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1. 发明申请

US20080045779A1 VENTRICULAR ASSIST DEVICE AND RELATED COMPUTER PROGRAM PRODUCT 审中-公开
标题翻译：航空辅助设备及相关计算机程序产品
公开(公告)号：US20080045779A1
公开(公告)日：2008-02-21
申请号：US11779656
申请日：2007-07-18
申请人： Stefano RINALDI , Maurizio ZAGARA , Manlio FIERLI , Gloria PESCE DELFINO , Mauro ERCOLANI
发明人： Stefano RINALDI , Maurizio ZAGARA , Manlio FIERLI , Gloria PESCE DELFINO , Mauro ERCOLANI
IPC分类号： A61M1/10
CPC分类号： F04B43/04 , A61M1/1005 , A61M1/1037 , A61M1/1046 , A61M1/106 , A61M1/1086 , A61M1/122 , A61M1/127
摘要： A cardiac ventricular assist device or VAD includes a pumping unit with a variable-volume chamber capable of receiving a mass of blood, and a control unit to control the pumping unit to obtain contraction of the variable-volume chamber, with consequent expulsion of the blood collected in the chamber, and expansion of the variable-volume chamber consequent on the flow of blood into the chamber. A flow line is included, such as a transcutaneous line, for a gaseous flow caused by the contraction and expansion of the variable-volume chamber. A sensor sensitive to the gaseous flow in the flow line generates a flow-meter signal that is indicative of the expulsion and inflow of blood with regard to the variable-volume chamber. The control unit is sensitive to said flow-meter signal and utilises that signal to control the pumping unit, for example to cause the pumping unit to operate in a condition of synchronous counterpulsation with regard to the natural heart, that is with the variable-volume chamber capable of receiving blood from the assisted heart when it is in a systolic phase and the variable-volume chamber that expels the blood collected in the chamber, when the assisted heart is in a diastolic phase.
摘要翻译：心脏心室辅助装置或VAD包括具有能够接收大量血液的可变容积腔的泵送单元和控制单元以控制泵送单元以获得可变体积腔室的收缩，从而导致血液收集在腔室中，并且随着血液流入腔室而使可变体积腔室膨胀。包括由可变容积室的收缩和膨胀引起的气流的流动线，例如经皮线。对流线中的气流敏感的传感器产生一个流量计信号，该信号表示血液相对于可变体积腔室的排出和流入。控制单元对所述流量计信号敏感并且利用该信号来控制泵送单元，例如使得泵送单元在相对于自然心脏的同步反搏的状态下运行，即具有可变容积当辅助心脏处于舒张期时能够从辅助心脏接收血液，当其处于收缩期时，以及当辅助心脏处于舒张期时，能够将收集在腔室中的血液排出的可变体积腔室。

2. 发明授权

US5002567A Prosthetic heart valve 失效
标题翻译：假心脏瓣膜
公开(公告)号：US5002567A
公开(公告)日：1991-03-26
申请号：US278273
申请日：1988-11-30
申请人： Gioachino Bona , Stefano Rinaldi , Franco Vallana
发明人： Gioachino Bona , Stefano Rinaldi , Franco Vallana
IPC分类号： A61F2/24
CPC分类号： A61F2/2406 , Y10T137/7839 , Y10T137/7898
摘要： In a prosthetic heart valve comprising a generally annular stent and at least two obturators mounted in the stent so as to be above to pivot between an open position and a closed position, the stent is provided with at least one element which projects inwardly of the stent itself, while each of the obturators has recesses which cooperate with the projecting element of the stent with clearance in a generally-hinged configuration which enables the obturators to pivot between the open position and the closed position.

3. 发明申请

US20080306328A1 DUCT FOR VENTRICULAR-ASSISTANCE DEVICE 审中-公开
标题翻译：管道辅助装置
公开(公告)号：US20080306328A1
公开(公告)日：2008-12-11
申请号：US12128723
申请日：2008-05-29
申请人： Mauro Ercolani , Francesco Minoletti , Flavio Torriani , Stefano Rinaldi
发明人： Mauro Ercolani , Francesco Minoletti , Flavio Torriani , Stefano Rinaldi
IPC分类号： A61M1/10
CPC分类号： A61M1/1087 , A61M1/1008 , A61M1/1037 , A61M1/122
摘要： A duct for carrying blood for ventricular-assistance devices (VADs) has a tubular body and an end having associated thereto a valve for enabling the flow of blood unidirectionally in the duct. The valve has an annular reinforcement, and the end of the duct is provided with a slot for receiving the annular reinforcement of the valve with the reinforcement in a retracted position in said slot. The aforesaid end and the aforesaid tubular body of the duct are provided with a continuous coating of haemocompatible material, such as a polyurethane.
摘要翻译：用于携带用于心室辅助装置（VAD）的血液的管道具有管状体和与其相关联的端部，用于使血液在导管中单向流动。阀具有环形加强件，并且管道的端部设置有用于接收阀的环形加强件的槽，其中钢筋处于所述槽中的缩回位置。管道的上述端部和前述管状体设置有诸如聚氨酯的血液相容性材料的连续涂层。

4. 发明授权

US06572642B2 Method for treating a prosthesis having an apertured structure and associated devices 失效
公开(公告)号：US06572642B2
公开(公告)日：2003-06-03
申请号：US10135639
申请日：2002-04-30
申请人： Stefano Rinaldi , Arnaldo Giannetti , Enrico Pasquino
发明人： Stefano Rinaldi , Arnaldo Giannetti , Enrico Pasquino
IPC分类号： A61L2700
CPC分类号： A61L27/00 , A61F2/0077 , A61F2/0095 , A61F2/02 , A61F2/06 , A61F2/2409 , A61L33/0005 , Y10T156/1744
摘要： A prosthesis having an apertured structure is located in a chamber (11) which is taken to sub-atmospheric pressure. Once sub-atmospheric pressure has been reached, a liquid, optionally containing pharmacological agents, is introduced into the chamber. Drawn by the sub-atmospheric pressure, the liquid saturates the apertured structure of the prosthesis. In this way, the invention eliminates the risk of air being trapped in the apertured structure that could give rise to the formation of blood clots after implantation of the prosthesis. The liquid can contain drugs that penetrate the prosthesis, performing their therapeutic action locally and over time after implantation.

5. 发明授权

US5897548A Method for reducing foam in a blood substance and antifoaming agents 失效
标题翻译：减少血液中泡沫的方法和消泡剂
公开(公告)号：US5897548A
公开(公告)日：1999-04-27
申请号：US744497
申请日：1996-11-07
申请人： Silvio Sacco , Giampero Porro , Stefano Rinaldi , Leopoldo Della Ciana
发明人： Silvio Sacco , Giampero Porro , Stefano Rinaldi , Leopoldo Della Ciana
IPC分类号： A61M1/36 , B01D19/04 , A61M1/34
CPC分类号： B01D19/0404
摘要： A method for reducing foam in a blood substance comprising contacting at least a portion of the blood substance with a contact-generating substrate which comprises an antifoaming agent, wherein the antifoaming agent comprises a triglyceride of one or more saturated or unsaturated C.sub.14 -C.sub.24 fatty acids or a mixture of triglycerides having one or more saturated or unsaturated C.sub.14 -C.sub.24 fatty acids, wherein the triglyceride or mixture of triglycerides has a hydrophilic-lipophilic balance of from 5 to 10.
摘要翻译：一种用于减少血液中泡沫的方法，包括将至少一部分血液物质与包含消泡剂的接触产生底物接触，其中消泡剂包含一种或多种饱和或不饱和C 14 -C 24脂肪酸的甘油三酯或具有一种或多种饱和或不饱和C 14 -C 24脂肪酸的甘油三酯的混合物，其中甘油三酸酯或甘油三酯的混合物具有5至10的亲水亲油平衡。

6. 发明授权

US5423886A Cyclically deformable haemocompatible and biocompatible devices coated with biocompatible carbonaceous material 失效
标题翻译：用生物相容性碳质材料涂覆的可循环变形的血液兼容性和生物相容性装置
公开(公告)号：US5423886A
公开(公告)日：1995-06-13
申请号：US110419
申请日：1993-08-23
申请人： Pietro Arru , Stefano Rinaldi , Marco Santi , Franco Vallana
发明人： Pietro Arru , Stefano Rinaldi , Marco Santi , Franco Vallana
IPC分类号： A61F2/24 , A61M1/10 , A61F2/06
CPC分类号： A61F2/2412 , A61M1/10
摘要： There are disclosed devices for conditioning a blood flow which include at least one element with portions which are exposed to the blood and are deformable cyclically at a frequency comparable to the frequency of the heartbeat, in which the cyclically deformable portions have a continuous coating of biocompatible carbonaceous material comprised of carbon crystals having a density of greater than 2.1 grams per cubic centimeter applied by sputtering directly on and completely covering at least those portions of the device which are exposed to the blood.
摘要翻译：已经公开了用于调节血流的装置，其包括至少一个元件，其具有暴露于血液的部分并且以与心跳频率相当的频率周期性变形，其中可循环变形部分具有生物相容性的连续涂层碳质材料由具有大于2.1克/立方厘米密度的碳晶体组成，通过溅射直接溅射并完全覆盖暴露于血液的装置的至少那些部分。

7. 发明授权

US06379740B1 Method for treating a prosthesis having an apertured structure and associated devices 失效
标题翻译：用于治疗具有孔结构和相关装置的假体的方法
公开(公告)号：US06379740B1
公开(公告)日：2002-04-30
申请号：US09209433
申请日：1998-12-10
申请人： Stefano Rinaldi , Arnaldo Giannetti , Enrico Pasquino
发明人： Stefano Rinaldi , Arnaldo Giannetti , Enrico Pasquino
IPC分类号： A61L2700
CPC分类号： A61L27/00 , A61F2/0077 , A61F2/0095 , A61F2/02 , A61F2/06 , A61F2/2409 , A61L33/0005 , Y10T156/1744
摘要： A prosthesis having an apertured structure is located in a chamber (11) which is taken to sub-atmospheric pressure. Once sub-atmospheric pressure has been reached, a liquid, optionally containing pharmacological agents, is introduced into the chamber. Drawn by the sub-atmospheric pressure, the liquid saturates the apertured structure of the prosthesis. In this way, the invention eliminates the risk of air being trapped in the apertured structure that could give rise to the formation of blood clots after implantation of the prosthesis. The liquid can contain drugs that penetrate the prosthesis, performing their therapeutic action locally and over time after implantation.
摘要翻译：具有有孔结构的假体位于室（11）中，该室被采取为低于大气压。一旦达到低于大气压的压力，就可以将任选含有药剂的液体引入腔室。通过亚大气压力拉伸，液体饱和假体的有孔结构。以这种方式，本发明消除空气被困在有孔结构中的风险，其可能在植入假体后引起血块的形成。液体可以含有穿透假体的药物，在植入后局部和随着时间的推移执行其治疗作用。

8. 发明授权

US5873812A Method of preparing biological implantation material 失效
标题翻译：生物植入材料的制备方法
公开(公告)号：US5873812A
公开(公告)日：1999-02-23
申请号：US818783
申请日：1997-03-11
申请人： Leopoldo Della Ciana , Stefano Rinaldi , Andrea Grignani , Silvia Pascale
发明人： Leopoldo Della Ciana , Stefano Rinaldi , Andrea Grignani , Silvia Pascale
IPC分类号： A61L27/36 , A61F2/04
CPC分类号： A61L27/3687 , Y10S623/918
摘要： A method of preparing biological implantation material fixed by means of aldehydes, in which the excess aldehyde is bound by treatment with an aminocarboxylic acid and the acid is selected from compounds of the general formula: ##STR1## in which n is 1 or 2 and X is a sulpho- (--SO.sub.3 H) or phosphono- (--PO.sub.3 H) group, and mixtures of such compounds.
摘要翻译：制备通过醛固定的生物植入材料的方法，其中过量的醛通过用氨基羧酸和酸处理而结合，该酸选自下列通式的化合物：（ⅠB）其中n为1或2，X为磺基 - （ - SO 3 H）或膦 - （ - PO 3 H）基团，以及这些化合物的混合物。

9. 发明授权

US5762870A Exchange structure for biomedical equipment 失效
标题翻译：生物医学设备的交换结构
公开(公告)号：US5762870A
公开(公告)日：1998-06-09
申请号：US831960
申请日：1997-04-02
申请人： Franco Vallana , Stefano Rinaldi , Giampiero Porro , Massimo Fini
发明人： Franco Vallana , Stefano Rinaldi , Giampiero Porro , Massimo Fini
IPC分类号： A61M1/16 , A61M1/20 , B01D63/02 , B01D63/06 , B01D65/08 , F28F13/06 , F28F21/06
CPC分类号： B01D65/08 , B01D63/027 , B01D63/06 , F28F13/06 , F28F21/062 , A61M1/1698 , B01D2321/2016
摘要： The structure has a core which may be a strand or braid, as well as a sheath surrounding the core and defining the exchange surface. Preferred applications are for biomedical equipment such as blood oxygenators and blood purification equipment.
摘要翻译：该结构具有可以是线或编织物的芯，以及围绕芯并且限定交换表面的护套。优选的应用是用于生物医学设备，例如血液氧合器和血液净化设备。

10. 发明授权

US5728069A Device for the pulsed pumping of liquids, particularly blood 失效
标题翻译：脉冲泵送液体，特别是血液的装置
公开(公告)号：US5728069A
公开(公告)日：1998-03-17
申请号：US597492
申请日：1996-02-02
申请人： Franco Montevecchi , Fabio Inzoli , Stefano Rinaldi
发明人： Franco Montevecchi , Fabio Inzoli , Stefano Rinaldi
IPC分类号： F04B53/10 , A61M1/10 , A61M1/16 , A61M1/36 , F04B43/02 , A61M1/00
CPC分类号： A61M1/1037 , A61M1/1006 , A61M1/1055 , A61M1/267 , A61M1/106 , A61M1/1698 , A61M1/3627
摘要： A device for the pulsed pumping of liquids, particularly blood, has a body in which are formed a pumping chamber in which a pulsed flow is imparted to the liquid, an inlet duct upstream of the pumping chamber and communicating therewith, and a delivery duct downstream of the pumping chamber and communicating therewith. Two valve members constituted by lip valves are provided for regulating the one-way flow of fluid in the body from the inlet duct to the pumping chamber and from the latter to the delivery duct. Low levels of hemolysis can be achieved, if the device is pumping blood. Moreover, the device has a low production cost and is quiet. The pumping device may be incorporated into a cardiopulmonary bypass device which includes a venous reservoir, a heat exchanger and an oxygenator.
摘要翻译：用于液体，特别是血液的脉冲泵送的装置具有主体，其中形成有泵送室，其中脉冲流被施加到液体，在泵送室的上游并与之连通的入口管道以及与之相连的输送管道并与之连通。设置由唇形阀构成的两个阀构件，用于调节主体中的流体从入口管道到泵送室的单向流动，并从后者到输送管道。如果设备正在抽血，可以实现低水平的溶血。此外，该设备的生产成本低，安静。抽吸装置可以并入包括静脉储存器，热交换器和充氧器的心肺旁路装置中。

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