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1. 发明授权

US06939569B1 Medical device having anti-infective and contraceptive properties 有权
标题翻译：具有抗感染和避孕特性的医疗器械
公开(公告)号：US06939569B1
公开(公告)日：2005-09-06
申请号：US09336392
申请日：1999-06-18
申请人： Terrence R. Green , Jack Fellman
发明人： Terrence R. Green , Jack Fellman
IPC分类号： A61K47/30 , A61K9/00 , A61L27/00 , A61L27/54 , A61L29/00 , A61L29/16 , A61L31/00 , A61L31/16 , A61K33/08 , A01N25/00 , A61K31/19 , A61K33/40
CPC分类号： A61L31/16 , A61K9/0034 , A61K9/0036 , A61L27/54 , A61L29/16 , A61L2300/106 , A61L2300/11 , A61L2300/404 , A61M2025/0056 , Y10S514/953
摘要： There is disclosed a medical device for implantation that acts to prevent transmission of infectious agents. Specifically, the present invention provides implantable devices, such as catheters or living skin matrices or wound dressings, for insertion into various body cavities or over wound sites to confer to the site microbicidal or virucidal activity. Devices in the disclosure designed as vaginal inserts also exhibit contraceptive spermicidal activity. The coated devices or devices having the inventive polymeric material interspersed throughout are formed into appropriate shapes according to their contemplated uses (such as catheters or Foley catheters). Further, the present invention provides devices for providing therapeutic anti-microbial activity into an infected body cavity or on an infected wound site.
摘要翻译：公开了用于防止感染剂传播的用于植入的医疗装置。具体地，本发明提供了可植入装置，例如导管或活体皮肤基质或伤口敷料，用于插入各种体腔或伤口部位以赋予部位杀微生物或杀病毒活性。设计为阴道插入物的公开内容中的装置还具有避孕杀精活性。穿透整个本发明的聚合材料的涂覆的装置或装置根据其预期的用途（如导管或Foley导管）形成适当的形状。此外，本发明提供了用于向感染的体腔或感染的伤口部位提供治疗性抗微生物活性的装置。

2. 发明申请

US20120187041A1 INSECT-BASED REMOVAL OF ORGANIC SOLUTES FROM LIQUID 审中-公开
标题翻译：从液体中去除有机溶剂
公开(公告)号：US20120187041A1
公开(公告)日：2012-07-26
申请号：US13010654
申请日：2011-01-20
申请人： Radu Popa , Terrence R. Green
发明人： Radu Popa , Terrence R. Green
IPC分类号： C02F3/32 , C02F1/58 , A01K67/00
CPC分类号： C02F3/327 , A01K67/033 , Y02W10/18
摘要： Disclosed herein are methods of removing organic solutes from liquids. The methods include incubating fly larvae with a liquid that contains organic solutes. Also disclosed herein are methods of producing larva biomass. Additionally, apparatus for use with the disclosed methods are described.
摘要翻译：本文公开了从液体中除去有机溶质的方法。这些方法包括用含有有机溶质的液体孵化飞虫幼虫。本文还公开了生产幼虫生物质的方法。另外，描述了与所公开的方法一起使用的装置。

3. 发明授权

US06838050B1 Methods and devices for providing anti-infective activity to a medical device 有权
标题翻译：用于向医疗装置提供抗感染活性的方法和装置
公开(公告)号：US06838050B1
公开(公告)日：2005-01-04
申请号：US09585911
申请日：2000-06-02
申请人： Terrence R. Green , Jack Fellman
发明人： Terrence R. Green , Jack Fellman
IPC分类号： A61L2/18 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2/00
CPC分类号： A61L2/18 , A61L27/54 , A61L29/16 , A61L2300/404
摘要： Methods of providing anti-infective activity to a medical device including the steps of exposing the medical device to an anti-infective oxidant, and transferring the anti-infective oxidant into a wall of the medical device. One embodiment includes the step of exposing a medical device that is at least in part within a patient to the anti-infective oxidant. Another embodiment includes the steps of exposing a medical device to an aqueous solution which produces the anti-infective oxidant and transferring a sufficient amount of the anti-infective oxidant into the medical device wall to provide the medical device with anti-infective activity. Also provided is an oxidant releasing member that has anti-infective oxidant releasably contained therein and that is configured to be disposed adjacent to the medical device. Exemplary devices include catheters such as venous, arterial, and urinary catheters, generally containing an elongated catheter shaft having a lumen extending therein, and optionally having a balloon on the shaft in fluid communication with the catheter lumen.
摘要翻译：向医疗装置提供抗感染活性的方法，包括将医疗装置暴露于抗感染性氧化剂，以及将抗感染性氧化剂转移到医疗装置的壁中的步骤。一个实施方案包括将至少部分在患者体内的医疗装置暴露于抗感染性氧化剂的步骤。另一个实施方案包括将医疗装置暴露于产生抗感染氧化剂的水溶液并将足够数量的抗感染氧化剂转移到医疗装置壁中以向医疗装置提供抗感染活性的步骤。还提供了一种氧化剂释放部件，其具有可释放地包含在其中的抗感染氧化剂，并且被配置为邻近医疗装置设置。示例性装置包括导管，例如静脉，动脉和导尿管，通常包含细长的导管轴，其具有在其中延伸的腔，并且可选地在轴上具有与导管内腔流体连通的气囊。

4. 发明授权

US06592890B1 Conveyance of anti-infective activity to wound dressings 失效
标题翻译：传染性感染活动对伤口敷料
公开(公告)号：US06592890B1
公开(公告)日：2003-07-15
申请号：US09694104
申请日：2000-10-19
申请人： Terrence R. Green
发明人： Terrence R. Green
IPC分类号： A61L1516
CPC分类号： A61L15/46 , A61L15/24 , A61L15/26 , A61L15/38 , A61L2300/106 , A61L2300/254 , A61L2300/404 , C08L33/26
摘要： A wound dressing having anti-infective activity. The wound dressing provides stable and improved formulations of precursors required in generating anti-infective iodine specifically within a wound site where the oxygen tension may be very low. Furthermore, the design of the invention precludes interference by catalase (and other heme proteins.) in competing for hydrogen peroxide where hydrogen peroxide is used as a component of the iodine generating formulation, ensuring more efficient and sustained production of free iodine as a potent anti-infective agent. The invention takes advantage of the physical design of the wound dressing, and the permeation of body fluid into the dressing, which together serve to initiate formation of nascent iodine concomitant with placement of the dressing into, or over, a wound site. The invention circumvents the problem of trapping elemental iodine in the form of tri-iodide, which lacks microbicidal activity, by the chemical method of generating iodine de novo, and in the presence of excess oxidant. Newly formed iodine is thus able to egress and disperse throughout the wound site before there is an opportunity for it to become fully bound as tri-iodide, conferring to the wound site anti-infective activity. Two embodiments of the wound dressing invention are described comprising a mono- and bilayer configuration which, when placed in a wound site, confer to the site anti-infective properties.
摘要翻译：伤口敷料具有抗感染活性。创伤敷料提供稳定和改进的前体制剂，其特别是在氧压力可能非常低的伤口部位产生抗感染性碘所需的前体制剂。此外，本发明的设计排除了过氧化氢酶（和其他血红素蛋白质）在竞争过氧化氢中的干扰，其中过氧化氢被用作碘产生制剂的组分，确保更有效和持续地生产游离碘作为有效的抗有效代理。本发明利用伤口敷料的物理设计，以及体液渗透到敷料中，这些一起用于起始形成新生碘，同时将敷料放置在伤口部位中或上方。本发明通过从过去产生碘的化学方法，在过量的氧化剂存在下，克服了以三碘化物形式捕获元素碘，缺乏杀菌活性的问题。因此，新形成的碘能够在整个伤口部位出口并分散，在其有机会完全结合为三碘化物，赋予伤口部位抗感染活性。描述了伤口敷料发明的两个实施方案，其包括单层和双层构型，其在置于伤口部位时赋予该部位抗感染性质。

5. 发明授权

US06482309B1 Electrolytic generation of nascent iodine as a method of treatment and for the prevention of infections associated with medical implant devices 有权
标题翻译：新生碘的电解产生作为治疗方法和预防与医疗植入装置相关的感染
公开(公告)号：US06482309B1
公开(公告)日：2002-11-19
申请号：US09694110
申请日：2000-10-19
申请人： Terrence R. Green , Jack H. Fellman
发明人： Terrence R. Green , Jack H. Fellman
IPC分类号： C25B124
CPC分类号： C02F1/4674 , A61L2/035 , A61L2/18 , C02F1/46104 , C02F1/4672 , C02F2201/46165 , C02F2303/04
摘要： An anti-infective device generally comprising an oxidant generating formulation contained within at least a section of the device configured to electrolytically generate an anti-infective oxidant. The device has at least one of a cathode member and an anode member in the section of the device, configured to electrolyze the oxidant generating formulation to electrolytically generate the anti-infective oxidant. A power source is electrically connected to the cathode and anode members such that current passes between the cathode and anode members. In one embodiment, the oxidant generating formulation comprises a solid dispersed in a polymeric wall of the device. In a presently preferred embodiment, the cathode and anode members are completely embedded within the polymeric wall of the device, although in some embodiments they may be partially embedded within the polymeric wall of the device. In another embodiment, the oxidant generating formulation comprises a solution contained within a chamber in the device. The cathode and anode members are located within the chamber in contact with the solution. The electrolytically generated anti-infective substance is preferably elemental iodine. In one embodiment, the oxidant generating formulation comprises an iodide, which is oxidized at the anode member. In another embodiment, the oxidant generating formulation comprises an iodate which is reduced at the cathode member. Preferably, a proton donor is also present in the iodate containing oxidant generating formulation.
摘要翻译：一种抗感染装置，通常包含氧化剂生成制剂，其包含在构造成电解产生抗感染氧化剂的装置的至少一部分内。该装置在装置的截面中具有阴极部件和阳极部件中的至少一个，构造成电解氧化剂发生配方以电解产生抗感染氧化剂。电源电连接到阴极和阳极部件，使得电流在阴极和阳极部件之间通过。在一个实施方案中，氧化剂生成制剂包含分散在该装置的聚合物壁中的固体。在目前优选的实施例中，阴极和阳极构件完全嵌入设备的聚合物壁内，尽管在一些实施方式中，它们可以部分地嵌入设备的聚合物壁内。在另一个实施方案中，氧化剂生成制剂包含包含在装置中的室内的溶液。阴极和阳极构件位于室内，与溶液接触。电解产生的抗感染物质优选为元素碘。在一个实施方案中，氧化剂生成制剂包含在阳极部件处被氧化的碘化物。在另一个实施方案中，氧化剂生成制剂包含在阴极部件处还原的碘酸酯。优选地，质子供体也存在于含碘酸的氧化剂生成制剂中。

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