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1. 发明申请

US20140313665A1 A Computing System Including A First And Second Housing And Polar Magnets 审中-公开
标题翻译：包括第一和第二壳和极地磁铁的计算系统
公开(公告)号：US20140313665A1
公开(公告)日：2014-10-23
申请号：US14355030
申请日：2011-12-05
申请人： Michael Delpier , Stacy L. Wolff , Kevin L. Massaro , Daniel Koelker , Steven Jacobs , Dimitre Mehandjiysky
发明人： Michael Delpier , Stacy L. Wolff , Kevin L. Massaro , Daniel Koelker , Steven Jacobs , Dimitre Mehandjiysky
IPC分类号： G06F1/16
CPC分类号： G06F1/1681 , G06F1/1616 , G06F1/1654 , G06F1/1669 , G06F1/1679 , G06F1/1683 , Y10T29/49002
摘要： A first housing with a polar magnet on a first side. The first housing can include an opening on the first side. A second housing can include a sliding latch. An opposite polar magnet attached to the sliding latch. The polar magnet attracts the opposite polar magnet on the sliding latch to move the sliding latch to a latched position.
摘要翻译：在第一侧具有极性磁体的第一壳体。第一壳体可以包括第一侧上的开口。第二壳体可以包括滑动闩锁。一个相对的极性磁铁连接到滑动闩锁。极性磁铁吸引滑动闩锁上的相反极性磁体，以将滑动闩锁移动到锁定位置。

2. 发明申请

US20130096019A1 Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses 有权
标题翻译：纤连蛋白III型域支架组合物，方法和用途
公开(公告)号：US20130096019A1
公开(公告)日：2013-04-18
申请号：US13595484
申请日：2012-08-27
申请人： Steven Jacobs , Karyn O'Neil
发明人： Steven Jacobs , Karyn O'Neil
IPC分类号： C07K14/78
CPC分类号： C07K14/78 , C40B40/08 , C40B50/06
摘要： A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.
摘要翻译：基于纤连蛋白III（FN3）蛋白的共有序列的蛋白质支架，例如来自人纤连蛋白（人腱生蛋白）的第十FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。特别地，已经鉴定了结合IgG的蛋白质支架分子可用于诊断和/或治疗应用。

3. 发明申请

US20110189790A1 Methods of Predicting Antibody Solubility 审中-公开
标题翻译：预测抗体溶解度的方法
公开(公告)号：US20110189790A1
公开(公告)日：2011-08-04
申请号：US12863489
申请日：2009-01-20
申请人： Karyn O'Neil , Steven Jacobs , Shong-Juin Wu , Deldra Bethea , Ylqing Feng
发明人： Karyn O'Neil , Steven Jacobs , Shong-Juin Wu , Deldra Bethea , Ylqing Feng
IPC分类号： G01N30/02
CPC分类号： G01N33/6854 , B01D15/3809
摘要： The invention provides methods for testing and ranking therapeutic antibody candidates for biophysical properties related to solubility and the susceptibility of the antibody to aggregate in aqueous solutions. The methods are useful for selecting among antibody libraries or variants for candidates which can be formulated at high concentrations.
摘要翻译：本发明提供了用于测试和评估与溶解度相关的生物物理性质的治疗性抗体候选物和抗体在水溶液中聚集的易感性的方法。该方法可用于在可以以高浓度配制的候选物之间选择抗体文库或变体。

4. 发明申请

US20100076599A1 MANUALLY DRIVEN DETERMINATION OF A REGION OF INTEREST (ROI) OR A PATH OF INTEREST (POI) FOR A ROBOTIC DEVICE 审中-公开
标题翻译：手动驱动一个兴趣区域（ROI）或一个机器人的兴趣之路（POI）的确定
公开(公告)号：US20100076599A1
公开(公告)日：2010-03-25
申请号：US12234633
申请日：2008-09-20
申请人： Steven Jacobs , Kipp Knutson , David Wood
发明人： Steven Jacobs , Kipp Knutson , David Wood
IPC分类号： B25J19/02 , B25J9/22
CPC分类号： G05D1/0272 , G05D1/0221 , G05D1/0255 , G05D1/028
摘要： A robotic device is manually driven along a perimeter of a Region Of Interest (ROI) or along a Path Of Interest (POI) for future autonomous operation. An Initial Point (IP) is established by identifying a unique machine recognizable feature, for example, a Radio Frequency Identification (RFID) tag located at the IP. The robotic device is then manually driven along the perimeter or along the path and sensors carried by the robotic device collects data to characterize the ROI or POI. The sensors may include sonar, vision systems, laser, or radar devices for measuring relative positions of a wall, stairs, or obstacles. Wheel odometry may be used to track distances traveled and data fusion exercised to combine the odometry data with the sonar and/or laser measurements to model the ROI or POI. Characterization is performed by collecting points along a wall, fitting a line to the points, and finding the intersections of consecutive lines.
摘要翻译：机器人装置沿着感兴趣区域（ROI）或沿着感兴趣路径（POI）的周边手动驱动以用于将来的自主操作。通过识别唯一的机器可识别特征（例如位于IP处的射频识别（RFID））标签来建立初始点（IP）。然后机器人装置沿着周边或沿着路径手动驱动，并且机器人装置携带的传感器收集数据以表征ROI或POI。传感器可以包括用于测量墙壁，楼梯或障碍物的相对位置的声纳，视觉系统，激光或雷达装置。轨迹测距可用于跟踪所行驶的距离和数据融合，以将测距数据与声纳和/或激光测量结合以对ROI或POI进行建模。通过沿着墙壁收集点，将线拟合到点上并找到连续线的交点来进行表征。

5. 发明申请

US20050259933A1 Photonic crystal fibers and medical systems including photonic crystal fibers 有权
标题翻译：光子晶体纤维和医疗系统，包括光子晶体纤维
公开(公告)号：US20050259933A1
公开(公告)日：2005-11-24
申请号：US11101915
申请日：2005-04-08
申请人： Burak Temelkuran , Charalambos Anastassiou , David Torres , Gil Shapira , Max Shurgalin , Gregor Dellemann , Ori Weisberg , Steven Jacobs , Tairan Wang , Uri Kolodny , Robert Payne , Yoel Fink
发明人： Burak Temelkuran , Charalambos Anastassiou , David Torres , Gil Shapira , Max Shurgalin , Gregor Dellemann , Ori Weisberg , Steven Jacobs , Tairan Wang , Uri Kolodny , Robert Payne , Yoel Fink
IPC分类号： A61B1/018 , A61B18/22 , G02B6/02 , G02B6/06
CPC分类号： G02B6/02304 , A61B1/018 , A61B18/201 , A61B18/22 , A61B2018/2272 , A61F9/008 , A61F9/00802 , A61F9/00821 , A61F9/00825 , A61F2009/00863 , A61F2009/00891 , C03B2201/86 , C03B2203/12 , C03B2203/14 , C03B2203/16 , C03B2203/18 , C03B2203/42 , G02B6/023 , G02B6/02385 , G02B6/03622 , G02B6/03638 , G02B6/03694 , Y02P40/57
摘要： In general, in one aspect, the invention features systems, including a photonic crystal fiber including a core extending along a waveguide axis and a dielectric confinement region surrounding the core, the dielectric confinement region being configured to guide radiation along the waveguide axis from an input end to an output end of the photonic crystal fiber. The systems also includes a handpiece attached to the photonic crystal fiber, wherein the handpiece allows an operator to control the orientation of the output end to direct the radiation to a target location of a patient.
摘要翻译：通常，在一个方面，本发明的特征在于系统，其包括光子晶体光纤，其包括沿着波导轴延伸的芯和围绕该芯的介电限制区，所述介电限制区被配置为沿着波导轴从输入引导辐射结束于光子晶体光纤的输出端。所述系统还包括附接到光子晶体光纤的手持件，其中所述手持件允许操作者控制所述输出端的取向以将所述辐射引导到患者的目标位置。

6. 外观设计

USD377415S Expandable schoolbag with front utility compartment 失效
公开(公告)号：USD377415S
公开(公告)日：1997-01-21
申请号：US40462
申请日：1995-06-19
申请人： Steven Jacobs , Julie B. Kampf
设计人： Steven Jacobs , Julie B. Kampf

7. 发明授权

US08415291B2 Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses 有权
标题翻译：抗TNFα纤连蛋白III型结构域的支架组合物，方法和用途
公开(公告)号：US08415291B2
公开(公告)日：2013-04-09
申请号：US12606396
申请日：2009-10-27
申请人： Steven Jacobs , Karyn O'Neil
发明人： Steven Jacobs , Karyn O'Neil
IPC分类号： A61K38/00 , C07K1/00 , C07K16/00 , C12P21/08
CPC分类号： G01N33/54306 , A61K38/39 , C07K14/78 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/463
摘要： A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, preferably human Tenascin, that binds to human TNFα including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译：基于来自人纤连蛋白（优选人腱生蛋白）的第十纤维连接蛋白III型（FN3）重复序列的蛋白质支架，其结合人TNFα，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。

8. 发明申请

US20130079243A1 Fibronectin Type III Repeat Based Protein Scaffolds with Alternative Binding Surfaces 审中-公开
标题翻译：具有替代结合表面的纤连蛋白III型重复基于蛋白质支架
公开(公告)号：US20130079243A1
公开(公告)日：2013-03-28
申请号：US13628393
申请日：2012-09-27
申请人： Michael Diem , Steven Jacobs
发明人： Michael Diem , Steven Jacobs
IPC分类号： C40B40/10 , C40B30/04 , C40B50/06
CPC分类号： G01N33/6845 , C12N15/1044 , C40B30/04 , C40B40/08 , C40B50/06 , G01N2333/78
摘要： Protein scaffolds and scaffold libraries based on a fibronectin type III (FN3) repeat with an alternative binding surface design, isolated nucleic acids encoding the protein scaffolds, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
摘要翻译：基于具有替代结合表面设计的纤连蛋白III型（FN3）重复的蛋白质支架和支架文库，编码蛋白质支架的分离的核酸，载体，宿主细胞及其制备方法可用于产生治疗分子和治疗和疾病和病症的诊断。

9. 发明申请

US20110274623A1 Stabilized Fibronectin Domain Compositions, Methods and Uses 有权
标题翻译：稳定的纤连蛋白结构域组成，方法和用途
公开(公告)号：US20110274623A1
公开(公告)日：2011-11-10
申请号：US13097587
申请日：2011-04-29
申请人： Steven Jacobs
发明人： Steven Jacobs
IPC分类号： A61K49/00 , C40B50/00 , C40B40/08 , C40B40/02 , C40B30/04 , C07H21/00 , C12N15/63 , C12N1/21 , C12N1/19 , C12N5/10 , A61K38/16 , A61P25/00 , A61K38/22 , A61P7/00 , A61P27/02 , A61P35/00 , A61P9/00 , A61P27/16 , A61P11/00 , A61P1/00 , A61P43/00 , A61P37/02 , A61P11/02 , A61P31/00 , C07K14/00
CPC分类号： C12N15/1044 , A61K38/00 , C07K14/78 , C07K16/18 , C07K2318/20 , Y02A50/473
摘要： A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof, exhibit enhanced thermal and chemical stability while presenting six modifiable loop domains which can be engineered to form a binding partner capable of binding to a target for applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译：基于纤连蛋白III（FN3）蛋白的共有序列的蛋白质支架，例如来自人纤连蛋白（人腱生蛋白）的第十FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法并且其使用表现出增强的热和化学稳定性，同时呈现六个可修饰的环结构域，其可被工程化以形成能够结合靶标的结合配偶体，用于诊断和/或治疗组合物，方法和装置中的应用。

10. 发明申请

US20100255056A1 Fibronectin Type III Domain Based Scaffold Compositions, Methods And Uses 有权
标题翻译：纤连蛋白III型域支架组合物，方法和用途
公开(公告)号：US20100255056A1
公开(公告)日：2010-10-07
申请号：US12704824
申请日：2010-02-12
申请人： Steven Jacobs , Karyn O'Neil
发明人： Steven Jacobs , Karyn O'Neil
IPC分类号： A61K9/00 , C07K14/78 , C40B50/00 , C07H21/00 , C12N15/74 , C40B40/10 , C12N1/21 , C12N1/19 , C12N5/10 , A61K38/14 , A61P35/00 , A61P9/10 , A61P25/00 , A61P11/00
CPC分类号： C12N15/1044 , A61K38/00 , C07K14/78 , C40B40/08 , C40B50/06
摘要： A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG based on the consensus sequence have been identified as useful for diagnostic and/or therapeutic applications.
摘要翻译：基于来自人纤连蛋白的第十纤维连接蛋白III型（FN3）重复共有序列的蛋白质支架，包括编码蛋白质支架的分离的核酸，载体，宿主细胞及其制备和使用的方法具有诊断和/ 或治疗组合物，方法和装置。特别地，已经鉴定了基于共有序列与IgG结合的蛋白质支架分子对于诊断和/或治疗应用是有用的。

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