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    • 7. 发明申请
    • MEDICAL PRODUCT
    • 医疗产品
    • US20090041682A1
    • 2009-02-12
    • US12255086
    • 2008-10-21
    • Thomas NilssonMattias MyrmanSven CalanderAlf Niemi
    • Thomas NilssonMattias MyrmanSven CalanderAlf Niemi
    • A61K9/72A61K31/46A61M11/00
    • A61K9/0075A61K9/008A61K31/439
    • The invention discloses a medical product for use in a treatment of respiratory disorders, and comprises a metered dose of a tiotropium dry powder formulation, directly loaded and sealed into a container made to act as a dry high barrier seal to prevent the capture and ingress of moisture into the tiotropium powder. The dose of tiotropium is further adapted for inhalation and the container is so tight that the efficacy of the dose when delivered is unaffected by moisture. In a further aspect of the invention a type of inhaler is illustrated, which may accept at least one sealed, moisture-tight container of a dose of tiotropium, to deliver the dose with a consistent fine particle dose, over the expected shelf life of the product.
    • 本发明公开了一种用于治疗呼吸系统疾病的医疗产品,并且包括计量剂量的噻托溴铵干粉制剂,其直接装载并密封在容器中,作为干燥的高隔离密封件,以防止捕获和进入 水分进入噻托铵粉。 噻托溴铵的剂量进一步适于吸入,并且容器如此紧密,使得当递送时的剂量的功效不受潮气的影响。 在本发明的另一方面,示出了一种类型的吸入器,其可以接受至少一个剂量的噻托溴铵的密封且不透气的容器,以在所期望的保质期内以一致的细粒剂量输送剂量 产品。
    • 8. 发明申请
    • Combined doses of formoterol and an anticholinergic agent
    • 联合剂量的福莫特罗和抗胆碱剂
    • US20050063911A1
    • 2005-03-24
    • US10870945
    • 2004-06-21
    • Thomas NilssonMattias MyrmanClaes FribergSven Calander
    • Thomas NilssonMattias MyrmanClaes FribergSven Calander
    • A61J1/00A61K20060101A61K9/14A61K45/06A61L9/04A61M15/00A61P11/06A61P11/08
    • A61K9/0075
    • The present invention discloses pharmaceutical dry powder combined doses for the administration by inhalation of metered dry powder combined doses of finely divided dry medication powders. Formoterol and an anticholinergic agent are selected medicaments for forming the combined doses. Metered dry powder medicinal combined doses comprising separately metered deposits of medicinally suitable quantities of each of the selected medicaments are prepared, in which the sum of the metered deposits constitutes the metered quantities of powder of the combined doses and the medicinal combined doses are introduced into an adapted inhaler device for a generally simultaneous or sequential delivery of the medicinal combined doses during the course of a single inhalation by a user, such that each one of the delivered medicinal combined doses is composed of a high proportion of de-aggregated fine particles of the selected medicament or medicaments, whereby a desired therapeutic or treating effect to the user is achieved.
    • 本发明公开了用于通过吸入计量干粉末组合剂量的细碎干药物粉末施用的药物干粉组合剂量。 选择福莫特罗和抗胆碱剂是用于形成组合剂量的药物。 制备计量的干粉药物组合剂量,其包含分别计量的每种药物合适量的定量沉积物,其中计量沉积物的总量构成组合剂量的计量量的粉末,并且药物组合剂量被引入 适合的吸入器装置,用于在用户单次吸入过程中大致同时或顺序递送药物组合剂量,使得每一个递送的药物组合剂量由高比例的 选择的药物或药物,从而实现对用户的期望的治疗或治疗效果。