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1. 发明授权

US09863939B2 Analyte detection with magnetic sensors 有权
公开(公告)号：US09863939B2
公开(公告)日：2018-01-09
申请号：US12234506
申请日：2008-09-19
申请人： Shan X. Wang , Sebastian J. Osterfeld , Heng Yu , Nader Pourmand , Robert L. White
发明人： Shan X. Wang , Sebastian J. Osterfeld , Heng Yu , Nader Pourmand , Robert L. White
IPC分类号： G01N33/00 , G01N33/543 , G01N27/00
CPC分类号： G01N33/54326 , Y10T436/143333
摘要： Methods for analyte detection with magnetic sensors are provided. Aspects of the methods include producing a magnetic sensor device having a magnetically labeled analyte from a sample, such as a serum sample, bound to a surface of a magnetic sensor thereof; and obtaining a signal, e.g., a real-time signal, from the magnetic sensor to determine whether the analyte is present in the sample. Also provided are devices, systems and kits that find use in practicing the methods of the invention. The methods, devices, systems and kits of the invention find use in a variety of different applications, including detection of biomarkers, such as disease markers.

2. 发明申请

US20090104707A1 ANALYTE DETECTION WITH MAGNETIC SENSORS 有权
标题翻译：用磁传感器进行分析检测
公开(公告)号：US20090104707A1
公开(公告)日：2009-04-23
申请号：US12234506
申请日：2008-09-19
申请人： Shan X. Wang , Sebastian J. Osterfeld , Heng Yu , Nader Pourmand , Robert L. White
发明人： Shan X. Wang , Sebastian J. Osterfeld , Heng Yu , Nader Pourmand , Robert L. White
IPC分类号： G01N33/00 , G01N27/00 , B01J19/00
CPC分类号： G01N33/54326 , Y10T436/143333
摘要： Methods for analyte detection with magnetic sensors are provided. Aspects of the methods include producing a magnetic sensor device having a magnetically labeled analyte from a sample, such as a serum sample, bound to a surface of a magnetic sensor thereof; and obtaining a signal, e.g., a real-time signal, from the magnetic sensor to determine whether the analyte is present in the sample. Also provided are devices, systems and kits that find use in practicing the methods of the invention. The methods, devices, systems and kits of the invention find use in a variety of different applications, including detection of biomarkers, such as disease markers.
摘要翻译：提供了使用磁传感器进行分析物检测的方法。所述方法的方面包括制备具有磁性标记的分析物的磁性传感器装置，所述磁性传感器装置与来自其磁性传感器的表面的样品（例如血清样品）结合; 以及从磁传感器获得信号，例如实时信号，以确定分析物是否存在于样品中。还提供了用于实践本发明的方法的装置，系统和试剂盒。本发明的方法，装置，系统和试剂盒可用于各种不同的应用，包括检测生物标志物，例如疾病标记物。

3. 发明授权

US09151763B2 Systems and methods for high-throughput detection of an analyte in a sample 有权
标题翻译：用于样品中分析物的高通量检测的系统和方法
公开(公告)号：US09151763B2
公开(公告)日：2015-10-06
申请号：US13416928
申请日：2012-03-09
申请人： Sebastian J. Osterfeld , Shan X. Wang
发明人： Sebastian J. Osterfeld , Shan X. Wang
IPC分类号： G01N27/00 , G01N33/58 , C40B60/12 , B01L3/00 , B82Y15/00 , B82Y30/00 , G01N27/327 , G01R33/12 , G01N27/74 , G01N35/00 , G01R33/00 , B01L9/00 , B82Y10/00 , G01N35/02
CPC分类号： G01N33/585 , B01J2219/00317 , B01J2219/00655 , B01J2219/00662 , B01L3/5085 , B01L9/523 , B01L2300/0829 , B82Y10/00 , B82Y15/00 , B82Y30/00 , C40B60/12 , G01N27/3276 , G01N27/745 , G01N33/587 , G01N35/0098 , G01N35/026 , G01R33/0094 , G01R33/1269 , Y10S977/773 , Y10S977/92
摘要： Provided are high-throughput detection systems. The systems include a magnetic sensor device, a magnetic field source and a reservoir plate that includes a plurality of fluid reservoirs. The magnetic sensor device includes a support with two or more elongated regions each having a magnetic sensor array disposed at a distal end. Also provided are methods in which the subject high-throughput detection systems find use.
摘要翻译：提供高通量检测系统。这些系统包括磁传感器装置，磁场源和包括多个流体储存器的储存器板。磁传感器装置包括具有两个或多个细长区域的支撑件，每个细长区域具有设置在远端的磁性传感器阵列。还提供了本发明的高通量检测系统使用的方法。

4. 发明申请

US20120231960A1 SYSTEMS AND METHODS FOR HIGH-THROUGHPUT DETECTION OF AN ANALYTE IN A SAMPLE 有权
标题翻译：用于高样本检测样品中分析物的系统和方法
公开(公告)号：US20120231960A1
公开(公告)日：2012-09-13
申请号：US13416928
申请日：2012-03-09
申请人： Sebastian J. Osterfeld , Shan X. Wang
发明人： Sebastian J. Osterfeld , Shan X. Wang
IPC分类号： C40B60/12 , C40B30/00
CPC分类号： G01N33/585 , B01J2219/00317 , B01J2219/00655 , B01J2219/00662 , B01L3/5085 , B01L9/523 , B01L2300/0829 , B82Y10/00 , B82Y15/00 , B82Y30/00 , C40B60/12 , G01N27/3276 , G01N27/745 , G01N33/587 , G01N35/0098 , G01N35/026 , G01R33/0094 , G01R33/1269 , Y10S977/773 , Y10S977/92
摘要： Provided are high-throughput detection systems. The systems include a magnetic sensor device, a magnetic field source and a reservoir plate that includes a plurality of fluid reservoirs. The magnetic sensor device includes a support with two or more elongated regions each having a magnetic sensor array disposed at a distal end. Also provided are methods in which the subject high-throughput detection systems find use.
摘要翻译：提供高通量检测系统。这些系统包括磁传感器装置，磁场源和包括多个流体储存器的储存器板。磁传感器装置包括具有两个或多个细长区域的支撑件，每个细长区域具有设置在远端的磁性传感器阵列。还提供了本发明的高通量检测系统使用的方法。

5. 发明申请

US20100231203A1 Temperature and drift compensation in magnetoresistive sensors 有权
标题翻译：磁阻传感器的温度和漂移补偿
公开(公告)号：US20100231203A1
公开(公告)日：2010-09-16
申请号：US12661158
申请日：2010-03-10
申请人： Drew A. Hall , Richard Gaster , Sebastian J. Osterfeld , Shan X. Wang
发明人： Drew A. Hall , Richard Gaster , Sebastian J. Osterfeld , Shan X. Wang
IPC分类号： G01R35/00 , G01R33/18
CPC分类号： G01R33/1269 , B82Y25/00 , G01R33/09 , G01R33/093
摘要： Double modulation of a magnetoresistive sensor entails modulating both an excitation (e.g., voltage or current) applied to the sensor and a tickling magnetic field applied to the sensor. The excitation and magnetic field are modulated at different frequencies fc and ff, respectively. As a result of the double modulation, the sensor output spectrum includes a carrier tone (CT) at frequency fc and side tones (STs) at frequencies fc±ff. A baseline relation between CT amplitude and ST amplitude is determined (e.g., by measuring CT and ST amplitude while drift occurs in the absence of a sample). During sensor operation, raw ST measurements are corrected using corresponding raw CT measurements to provide corrected ST measurements as the sensor output.
摘要翻译：磁阻传感器的双重调制需要调制施加到传感器的激励（例如，电压或电流）以及施加到传感器的挠曲磁场。励磁和磁场分别以不同频率fc和ff进行调制。作为双调制的结果，传感器输出频谱包括频率为fc的载波音（CT）和频率fc±ff的侧音（ST）。确定CT幅度和ST幅度之间的基线关系（例如，通过测量CT和ST振幅，而在不存在样本的情况下发生漂移）。在传感器操作期间，使用相应的原始CT测量来校正原始ST测量值，以提供校正的ST测量作为传感器输出。

6. 发明授权

US08405385B2 Temperature and drift compensation in magnetoresistive sensors 有权
标题翻译：磁阻传感器的温度和漂移补偿
公开(公告)号：US08405385B2
公开(公告)日：2013-03-26
申请号：US12661158
申请日：2010-03-10
申请人： Drew A. Hall , Richard Gaster , Sebastian J. Osterfeld , Shan X. Wang
发明人： Drew A. Hall , Richard Gaster , Sebastian J. Osterfeld , Shan X. Wang
IPC分类号： G01B7/14 , G01R35/00
CPC分类号： G01R33/1269 , B82Y25/00 , G01R33/09 , G01R33/093
摘要： Double modulation of a magnetoresistive sensor entails modulating both an excitation (e.g., voltage or current) applied to the sensor and a tickling magnetic field applied to the sensor. The excitation and magnetic field are modulated at different frequencies fc and ff, respectively. As a result of the double modulation, the sensor output spectrum includes a carrier tone (CT) at frequency fc and side tones (STs) at frequencies fc±ff. A baseline relation between CT amplitude and ST amplitude is determined (e.g., by measuring CT and ST amplitude while drift occurs in the absence of a sample). During sensor operation, raw ST measurements are corrected using corresponding raw CT measurements to provide corrected ST measurements as the sensor output.
摘要翻译：磁阻传感器的双重调制需要调制施加到传感器的激励（例如，电压或电流）以及施加到传感器的挠曲磁场。励磁和磁场分别以不同频率fc和ff进行调制。作为双调制的结果，传感器输出频谱包括频率为fc的载波音（CT）和频率fc±ff的侧音（ST）。确定CT幅度和ST幅度之间的基线关系（例如，通过测量CT和ST振幅，而在不存在样本的情况下发生漂移）。在传感器操作期间，使用相应的原始CT测量来校正原始ST测量值，以提供校正的ST测量作为传感器输出。

7. 发明授权

US07419639B2 Multilayer microfluidic device 有权
标题翻译：多层微流体装置
公开(公告)号：US07419639B2
公开(公告)日：2008-09-02
申请号：US11388223
申请日：2006-03-22
申请人： Sebastian J Osterfeld , Shan X. Wang
发明人： Sebastian J Osterfeld , Shan X. Wang
IPC分类号： B01L3/02 , G01N15/06 , G01N33/00 , G01N33/48
CPC分类号： B01L3/502707 , B01L9/527 , B01L2200/0689 , B01L2200/12 , B01L2300/0636 , B01L2300/0816 , B01L2300/123 , B01L2400/0415 , B01L2400/043 , B81B2201/058 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： The present invention provides microfluidic devices constructed from four layers. The layers include a rigid substrate layer, a patterned rigid layer having thickness t, a patterned elastomeric layer having thickness greater than t, and a rigid support layer. Microfluidic structures in the devices are defined by the alignment of openings in the patterned rigid layer and the patterned elastomeric layer. The rigid support layer, rigid substrate layer, and patterned rigid layer may be made of any rigid material, including but not limited to plastic or silicon-containing materials, such as glass, quartz, or SiO2-coated materials. Similarly, the patterned elastomeric layer may be made of any elastomeric material, including but not limited to polydimethylsiloxanes, polymethylmethacrylates, perfluoropolyethers, or combinations thereof. Microfluidic devices according to the present invention may include sensors or sensor arrays. The microfluidic devices are fabricated using the provided error-tolerant alignment, biocompatible process.
摘要翻译：本发明提供了由四层构成的微流体装置。这些层包括刚性基底层，具有厚度t的图案化刚性层，厚度大于t的图案化弹性体层和刚性支撑层。器件中的微流体结构通过图案化刚性层和图案化的弹性体层中的开口的对准来限定。刚性支撑层，刚性基底层和图案化刚性层可以由任何刚性材料制成，包括但不限于塑料或含硅材料，例如玻璃，石英或SiO 2 - 涂层材料。类似地，图案化的弹性体层可以由任何弹性体材料制成，包括但不限于聚二甲基硅氧烷，聚甲基丙烯酸甲酯，全氟聚醚或其组合。根据本发明的微流体装置可以包括传感器或传感器阵列。使用提供的容错对准，生物相容性方法制造微流体装置。

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