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1. 发明申请

US20120247577A1 FLUID HANDLING APPARATUS AND FLUID HANDLING SYSTEM 有权
标题翻译：流体处理装置和流体处理系统
公开(公告)号：US20120247577A1
公开(公告)日：2012-10-04
申请号：US13438261
申请日：2012-04-03
申请人： Tomoki NAKAO , Koichi Ono
发明人： Tomoki NAKAO , Koichi Ono
IPC分类号： F16L53/00
CPC分类号： G01N27/44791 , B01L3/502707 , Y10T137/2224 , Y10T137/6606
摘要： Bottomed first regions 23a′ and 23b′, and second regions 24a′ and 24b′ are formed by joining film 14 to undersurface 21 of chip body 12 of a micro-channel chip. Third regions 25a′ and 25b′ are formed between first regions 23a′ and 23b′, and second regions 24a′ and 24b′ so as to be located on carbon inks 16a and 16b. The width of third regions 25a′ and 25b′ is formed so as to be greater than the width of carbon inks 16a and 16b.
摘要翻译：底部的第一区域23a'和23b'以及第二区域24a'和24b'通过将薄膜14接合到微通道芯片的芯片体12的下表面21而形成。在第一区域23a'和23b'之间形成第三区域25a'和25b'以及第二区域24a'和24b'，以便位于碳墨16a和16b上。第三区域25a'和25b'的宽度形成为大于碳墨16a和16b的宽度。

2. 发明授权

US09120098B2 Fluid handling device and fluid handling system 有权
标题翻译：流体处理装置和流体处理系统
公开(公告)号：US09120098B2
公开(公告)日：2015-09-01
申请号：US14110086
申请日：2012-03-12
申请人： Tomoki Nakao , Koichi Ono
发明人： Tomoki Nakao , Koichi Ono
IPC分类号： B01L3/00 , G01N27/00 , B01J19/00 , B81C3/00 , B01L7/00 , F16L53/00 , G01N27/403 , G01N27/447 , B29C65/00 , B29L31/00 , B29K707/04 , B29C65/48
CPC分类号： B01L3/56 , B01J19/0093 , B01J19/123 , B01J2219/00783 , B01J2219/00808 , B01J2219/00833 , B01J2219/00853 , B01J2219/00988 , B01L3/502707 , B01L3/502715 , B01L7/525 , B01L2200/0689 , B01L2300/0645 , B01L2300/0816 , B01L2300/0887 , B01L2300/1827 , B01L2400/0406 , B01L2400/0421 , B29C65/4855 , B29C66/112 , B29C66/114 , B29C66/53461 , B29C66/71 , B29C66/7352 , B29K2707/04 , B29L2031/756 , B81C3/001 , G01N27/403 , G01N27/44704 , G01N27/44791 , B29K2067/003 , B29K2069/00 , B29K2033/12 , B29K2027/06 , B29K2023/12 , B29K2071/00 , B29K2023/06
摘要： The present invention relates to a microchannel chip capable of preventing fluid leakage caused by a lamination defect. Bottomed first regions, second regions, and third regions are formed by joining a film to a lower surface of the chip main body of a microchannel chip. The third regions are in communication with the second regions and are formed on carbon inks. The third regions are formed wider than the carbon inks are. The third regions are filled with an electroconductive adhesive.
摘要翻译：本发明涉及能够防止层叠缺陷引起的流体泄漏的微通道芯片。通过将薄膜连接到微通道芯片的芯片主体的下表面而形成底部的第一区域，第二区域和第三区域。第三区域与第二区域连通并且形成在碳墨水上。第三区域形成为比碳墨水更宽。第三区域填充有导电粘合剂。

3. 发明授权

US08997787B2 Fluid handling apparatus and fluid handling system 有权
标题翻译：流体处理设备和流体处理系统
公开(公告)号：US08997787B2
公开(公告)日：2015-04-07
申请号：US13438261
申请日：2012-04-03
申请人： Tomoki Nakao , Koichi Ono
发明人： Tomoki Nakao , Koichi Ono
IPC分类号： F15C1/06 , G01N27/447 , B01L3/00
CPC分类号： G01N27/44791 , B01L3/502707 , Y10T137/2224 , Y10T137/6606
摘要： Bottomed first regions 23a′ and 23b′, and second regions 24a′ and 24b′ are formed by joining film 14 to undersurface 21 of chip body 12 of a micro-channel chip. Third regions 25a′ and 25b′ are formed between first regions 23a′ and 23b′, and second regions 24a′ and 24b′ so as to be located on carbon inks 16a and 16b. The width of third regions 25a′ and 25b′ is formed so as to be greater than the width of carbon inks 16a and 16b.
摘要翻译：底部的第一区域23a'和23b'以及第二区域24a'和24b'通过将薄膜14接合到微通道芯片的芯片体12的下表面21而形成。在第一区域23a'和23b'之间形成第三区域25a'和25b'以及第二区域24a'和24b'，以便位于碳墨16a和16b上。第三区域25a'和25b'的宽度形成为大于碳墨16a和16b的宽度。

4. 发明授权

US08362468B2 Micro-channel chip and micro-analysis system 有权
标题翻译：微通道芯片和微分析系统
公开(公告)号：US08362468B2
公开(公告)日：2013-01-29
申请号：US12845900
申请日：2010-07-29
申请人： Koichi Ono , Tomoki Nakao , Akira Niwayama
发明人： Koichi Ono , Tomoki Nakao , Akira Niwayama
IPC分类号： H01L29/08 , H01L51/00 , H01L27/14
CPC分类号： G01N21/05 , B01L3/502707 , B01L2300/12 , B01L2300/16 , G01N2021/0346 , G01N2021/056
摘要： A micro-channel chip can be coated uniformly with a thin inorganic oxide film and can prevent an ionic hydrophobic substance from adsorbing through a surface of an inorganic oxide film. In the micro-channel chip, surfaces of inner walls of through-holes in an upper plate member and a channel of a lower plate member are entirely coated with a SiO 2 film. The SiO 2 film is formed of two layers, namely a bottom layer that contains a high content of carbon atoms and is formed in a part that contacts a resin substrate, and a surface layer that contains nearly zero content of carbon atoms and t is formed in a part that is exposed on the surface of a channel.
摘要翻译：可以用薄的无机氧化物膜均匀地涂布微通道芯片，并且可以防止离子疏水性物质通过无机氧化物膜的表面吸附。在微通道芯片中，上板构件的通孔的内壁表面和下板构件的通道的表面全部被SiO 2膜覆盖。 SiO 2膜由两层构成，即含有高含量碳原子并形成在与树脂基板接触的部分中的底层，并且形成含有几乎零含量的碳原子和t的表面层在暴露在通道表面上的部分。

5. 发明申请

US20110241134A1 MICRO-CHANNEL CHIP AND MICRO-ANALYSIS SYSTEM 有权
标题翻译：微通道芯片和微分析系统
公开(公告)号：US20110241134A1
公开(公告)日：2011-10-06
申请号：US12845900
申请日：2010-07-29
申请人： Koichi ONO , Tomoki Nakao , Akira Niwayama
发明人： Koichi ONO , Tomoki Nakao , Akira Niwayama
IPC分类号： H01L29/66 , H01L29/02
CPC分类号： G01N21/05 , B01L3/502707 , B01L2300/12 , B01L2300/16 , G01N2021/0346 , G01N2021/056
摘要： A micro-channel chip can be coated uniformly with a thin inorganic oxide film and can prevent an ionic hydrophobic substance from adsorbing through a surface of an inorganic oxide film. In the micro-channel chip, surfaces of inner walls of through-holes in an upper plate member and a channel of a lower plate member are entirely coated with a SiO 2 film. The SiO 2 film is formed of two layers, namely a bottom layer that contains a high content of carbon atoms and is formed in a part that contacts a resin substrate, and a surface layer that contains nearly zero content of carbon atoms and t is formed in a part that is exposed on the surface of a channel.
摘要翻译：可以用薄的无机氧化物膜均匀地涂布微通道芯片，并且可以防止离子疏水性物质通过无机氧化物膜的表面吸附。在微通道芯片中，上板构件的通孔的内壁表面和下板构件的通道的表面全部被SiO 2膜覆盖。 SiO 2膜由两层构成，即含有高含量碳原子并形成在与树脂基板接触的部分中的底层，并且形成含有几乎零含量的碳原子和t的表面层在暴露在通道表面上的部分。

6. 发明授权

US07686029B2 Microfluidic device for trapping air bubbles 失效
标题翻译：用于捕获气泡的微流体装置
公开(公告)号：US07686029B2
公开(公告)日：2010-03-30
申请号：US11605593
申请日：2006-11-28
申请人： Tomoki Nakao
发明人： Tomoki Nakao
IPC分类号： B01D19/00
CPC分类号： B01L3/502746 , B01L3/502723 , B01L2200/0684 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , B01L2400/0487 , B01L2400/086 , Y10T137/2076 , Y10T137/2224 , Y10T137/3021
摘要： There is provided a microfluidic device capable of preventing the flow of a fluid from being interrupted by bubbles generated in a micro flow passage. In a microfluidic device 10 wherein a micro flow passage 16 having a substantially constant height is formed for allowing a fluid to flow therein and wherein a narrow portion is formed in a portion of the micro flow passage by forming a columnar portion 12c or the like in the micro flow passage, an extending recessed portion 14c for extending the micro flow passage upwards is formed upstream of the narrow portion, and a plurality of raised portions extending in substantially parallel to longitudinal directions of the micro flow passage are formed on a portion of the bottom face of the micro flow passage facing the extending recessed portion if necessary.
摘要翻译：提供了一种微流体装置，其能够防止流体被微通道中产生的气泡中断。在微流体装置10中，其中形成具有基本上恒定的高度的微流体通道16，以允许流体流入其中，并且其中通过在微流体通道的一部分中形成狭窄的部分，形成柱状部分12c等微通道，用于将微通道向上延伸的延伸凹部14c形成在窄部的上游，并且在微流路的长度方向上大致平行延伸的多个凸起部分形成在如果需要，微通道的底面面向延伸的凹部。

7. 发明申请

US20070125434A1 Microfluidic device 失效
标题翻译：微流控装置
公开(公告)号：US20070125434A1
公开(公告)日：2007-06-07
申请号：US11605593
申请日：2006-11-28
申请人： Tomoki Nakao
发明人： Tomoki Nakao
IPC分类号： F15B21/00
CPC分类号： B01L3/502746 , B01L3/502723 , B01L2200/0684 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , B01L2400/0487 , B01L2400/086 , Y10T137/2076 , Y10T137/2224 , Y10T137/3021
摘要： There is provided a microfluidic device capable of preventing the flow of a fluid from being interrupted by bubbles generated in a micro flow passage. In a microfluidic device 10 wherein a micro flow passage 16 having a substantially constant height is formed for allowing a fluid to flow therein and wherein a narrow portion is formed in a portion of the micro flow passage by forming a columnar portion 12c or the like in the micro flow passage, an extending recessed portion 14c for extending the micro flow passage upwards is formed upstream of the narrow portion, and a plurality of raised portions extending in substantially parallel to longitudinal directions of the micro flow passage are formed on a portion of the bottom face of the micro flow passage facing the extending recessed portion if necessary.
摘要翻译：提供了一种微流体装置，其能够防止流体被微通道中产生的气泡中断。在微流体装置10中，其中形成具有基本上恒定的高度的微流道16，用于允许流体在其中流动，并且其中通过形成柱状部分12c等在微流道的一部分中形成狭窄部分在微流路中，在微细流动通道的上游形成用于向上延伸微通道的延伸凹部14c，并且在微流道的长度方向上大致平行延伸的多个凸部形成在如果需要，微通道的底面面向延伸凹部。

8. 发明授权

US08619254B2 Analysis tool and microanalysis system 有权
标题翻译：分析工具和微量分析系统
公开(公告)号：US08619254B2
公开(公告)日：2013-12-31
申请号：US13112511
申请日：2011-05-20
申请人： Tomoki Nakao
发明人： Tomoki Nakao
IPC分类号： G01N1/10 , G01N35/00
CPC分类号： G01N35/00029 , B01L3/502715 , B01L7/52 , B01L2200/025 , B01L2300/0654 , B01L2300/0816 , B01L2400/0421 , G01N27/44734
摘要： In a case of generating a main body of an analysis tool and a micro flow path chip as separate components, to obtain an accurate sample analysis result and to accurately adjust fluid temperature inside the micro flow path chip without damaging an analytical light receiving section of the micro flow path chip. In analysis tool body (10) that detachably holds micro flow path chip (30) in a fixed manner, notch section (21) is formed in mount surface (13) onto which micro flow path chip (30) is to be mounted. Notch section (21) is formed in a predetermined range including a part corresponding to optical path L of light emitted from a lens of optical unit (60) in a state where analysis tool (1) is arranged on heat block (50).
摘要翻译：在分析工具的主体和微流路芯片作为分离的部件生成的情况下，为了获得准确的样品分析结果并精确地调节微流路芯片内的流体温度，而不损坏微流路芯片的分析光接收部分微流路芯片。在以可固定的方式可拆卸地保持微流路芯片（30）的分析工具主体（10）中，在安装表面（13）上形成切口部分（21），微流路芯片（30）将被安装在该表面上。在分析工具（1）布置在热块（50）上的状态下，在包括与从光学单元（60）的透镜发射的光的光路L相对应的部分的预定范围内形成凹口部分（21）。

9. 发明申请

US20110285990A1 ANALYSIS TOOL AND MICROANALYSIS SYSTEM 有权
标题翻译：分析工具和微观分析系统
公开(公告)号：US20110285990A1
公开(公告)日：2011-11-24
申请号：US13112511
申请日：2011-05-20
申请人： Tomoki NAKAO
发明人： Tomoki NAKAO
IPC分类号： G01N1/10
CPC分类号： G01N35/00029 , B01L3/502715 , B01L7/52 , B01L2200/025 , B01L2300/0654 , B01L2300/0816 , B01L2400/0421 , G01N27/44734
摘要： In a case of generating a main body of an analysis tool and a micro flow path chip as separate components, to obtain an accurate sample analysis result and to accurately adjust fluid temperature inside the micro flow path chip without damaging an analytical light receiving section of the micro flow path chip. In main body of analysis tool (10) that detachably holds micro flow path chip (30) in a fixed manner, notch section (21) is formed in mount surface (13) onto which micro flow path chip (30) is to be mounted. Notch section (21) is formed in a predetermined range including a part corresponding to optical path L of light emitted from a lens of optical unit (60) in a state where analysis tool (1) is arranged on heat block (50).
摘要翻译：在分析工具的主体和微流路芯片作为分离的部件生成的情况下，为了获得精确的样品分析结果并精确地调节微流路芯片内的流体温度，而不损坏微流路芯片的分析光接收部分微流路芯片。在以可固定的方式可拆卸地保持微流路芯片（30）的分析工具（10）的主体中，在安装面（13）上形成切口部（21），微流路芯片（30）将被安装在该安装面。在分析工具（1）布置在热块（50）上的状态下，在包括与从光学单元（60）的透镜发射的光的光路L相对应的部分的预定范围内形成凹口部分（21）。

10. 发明申请

US20060042951A1 Sample analyzing apparatus 审中-公开
标题翻译：样品分析仪
公开(公告)号：US20060042951A1
公开(公告)日：2006-03-02
申请号：US11212275
申请日：2005-08-26
申请人： Takuhito Ohse , Tomoki Nakao
发明人： Takuhito Ohse , Tomoki Nakao
IPC分类号： C07K1/26 , G01N27/447
CPC分类号： G01N27/44717 , B01L3/5027 , B03C5/005 , G01N27/4473
摘要： There is provided a sample analyzing apparatus capable of simply and rapidly carrying out each step of electrophoresis, transfer and detection to analyze a substance, such as a biosubstance, in a sample. By sticking an upper plate member 14 to a lower plate member 12 having a fine groove 12a, an electrophoresis passage 13 is formed in the apparatus. A pair of separating electrodes 18 and 20 are provided for moving a substance, such as a biosubstance, along the electrophoresis passage 13 by electrophoresis, and a pair of transferring electrodes 16 and 22 are arranged in the electrophoresis passage 13 for transferring the substance to a capturing material 24 by electrophoresis. After a voltage is applied between the separating electrodes 18 and 20 to carry out electrophoresis, a voltage is applied between the transferring electrodes 16 and 20 to change the direction of electrophoresis to carry out transfer to the capturing material 24, and thereafter, a detecting reaction is allowed in the electrophoresis passage 13 to analyze the substance.
摘要翻译：提供了能够简单快速地进行电泳，转移和检测的每个步骤以分析样品中的物质如生物样品的样品分析装置。通过将上板构件14粘贴到具有细槽12b的下板构件12上，在该装置中形成电泳通道13。设置一对分离电极18和20，用于通过电泳沿着电泳通道13移动诸如生物物质的物质，并且在电泳通道13中布置一对转移电极16和22，以将物质转移到通过电泳捕获材料24。在分离电极18和20之间施加电压以进行电泳之后，在转印电极16和20之间施加电压以改变电泳方向以进行到捕获材料24的转移，然后进行检测反应在电泳通道13中允许分析物质。

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