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1. 发明申请

US20070254941A1 Subtantially pure ropinirole hydrochloride, polymorphic form of ropinirole and process for their preparation 审中-公开
标题翻译：碱性纯罗哌尼罗盐酸盐，罗哌尼罗多晶型及其制备方法
公开(公告)号：US20070254941A1
公开(公告)日：2007-11-01
申请号：US11788676
申请日：2007-04-20
申请人： Bobba Venkata Kumar , Sanjay Kale , Ajay Audi , Nitin Sharad Pradhan
发明人： Bobba Venkata Kumar , Sanjay Kale , Ajay Audi , Nitin Sharad Pradhan
IPC分类号： A61K31/404 , C07D209/36
CPC分类号： C07D209/34
摘要： Ropinirole hydrochloride substantially free of impurities and a process for its preparation is provided. Also provided is ropinirole base substantially in polymorph Form A and a process for its preparation. Pharmaceutical compositions containing the same are also provided.
摘要翻译：提供了基本上不含杂质的罗哌卡罗盐酸盐及其制备方法。还提供了基本上呈多晶型A的罗匹尼罗碱及其制备方法。还提供含有该组合物的药物组合物。

2. 发明申请

US20050203297A1 Process for the preparation of carboxamide compounds 失效
标题翻译：制备羧酰胺化合物的方法
公开(公告)号：US20050203297A1
公开(公告)日：2005-09-15
申请号：US11077723
申请日：2005-03-11
申请人： Bobba Sivakumar , Shekhar Bhirud , Chandrasekhar Batchu , Sanjay Kale
发明人： Bobba Sivakumar , Shekhar Bhirud , Chandrasekhar Batchu , Sanjay Kale
IPC分类号： C07D223/18
CPC分类号： C07D223/28 , C07D223/26
摘要： A process for preparing 5H-dibenz[b,f]azepine-5-carboxamide of the general formula: wherein R1, R2, R3 and R4 are the same or different and can be hydrogen, halogen, nitro, cyano, carboxyl, R, —CO(R), —OCO(R), —O(R), —N(R)2, —CON(R)2, and —COO(R), wherein R is selected from the group consisting of C1-C10 alkyl, C3-C10 cycloalkyl, C2-C10 alkenyl, C5-C10 cycloalkenyl, C2-C10 alkynyl, and C6-C20 aryl, wherein the two A groups of —N(A)2 and —CON(A)2 can be the same or different, and wherein R2 and R3 can together form a bond is provided; the process comprising reacting 5H-dibenz[b,f]azepine of the general formula wherein R1, R2, R3 and R4 have the aforementioned meanings, with one or more alkali or alkaline-earth cyanates and in the presence of one or more unsaturated dicarboxylic acids.
摘要翻译：制备通式如下的5H-二苯并[b，f]吖庚因-5-甲酰胺的方法：其中R 1，R 2，R 3，（R），-O（R）， - OCO（R），-O（R）， -N（R）2，-CON（R）2，和-COO（R），其中R选自C 1〜 C 1 -C 10烷基，C 3 -C 10环烷基，C 2 -C 10烷基，C 1 -C 10烷基， 10个亚烷基，C 5 -C 10环烯基，C 2 -C 10炔基，以及 C 6 -C 20芳基，其中-N（A）2和-CON（A）2的两个A基团可以相同或不同，并且其中R 2和R 3可以一起形成键; 该方法包括使通式为的5H-二苯并[b，f]吖庚因其中R 1，R 2，R 3，R 3和R 3，具有上述含义，具有一种或多种碱金属或碱土氰酸盐，并且在一种或多种不饱和二羧酸存在下。

3. 发明申请

US20070105923A1 Substantially pure olmesartan medoxomil and processes for its preparation 审中-公开
标题翻译：基本上纯的奥美沙坦酯和其制备方法
公开(公告)号：US20070105923A1
公开(公告)日：2007-05-10
申请号：US11521166
申请日：2006-09-14
申请人： Bobba Venkata Siva Kumar , Sanjay Kale , Raju Choudhari , Nitin Sharad Pradhan
发明人： Bobba Venkata Siva Kumar , Sanjay Kale , Raju Choudhari , Nitin Sharad Pradhan
IPC分类号： A61K31/4178 , C07D403/14
CPC分类号： C07D403/14
摘要： A process for purifying olmesartan medoxomil is provided comprising (a) dissolving olmesartan medoxomil in a solvent system comprising a ketone and at least one solvent selected from the group consisting of an alcohol-containing solvent, an ester-containing solvent and mixtures thereof to obtain a solution; and (b) recovering substantially pure olmesartan medoxomil. Also disclosed is substantially pure olmesartan medoxomil and pharmaceutical compositions containing same.
摘要翻译：提供了一种纯化奥美沙坦酯的方法，包括（a）将奥美沙坦酯在含酮和至少一种选自含醇溶剂，含酯溶剂及其混合物的溶剂体系的溶剂体系中溶解，得到解; 和（b）回收基本上纯的奥美沙坦酯。还公开了基本上纯的奥美沙坦酯和含有它们的药物组合物。

4. 发明申请

US20070135472A1 Novel crystalline forms of desloratadine and processes for their preparation 审中-公开
标题翻译：地氯雷他定的新型结晶形式及其制备方法
公开(公告)号：US20070135472A1
公开(公告)日：2007-06-14
申请号：US11607229
申请日：2006-12-01
申请人： Bobba Kumar , Sanjay Kale , Raju Choudhari , Nitin Pradhan
发明人： Bobba Kumar , Sanjay Kale , Raju Choudhari , Nitin Pradhan
IPC分类号： A61K31/473
CPC分类号： C07D401/04
摘要： Novel polymorph Forms III and V of desloratadine are provided. Pharmaceutical compositions containing such polymorphs are also provided.
摘要翻译：提供了地氯雷他定的新型多晶型III和V. 还提供了含有这种多晶型物的药物组合物。

5. 发明申请

US20060084814A1 Process for the preparation of zonisamide 审中-公开
标题翻译：制备唑尼沙胺的方法
公开(公告)号：US20060084814A1
公开(公告)日：2006-04-20
申请号：US11133543
申请日：2005-05-20
申请人： Bobba Siva Kumar , Shekhar Bhirud , Batchu Chandrasekhar , Sanjay Kale
发明人： Bobba Siva Kumar , Shekhar Bhirud , Batchu Chandrasekhar , Sanjay Kale
IPC分类号： C07D261/20
CPC分类号： C07D261/20
摘要： The present invention provides an improved process for the preparation of zonisamide or a derivative thereof comprising (a) reacting 1,2-benzisoxazole-3-methane-sulfonic acid with a halogenating agent in a first organic solvent to provide benzisoxazole methane sulfonyl halide; and, (b) reacting benzisoxazole methane sulfonyl halide with an amine in a second organic solvent to form zonisamide or a derivative thereof.
摘要翻译：本发明提供了制备唑尼沙胺或其衍生物的改进方法，其包括（a）在第一有机溶剂中使1,2-苯并异恶唑-3-甲磺酸与卤化剂反应，得到苯并异恶唑甲磺酰卤; 和（b）使苯并异恶唑甲磺酰卤与胺在第二有机溶剂中反应以形成唑尼沙胺或其衍生物。

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