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1. 发明授权

US08628649B2 Nanopore and carbon nanotube based DNA sequencer and a serial recognition sequencer 有权
标题翻译：纳米孔和基于碳纳米管的DNA测序仪和序列识别测序仪
公开(公告)号：US08628649B2
公开(公告)日：2014-01-14
申请号：US12920809
申请日：2009-03-18
申请人： Stuart Lindsay , Jin He , Peiming Zhang , Kevin Reinhart
发明人： Stuart Lindsay , Jin He , Peiming Zhang , Kevin Reinhart
IPC分类号： G01N27/327
CPC分类号： C12Q1/6869 , B82Y15/00 , G01N33/48721 , C12Q2565/631
摘要： The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer.
摘要翻译：本发明涉及用于识别生物聚合物的系统，装置和方法，例如当DNA通过诸如碳纳米管纳米孔的收缩体时，DNA的链。更具体地，本发明涉及这样的系统，装置和方法，其中生物聚合物的新易位部分在纳米管纳米孔和也可以是纳米管的第二电极之间形成临时电路。此外，本发明涉及这样的系统，装置和方法，其中收缩部设置有功能化单元，其与生物聚合物的新易位部分一起形成临时电路，其可用于表征该部分的生物聚合物。

2. 发明申请

US20120009311A1 PREPARED FOOD PRODUCT, METHOD OF PREPARATION AND BAKING APPARATUS FOR SAID PREPARED FOOD PRODUCT 审中-公开
标题翻译：准备食品，准备食品的制备方法和烘焙设备
公开(公告)号：US20120009311A1
公开(公告)日：2012-01-12
申请号：US12834004
申请日：2010-07-11
申请人： JEFFREY STUART LINDSAY , Ann Currylindsay
发明人： JEFFREY STUART LINDSAY , Ann Currylindsay
IPC分类号： A21D13/00 , B21J13/00
CPC分类号： A21D6/001 , A21B3/155 , A21D13/31 , A21D13/41
摘要： A method of preparing a food product comprising the steps of obtaining an amount of suitable baking dough; placing the dough on a flat surface and shaping it into a rectangle; placing a suitable amount of flavoured sauce on the top surface of the dough; preparing a food skewer and placing it on the sauce; placing grated cheese on top of the food skewer; folding the dough rectangle partially over the food skewer to form a folded assembled food product. The product can then be baked in an novel baking pan comprising three baking chambers or the product can be frozen for future consumption.
摘要翻译：一种制备食品的方法，包括以下步骤：获得一定量的合适的烘焙面团; 将面团放置在平坦的表面上并将其成型为矩形; 将适量的调味酱放在面团的顶面上; 准备食物串并将其放在酱汁上; 将磨碎的奶酪放在食物串上; 将面团矩形部分地折叠在食物串上以形成折叠的组装食品。然后可以在包含三个烘烤室的新型烘烤盘中烘烤产品，或者将产品冷冻以备将来消费。

3. 发明授权

US07745206B2 AFM for simultaneous recognition of multiple factors 有权
标题翻译： AFM同时识别多个因素
公开(公告)号：US07745206B2
公开(公告)日：2010-06-29
申请号：US12022072
申请日：2008-01-29
申请人： Hongda Wang , Stuart Lindsay
发明人： Hongda Wang , Stuart Lindsay
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01Q60/42 , G01Q30/04
摘要： An atomic force microscope and a method for detecting interactions between a probe and two or more sensed agents on a scanned surface and determining the relative location of two or more sensed agents is provided. The microscope has a scanning probe with a tip that is sensitive to two or more sensed agents on said scanned surface; two or more sensing agents tethered to the tip of the probe; and a device for recording the displacement of said probe tip as a function of time, topographic images, and the spatial location of interactions between said probe and the two or more sensed agents on said surface.
摘要翻译：提供了一种原子力显微镜和用于检测探针与扫描表面上的两个或更多个感测到的试剂之间的相互作用并确定两个或更多个感测到的试剂的相对位置的方法。显微镜具有扫描探针，其具有对所述扫描表面上的两个或更多个感测到的试剂敏感的尖端; 两个或更多个感测剂束缚于探针的尖端; 以及用于根据时间，地形图像以及所述探针与所述表面上的两个或更多个感测到的试剂之间的相互作用的空间位置记录所述探针尖端的位移的装置。

4. 发明申请

US20190195856A1 NON-HYDROGEN-BONDING UNIVERSAL READER FOR DNA SEQUENCING 审中-公开
公开(公告)号：US20190195856A1
公开(公告)日：2019-06-27
申请号：US16327232
申请日：2017-08-21
申请人： Peiming ZHANG , Sovan BISWAS , Suman SEN , Stuart LINDSAY
发明人： Peiming ZHANG , Sovan BISWAS , Suman SEN , Stuart LINDSAY
IPC分类号： G01N33/487 , C07C321/10 , C12Q1/6869
CPC分类号： G01N33/48721 , C07C321/10 , C07C2603/50 , C12Q1/6869 , C12Q2563/116 , C12Q2563/157 , C12Q2565/607
摘要： The present disclosure provides apparatus and methods for determining the sequence of a nucleic acid. The apparatus comprises electrodes that form a tunnel gap through which the nucleic acid can pass. The electrodes comprise a reagent that is capable of selectively interacting with a nucleobase of the nucleic acid sequence. When the reagent interacts with a nucleobase, a detectable signal is produced and used to identify the nucleobase of the nucleic acid. Advantageously, the apparatus of this disclosure is specific to identifying nucleic acids.

5. 发明授权

US08685894B2 Modified nucleic acid nanoarrays and uses therefor 有权
标题翻译：修饰的核酸纳米阵列及其用途
公开(公告)号：US08685894B2
公开(公告)日：2014-04-01
申请号：US12301884
申请日：2007-05-23
申请人： John Chaput , Stuart Lindsay , Hao Yan , Peiming Zhang
发明人： John Chaput , Stuart Lindsay , Hao Yan , Peiming Zhang
IPC分类号： C40B40/06
CPC分类号： C12Q1/6809 , B01J19/0046 , B01J2219/00515 , B01J2219/00527 , B01J2219/00572 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00637 , B01J2219/00657 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B82Y30/00 , C12Q1/6837 , C12Q2565/501 , C12Q2525/113 , C12Q2565/601 , C12Q2565/543 , C12Q2565/513
摘要： The present invention provides finite, addressable, and self-assembling nucleic acid tiling arrays, and methods for their use.
摘要翻译：本发明提供有限的，可寻址的和自组装的核酸平铺阵列及其使用的方法。

6. 发明申请

US20110120868A1 Nanopore and Carbon Nanotube Based DNA Sequencer and a Serial Recognition Sequencer 有权
标题翻译：基于纳米孔和碳纳米管的DNA测序仪和串行识别测序仪
公开(公告)号：US20110120868A1
公开(公告)日：2011-05-26
申请号：US12920809
申请日：2009-03-18
申请人： Stuart Lindsay , Jin He , Peiming Zhang , Kevin Reinhart
发明人： Stuart Lindsay , Jin He , Peiming Zhang , Kevin Reinhart
IPC分类号： G01N27/447 , H05K3/06 , H05K3/02 , B82Y99/00
CPC分类号： C12Q1/6869 , B82Y15/00 , G01N33/48721 , C12Q2565/631
摘要： The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer.
摘要翻译：本发明涉及用于识别生物聚合物的系统，装置和方法，例如当DNA通过诸如碳纳米管纳米孔的收缩体时，DNA的链。更具体地，本发明涉及这样的系统，装置和方法，其中生物聚合物的新易位部分在纳米管纳米孔和也可以是纳米管的第二电极之间形成临时电路。此外，本发明涉及这样的系统，装置和方法，其中收缩部设置有功能化单元，其与生物聚合物的新易位部分一起形成临时电路，其可用于表征该部分的生物聚合物。

7. 发明申请

US20100091245A1 STIMULUS METHOD FOR MULTIFOCAL VISUAL EVOKED POTENTIAL 有权
标题翻译：用于多视觉可视化潜能的刺激方法
公开(公告)号：US20100091245A1
公开(公告)日：2010-04-15
申请号：US12527466
申请日：2008-02-15
申请人： Alexander Klistorner , Stuart Lindsay Graham
发明人： Alexander Klistorner , Stuart Lindsay Graham
IPC分类号： A61B3/10 , A61B3/00
CPC分类号： A61B3/024 , A61B5/04842
摘要： Disclosed herein is a method of producing a stimulus for electrophysiological assessment of a visual field. The method comprises the steps of: generating a pseudorandom sequence of elements selected from at least two different element types, wherein elements of the sequence are assigned equal time intervals; and displaying the pseudorandom sequence. Each element of a first element type is associated with a baseline value, the baseline value being constant throughout a respective assigned time interval. Each time interval assigned to an element of a second element type is divided into a plurality of portions, each successive portion being associated with a display value of the element, wherein display values associated with, adjacent portions differ from one another, and further wherein display values associated with at least two of the portions are different from the baseline value.
摘要翻译：本文公开了产生用于视野的电生理学评估的刺激物的方法。该方法包括以下步骤：产生选自至少两种不同元素类型的元素的伪随机序列，其中该序列的元素被分配相等的时间间隔; 并显示伪随机序列。第一元素类型的每个元素与基线值相关联，基线值在相应的分配的时间间隔内是恒定的。分配给第二元素类型的元素的每个时间间隔被分成多个部分，每个连续部分与元素的显示值相关联，其中与相邻部分相关联的显示值彼此不同，并且其中显示与至少两个部分相关联的值与基线值不同。

8. 发明申请

US20090018028A1 Self-Assembled Nucleic Acid Nanoarrays and Uses Therefor 审中-公开
标题翻译：自组装核酸纳米阵列及其用途
公开(公告)号：US20090018028A1
公开(公告)日：2009-01-15
申请号：US11913684
申请日：2006-02-15
申请人： Stuart Lindsay , Hao Yan , John Chaput , Yan Liu , Peiming Zhang
发明人： Stuart Lindsay , Hao Yan , John Chaput , Yan Liu , Peiming Zhang
IPC分类号： C40B30/04 , C40B40/06 , C40B40/08 , C40B50/04
CPC分类号： B82Y30/00 , B82Y5/00 , B82Y15/00 , C12N15/10 , C12Q1/6837 , C12Q2565/601 , C12Q2525/185
摘要： The present invention provides self-assembling, finite nucleic acid tiling arrays, and methods for their synthesis and use, which overcome a major hurdle in self-assembled DNA nanostructures, and therefore have numerous potential applications for nanofabrication of complex structures and useful devices, as further disclosed herein.
摘要翻译：本发明提供自组装的有限核酸贴片阵列及其合成和使用的方法，其克服了自组装DNA纳米结构中的主要障碍，因此具有许多用于复合结构和有用器件纳米制造的潜在应用，如本文进一步公开。

9. 发明授权

US5794612A MDI device with ultrasound sensor to detect aerosol dispensing 失效
标题翻译：带超声波传感器的MDI设备，用于检测气溶胶分配
公开(公告)号：US5794612A
公开(公告)日：1998-08-18
申请号：US832369
申请日：1997-04-02
申请人： Allan Wachter , Stuart Lindsay
发明人： Allan Wachter , Stuart Lindsay
IPC分类号： A61M15/00 , A61M11/00 , A62B7/00 , A62B9/04
CPC分类号： A61M15/0086 , A61M15/002 , A61M15/0021 , A61M15/008 , A61M15/0088 , A61M15/0085 , A61M2205/583 , A61M2206/10
摘要： An intrapulmonary delivery device is provided for delivery of a propellant driven medicament. The device has an indicating system with a sensor responsive to a selected range of ultrasound, a controller associated with the sensor for signalling the detected ultrasound, a differential pressure sensor and a display for the signals. The controller is associated with a microprocessor where the signal level the duration and time of actuation is stored in memory.
摘要翻译：提供肺内输送装置用于输送推进剂驱动的药剂。该装置具有响应于所选择的超声波范围的传感器的指示系统，与传感器相关联的用于发送检测到的超声信号的控制器，差压传感器和用于信号的显示器。控制器与微处理器相关联，其中信号水平将致动的持续时间和时间存储在存储器中。

10. 发明授权

US09705239B2 Flexible electrode assembly and apparatus for measuring electrophysiological signals 有权
公开(公告)号：US09705239B2
公开(公告)日：2017-07-11
申请号：US12439211
申请日：2007-08-30
申请人： Arthur Cheng , Alexander Klistorner , Stuart Lindsay Graham
发明人： Arthur Cheng , Alexander Klistorner , Stuart Lindsay Graham
IPC分类号： A61B5/04 , H01R13/52 , A61B5/0408
CPC分类号： H01R13/5224 , A61B5/04085
摘要： A flexible electrode assembly comprises a central portion having electrical contacts disposed thereon and a plurality of elongated portions extending radially outwards from the central portion. One or more of the elongated portions has an electrode disposed in the vicinity of a distal end thereof. The electrodes are electrically coupled to respective ones of the electrical contacts disposed on the central portion. An apparatus for measuring electrophysiological signals in a human or animal body that incorporates the flexible electrode assembly is also disclosed.

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