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    • 3. 发明授权
    • Transposition operation device, integrated circuit for the same, and transposition method
    • 换位操作装置,集成电路相同,换位方式
    • US09201899B2
    • 2015-12-01
    • US13824865
    • 2012-09-11
    • Takashi NishimuraHiroyuki Morishita
    • Takashi NishimuraHiroyuki Morishita
    • G06F17/30G06F9/30
    • G06F17/30244G06F9/30032G06F9/30036G06F9/30109
    • A transposition operation device includes: a register group storing a matrix of data such that elements are readable one at a time; an output data rearrangement unit rearranging elements in each row of the matrix so that elements in a same column of the matrix are in different columns of the matrix after rearrangement; a register access unit writing the matrix after rearrangement to the register group and reading the elements in the same column by using column position information indicating positions in the register group at which the elements in the same column are stored; an input data rearrangement unit rearranging the read elements; an operation unit performing an operation on the rearranged elements; and a transposition control unit generating rearrangement information and the column position information to control rearrangement, and performs transposition at high speed by performing rearrangement at the time of storing/reading data in/from the register group.
    • 移位操作装置包括:存储数据矩阵的寄存器组,使得元素一次可读; 输出数据重排单元重新排列矩阵的每行中的元素,使得矩阵的同一列中的元素在重新排列之后处于矩阵的不同列中; 寄存器访问单元,通过使用指示存储同一列中的元素的寄存器组中的位置的列位置信息,将重排后的矩阵写入寄存器组并读取同一列中的元素; 输入数据重排单元重新排列读取的元件; 对重新排列的元件执行操作的操作单元; 以及转置控制单元,其生成重排信息和列位置信息以控制重排,并且通过在从寄存器组中存储/读取数据时执行重排来高速执行转置。
    • 10. 发明申请
    • ANTIGENIC POLYPEPTIDE USABLE AS THERAPEUTIC AGENT FOR MALIGNANT NEOPLASM
    • 抗恶性多糖可作为恶性肿瘤治疗药物使用
    • US20100034841A1
    • 2010-02-11
    • US12312232
    • 2007-10-02
    • Takashi Nishimura
    • Takashi Nishimura
    • A61K39/00C12N5/02C12N15/63C07K7/08C07K16/18C07H21/04
    • C07K14/4748A61K39/0011A61K2039/5158A61K2039/57C07K16/30C07K2317/34
    • This invention provides a new tumor antigen having an epitope that induces a Th1 cell (a CD4-positive T cell specific to MAGE-A4), and a method of application thereof.Specifically, this invention provides a polypeptide that includes an amino acid sequence having the following characteristic a), b), c), d), e) or f) and has a cytokine-producing activity in a Th cell specific to MAGE-A4: a) An amino acid sequence represented by SEQ ID No: 1 or No: 2; b) An amino acid sequence, wherein one to several tens of any amino acids are added to N terminus and/or C terminus of an amino acid sequence represented by SEQ ID No: 1 or No: 2; c) An amino acid sequence, wherein one to five amino acids from N terminus and/or C terminus of an amino acid sequence represented by SEQ ID No: 1 or No: 2 are deleted; d) An amino acid sequence, wherein one to several amino acid residues of an amino acid sequence represented by SEQ ID No: 1 or No: 2 are substituted and/or deleted; e) An amino acid sequence, wherein one to several tens of any amino acids are added to N terminus and/or C terminus of an amino acid sequence, wherein one to several amino acid residues of an amino acid sequence represented by SEQ ID No: 1 or No: 2 are substituted and/or deleted; and f) An amino acid sequence, wherein one to several amino acid residues are substituted in an amino acid sequence, wherein one to five amino acids from N terminus and/or C terminus of an amino acid sequence represented by SEQ ID No: 1 or No: 2 are deleted.
    • 本发明提供具有诱导Th1细胞(MAGE-A4特异性的CD4阳性T细胞)表位的新型肿瘤抗原及其应用方法。 具体而言,本发明提供了包含具有以下特征a),b),c),d),e)或f)特征的氨基酸序列的多肽,并且在特异于MAGE-A4的Th细胞中具有细胞因子产生活性 a)由SEQ ID No:1或No.2表示的氨基酸序列; b)氨基酸序列,其中在SEQ ID No:1或No.2所表示的氨基酸序列的N末端和/或C末端加入一至数十个氨基酸; c)缺失由SEQ ID No:1或No.2表示的氨基酸序列的N末端和/或C末端的一至五个氨基酸的氨基酸序列; d)氨基酸序列,其中由SEQ ID No:1或No:2表示的氨基酸序列的一个至几个氨基酸残基被取代和/或缺失; e)氨基酸序列,其中将一至几十个任何氨基酸加入氨基酸序列的N末端和/或C末端,其中SEQ ID NO:1所示的氨基酸序列的一个至多个氨基酸残基, 1或No:2被替换和/或删除; 和f)氨基酸序列,其中一个至几个氨基酸残基被氨基酸序列取代,其中由SEQ ID No:1表示的氨基酸序列的N末端和/或C末端的一至五个氨基酸或 否:2被删除。