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1. 发明授权

US06815179B2 Methods for measuring stiffness of cultured tissue, for determining transplant compatibility, for quality control, and for preparing transplant-compatible cultured tissue 失效
标题翻译：用于测量培养组织的硬度，确定移植物兼容性，质量控制以及制备移植相容培养组织的方法
公开(公告)号：US06815179B2
公开(公告)日：2004-11-09
申请号：US10083583
申请日：2002-02-27
申请人： Mitsuo Ochi , Junji Iwasa , Masatoshi Tobita , Masakazu Katoh , Takeyuki Yamamoto , Rika Fukushima , Toyokazu Kurushima
发明人： Mitsuo Ochi , Junji Iwasa , Masatoshi Tobita , Masakazu Katoh , Takeyuki Yamamoto , Rika Fukushima , Toyokazu Kurushima
IPC分类号： C12P100
CPC分类号： G01N3/32 , G01N3/405 , G01N2203/0005 , G01N2203/0051 , G01N2203/0676 , G01N2203/0682 , G01N2203/0688
摘要： To determine the transplant compatibility of an in vitro cultured tissue, a method measures the stiffness of the cultured tissue by using a stiffness measuring device, which stiffness measuring device includes a detecting unit and calculation means, the detecting unit includes a contact unit, a vibrator connected to the contact unit, and a vibration detecting unit for detecting the vibration of the vibrator, and the calculation means determines stiffness information by calculation based on the detected result from the vibration detecting element; and by bringing the contact unit into contact with the cultured tissue. With this method the transplant compatibility of the cultured tissue can be nondestructively and easily determined easily and the quality of the cultured tissue can be appropriately controlled.

2. 发明授权

US5609432A Ballpoint pen containing an aqueous ink composition 失效
标题翻译：含有水性油墨组合物的圆珠笔
公开(公告)号：US5609432A
公开(公告)日：1997-03-11
申请号：US446072
申请日：1995-05-19
申请人： Takeyuki Yamamoto , Yasuyuki Sugimoto , Itaru Wakagi , Shinichi Murakata , Yasuzo Murata
发明人： Takeyuki Yamamoto , Yasuyuki Sugimoto , Itaru Wakagi , Shinichi Murakata , Yasuzo Murata
IPC分类号： B43K1/08 , C09D11/18 , B43K7/00 , B43K7/08 , B43K7/10
CPC分类号： C09D11/18 , B43K1/08
摘要： A ballpoint pen contains an aqueous ink composition into which ink is directly filled. The pen is free from ink dripping and has improved writing performance. The aqueous ink composition is directly filled into an ink reservoir tube equipped with a ballpoint pen tip. The aqueous ink composition includes (a) an aqueous medium, (b) a pigment and (c) a carboxyl group-containing crosslinked hydrophilic polymer. The hydrophilic polymer swells and disperses in a gel state in the form of particles having a particle diameter of 0.5 to 10 .mu.m. The polymer is crosslinked with a crosslinkable monomer having at least two polymerizable unsaturated groups in an amount of 0.5 mol % or more based on the total of a carboxyl group-containing monomer and a copolymerizable monoethylenic monomer used together, if desired. The ink reservoir tube tip has a clearance between a ball and a ball receiver in the range of 10 to 40 .mu.m.
摘要翻译：圆珠笔包含油墨直接填充到其中的水性油墨组合物。笔无墨滴，具有改进的书写表现。将水性油墨组合物直接填充到装有圆珠笔笔尖的储墨管中。水性油墨组合物包含（a）水性介质，（b）颜料和（c）含羧基交联的亲水性聚合物。亲水性聚合物以粒径为0.5-10μm的颗粒的形式溶胀并分散在凝胶状态。如果需要，聚合物与具有至少两个可聚合不饱和基团的交联单体交联，其量为基于含羧基的单体和可共聚的单烯属单体的总量的0.5mol％或更多。墨水储存器管头在球和接收器之间的间隙在10至40μm的范围内。

3. 发明授权

US09205544B2 Fastening part tightening management system 有权
标题翻译：紧固件收紧管理系统
公开(公告)号：US09205544B2
公开(公告)日：2015-12-08
申请号：US13813449
申请日：2011-07-29
申请人： Takeyuki Yamamoto , Michihiro Maeda , Katsuo Tokida
发明人： Takeyuki Yamamoto , Michihiro Maeda , Katsuo Tokida
IPC分类号： B25B23/15 , B23P19/06 , B25B23/14 , G05B19/418 , B43K29/00
CPC分类号： B25B23/15 , B23P19/066 , B25B23/14 , B43K29/00 , G05B19/41805 , G05B19/41875 , G05B2219/31027 , G05B2219/32181 , G05B2219/45127 , Y02P90/04
摘要： A fastening part tightening management system (1) that manages a tightening state of a fastening part such as a screw to fix a constituent part of an aircraft in an aircraft assembling process includes a manual torque wrench (2) that tightens a fastening part up to a set torque while activating a tightening torque and detects and transmits tightening torque information acting on the fastening part, a marking pen (3) that performs marking to the fastening part, the tightening operation of which is ended by the manual torque wrench (2), detects a writing pressure in the marking, and transmits marking completion information; an information processing device (5) that determines a tightening state of the fastening part based on the tightening torque information and the marking completion information, and a mobile information terminal (4) that notifies an operator of a determination result obtained by the information processing device (5).
摘要翻译：一种用于管理诸如螺钉的紧固部件的紧固状态的紧固部件紧固管理系统（1），用于在飞行器组装过程中固定飞行器的构成部分，其包括手动扭矩扳手（2），其将紧固部分紧固至在激活紧固扭矩的同时设定扭矩，并且检测和传递作用在紧固部件上的紧固扭矩信息;标记笔（3），其通过手动扭矩扳手（2）结束紧固部件的标记; 检测标记中的书写压力，并发送标记完成信息; 信息处理装置（5），其基于所述紧固扭矩信息和所述标记完成信息来确定所述紧固部的紧固状态;以及移动信息终端（4），其向所述操作者通知所述信息处理装置（5）。

4. 发明申请

US20130174698A1 FASTENING PART TIGHTENING MANAGEMENT SYSTEM 有权
标题翻译：紧固部件紧固管理系统
公开(公告)号：US20130174698A1
公开(公告)日：2013-07-11
申请号：US13813449
申请日：2011-07-29
申请人： Takeyuki Yamamoto , Michihiro Maeda , Katsuo Tokida
发明人： Takeyuki Yamamoto , Michihiro Maeda , Katsuo Tokida
IPC分类号： B25B23/15
CPC分类号： B25B23/15 , B23P19/066 , B25B23/14 , B43K29/00 , G05B19/41805 , G05B19/41875 , G05B2219/31027 , G05B2219/32181 , G05B2219/45127 , Y02P90/04
摘要： A fastening part tightening management system (1) that manages a tightening state of a fastening part such as a screw to fix a constituent part of an aircraft in an aircraft assembling process includes a manual torque wrench (2) that tightens a fastening part up to a set torque while activating a tightening torque and detects and transmits tightening torque information acting on the fastening part, a marking pen (3) that performs marking to the fastening part, the tightening operation of which is ended by the manual torque wrench (2), detects a writing pressure in the marking, and transmits marking completion information; an information processing device (5) that determines a tightening state of the fastening part based on the tightening torque information and the marking completion information, and a mobile information terminal (4) that notifies an operator of a determination result obtained by the information processing device (5).
摘要翻译：一种用于管理诸如螺钉的紧固部件的紧固状态的紧固部件紧固管理系统（1），用于在飞行器组装过程中固定飞机的构成部分，其包括手动扭矩扳手（2），其将紧固部分紧固至在激活紧固扭矩的同时设定扭矩，并且检测和传递作用在紧固部件上的紧固扭矩信息;标记笔（3），其通过手动扭矩扳手（2）结束紧固部件的标记; 检测标记中的书写压力，并发送标记完成信息; 信息处理装置（5），其基于所述紧固扭矩信息和所述标记完成信息来确定所述紧固部的紧固状态;以及移动信息终端（4），其向所述操作者通知所述信息处理装置（5）。

5. 发明授权

US07198908B2 Method for measuring stiffness of a cultured tissue, using a stiffness measurement device having a vibration detective unit 有权
标题翻译：使用具有振动检测单元的刚度测量装置测量培养组织的刚度的方法
公开(公告)号：US07198908B2
公开(公告)日：2007-04-03
申请号：US10921339
申请日：2004-08-19
申请人： Mitsuo Ochi , Junji Iwasa , Masatoshi Tobita , Masakazu Katoh , Takeyuki Yamamoto , Rika Fukushima , Toyokazu Kurushima
发明人： Mitsuo Ochi , Junji Iwasa , Masatoshi Tobita , Masakazu Katoh , Takeyuki Yamamoto , Rika Fukushima , Toyokazu Kurushima
IPC分类号： C12P1/00
CPC分类号： G01N3/32 , G01N3/405 , G01N2203/0005 , G01N2203/0051 , G01N2203/0676 , G01N2203/0682 , G01N2203/0688
摘要： To determine the transplant compatibility of an in vitro cultured tissue, a method measures the stiffness of the cultured tissue by using a stiffness measuring device, which stiffness measuring device includes a detecting unit and calculation means, the detecting unit includes a contact unit, a vibrator connected to the contact unit, and a vibration detecting unit for detecting the vibration of the vibrator, and the calculation means determines stiffness information by calculation based on the detected result from the vibration detecting element; and by bringing the contact unit into contact with the cultured tissue. With this method the transplant compatibility of the cultured tissue can be nondestructively and easily determined easily and the quality of the cultured tissue can be appropriately controlled.
摘要翻译：为了确定体外培养的组织的移植相容性，一种方法通过使用刚度测量装置测量培养组织的刚度，所述刚度测量装置包括检测单元和计算装置，所述检测单元包括接触单元，振动器连接到所述接触单元的振动检测单元，以及用于检测所述振动器的振动的振动检测单元，并且所述计算单元基于来自所述振动检测元件的检测结果，通过计算来确定刚度信息; 并使接触单元与培养的组织接触。通过这种方法，培养的组织的移植相容性可以非破坏性且容易地确定，并且可以适当地控制培养的组织的质量。

6. 发明申请

US20050019748A1 Method for measuring stiffness of a cultured tissue, using a stiffness measurement device having a vibration detective unit 有权
标题翻译：使用具有振动检测单元的刚度测量装置测量培养组织的刚度的方法
公开(公告)号：US20050019748A1
公开(公告)日：2005-01-27
申请号：US10921339
申请日：2004-08-19
申请人： Mitsuo Ochi , Junji Iwasa , Masatoshi Tobita , Masakazu Katoh , Takeyuki Yamamoto , Rika Fukushima , Toyokazu Kurushima
发明人： Mitsuo Ochi , Junji Iwasa , Masatoshi Tobita , Masakazu Katoh , Takeyuki Yamamoto , Rika Fukushima , Toyokazu Kurushima
IPC分类号： G01N3/00 , G01N3/06 , G01N3/32 , G01N3/40 , C12Q1/00
CPC分类号： G01N3/32 , G01N3/405 , G01N2203/0005 , G01N2203/0051 , G01N2203/0676 , G01N2203/0682 , G01N2203/0688
摘要： To determine the transplant compatibility of an in vitro cultured tissue, a method measures the stiffness of the cultured tissue by using a stiffness measuring device, which stiffness measuring device includes a detecting unit and calculation means, the detecting unit includes a contact unit, a vibrator connected to the contact unit, and a vibration detecting unit for detecting the vibration of the vibrator, and the calculation means determines stiffness information by calculation based on the detected result from the vibration detecting element; and by bringing the contact unit into contact with the cultured tissue. With this method the transplant compatibility of the cultured tissue can be nondestructively and easily determined easily and the quality of the cultured tissue can be appropriately controlled.
摘要翻译：为了确定体外培养的组织的移植相容性，一种方法通过使用刚度测量装置测量培养组织的刚度，所述刚度测量装置包括检测单元和计算装置，所述检测单元包括接触单元，振动器连接到所述接触单元的振动检测单元，以及用于检测所述振动器的振动的振动检测单元，并且所述计算单元基于来自所述振动检测元件的检测结果，通过计算来确定刚度信息; 并使接触单元与培养的组织接触。通过这种方法，培养的组织的移植相容性可以非破坏性且容易地确定，并且可以适当地控制培养的组织的质量。

7. 发明申请

US20070172812A1 Tissue equivalent for transplantation and method for producing same 审中-公开
标题翻译：移植组织等价物及其生产方法
公开(公告)号：US20070172812A1
公开(公告)日：2007-07-26
申请号：US11727521
申请日：2007-03-27
申请人： Mitsuo Ochi , Yuji Uchio , Kenzo Kawasaki , Masakazu Katoh , Takeyuki Yamamoto , Rika Fukushima , Toyokazu Kurushima
发明人： Mitsuo Ochi , Yuji Uchio , Kenzo Kawasaki , Masakazu Katoh , Takeyuki Yamamoto , Rika Fukushima , Toyokazu Kurushima
IPC分类号： A01N1/02 , C12N5/08 , C12N5/06
CPC分类号： A61L27/3821 , A61L27/3633 , A61L27/3817 , A61L27/3895
摘要： A tissue equivalent for transplantation having a three-dimensional structure which is cultured in vitro, contains cells to be transplanted and which can be transplanted into a living body after the culture, characterized by including a scaffold layer mainly culturing a scaffold constituting the three-dimensional structure and a cell layer which is localized at least in a part of the surface of the tissue equivalent for transplantation continuously with the scaffold layer and which contains the cells to be transplanted or extra cellular matrix in a larger amount than the scaffold layer. This tissue equivalent is appropriately employed as a tissue equivalent for transplantation in a relatively large size. This tissue equivalent enables realization of prompt fixation to the neighborhood of the transplanted tissue and prevention of falling off.
摘要翻译：具有体外培养的具有三维结构的移植组织当量含有待移植的细胞，并且可以在培养后移植到生物体中，其特征在于包括主要培养构成三维的支架的支架层结构和细胞层，其至少在组织的表面的一部分中等同于与支架层连续移植，并且其含有比支架层更大量的要移植的细胞或细胞外基质。这种组织当量适当地用作相对较大尺寸移植的组织当量。这种组织等效使得能够实现对移植组织附近的迅速固定并防止脱落。

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