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1. 发明申请

US20120011975A1 THIN SECTION PREPARING METHOD 审中-公开
标题翻译：薄部分准备方法
公开(公告)号：US20120011975A1
公开(公告)日：2012-01-19
申请号：US13238922
申请日：2011-09-21
申请人： Tetsumasa ITO , Koji FUJIMOTO
发明人： Tetsumasa ITO , Koji FUJIMOTO
IPC分类号： G01N1/06
CPC分类号： B26D3/28 , B26D5/20 , G01N1/06 , Y10T83/04 , Y10T83/0515 , Y10T83/162 , Y10T83/6668
摘要： An apparatus that slices an embedded block having a biological sample embedded therein to prepare a thin section, includes: a cutter that slices the embedded block; a moving mechanism that relatively moves the block and the cutter along an approaching and separating direction in which they approach and separate from each other; a height adjusting mechanism that relatively moves them along a vertical direction; a sliding mechanism that relatively moves them along a sliding direction nearly orthogonal to the approaching and separating direction; and a control unit that controls them to begin to move at initial positions set in advance, the block to be brought into contact at the same point of a nose of the cutter, and the cutter to be slid in the same direction as a ratio between a velocity in the approaching and separating direction and a velocity in the sliding direction is kept the same.
摘要翻译：一种将具有嵌入其中的生物样本的嵌入块切割以制备薄部分的装置，包括：切割嵌入块的切割器; 移动机构，其沿着接近和分离方向使块和切割器相对移动; 高度调节机构，使其沿着垂直方向相对移动; 滑动机构，其沿着与接近分离方向大致正交的滑动方向相对移动; 以及控制单元，其控制它们开始在预先设定的初始位置移动，要在刀具的鼻子的相同点处接触的块，并且刀具沿相同的方向滑动，在接近和分离方向上的速度和滑动方向上的速度保持相同。

2. 发明授权

US08087334B2 Sectioning instrument 有权
标题翻译：切片仪
公开(公告)号：US08087334B2
公开(公告)日：2012-01-03
申请号：US11643922
申请日：2006-12-20
申请人： Tatsuya Miyatani , Tetsumasa Ito , Hirohito Fujiwara , Koji Fujimoto
发明人： Tatsuya Miyatani , Tetsumasa Ito , Hirohito Fujiwara , Koji Fujimoto
IPC分类号： G01N1/06
CPC分类号： G01N1/06 , Y10T83/2098 , Y10T83/2194 , Y10T83/869 , Y10T83/929 , Y10T83/9454
摘要： A sectioning instrument fabricates a section having an accurate and uniform thickness to be carried to a next step automatically without deforming a surface of an embedded block and while observing the surface of the embedded block. The sectioning instrument includes a sample base for fixing an embedded block, a cutter for fabricating a section by sectioning the embedded block, a carrier for carrying the section, and a feed mechanism for moving the sample base in a predetermined feed direction. The carrier includes a belt, a direction switching portion provided on an upper side of the cutter, and a rear roller. The belt is inserted to between the cutter and the direction switching portion from a rear side of the cutter, folded back to an upper side by the direction switching portion and is reeled back to the rear side of the cutter by the rear roller substantially in parallel with the feed direction of the feed mechanism in a plane view.
摘要翻译：切割仪器制造具有精确和均匀厚度的部分，以自动地承载到下一步骤，而不会使嵌入块的表面变形，同时观察嵌入块的表面。切割仪包括用于固定嵌入块的样品基底，用于通过切割嵌入块来制造截面的切割器，用于承载该部分的载体和用于沿预定进给方向移动样品基底的进给机构。载体包括带，设置在切割器的上侧的方向切换部和后辊。带从切割器的后侧插入到切割器和方向切换部之间，由方向切换部分折回到上侧，并且通过后辊基本上平行地卷绕回切割器的后侧进给机构的进给方向在平面图中。

3. 发明授权

US08074547B2 Automatic slicing apparatus 有权
标题翻译：自动切片机
公开(公告)号：US08074547B2
公开(公告)日：2011-12-13
申请号：US11657274
申请日：2007-01-24
申请人： Tetsumasa Ito , Tatsuya Miyatani , Koji Fujimoto
发明人： Tetsumasa Ito , Tatsuya Miyatani , Koji Fujimoto
IPC分类号： G01N1/31 , G01N1/06 , G01N1/04
CPC分类号： G01N1/06 , Y10S83/919 , Y10T83/04 , Y10T83/145 , Y10T83/178 , Y10T83/222 , Y10T83/263 , Y10T83/839
摘要： An automatic slicing apparatus reduces the likelihood of failure to make a sliced piece specimen even if continuously operated. The apparatus, on the basis of an exchange command signal, detaches a sample block attached to a cutting base and attaches a new sample block to the cutting base. The apparatus cuts a sliced piece of a predetermined thickness by moving a knife with respect to the sample block having been attached to the cutting base. The apparatus also observes the sliced piece having been cut and judges the sliced piece by comparing an observation data obtained by the observation means and a sample block cut face data. When the apparatus judges that the sliced piece is good, the apparatus transmits an exchange command signal.
摘要翻译：自动切片装置即使连续操作，也可以降低成型片试样失败的可能性。该装置基于交换指令信号，将附接到切割基座的样本块分离并将新的样品块附接到切割基部。该装置通过相对于已经附接到切割基座的样品块移动刀来切割预定厚度的切片。该装置还观察切片，并通过比较观察装置得到的观察数据和样本块切割面数据来判断切片。当设备判断切片良好时，装置发送交换命令信号。

4. 发明授权

US07866464B2 Thin-section conveyor apparatus, thin-section scooping tool, and method for transporting thin sections 失效
标题翻译：薄型输送装置，薄型舀取工具，以及输送薄型材的方法
公开(公告)号：US07866464B2
公开(公告)日：2011-01-11
申请号：US11829555
申请日：2007-07-27
申请人： Tatsuya Miyatani , Koji Fujimoto , Tetsumasa Ito
发明人： Tatsuya Miyatani , Koji Fujimoto , Tetsumasa Ito
IPC分类号： B65G15/30 , G01N1/06 , G01N35/04
CPC分类号： G01N1/06 , G01N1/312 , G01N1/4077 , G01N35/00009 , G01N35/04
摘要： A thin-section conveyor apparatus for transporting thin sections that have been prepared by thinly cutting an embedded block, which transports the thin sections to a liquid bath by mounting them on the upper plane of a conveyor belt having a longitudinal linear body extended along the direction of transportation and a transverse linear body disposed perpendicular to the longitudinal linear body, provided that the density of the transverse linear body for the part on which the thin sections are to be mounted is lower than that of the transverse linear body of the other places. It provides thin sections almost free of entraining bubbles. A thin-section scooping tool and a method for transporting thin sections are also proposed.
摘要翻译：一种输送薄片输送装置的薄型输送装置，该薄片部分通过薄切割嵌入块来制备，该嵌入块通过将薄壁部分安装到具有沿着方向延伸的纵向线性体的输送带的上平面并且垂直于纵向线性体设置的横向线状体，其中，用于其上安装有薄壁部分的部分的横向线状体的密度低于其它位置的横向线状体的密度。它提供了几乎没有夹带气泡的薄部分。还提出了一种薄型舀取工具和一种输送薄片的方法。

5. 发明申请

US20070204734A1 Automatic sliced piece fabricating apparatus and automatic sliced piece sample fabricating apparatus 有权
标题翻译：自动切片制造装置和自动切片试样制造装置
公开(公告)号：US20070204734A1
公开(公告)日：2007-09-06
申请号：US11651714
申请日：2007-01-10
申请人： Tetsumasa Ito , Tatsuya Miyatani , Koji Fujimoto
发明人： Tetsumasa Ito , Tatsuya Miyatani , Koji Fujimoto
IPC分类号： G01N1/06 , B26D7/10 , B26D7/08 , G01N1/28
CPC分类号： G01N1/06 , G01N1/42 , Y10T83/041 , Y10T83/263 , Y10T83/283
摘要： To fabricate automatically a high quality sliced piece by preventing a temperature change of a surface of an enveloped block, there is provided an automatic sliced piece fabricating apparatus including a fixed base for mounting to fix an enveloped block, cutting means including a cut blade arranged on the fixed base for cutting out a sliced piece from the enveloped block by moving the cut blade and the fixed base relative to each other, a cabinet for containing the fixed base and the cutting means at inside thereof, sliced piece carrying means for carrying the cut-out sliced piece to outside of the cabinet, and temperature adjusting means for adjusting at least a surrounding temperature of the enveloped block to a predetermined temperature by supplying cold wind a temperature of which is controlled from outside at inside of the cabinet.
摘要翻译：为了通过防止包封块的表面的温度变化来自动制造高质量的切片，提供了一种自动切片制造装置，包括：固定基座，用于安装以固定包封块;切割装置，包括设置在固定基座，用于通过相对于彼此移动切割刀片和固定基座来从包封块切割切片，用于在其内侧容纳固定基座和切割装置的机壳，用于承载切割的切片片承载装置以及温度调节装置，用于通过从壳体内部的外部供给温度控制的冷风来调节至少包围的块的周围温度至预定的温度。

6. 发明授权

US5334834A Inductively coupled plasma mass spectrometry device 失效
标题翻译：电感耦合等离子体质谱仪
公开(公告)号：US5334834A
公开(公告)日：1994-08-02
申请号：US45422
申请日：1993-04-13
申请人： Tetsumasa Ito , Yoshitomo Nakagawa
发明人： Tetsumasa Ito , Yoshitomo Nakagawa
IPC分类号： G01N27/62 , H01J49/10 , H01J49/12 , B01D59/44 , H01J49/00
CPC分类号： H01J49/105
摘要： A structure for enabling control of the plasma potential of an ICP-MS. The structure includes: a shield plate 10 made of metal inserted between a plasma torch 1 and a high-frequency coil 2, a variable capacitor 11 connected between the shield plate 10 and ground, and an insulation member 15 is arranged to prevent contact of the high-frequency coil 2 with the shield plate 10. Even if a sample is introduced into ICP by any known method, it becomes capable to perform ICP-MS analysis while optimizing the response to interfering ions and detection sensitivity.
摘要翻译：一种能够控制ICP-MS的等离子体电位的结构。该结构包括：插入在等离子体焰炬1和高频线圈2之间的金属制的屏蔽板10，连接在屏蔽板10和地之间的可变电容器11和绝缘构件15，以防止高频线圈2与屏蔽板10.即使通过任何已知的方法将样品引入ICP中，也能够在优化对干扰离子的响应和检测灵敏度的同时进行ICP-MS分析。

7. 发明授权

US08156853B2 Automatic thin-section manufacturing system 有权
标题翻译：自动薄片制造系统
公开(公告)号：US08156853B2
公开(公告)日：2012-04-17
申请号：US12033474
申请日：2008-02-19
申请人： Hirohito Fujiwara , Tetsumasa Ito , Koji Fujimoto , Tatsuya Miyatani
发明人： Hirohito Fujiwara , Tetsumasa Ito , Koji Fujimoto , Tatsuya Miyatani
IPC分类号： B26D7/26 , B26D7/06 , B23D19/00
CPC分类号： G01N1/06 , Y10T83/6492 , Y10T83/9459
摘要： A manufacturing system for producing thin sections of a biological sample embedded in a block. The system includes, a blade holder disposed at a rake angle relative to the block, a mounting plane on which a plurality of cutting blades are mounted, an adsorptive member on the mounting plane that maintains the posture of the cutting blades, a pressing member that presses a selected cutting blade against the mounting plane, a conveyor unit that slides out the cutting blades by sequentially conveying the plurality of cutting blades to feed them one by one on the mounting plane, a transportation unit that moves the block relative to the holder, such that the cutting blade cuts out a thin section from the sample, and a control unit that operates the conveyor unit to exchange the selected cutting blade.
摘要翻译：用于生产嵌入块中的生物样品的薄片的制造系统。该系统包括：相对于块设置成前倾角的刀片保持架，安装有多个切割刀片的安装平面，保持切割刀片姿态的安装平面上的吸附构件，压紧构件，将选定的切割刀片压靠在安装平面上;传送单元，其通过依次传送多个切割刀片，在安装平面上一个接一个地将切割刀片滑出切割刀片;使传动单元相对于保持器移动，使得切割刀片从样品切出薄的部分，以及控制单元，其操作输送单元以交换所选择的切割刀片。

8. 发明授权

US07966091B2 Automatic thin-section slides manufacturing system and method 有权
标题翻译：自动薄截面滑块制造系统和方法
公开(公告)号：US07966091B2
公开(公告)日：2011-06-21
申请号：US12223406
申请日：2007-02-07
申请人： Koji Fujimoto , Tetsumasa Ito , Tatsuya Miyatani
发明人： Koji Fujimoto , Tetsumasa Ito , Tatsuya Miyatani
IPC分类号： G06F19/00
CPC分类号： G01N1/06 , G01N1/312 , G01N2001/368 , Y10T83/6492
摘要： Thin-section slide samples are manufactured from respective embedding blocks containing a biological sample and held in an embedding cassette having imprinted thereon individual data. The embedding cassette is transported to a cutting position where an embedding block is cut into sheet-like thin sections, and the individual data is read out. Each of thin sections is flattened and transferred onto a substrate to form a thin-section slide sample. A memory part stores the individual data read out and a condition table into which is input manufacturing conditions for manufacturing the thin sections. Thereafter, it is evaluated whether or not each of the thin sections is prepared in accordance with the manufacturing conditions input into the condition table.
摘要翻译：薄片滑动样品由含有生物样品的相应嵌入块制成并保持在其上印有单独数据的嵌入盒中。将嵌入盒输送到切割位置，在该切割位置将嵌入块切割成片状薄片部分，并读出单独的数据。每个薄部分被压平并转移到基底上以形成薄片载玻片样品。存储器部分存储读出的各个数据和输入制造薄片部分的制造条件的条件表。此后，根据输入到条件表中的制造条件来评价每个薄部分是否被制备。

9. 发明申请

US20100229702A1 Automatic Prepared Slide Fabricating Apparatus and Automatic Prepared Slide Fabricating Method 审中-公开
标题翻译：自动准备的滑动装置和自动准备的滑动制造方法
公开(公告)号：US20100229702A1
公开(公告)日：2010-09-16
申请号：US12223893
申请日：2007-02-07
申请人： Koji Fujimoto , Tetsumasa Ito , Tatsuya Miyatani
发明人： Koji Fujimoto , Tetsumasa Ito , Tatsuya Miyatani
IPC分类号： G01N1/06 , B26D7/27 , B26D7/06
CPC分类号： G01N1/06 , G01N1/312 , G01N2001/368 , Y10T83/0448 , Y10T83/6571
摘要： To enable to alleviate a burden on an operator and fabricate automatically an optimum and high quality prepared slide in accordance with a kind of an embedding block, there is provided an automatic prepared slide fabricating apparatus including first carrying means capable of carrying an embedding cassette to a cut position, cutting means for cutting out a section in a sheet-like shape by cutting an embedding block by a predetermined thickness after having been carried to the cut position, elongating means for elongating the section, second carrying means for carrying the cut section to the elongating means, transcribing means for transcribing the elongated section onto a board to fabricate a prepared slide, and controlling means for respectively controlling the respective means and having a condition table previously inputted with a fabricating condition in fabricating the prepared slide, in which the controlling means controls the respective means such that the embedding cassette carried by the first carrying means is checked with the fabricating condition inputted to the condition table, thereafter, fabricated by the condition in accordance with the embedding cassette.
摘要翻译：为了减轻操作者的负担并且根据一种嵌入块自动制造最佳和高质量的制备的滑动件，提供了一种自动准备的滑动制造装置，其包括能够将嵌入盒带到一个切割位置，切割装置，用于通过在被运送到切割位置之后将嵌入块切割预定厚度来切割片状形状的切割装置，用于延伸该部分的延伸装置，用于将切割部分携带的第二传送装置伸长装置，用于将细长部分转印到板上以制造准备的滑块的转录装置，以及用于分别控制各个装置并具有在制造准备的滑块中预先输入制造条件的状态表的控制装置，其中控制装置控制相应的装置，使得嵌入式盒式车厢用输入到条件表的制造条件检查第一承载装置的后缘，然后通过根据嵌入盒的条件制造。

10. 发明申请

US20100030364A1 Automatic Thin-Section Slides Manufacturing System and Automated Thin-Section Slides Manufacturing Method 有权
标题翻译：自动薄截面滑片制造系统和自动薄截面滑片制造方法
公开(公告)号：US20100030364A1
公开(公告)日：2010-02-04
申请号：US12223406
申请日：2007-02-07
申请人： Koji Fujimoto , Tetsumasa Ito , Tatsuya Miyatani
发明人： Koji Fujimoto , Tetsumasa Ito , Tatsuya Miyatani
IPC分类号： B26D7/06 , G06F17/00
CPC分类号： G01N1/06 , G01N1/312 , G01N2001/368 , Y10T83/6492
摘要： An automatic thin-section slides manufacturing system which reduces the burden of operators and automatically manufactures required number of thin section slide samples from plural embedded blocks while completely relating the manufactured thin section slide samples to the original embedded blocks to enable quality control at high precision, which comprises: a first transportation unit which is capable of transporting an arbitrarily selected embedded cassette from the plural embedded cassettes to the cutting position; a cutting unit which, after the embedded cassette is transported to the cutting position, cuts the embedded block to provide sheet-like thin sections at a predetermined thickness; a readout unit which reads out the individual data when the embedded cassette is transported to the cutting position; a flattening unit for flattening the thin section, which comprises a storage tank containing a liquid stored therein; a second transportation unit which transports the thin sections cut out by the cutting unit to the storage tank and sets them a float on the liquid surface; a transfer unit which prepares the thin section slide samples by transferring the thin section flattened in the flattening unit onto a substrate; a control unit which comprises a memory part for memorizing the individual data read out by the readout unit; and a recording unit which records the memorized individual data on the substrate upon receiving a command from the control unit.
摘要翻译：一种自动薄截面滑块制造系统，其减少操作者的负担并且自动制造来自多个嵌入块的所需数量的薄截面滑动样本，同时将制造的薄截面滑动样本完全关联到原始嵌入块，以实现高精度的质量控制，其包括：第一运送单元，其能够将任意选择的嵌入式盒从多个嵌入盒运送到切割位置; 切割单元，其在嵌入的盒被输送到切割位置之后切割嵌入块以提供预定厚度的片状薄片; 读取单元，当所嵌入的盒被输送到切割位置时，读出单个数据; 用于使薄部分变平的扁平单元，其包括容纳存储在其中的液体的储存罐; 第二输送单元，其将由切割单元切出的薄部分输送到储罐并将其设置在液面上的浮子; 传送单元，其通过将在平坦化单元中平坦化的薄部分转印到基板上来准备薄片滑动样品; 控制单元，包括用于存储由读出单元读出的各个数据的存储部分; 以及记录单元，其在从所述控制单元接收到命令时将所存储的个体数据记录在所述基板上。

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