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1. 发明申请

US20030029566A1 Remote exposure of workpieces using a plasma 有权
标题翻译：使用等离子体远程暴露工件
公开(公告)号：US20030029566A1
公开(公告)日：2003-02-13
申请号：US10156394
申请日：2002-05-28
申请人： The University of Tennessee Research Corporation
发明人： J. Reece Roth
IPC分类号： H05H001/24 , B05D005/12 , C23F001/00 , H01L021/306 , C23C016/00
CPC分类号： H01J37/32357 , A61L2/14 , B29C59/14 , C23C16/452 , H01J37/32366 , H01J2237/336 , H05H1/46 , H05H2001/466 , H05H2240/10 , H05H2240/20 , H05H2245/123 , H05H2277/14
摘要： An OAUGD plasma is generated using, for example, paraelectric or peristaltic electrohydrodynamic (EHD) techniques, in the plasma generator of a remote-exposure reactor, wherein one or more active species, especially oxidizing species in the plasma are convected away from the plasma-generation region and directed towards a workpiece that is located outside of the plasma-generation region (e.g., within an optional remote-exposure chamber configured to the plasma generator). In this way, the workpiece can be subjected to the one or more active species without directly being subjected to either the plasma or to the electric fields used to generate the plasma. The plasma generator may have a set of flat panels arranged within an air baffle to convect the active species in a serpentine manner through the plasma generator. The remote-exposure reactor can also be configured as a portable backpack unit with tubing that is used to direct the active species onto the workpiece, rather than placing the workpiece within a remote-exposure chamber of the reactor.
摘要翻译：在远程暴露反应器的等离子体发生器中使用例如顺电或蠕动电动力学（EHD）技术产生OAUGD等离子体，其中一个或多个活性物质，特别是等离子体中的氧化物质与等离子体 - 并且指向位于等离子体产生区域外部的工件（例如，在配置到等离子体发生器的可选的远程曝光室内）。以这种方式，工件可以经受一种或多种活性物质而不直接经受等离子体或用于产生等离子体的电场。等离子体发生器可以具有布置在空气挡板内的一组平板，以通过等离子体发生器以蛇形方式对流活性物质。远程曝光反应器也可以配置为具有用于将活性物质引导到工件上的管道的便携式背包单元，而不是将工件放置在反应器的远程暴露室内。

2. 发明申请

US20020035080A1 cDNA encoding P2P proteins and use of P2P cDNA-derived antibodies and antisense reagents in determining the proliferative potential of normal, abnormal, and cancer cells in animals and humans 审中-公开
标题翻译：编码P2P蛋白的cDNA和使用P2P cDNA衍生的抗体和反义试剂来确定动物和人类正常，异常和癌细胞的增殖潜力
公开(公告)号：US20020035080A1
公开(公告)日：2002-03-21
申请号：US09811045
申请日：2001-03-16
申请人： The University of Tennessee Research Corporation
发明人： Robert E. Scott
IPC分类号： A61K048/00 , A61K038/17 , C07K014/435 , C07H021/02 , C07H021/04
CPC分类号： C07K14/47 , A61K39/00 , A61K48/00 , C12N15/113 , C12N2310/11
摘要： Terminal differentiation is associated with repression in the expression of the P2P subset of hnRNP proteins. The 5173 base pair P2P cDNA was cloned and characterized. The cDNA contains a 4214 base pair open reading frame. Probes to the P2P cDNA detect a single 8 kb mRNA in multiple murine tissues, in proliferating murine 3T3T cells but not in terminally differentiated 3T3T adipocytes. Evidence that the P2P cDNA can encode proteins with domains for hnRNP association was established by showing that the C130 monoclonal antibody, produced against a fusion protein derived from the P2P cDNA, selectively detects native P2P hnRNP proteins. In addition, it was shown that P2P antisense oligonucleotides selectively repressed 30-40 kDa P2P expression. Since terminal differentiation is also associated with modulation in Rb1 function, assays were performed which demonstrated that P2P cDNA products interact with Rb1. Evidence that the P2P cDNA encodes a protein domain that binds Rb1 was established using a GST-P2P fusion protein to selectively precipitate Rb1. Data also show that this binding is competed by the adenovirus E1a protein, indicating that binding occurs through the nullpocketnull domain of Rb1. These results establish that the P2P cDNA encodes protein domains involved in both hnRNP association and Rb1 binding and complement recent reports that localize Rb1 to sites of RNA processing in the nucleus. The interaction of P2P cDNA products and Rb1 may therefore serve to modulate cell proliferation and/or other biological functions associated with tumor suppression by an RNA processing mechanism.
摘要翻译：终末分化与hnRNP蛋白的P2P亚型表达的抑制有关。克隆并表征5173碱基对P2P cDNA。该cDNA包含一个4214碱基对的可读框。针对P2P cDNA的探针在增殖性鼠3T3T细胞中检测到多个鼠组织中的单个8kb mRNA，但在终末分化的3T3T脂肪细胞中检测不到。通过显示针对源自P2P cDNA的融合蛋白产生的C130单克隆抗体选择性检测本地P2P hnRNP蛋白，建立了P2P cDNA可以编码具有hnRNP结合域的蛋白质的证据。此外，显示P2P反义寡核苷酸选择性抑制30-40kDa的P2P表达。由于终末分化也与Rb1功能的调节有关，因此进行了分析，表明P2P cDNA产物与Rb1相互作用。使用GST-P2P融合蛋白建立P2P cDNA编码结合Rb1的蛋白质结构域的证据，以选择性沉淀Rb1。数据还显示该结合受到腺病毒E1a蛋白竞争，表明通过Rb1的“口袋”结构发生结合。这些结果表明，P2P cDNA编码涉及hnRNP结合和Rb1结合的蛋白质结构域，并补充了最近的报道，将Rb1定位于细胞核中RNA加工位点。因此，P2P cDNA产物和Rb1的相互作用可用于通过RNA加工机制调节与肿瘤抑制相关的细胞增殖和/或其它生物功能。

3. 发明申请

US20030138419A1 Recombinant antibody fusion proteins and methods for detection of apoptotic cells 审中-公开
标题翻译：重组抗体融合蛋白和检测凋亡细胞的方法
公开(公告)号：US20030138419A1
公开(公告)日：2003-07-24
申请号：US10295757
申请日：2002-11-15
申请人： The University of Tennessee Research Corporation
发明人： Marko Z. Radic , Brian A. Cocca
IPC分类号： A61K039/395 , C07K016/30
CPC分类号： C07K16/28 , C07K2317/622
摘要： Recombinant antibody single chain variable fragments (scFv) useful for detecting apoptotic cells are disclosed. The antibodies selectively bind on the surface of apoptotic cells. Methods of generating and employing the antibodies are also provided. Methods of detecting modulation of apoptosis are disclosed. Methods of evaluating the efficacy of a candidate therapeutic compound adapted to effect a change in apoptosis are also disclosed. Additionally, a kit for the detection of apoptotic cells is also disclosed.
摘要翻译：公开了可用于检测凋亡细胞的重组抗体单链可变片段（scFv）。抗体选择性结合凋亡细胞的表面。还提供产生和使用抗体的方法。公开了检测凋亡调节的方法。还公开了评估适于影响凋亡变化的候选治疗化合物的功效的方法。此外，还公开了用于检测凋亡细胞的试剂盒。

4. 发明申请

US20030186918A1 Increasing growth factor production by cells 审中-公开
标题翻译：细胞生长因子生长增加
公开(公告)号：US20030186918A1
公开(公告)日：2003-10-02
申请号：US10397933
申请日：2003-03-26
申请人： The University of Tennessee Research Corporation
发明人： Edward Chaum
IPC分类号： A61K048/00
CPC分类号： A61K48/005 , C07K2319/60
摘要： Disclosed are methods and compositions for growth factor gene therapy for conditions involving degeneration or injury of cells of the retina, including age-related macular degeneration. Included in the invention are non-viral vectors for delivery of growth factor fusion proteins, cells transduced with such vectors, and methods of treatment using these vectors.
摘要翻译：公开了用于生长因子基因治疗涉及视网膜细胞变性或损伤的病症的方法和组合物，包括年龄相关性黄斑变性。本发明包括用于递送生长因子融合蛋白的非病毒载体，用这些载体转导的细胞，以及使用这些载体的治疗方法。

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