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1. 发明授权

US09347957B2 Reagent for assaying D-dimer and kit of reagent for assaying D-dimer 有权
标题翻译：用于测定D-二聚体的试剂和用于测定D-二聚体的试剂盒
公开(公告)号：US09347957B2
公开(公告)日：2016-05-24
申请号：US13190146
申请日：2011-07-25
申请人： Keisuke Nagai , Kazuaki Yamashita , Susumu Hoshiko , Takeshi Suzuki
发明人： Keisuke Nagai , Kazuaki Yamashita , Susumu Hoshiko , Takeshi Suzuki
IPC分类号： G01N33/566 , G01N33/86
CPC分类号： G01N33/86 , G01N2333/75
摘要： The present invention provides a reagent for assaying D-dimer which includes carriers sensitized to first and second monoclonal antibodies which react with D-dimer, but have different reactivity to D-dimer in which the first monoclonal antibody reacts with high- and low-molecular fractions of D-dimer, the second monoclonal antibody reacts with the high-molecular fraction, but reactivity of the second monoclonal antibody with the low-molecular fraction is different from that of the first monoclonal antibody and a kit of reagent for assaying D-dimer.
摘要翻译：本发明提供了一种用于测定D-二聚体的试剂，其包括对与D-二聚体反应但对D-二聚体具有不同反应性的第一和第二单克隆抗体敏感的载体，其中第一单克隆抗体与高分子和低分子 D-二聚体的部分，第二单克隆抗体与高分子部分反应，但是第二单克隆抗体与低分子级分的反应性与第一单克隆抗体的反应性不同，以及用于测定D-二聚体的试剂盒。

2. 发明申请

US20050202509A1 Reagent for measuring clotting time and method for measuring clotting time 审中-公开
标题翻译：用于测定凝血时间的试剂和测定凝血时间的方法
公开(公告)号：US20050202509A1
公开(公告)日：2005-09-15
申请号：US10995382
申请日：2004-11-24
申请人： Masahiro Okuda , Susumu Hoshiko
发明人： Masahiro Okuda , Susumu Hoshiko
IPC分类号： G01N33/53 , G01N33/86
CPC分类号： G01N33/86 , G01N2333/7454 , G01N2333/7456 , G01N2333/75
摘要： The present invention provides a reagent for measuring clotting time that allows accurate analysis of blood coagulation in samples containing antiphospholipid antibodies, wherein the clotting time is measured by using a sample containing an antiphospholipid antibody, a causative substance of antiphospholipid antibody syndromes, and the reagent for measuring clotting time containing antibody, serum, plasma and immunoglobulin of vertebrates except human.
摘要翻译：本发明提供一种用于测定凝血时间的试剂，其允许精确分析含有抗磷脂抗体的样品中的凝血的试剂，其中通过使用含有抗磷脂抗体，抗磷脂抗体综合征的致病物质的样品和所述抗磷脂抗体综合征的试剂测量凝血时间测量包含除人之外的脊椎动物的抗体，血清，血浆和免疫球蛋白的凝血时间。

3. 发明授权

US08753808B2 Platelet aggregation measuring method and platelet aggregation measuring apparatus 有权
标题翻译：血小板聚集测定方法及血小板聚集测定仪
公开(公告)号：US08753808B2
公开(公告)日：2014-06-17
申请号：US12146988
申请日：2008-06-26
申请人： Susumu Hoshiko , Katsushi Kobayashi
发明人： Susumu Hoshiko , Katsushi Kobayashi
IPC分类号： C12Q1/00
CPC分类号： G01N33/86 , G01N33/4905 , G01N2333/755
摘要： A platelet aggregation measuring method comprising: preparing a measurement sample which contains a sample and a reagent which includes a platelet activator; mixing the measurement sample at a first speed; mixing the measurement sample at a second speed which is greater than the first speed after mixing the sample at the first speed; obtaining optical information from the measurement sample while mixing the measurement sample at the second speed; and analyzing aggregation of platelets in the sample based on the optical information is disclosed. A platelet aggregation measuring apparatus is also disclosed.
摘要翻译： 1.一种血小板聚集测定方法，其特征在于，包括：准备含有试样的测定试样和含有血小板活化剂的试剂; 以第一速度混合测量样品; 在以第一速度混合样品之后，以大于第一速度的第二速度混合测量样品; 在测量样品以第二速度混合的同时从测量样品获得光学信息; 并且基于光学信息分析样品中血小板的聚集。还公开了血小板聚集测量装置。

4. 发明授权

US07760340B2 Sample analyzer 有权
标题翻译：样品分析仪
公开(公告)号：US07760340B2
公开(公告)日：2010-07-20
申请号：US11724934
申请日：2007-03-16
申请人： Susumu Hoshiko , Naohiko Matsuo , Katsushi Kobayashi , Norimasa Yamamoto
发明人： Susumu Hoshiko , Naohiko Matsuo , Katsushi Kobayashi , Norimasa Yamamoto
IPC分类号： G01N33/48
CPC分类号： G01N21/314 , G01J2003/123 , G01N21/0332 , G01N21/253 , G01N21/272 , G01N21/274 , G01N21/82 , G01N33/49 , G01N35/00603 , G01N2021/3148 , G01N2021/3155 , G01N2021/3174 , G01N2021/825 , G01N2035/00356 , G01N2035/0455 , G01N2201/0618 , G01N2201/0826
摘要： A sample analyzer includes (a) a measuring part for measuring optical information of a sample at first wavelength, second wavelength, and third wavelength, first light of the first wavelength and second light of the second wavelength being absorbed by a second substance but substantially not absorbed by a first substance, and third light of the third wavelength being absorbed by the first substance; and (b) an obtaining part for obtaining content of the first substance in the sample, and content of the second substance in the sample, influence by the second substance being excluded from the content of the first substance, based on the optical information at the first wavelength, second wavelength, and third wavelength measured by the measuring part.
摘要翻译：样品分析仪包括：（a）测量部件，用于测量第一波长，第二波长和第三波长处的样品的光学信息，第一波长的第一光和第二波长的第二光被第二物质吸收，但基本上不被第一物质吸收，第三波长的第三光被第一物质吸收; 和（b）获取部分，用于获得样品中第一物质的含量和样品中第二物质的含量，第二物质的含量根据第一物质的含量而被排除在第一物质的含量之外第一波长，第二波长和第三波长由测量部件测量。

5. 发明申请

US20090004681A1 PLATELET AGGREGATION MEASURING METHOD AND PLATELET AGGREGATION MEASURING APPARATUS 有权
标题翻译：电极聚集测量方法和电极聚集测量装置
公开(公告)号：US20090004681A1
公开(公告)日：2009-01-01
申请号：US12146988
申请日：2008-06-26
申请人： Susumu Hoshiko , Katsushi Kobayashi
发明人： Susumu Hoshiko , Katsushi Kobayashi
IPC分类号： C12Q1/56 , C12Q1/02 , C12M1/34
CPC分类号： G01N33/86 , G01N33/4905 , G01N2333/755
摘要： A platelet aggregation measuring method comprising: preparing a measurement sample which contains a sample and a reagent which includes a platelet activator; mixing the measurement sample at a first speed; mixing the measurement sample at a second speed which is greater than the first speed after mixing the sample at the first speed; obtaining optical information from the measurement sample while mixing the measurement sample at the second speed; and analyzing aggregation of platelets in the sample based on the optical information is disclosed. A platelet aggregation measuring apparatus is also disclosed.
摘要翻译： 1.一种血小板聚集测定方法，其特征在于，包括：准备含有试样的测定试样和含有血小板活化剂的试剂; 以第一速度混合测量样品; 在以第一速度混合样品之后，以大于第一速度的第二速度混合测量样品; 在测量样品以第二速度混合的同时从测量样品获得光学信息; 并且基于光学信息分析样品中血小板的聚集。还公开了血小板聚集测量装置。

6. 发明授权

US6043205A Hematological analyzer sampling probe cleansing composition and method of using 有权
标题翻译：血液分析仪采样探头清洗组合物及使用方法
公开(公告)号：US6043205A
公开(公告)日：2000-03-28
申请号：US161672
申请日：1998-09-29
申请人： Susumu Hoshiko , Miki Miyaji
发明人： Susumu Hoshiko , Miki Miyaji
IPC分类号： G01N35/10 , C11D1/72 , C11D1/74 , C11D3/30 , C11D3/33 , C11D11/00 , C11D17/08 , C11D7/08
CPC分类号： G01N35/1004 , C11D1/72 , C11D1/74 , C11D11/0041 , C11D3/30 , C11D3/33
摘要： A cleansing composition and method of use are disclosed for cleansing a quantitatively aspirating sampling probe in an automated hematological analyzer. The cleansing composition is formulated to cleanse instantaneously on contact, and practically eliminates carry-over of hematological sample material, assaying reagents or of the cleansing composition itself. The cleansing composition is an acidic aqueous solution of pH 5.0 or less, including (1) a substance having a primary amino group; and (2) one or more nonionic surfactants selected from the group consisting of polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene alkyl ester and polyoxyethylene sorbitan ester.
摘要翻译：公开了一种清洁组合物和使用方法，用于在自动血液分析仪中清洗定量抽吸取样探针。配制清洁组合物以在接触时立即进行清洁，并且实际上消除了血液样品材料的残留，测定试剂或清洁组合物本身。所述清洁组合物为pH5.0以下的酸性水溶液，包括（1）具有伯氨基的物质; 和（2）一种或多种选自聚氧乙烯烷基醚，聚氧乙烯烷基苯基醚，聚氧乙烯烷基酯和聚氧乙烯脱水山梨糖醇酯的非离子表面活性剂。

7. 发明授权

US07962292B2 Sample analyzer and sample analyzing method 有权
标题翻译：样品分析仪和样品分析方法
公开(公告)号：US07962292B2
公开(公告)日：2011-06-14
申请号：US12012431
申请日：2008-01-31
申请人： Naohiko Matsuo , Hiroyuki Fujino , Mitsuyo Koya , Susumu Hoshiko
发明人： Naohiko Matsuo , Hiroyuki Fujino , Mitsuyo Koya , Susumu Hoshiko
IPC分类号： G01N31/00
CPC分类号： G01N35/00594 , G01N15/12 , G01N15/1459 , G01N21/272 , G01N21/82 , G01N33/4905 , G01N2015/0073 , G01N2015/0076 , G01N2015/008 , G01N2015/1486
摘要： A sample analyzer optically measures reaction of a sample mixed with reagent, and obtains optical information therefrom; generates a reaction curve representing change in the optical information over time; determines a first area prior to an evaluation target time (t0) and a second area after the evaluation target time (t0) wherein the first and second areas are formed between a baseline which is parallel to the time axis and a reaction curve from a first time (t1) prior to the optional evaluation target time (t0) to a second time (t2) after the evaluation target time, and determines the reaction end point based on the first and second areas; and obtains a characteristic of a sample based on the determined reaction end point, is disclosed. a sample analyzing method is also disclosed.
摘要翻译：样品分析仪光学测量与试剂混合的样品的反应，并从中获得光学信息; 产生表示光信息随时间变化的反应曲线; 确定在评估目标时间（t0）之前的第一区域和在评估目标时间（t0）之后的第二区域，其中在与时间轴平行的基线和来自第一个时间轴的反应曲线之间形成第一和第二区域在评估目标时间之后的可选评估目标时间（t0）到第二时间（t2）之前的时间（t1），并且基于第一和第二区域确定反应结束点; 并且基于所确定的反应终点获得样品的特性。还公开了一种样品分析方法。

8. 发明申请

US20110014640A1 BLOOD COAGULATION ANALYZER, BLOOD COAGULATION ANALYSIS METHOD, AND COMPUTER PROGRAM PRODUCT 有权
标题翻译：血液凝聚分析仪，血液凝聚分析方法和计算机程序产品
公开(公告)号：US20110014640A1
公开(公告)日：2011-01-20
申请号：US12893640
申请日：2010-09-29
申请人： Norimasa Yamamoto , Hiroyuki Fujino , Takamichi Naito , Naohiko Matsuo , Susumu Hoshiko
发明人： Norimasa Yamamoto , Hiroyuki Fujino , Takamichi Naito , Naohiko Matsuo , Susumu Hoshiko
IPC分类号： C12Q1/56 , C12M1/36
CPC分类号： G01N21/5907 , G01N33/4905 , G01N33/86 , G01N35/00603 , Y10T436/101666 , Y10T436/2575
摘要： A blood coagulation analyzer is provided by which, while the measurement using reagent for measuring a Fbg (fibrinogen concentration) is being minimized, the result of a measurement such as a PT measurement can be used to accurately acquire a fibrinogen concentration. The blood coagulation analyzer (1) includes a detector for detecting a transmitted light intensity from a first measurement sample prepared from a blood and a PT measurement reagent; a dFbg acquisition means for acquiring, based on the light detected from the first measurement sample, a dFbg value reflecting a Fbg in the blood; a determination means for determining whether the dFbg value is within a predetermined range or not; a detector for detecting a transmitted light intensity from a second measurement sample prepared from the blood and a Fbg measurement reagent when the dFbg value is outside the predetermined range; and a Fbg acquisition means for acquiring, based on a transmitted light intensity from the second measurement sample detected, a Fbg concentration in the blood sample.
摘要翻译：提供一种血液凝固分析装置，通过该血液凝固分析装置，通过使用用于测定Fbg（纤维蛋白原浓度）的试剂的测定值最小化，可以使用PT测定等测定结果精确地获得纤维蛋白原浓度。血液凝固分析装置（1）具备检测由血液和PT测定试剂制备的第一测定试样的透射光强度的检测器， dFbg获取装置，用于基于从第一测量样本检测到的光获取反映血液中的Fbg的dFbg值; 确定装置，用于确定dFbg值是否在预定范围内; 检测器，当所述dFbg值在所述预定范围之外时，从由所述血液制备的第二测量样品和Fbg测量试剂检测透射光强度; 以及Fbg获取装置，用于基于来自所检测的第二测量样本的透射光强度获取血样中的Fbg浓度。

9. 发明申请

US20080183431A1 Sample analyzer and sample analyzing method 有权
标题翻译：样品分析仪和样品分析方法
公开(公告)号：US20080183431A1
公开(公告)日：2008-07-31
申请号：US12012431
申请日：2008-01-31
申请人： Naohiko Matsuo , Hiroyuki Fujino , Mitsuyo Koya , Susumu Hoshiko
发明人： Naohiko Matsuo , Hiroyuki Fujino , Mitsuyo Koya , Susumu Hoshiko
IPC分类号： G06F17/40
CPC分类号： G01N35/00594 , G01N15/12 , G01N15/1459 , G01N21/272 , G01N21/82 , G01N33/4905 , G01N2015/0073 , G01N2015/0076 , G01N2015/008 , G01N2015/1486
摘要： A sample analyzer optically measures reaction of a sample mixed with reagent, and obtains optical information therefrom; generates a reaction curve representing change in the optical information over time; determines a first area prior to an evaluation target time (t0) and a second area after the evaluation target time (t0) wherein the first and second areas are formed between a baseline which is parallel to the time axis and a reaction curve from a first time (t1) prior to the optional evaluation target time (t0) to a second time (t2) after the evaluation target time, and determines the reaction end point based on the first and second areas; and obtains a characteristic of a sample based on the determined reaction end point, is disclosed a sample analyzing method is also disclosed.
摘要翻译：样品分析仪光学测量与试剂混合的样品的反应，并从中获得光学信息; 产生表示光信息随时间变化的反应曲线; 确定在评估目标时间（t 0）之前的第一区域和在评估目标时间（t 0）之后的第二区域，其中第一和第二区域之间形成在与时间轴平行的基线和来自在评估目标时间之后的可选择的评估目标时间（t 0）到第二时间（t 2）之前的第一时间（t 1），并且基于第一和第二区域确定反应结束点; 并基于确定的反应终点获得样品的特性，公开了一种样品分析方法。

10. 发明申请

US20070222973A1 Sample analyzer 有权
标题翻译：样品分析仪
公开(公告)号：US20070222973A1
公开(公告)日：2007-09-27
申请号：US11724934
申请日：2007-03-16
申请人： Susumu Hoshiko , Naohiko Matsuo , Katsushi Kobayashi , Norimasa Yamamoto
发明人： Susumu Hoshiko , Naohiko Matsuo , Katsushi Kobayashi , Norimasa Yamamoto
IPC分类号： G01N21/00
CPC分类号： G01N21/314 , G01J2003/123 , G01N21/0332 , G01N21/253 , G01N21/272 , G01N21/274 , G01N21/82 , G01N33/49 , G01N35/00603 , G01N2021/3148 , G01N2021/3155 , G01N2021/3174 , G01N2021/825 , G01N2035/00356 , G01N2035/0455 , G01N2201/0618 , G01N2201/0826
摘要： A sample analyzer comprising: a measuring part for measuring optical information of a sample at first wavelength, second wavelength, and third wavelength, first light of the first wavelength and second light of the second wavelength being absorbed by a second substance but substantially not absorbed by a first substance, and third light of the third wavelength being absorbed by the first substance; and an obtaining means for obtaining content of the first substance in the sample, and content of the second substance in the sample, influence by the second substance being excluded from the content of the first substance, based on the optical information at the first wavelength, second wavelength, and third wavelength measured by the measuring part.
摘要翻译：一种样本分析器，包括：测量部分，用于测量第一波长，第二波长和第三波长处的样品的光学信息，第一波长的第一光和第二波长的第二光被第二物质吸收，但基本上不被第一物质和第三波长的第三光被第一物质吸收; 以及获取装置，用于根据第一波长的光学信息获得样品中第一物质的含量和样品中第二物质的含量，被第二物质排除在第一物质的含量之外的影响，第二波长和由测量部分测量的第三波长。

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