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    • 2. 发明授权
    • Methods of preparing metal-modified silica nanoparticles
    • 制备金属改性二氧化硅纳米粒子的方法
    • US08685178B2
    • 2014-04-01
    • US12335176
    • 2008-12-15
    • Bao Trong DoThomas David EhlertRobert Allen JanssenJohn Gavin MacDonaldPaul Warren RasmussenShiming Zhuang
    • Bao Trong DoThomas David EhlertRobert Allen JanssenJohn Gavin MacDonaldPaul Warren RasmussenShiming Zhuang
    • B06B3/00B22F9/16
    • B01F11/0258A61L9/014
    • A method of preparing metal-modified silica particles is disclosed. Specifically, a treatment chamber is provided in which a first and a second formulation are ultrasonically mixed to prepare metal-modified silica particles. The treatment chamber has an elongate housing through which the first and second formulations flow longitudinally from a first inlet port and a second inlet port, respectively, to an outlet port thereof. An elongate ultrasonic waveguide assembly extends within the housing and is operable at a predetermined ultrasonic frequency to ultrasonically energize the formulations within the housing. An elongate ultrasonic horn of the waveguide assembly is disposed at least in part intermediate the inlet and outlet ports, and has a plurality of discrete agitating members in contact with and extending transversely outward from the horn intermediate the inlet and outlet ports in longitudinally spaced relationship with each other. The horn and agitating members are constructed and arranged for dynamic motion of the agitating members relative to the horn at the predetermined frequency and to operate in an ultrasonic cavitation mode of the agitating members corresponding to the predetermined frequency and the formulations being mixed in the chamber.
    • 公开了一种制备金属改性二氧化硅颗粒的方法。 具体地说,提供一种处理室,其中第一和第二制剂被超声波混合以制备金属改性的二氧化硅颗粒。 处理室具有细长的外壳,第一和第二配方通过该外壳从第一入口端口和第二入口端口分别纵向流到其出口。 细长的超声波波导组件在壳体内延伸并且可以预定的超声频率操作以超声波地激励壳体内的配方。 波导组件的细长超声波喇叭至少部分地设置在入口和出口的中间,并且具有多个离散的搅拌构件,其与入口和出口端口处的喇叭中的接触并横向向外延伸,与纵向间隔开的关系 彼此。 喇叭和搅拌构件被构造和布置成用于搅动构件相对于喇叭以预定频率的动态运动,并且在对应于预定频率的搅拌构件的超声空化模式下操作,并且配方在腔室中混合。
    • 4. 发明授权
    • Ultrasonic treatment chamber for increasing the shelf life of formulations
    • 超声波处理室可提高配方的保质期
    • US08057573B2
    • 2011-11-15
    • US11966472
    • 2007-12-28
    • David William KoenigJohn Glen AhlesThomas David EhlertRobert Allen JanssenPaul Warren RasmussenSteve RoffersScott W. WenzelShiming Zhuang
    • David William KoenigJohn Glen AhlesThomas David EhlertRobert Allen JanssenPaul Warren RasmussenSteve RoffersScott W. WenzelShiming Zhuang
    • B01D51/08
    • B01D19/0094B01D19/0078
    • An ultrasonic treatment system having a treatment chamber for treating a formulation to increase the shelf life thereof. In one embodiment, the shelf life is produced by degassing the formulation using the treatment chamber. Specifically, the treatment chamber has an elongate housing through which a formulation flows longitudinally from an inlet port to a first outlet port and a second outlet port thereof. An elongate ultrasonic waveguide assembly extends within the housing and is operable at a predetermined ultrasonic frequency to ultrasonically energize the formulation within the housing. An elongate ultrasonic horn of the waveguide assembly is disposed at least in part intermediate the inlet and outlet ports, and has a plurality of discrete agitating members in contact with and extending transversely outward from the horn intermediate the inlet and outlet ports in longitudinally spaced relationship with each other. The horn and agitating members are constructed and arranged for dynamic motion of the agitating members relative to the horn at the predetermined frequency and to operate in an ultrasonic cavitation mode of the agitating members corresponding to the predetermined frequency and the formulation being treated in the chamber.
    • 一种超声处理系统,其具有用于处理制剂以增加其保质期的处理室。 在一个实施方案中,通过使用处理室对制剂进行脱气而产生保质期。 具体地说,处理室具有细长的外壳,制剂通过该外壳纵向从入口端口流向第一出口和第二出口。 细长的超声波波导组件在壳体内延伸并且可以预定的超声频率操作以超声波地激励壳体内的配方。 波导组件的细长超声波喇叭至少部分地设置在入口和出口的中间,并且具有多个离散的搅拌构件,其与入口和出口端口处的喇叭中的接触并横向向外延伸,与纵向间隔开的关系 彼此。 喇叭和搅拌构件被构造和布置成用于以预定频率相对于喇叭的动态运动,并且以对应于预定频率的搅拌构件的超声空化模式和在腔室中处理的配方进行操作。
    • 8. 发明申请
    • ULTRASONIC TREATMENT CHAMBER FOR PREPARING ANTIMICROBIAL FORMULATIONS
    • 超声波处理室用于制备抗菌制剂
    • US20090168590A1
    • 2009-07-02
    • US11966447
    • 2007-12-28
    • David William KoenigJohn Glen AhlesThomas David EhlertRobert Allen JanssenPaul Warren RasmussenSteve RoffersScott W. WenzelShiming Zhuang
    • David William KoenigJohn Glen AhlesThomas David EhlertRobert Allen JanssenPaul Warren RasmussenSteve RoffersScott W. WenzelShiming Zhuang
    • B01F11/02
    • B01F11/0258B01F2215/0009B01F2215/045B01F2215/0454
    • An ultrasonic mixing system having a treatment chamber in which antimicrobial agents, particularly, hydrophobic antimicrobial agents, can be mixed with one or more formulations is disclosed. Specifically, the treatment chamber has an elongate housing through which a formulation and antimicrobial agents flow longitudinally from a first inlet port and a second inlet port to an outlet port thereof. An elongate ultrasonic waveguide assembly extends within the housing and is operable at a predetermined ultrasonic frequency to ultrasonically energize the formulation and antimicrobial agents within the housing. An elongate ultrasonic horn of the waveguide assembly is disposed at least in part intermediate the inlet and outlet ports, and has a plurality of discrete agitating members in contact with and extending transversely outward from the horn intermediate the inlet and outlet ports in longitudinally spaced relationship with each other. The horn and agitating members are constructed and arranged for dynamic motion of the agitating members relative to the horn at the predetermined frequency and to operate in an ultrasonic cavitation mode of the agitating members corresponding to the predetermined frequency and the formulation and antimicrobial agents being mixed in the chamber.
    • 公开了一种具有处理室的超声波混合系统,其中抗微生物剂,特别是疏水性抗微生物剂可与一种或多种制剂混合。 具体地说,处理室具有细长的壳体,制剂和抗微生物剂通过其从第一入口和第二入口纵向流到其出口。 细长的超声波波导组件在壳体内延伸并且可以预定的超声频率操作,以超声波地激励壳体内的配方和抗微生物剂。 波导组件的细长超声波喇叭至少部分地设置在入口和出口的中间,并且具有多个离散的搅拌构件,其与入口和出口端口处的喇叭中的接触并横向向外延伸,与纵向间隔开的关系 彼此。 喇叭和搅拌构件被构造和布置成用于以预定频率使搅拌构件相对于喇叭的动态运动,并且在对应于预定频率的搅拌构件的超声空化模式下操作,并将制剂和抗微生物剂混合在 房间。
    • 9. 发明申请
    • ULTRASONIC TREATMENT CHAMBER FOR INCREASING THE SHELF LIFE OF FORMULATIONS
    • 超声波治疗室用于增加制剂寿命
    • US20090165654A1
    • 2009-07-02
    • US11966472
    • 2007-12-28
    • David William KoenigJohn Glen AhlesThomas David EhlertRobert Allen JanssenPaul Warren RasmussenSteve RoffersScott W. WenzelShiming Zhuang
    • David William KoenigJohn Glen AhlesThomas David EhlertRobert Allen JanssenPaul Warren RasmussenSteve RoffersScott W. WenzelShiming Zhuang
    • B01D19/00
    • B01D19/0094B01D19/0078
    • An ultrasonic treatment system having a treatment chamber for treating a formulation to increase the shelf life thereof. In one embodiment, the shelf life is produced by degassing the formulation using the treatment chamber. Specifically, the treatment chamber has an elongate housing through which a formulation flows longitudinally from an inlet port to a first outlet port and a second outlet port thereof. An elongate ultrasonic waveguide assembly extends within the housing and is operable at a predetermined ultrasonic frequency to ultrasonically energize the formulation within the housing. An elongate ultrasonic horn of the waveguide assembly is disposed at least in part intermediate the inlet and outlet ports, and has a plurality of discrete agitating members in contact with and extending transversely outward from the horn intermediate the inlet and outlet ports in longitudinally spaced relationship with each other. The horn and agitating members are constructed and arranged for dynamic motion of the agitating members relative to the horn at the predetermined frequency and to operate in an ultrasonic cavitation mode of the agitating members corresponding to the predetermined frequency and the formulation being treated in the chamber.
    • 一种超声处理系统,其具有用于处理制剂以增加其保质期的处理室。 在一个实施方案中,通过使用处理室对制剂进行脱气而产生保质期。 具体地说,处理室具有细长的外壳,制剂通过该外壳纵向从入口端口流向第一出口和第二出口。 细长的超声波波导组件在壳体内延伸并且可以预定的超声频率操作以超声波地激励壳体内的配方。 波导组件的细长超声波喇叭至少部分地设置在入口和出口的中间,并且具有多个离散的搅拌构件,其与入口和出口端口处的喇叭中的接触并横向向外延伸,与纵向间隔开的关系 彼此。 喇叭和搅拌构件被构造和布置成用于以预定频率相对于喇叭的动态运动,并且以对应于预定频率的搅拌构件的超声空化模式和在腔室中处理的配方进行操作。