsuya Watanabe , Jun Murakami , Takashi Mitsui
发明人： Takayuki Kawaguchi , Hidenori Akatsuka , Toru Iijima , Tatsuya Watanabe , Jun Murakami , Takashi Mitsui
IPC分类号： A61K31/444 , C07D491/048
CPC分类号： C07D491/04 , C07D213/75
摘要： The present invention provides a condensed furan compound of the formula (I): wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted saturated heterocyclic group, an optionally substituted unsaturated heterocyclic group; A is a single bond, lower alkylene, lower alkenylidene, lower alkenylene or an oxygen atom; R3 is hydrogen or the like; and, R4 is hydrogen, or the like, or pharmaceutically acceptable salts thereof, which is useful as a medicament, particularly, as an activated blood coagulation factor X inhibitor.
摘要翻译：本发明提供式（I）的缩合呋喃化合物：其中环X为苯，吡啶等; Y是任选取代的氨基，任选取代的环烷基，任选取代的芳基，任选取代的饱和杂环基，任选取代的不饱和杂环基; A是单键，低级亚烷基，低级亚烯基，低级亚烯基或氧原子; R3是氢等; 和R4为氢等，或其药学上可接受的盐，其可用作药物，特别是活性凝血因子X抑制剂。

5. 发明申请

US20090023716A1 Benzoxazines and Related Nitrogen-Containing Heterobicyclic Compounds Useful as Mineralocorticoid Receptor Modulating Agents 有权
标题翻译：可用作盐皮质激素受体调节剂的苯并恶嗪和相关含氮的杂环化合物
公开(公告)号：US20090023716A1
公开(公告)日：2009-01-22
申请号：US12162779
申请日：2007-02-01
申请人： Toru Iijima , Yasuo Yamamoto , Hidenori Akatsuka , Takayuki Kawaguchi
发明人： Toru Iijima , Yasuo Yamamoto , Hidenori Akatsuka , Takayuki Kawaguchi
IPC分类号： A61K31/538 , C07D265/36 , A61P9/00
CPC分类号： C07D265/36 , C07D279/16 , C07D413/04
摘要： The present invention relates to a compound, useful as a mineralocorticoid receptor-modulating agent, of the following formula [I]: wherein Ring A is a benzene ring optionally having a substituent(s) other than R1 etc, R1 is a group of the formula: RaSO2NH— etc, Ra is an alkyl group etc, R2 and R3 are each a hydrogen atom, a phenyl group, an optionally substituted alkyl group etc, X is an oxygen atom etc, Y is a group of the formula: —C(═O)— etc, Ar is an optionally substituted aryl group or an optionally substituted heteroaryl group, Q is a single bond, an alkylene group etc, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及可用作以下式[I]的盐皮质激素受体调节剂的化合物：其中环A为任选具有除R1等以外的取代基的苯环，R1为式：R a SO 2 NH-等，R a为烷基等，R 2和R 3各自为氢原子，苯基，任意取代的烷基等，X为氧原子等，Y为下式基团-C （-O） - 等，Ar是任选取代的芳基或任选取代的杂芳基，Q是单键，亚烷基等，或其药学上可接受的盐。

6. 发明申请

US20050282808A1 Benzofuran derivative 失效
标题翻译：苯并呋喃衍生物
公开(公告)号：US20050282808A1
公开(公告)日：2005-12-22
申请号：US10508512
申请日：2003-03-27
申请人： Takayuki Kawaguchi , Hidenori Akatsuka , Toru Iijima , Yasunori Tsuboi , Takashi Mitsui , Jun Murakami
发明人： Takayuki Kawaguchi , Hidenori Akatsuka , Toru Iijima , Yasunori Tsuboi , Takashi Mitsui , Jun Murakami
IPC分类号： A61P7/02 , C07D307/85 , C07D405/04 , C07D405/12 , C07D405/14 , A61K31/551 , A61K31/343 , A61K31/443 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377
CPC分类号： C07D413/14 , C07D307/85 , C07D405/12 , C07D405/14 , C07D417/14
摘要： The present invention provides a benzofuran derivative of the formula [1]: wherein x is a group of the formula: —N═ or —CH═; Y is an optionally substituted amino group, an optionally substituted cycloalkyl group or an optionally substituted saturated heterocyclic group; A is a single bond, a carbon chain optionally having a double bond within or at the end(s) of the chain, or an oxygen atom; R1 is a hydrogen atom or a halogen atom; Ring B is an optionally substituted benzene ring; and R3 is a hydrogen atom, or a pharmaceutically acceptable salt thereof, which is useful as a medicament, especially as an activated blood coagulation factor X inhibitor.
摘要翻译：本发明提供式[1]的苯并呋喃衍生物：其中x是下式的基团：-N-或-CH-; Y是任选取代的氨基，任选取代的环烷基或任选取代的饱和杂环基; A是单键，在链的末端或其末端具有双键的碳链或氧原子; R 1是氢原子或卤素原子; 环B是任选取代的苯环; R 3是氢原子或其药学上可接受的盐，其可用作药物，特别是作为活化凝血因子X抑制剂。

7. 发明授权

US6150018A Conductive flooring installation method and electroconductive welding rod 失效
标题翻译：导电地板安装方法和导电焊条
公开(公告)号：US6150018A
公开(公告)日：2000-11-21
申请号：US804395
申请日：1991-12-10
申请人： Toru Iijima , Rikio Sugimoto , Eiichi Tajima
发明人： Toru Iijima , Rikio Sugimoto , Eiichi Tajima
IPC分类号： B29C65/12 , B29C65/50 , E04F15/02 , D02G3/00
CPC分类号： B29C65/125 , B29C65/4815 , B29C65/4855 , B29C65/5035 , B29C66/1142 , B29C66/43 , E04F15/02016 , B29C66/435 , B29L2031/732 , Y10T428/12014 , Y10T428/1209 , Y10T428/2933 , Y10T428/2938
摘要： A method for installing an electroconductive flooring and an electroconductive welding rod for use in this method are disclosed. The electroconductive welding rod is composed of a joint material including as the main component a thermoplastic resin composition of a ribbon-shape or a rod-shape, with the peripheral surface thereof being coated with an electroconductive coating material. The method for installing the electroconductive flooring is composed of the steps of laying flooring sheets in mutual contact and cutting joint-forming grooves, or laying the flooring sheets with spaces therebetween for the formation of the joints of the adjacent flooring sheets, softening the electroconductive welding rod, filling the softened electroconductive welding rod into the grooves or the spaces between the flooring sheets, and welding the adjacent flooring sheets to form joints, whereby the flooring sheets are electrically integrated.
摘要翻译：公开了一种用于安装用于该方法的导电地板和导电焊条的方法。导电焊条由包括主要组分的带状或棒状的热塑性树脂组合物的接合材料组成，其外周表面涂覆有导电涂层材料。用于安装导电地板的方法包括以下步骤：铺设相互接触的地板和切割接合成形槽，或者将地板铺设在其间的空间以形成相邻地板的接头，软化导电焊接将软化的导电焊条填充到凹槽或地板之间的空间中，并焊接相邻的地板以形成接头，由此将地板进行电气集成。

8. 发明授权

US08975252B2 Morpholine derivative 有权
标题翻译：吗啉衍生物
公开(公告)号：US08975252B2
公开(公告)日：2015-03-10
申请号：US12664637
申请日：2008-06-16
申请人： Hidenori Akatsuka , Hiroshi Sugama , Nobumasa Awai , Takayuki Kawaguchi , Yoichi Takahashi , Toru Iijima , Jingkang Shen , Guangxin Xia , Jianshu Xie
发明人： Hidenori Akatsuka , Hiroshi Sugama , Nobumasa Awai , Takayuki Kawaguchi , Yoichi Takahashi , Toru Iijima , Jingkang Shen , Guangxin Xia , Jianshu Xie
IPC分类号： A61K31/535 , C07D265/30 , C07D209/08 , C07D209/14 , C07D209/30 , C07D209/34 , C07D209/42 , C07D231/56 , C07D265/36 , C07D403/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
CPC分类号： C07D265/30 , C07D209/08 , C07D209/14 , C07D209/30 , C07D209/34 , C07D209/42 , C07D231/56 , C07D265/36 , C07D403/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present invention provides a morpholine derivative of the formula [I]; wherein R1 is a substituted alkyl group, an optionally substituted aryl group, an optionally substituted heterocyclo group, a cycloalkyl group or an alkyl group; R2 is a substituted alkyl group, an optionally substituted aryl group, an optionally substituted heterocyclo group, an optionally substituted alkylcarbonyl group, an optionally substituted arylcarbonyl group, an optionally substituted heterocyclo-substituted carbonyl group or a cycloalkylcarbonyl group; T is a methylene group or a carbonyl group; R3, R4, R5 and R6 are the same or different and a hydrogen atom, an optionally substituted carbamoyl group or an optionally substituted alkyl group; or pharmaceutically acceptable salts thereof. These compounds are useful as a renin inhibitor.
摘要翻译：本发明提供式[I]的吗啉衍生物。其中R1是取代的烷基，任选取代的芳基，任选取代的杂环基，环烷基或烷基; R 2是取代的烷基，任选取代的芳基，任选取代的杂环基，任选取代的烷基羰基，任选取代的芳基羰基，任选取代的杂环取代的羰基或环烷基羰基; T是亚甲基或羰基; R3，R4，R5和R6相同或不同，氢原子，任选取代的氨基甲酰基或任选取代的烷基; 或其药学上可接受的盐。这些化合物可用作肾素抑制剂。

9. 发明授权

US08258131B2 Fused bicyclic compound 有权
标题翻译：稠合双环化合物
公开(公告)号：US08258131B2
公开(公告)日：2012-09-04
申请号：US12671479
申请日：2008-07-21
申请人： Yoichi Takahashi , Nobumasa Awai , Hidenori Akatsuka , Takayuki Kawaguchi , Toru Iijima
发明人： Yoichi Takahashi , Nobumasa Awai , Hidenori Akatsuka , Takayuki Kawaguchi , Toru Iijima
IPC分类号： C07D265/16 , A61K31/352 , A61K31/353
CPC分类号： C07D265/16 , C07D311/20 , C07D311/58 , C07D311/96 , C07D405/14 , C07D413/04
摘要： The present invention provides a novel fused bicyclic compound having an affinity to a receptor of mineral corticoid (MR), shown by the formula [I]: wherein the ring A is a benzene ring having a substituent R1, fused to an adjacent 6-membered heterocyclic ring and further optionally having a substituent(s) other than R1, R1 is an alkylsulfonylamino group etc., R2 and R3 are (a) the same of different and a hydrogen atom, an alkyl group or a substituted or unsubstituted aryl group, (b) combined each other to form an oxo group or (c) combined each other at its terminal together with the adjacent carbon atom to form a cycloalkyl group, X is a group of ═N—, ═C(R4)— or —CH(R4)—, R4 is (a) a hydrogen atom, (b) a cyano group, (c) a halogen atom, (d) an alkyl group, (e) an alkenyl group, (f) a cycloalkyl group (g) an alkanoyl group, (h) a carbamoyl group or (i) a cycloalkenyl group, Ar is an optionally substituted aromatic cyclic group and a dotted line means presence or absence of a double bond, or a pharmaceutically acceptable salt thereof, which is useful as an antihypertensive agent etc.
摘要翻译：本发明提供了对式[I]所示的对矿物质类皮质激素（MR）的受体具有亲和性的新的稠合双环化合物：其中环A是具有取代基R 1的苯环，与相邻的6元杂环，并且还可任选地具有除R1以外的取代基，R 1是烷基磺酰基氨基等，R 2和R 3是（a）不同的，和氢原子，烷基或取代或未取代的芳基，（b）彼此组合以形成氧代基团，或（c）在其末端与相邻的碳原子一起相互结合形成环烷基，X是一个= N - ， - C（R 4） - 或 - CH（R4） - ，R4是（a）氢原子，（b）氰基，（c）卤原子，（d）烷基，（e）烯基，（f）环烷基 g）烷酰基，（h）氨基甲酰基或（i）环烯基，Ar是任选取代的芳环基，虚线表示存在或不存在双键或其药学上可接受的盐，其可用作抗高血压剂等。

10. 发明授权

US07605158B2 Carbamoyl-type benzofuran derivatives 失效
标题翻译：氨基甲酰型苯并呋喃衍生物
公开(公告)号：US07605158B2
公开(公告)日：2009-10-20
申请号：US10571904
申请日：2004-09-24
申请人： Takayuki Kawaguchi , Hidenori Akatsuka , Masamichi Morimoto , Tatsuya Watanabe , Toru Iijima , Jun Murakami
发明人： Takayuki Kawaguchi , Hidenori Akatsuka , Masamichi Morimoto , Tatsuya Watanabe , Toru Iijima , Jun Murakami
IPC分类号： A61K31/5355 , A61K31/443 , C07D413/04 , C07D401/12 , C07D307/85
CPC分类号： C07D405/12 , C07D405/14
摘要： The present invention provides a carbamoyl-type benzofuran derivative of the formula [1]: wherein Ring Z is a group of the formula: etc.; A is a single bond, and the like; Y is a cycloalkanediyl group, etc.; R4 and R5 are the same or different and each is an optionally substituted lower alkyl group, etc.; R1 is a halogen atom, etc.; Ring B of the formula: is an optionally substituted benzene ring; and R3 is a hydrogen atom. etc., or a pharmaceutically acceptable salt thereof, which is useful as an FXa inhibitor.
摘要翻译：本发明提供式[1]的氨基甲酰基型苯并呋喃衍生物：其中环Z是下式的基团：等等; A是单键等; Y是环烷二基等; R4和R5相同或不同，各自为任选取代的低级烷基等; R1是卤素原子等; 下式的环B是任选取代的苯环; R3为氢原子。等等，或其药学上可接受的盐，其可用作FXa抑制剂。

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