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1. 发明申请

US20220143082A1 CELL TREATMENTS AND THERAPEUTIC REINFUSION METHODS 有权
公开(公告)号：US20220143082A1
公开(公告)日：2022-05-12
申请号：US17580419
申请日：2022-01-20
申请人： Todd Alamin , Avram Allan Edidin , Hugues Malandain , Healey Montague-Alamin
发明人： Todd Alamin , Avram Allan Edidin , Hugues Malandain , Healey Montague-Alamin
IPC分类号： A61K35/13 , C12M1/00 , C12N5/09
摘要： Tumor tissue, including soft and/or bony tissue, are harvested from a subject and morcellated. The morcellated tissue is placed in a cartridge which is placed in a containment chamber of a tumor tissue processing device. Cancer cells in the morcellated tumor tissue are destroyed without destroying tumor antigens therein. These cells are destroyed cryogenically by exposing the cartridge to a cooling fluid such as liquid nitrogen, optionally with a warming cycle, and optionally with more than one freezing/thawing cycle. The treated tissue and/or cells are then extracted from the cartridge and reintroduced to the subject after they have reached a threshold condition. The treated tissue and/or cells can be reintroduced via a containment sleeve or a reimplantation bag.

2. 发明申请

US20170319242A1 METHODS AND SYSTEMS FOR CONSTRAINT OF SPINOUS PROCESSES WITH ATTACHMENT 审中-公开
公开(公告)号：US20170319242A1
公开(公告)日：2017-11-09
申请号：US15409436
申请日：2017-01-18
申请人： Todd ALAMIN , Ian BENNETT , Louis FIELDING , Colin CAHILL
发明人： Todd ALAMIN , Ian BENNETT , Louis FIELDING , Colin CAHILL
IPC分类号： A61B17/70 , A61B17/84 , A61B17/68 , A61B17/00 , A61B17/04
CPC分类号： A61B17/7067 , A61B17/683 , A61B17/7053 , A61B17/7055 , A61B17/7062 , A61B17/842 , A61B17/846 , A61B2017/00862 , A61B2017/0417 , A61B2017/7073
摘要： Spinal implants for limiting flexion of the spine are implanted between a superior spinous process and an inferior spinous process or sacrum. The implants include upper straps which are placed over the upper spinous process, while the lower portions of the implant are attached to the adjacent vertebra or sacrum. The attachments may be fixed, for example using screws or other anchors, or may be non-fixed, for example by placing a loop strap through a hole in the spinous process or sacrum.

3. 发明申请

US20160256201A1 METHODS AND SYSTEMS FOR CONSTRAINT OF SPINOUS PROCESSES WITH ATTACHMENT 审中-公开
公开(公告)号：US20160256201A1
公开(公告)日：2016-09-08
申请号：US14875495
申请日：2015-10-05
申请人： Todd ALAMIN , Ian BENNETT , Louis FIELDING , Colin CAHILL
发明人： Todd ALAMIN , Ian BENNETT , Louis FIELDING , Colin CAHILL
IPC分类号： A61B17/70 , A61B17/84
CPC分类号： A61B17/7067 , A61B17/683 , A61B17/7053 , A61B17/7055 , A61B17/7062 , A61B17/842 , A61B17/846 , A61B2017/00862 , A61B2017/0417 , A61B2017/7073
摘要： Spinal implants for limiting flexion of the spine are implanted between a superior spinous process and an inferior spinous process or sacrum. The implants include upper straps which are placed over the upper spinous process, while the lower portions of the implant are attached to the adjacent vertebra or sacrum. The attachments may be fixed, for example using screws or other anchors, or may be non-fixed, for example by placing a loop strap through a hole in the spinous process or sacrum.

4. 发明授权

US09295499B2 Methods and systems for laterally stabilized constraint of spinous processes 有权
公开(公告)号：US09295499B2
公开(公告)日：2016-03-29
申请号：US13889581
申请日：2013-05-08
申请人： Todd Alamin , Ian Bennett , Colin Cahill , Louis Fielding , Manish Kothari , Jeffrey Schwardt
发明人： Todd Alamin , Ian Bennett , Colin Cahill , Louis Fielding , Manish Kothari , Jeffrey Schwardt
IPC分类号： A61B17/70 , A61B17/84
CPC分类号： A61B17/7065 , A61B17/7055 , A61B17/7062 , A61B17/842
摘要： A spinal implant for limiting flexion of the spine includes a tether structure for encircling adjacent spinal processes. Usually, a pair of compliance members will be provided as part of the tether structure for elastically limiting flexion while permitting an extension. A cross-member is provided between the compliance member or other portions of the tether structure to stabilize the tether structure and prevent misalignment after implantation.

5. 发明申请

US20130274748A1 METHODS AND APPARATUS FOR LOCKING A BAND 审中-公开
标题翻译：用于锁定带的方法和装置
公开(公告)号：US20130274748A1
公开(公告)日：2013-10-17
申请号：US13648061
申请日：2012-10-09
申请人： Ian BENNETT , Louis FIELDING , Hugues MALANDAIN , Todd ALAMIN
发明人： Ian BENNETT , Louis FIELDING , Hugues MALANDAIN , Todd ALAMIN
IPC分类号： A61B17/82
CPC分类号： A61B17/82 , A61B17/7053 , A61B17/7062 , A61B17/842 , A61B17/8869
摘要： A surgical fastening mechanism for releasably locking an implantable tether includes a housing having a central channel. The housing has an entry aperture, an exit aperture and a side channel extending therebetween. A roller element has a sidewall with an aperture therethrough and the roller is slidably disposed at least partially in the central channel such that the entry and exit apertures are at least partially aligned with the roller aperture. This permits passage of the tether therethrough. Rotation of the roller element in a first direction winds the tether around the roller thereby creating a friction interface between the roller element, the housing and the tether. A locking mechanism is operably connected with either the housing or the roller element and is adapted to prevent rotation of the roller in the central channel and also adapted to prevent release of the tether from the roller.
摘要翻译：用于可释放地锁定可植入系绳的手术紧固机构包括具有中心通道的壳体。壳体具有入口孔，出口孔和在其间延伸的侧通道。滚子元件具有通过其的孔的侧壁，并且该滚轮至少部分地可滑动地设置在中心通道中，使得入口孔和出口孔至少部分地与滚筒孔对准。这允许系绳穿过其中。滚子元件沿第一方向的旋转将围绕滚筒缠绕，从而在滚子元件，外壳和系绳之间产生摩擦接口。锁定机构与壳体或滚子元件可操作地连接，并且适于防止辊在中心通道中的旋转，并且还适于防止系绳从辊松开。

6. 发明申请

US20120209328A1 STRUCTURES AND METHODS FOR CONSTRAINING SPINAL PROCESSES WITH SINGLE CONNECTOR 审中-公开
标题翻译：用单个连接器约束脊柱过程的结构和方法
公开(公告)号：US20120209328A1
公开(公告)日：2012-08-16
申请号：US13455917
申请日：2012-04-25
申请人： Todd Alamin , Ian Bennett , Louis Fielding , Colin Cahill , Manish Kothari
发明人： Todd Alamin , Ian Bennett , Louis Fielding , Colin Cahill , Manish Kothari
IPC分类号： A61B17/70 , A61B17/88
CPC分类号： A61B17/7062 , A61B17/7055 , A61B17/842
摘要： Spinous process constraint structures include a first attachment element for placement over a first spinous process and a second attachment element for placement over a second spinous process. The attachment elements are joined by a single connector which may optionally include a compliance member for providing controlled elasticity between the spinous processes.
摘要翻译：旋转过程约束结构包括用于放置在第一棘突上的第一附接元件和用于放置在第二棘突上的第二附接元件。附接元件通过单个连接器连接，该连接器可以可选地包括用于在棘突之间提供受控弹性的柔顺构件。

7. 发明申请

US20120123482A1 SPINAL IMPLANT AND METHOD FOR RESTRICTING SPINAL FLEXION 有权
标题翻译：脊柱植入物和限制脊柱弯曲的方法
公开(公告)号：US20120123482A1
公开(公告)日：2012-05-17
申请号：US13340483
申请日：2011-12-29
申请人： Louis Fielding , Ian Bennett , Colin Cahill , Pat Arensdorf , Ralph Crisostomo , Todd Alamin
发明人： Louis Fielding , Ian Bennett , Colin Cahill , Pat Arensdorf , Ralph Crisostomo , Todd Alamin
IPC分类号： A61B17/88
CPC分类号： A61B17/7062
摘要： A spinal implant system for restricting flexion of a spine includes an elongate band proportioned to engage at least two spinous processes. During use, the band is positioned engaging the spinous processes at a spinal segment of interest, where it restricts flexion at the segment. The length and tension of the band may be adjustable following to implantation using percutaneous or transcutaneous means.
摘要翻译：用于限制脊柱弯曲的脊柱植入系统包括成比例的细长带以接合至少两个棘突。在使用期间，带被定位成与感兴趣的脊髓部分处的棘突接合，其中它限制了该部分的屈曲。在使用经皮或经皮手段进行植入之后，带的长度和张力可以是可调节的。

8. 发明授权

US07905874B2 Spinal diagnostic methods and apparatus 有权
标题翻译：脊柱诊断方法和装置
公开(公告)号：US07905874B2
公开(公告)日：2011-03-15
申请号：US11616222
申请日：2006-12-26
申请人： David R. Miller , Todd Alamin , Peter F. Campbell
发明人： David R. Miller , Todd Alamin , Peter F. Campbell
IPC分类号： A61M31/00
CPC分类号： A61B17/3478 , A61B17/3421 , A61B17/3472 , A61B2017/00261 , A61B2017/00469 , A61B2017/3488
摘要： Methods, devices and systems facilitate diagnosis, and in some cases treatment, of back pain originating in intervertebral discs. Methods generally involve introducing one or more substances into one or more discs using a catheter device. In one embodiment, a patient assumes a position that causes back pain, and a substance such as an anesthetic or analgesic is introduced into the disc to determine whether the substance relieves the pain. Injections into multiple discs may optionally be performed, to help pinpoint a disc as a source of the patient's pain. In some embodiments, the catheter device is left in place, and possibly coupled with another implantable device, to provide treatment of one or more discs. A catheter device includes at least one anchoring member for maintaining a distal portion of the catheter within a disc.
摘要翻译：方法，装置和系统便于在椎间盘中产生的背部疼痛的诊断以及在某些情况下治疗。方法通常包括使用导管装置将一种或多种物质引入一个或多个盘中。在一个实施方案中，患者承担引起背部疼痛的位置，并且将诸如麻醉剂或镇痛剂的物质引入椎间盘以确定该物质是否释放疼痛。可以可选地执行到多个盘中的注射，以帮助确定光盘作为患者疼痛的来源。在一些实施例中，导管装置留在原位，并且可能与另一种可植入装置联接，以提供对一个或多个盘的治疗。导管装置包括用于将导管的远侧部分保持在盘内的至少一个锚固构件。

9. 发明申请

US20100234890A1 SURGICAL TETHER APPARATUS AND METHODS OF USE 有权
标题翻译：外科手术器械和使用方法
公开(公告)号：US20100234890A1
公开(公告)日：2010-09-16
申请号：US12721198
申请日：2010-03-10
申请人： Todd Alamin , Louis Fielding , Colin Cahill , Manish Kothari
发明人： Todd Alamin , Louis Fielding , Colin Cahill , Manish Kothari
IPC分类号： A61B17/70 , A61B17/88 , A61F2/44
CPC分类号： A61B17/7062 , A61B17/7067 , A61B17/7097
摘要： A spinal treatment system includes a constraint device having an upper tether portion, a lower tether portion and a compliance member coupled therebetween. The upper tether portion is coupled with a superior spinous process of a spinal segment in a patient and the lower tether portion is coupled with an inferior spinous process or sacrum of the spinal segment. The length or tension in the constraint device is adjustable so that the construct of the tether portions and the compliance member provides a force resistant to flexion of the spinal segment. The system also includes a first prosthesis coupled with the spinal segment, wherein the constraint device modulates loads borne by the prosthesis or by tissue adjacent thereto.
摘要翻译：脊柱治疗系统包括约束装置，其具有上部系绳部分，下部系绳部分和联接在它们之间的顺应性部件。上部系绳部分与患者中的脊柱节段的优越棘突联接，并且下部系绳部分与脊柱节段的下棘突或骶骨联接。约束装置中的长度或张力是可调节的，使得系链部分和柔顺构件的构造提供抵抗脊椎节段屈曲的力。所述系统还包括与所述脊椎节段联接的第一假体，其中所述约束装置调节由假体或与其相邻的组织承载的负载。

10. 发明申请

US20090198282A1 SPINAL IMPLANT AND METHOD FOR RESTRICTING SPINAL FLEXION 有权
标题翻译：脊柱植入物和限制脊柱弯曲的方法
公开(公告)号：US20090198282A1
公开(公告)日：2009-08-06
申请号：US12364487
申请日：2009-02-02
申请人： Louis Fielding , Ian Bennett , Colin Cahill , Pat Arensdorf , Ralph Crisostomo , Todd Alamin
发明人： Louis Fielding , Ian Bennett , Colin Cahill , Pat Arensdorf , Ralph Crisostomo , Todd Alamin
IPC分类号： A61B17/88
CPC分类号： A61B17/7062
摘要： A spinal implant system for restricting flexion of a spine includes an elongate band proportioned to engage at least two spinous processes. During use, the band is positioned engaging the spinous processes at a spinal segment of interest, where it restricts flexion at the segment. The length and tension of the band may be adjustable following to implantation using percutaneous or transcutaneous means.
摘要翻译：用于限制脊柱弯曲的脊柱植入系统包括成比例的细长带以接合至少两个棘突。在使用期间，带被定位成与感兴趣的脊髓部分处的棘突接合，其中它限制了该部分的屈曲。在使用经皮或经皮手段进行植入之后，带的长度和张力可以是可调节的。

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