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    • 3. 发明授权
    • Catheter for uniform delivery of medication
    • 导管统一服药
    • US07780638B1
    • 2010-08-24
    • US10031913
    • 2000-07-19
    • Jose Castillo DeniegaRoger MassengaleKenneth W. Rake
    • Jose Castillo DeniegaRoger MassengaleKenneth W. Rake
    • A61M5/00A61M25/00
    • A61M25/0074A61M25/00A61M25/0023A61M25/0043A61M25/0068A61M25/0069A61M25/007A61M2025/0037A61M2025/0039A61M2025/0057A61M2025/0073
    • The present invention provides a catheter for the delivery of fluid medication across an anatomical region. In accordance with one embodiment, the catheter comprises an elongated tube with a plurality of exit holes along an infusion section of the catheter, and an elongated flexible porous member residing within the tube and forming an annular space between the tube and the member. In accordance with other embodiments, the catheter includes a tube having a plurality of exit holes in a side wall of the tube. The exit holes may combine to form a flow-restricting orifice of the catheter. Advantageously, fluid within the catheter flows through all of the exit holes, resulting in uniform distribution of fluid within an anatomical region. In one particular embodiment, the catheter comprises a tube having elongated exit slots therein. In accordance with other embodiments, the catheter includes an elongated tubular member made of a porous membrane. The porous membrane is configured so that a fluid introduced into an open end of the tubular member will flow through side walls of the tubular member at a substantially uniform rate along a length of the tubular member. In accordance with other embodiments, the catheter includes an elongated “weeping” tubular coil spring attached to an end of, or enclosed within, a tube. Fluid within the spring and greater than or equal to a threshold pressure advantageously flows radially outward between the spring coils. Advantageously, the fluid is dispensed substantially uniformly throughout a length of the spring.
    • 本发明提供一种用于在解剖区域上输送流体药物的导管。 根据一个实施例,导管包括细长管,其具有沿着导管的输注部分的多个出口孔,以及驻留在管内并在管与构件之间形成环形空间的细长柔性多孔构件。 根据其他实施例,导管包括管,其在管的侧壁中具有多个出口孔。 出口孔可以组合形成导管的限流孔。 有利地,导管内的流体流过所有出口孔,导致流体在解剖区域内的均匀分布。 在一个具体实施例中,导管包括其中具有细长出口槽的管。 根据其他实施例,导管包括由多孔膜制成的细长管状构件。 多孔膜被构造成使得引入到管状构件的开口端的流体将沿着管状构件的长度以基本均匀的速率流过管状构件的侧壁。 根据其他实施例,导管包括连接到管的端部或封闭在管内的细长的“哭泣”管状螺旋弹簧。 弹簧内的流体大于或等于阈值压力有利地在弹簧圈之间径向向外流动。 有利地,流体在弹簧的整个长度上基本均匀地分配。
    • 5. 发明申请
    • PRESSURE REGULATOR
    • 压力调节器
    • US20090250124A1
    • 2009-10-08
    • US12484988
    • 2009-06-15
    • Roger MassengaleStanley E. FryCharles J. McPhee
    • Roger MassengaleStanley E. FryCharles J. McPhee
    • F16K1/00
    • G05D16/0647Y10S137/903Y10T137/0379Y10T137/0396Y10T137/0497Y10T137/7825Y10T137/7871Y10T137/7922Y10T137/8225Y10T137/8326
    • A variable device for regulating the outlet pressure of a fluid from a valve body, includes a pressure-sensing chamber having a wall formed by a resilient self-restoring diaphragm which is responsive to pressure in the chamber. A valve element connected to the diaphragm controls flow into the chamber. Increased pressure in the chamber decreases the flow into the chamber and decreasing pressure increases flow whereby fluid flow out from the chamber is maintained at a desired pressure. The outlet pressure is adjusted by deflecting the diaphragm in a direction to open the valve while permitting a section of the diaphragm connected to the valve member to remain responsive to the pressure in the chamber. An adjustment cover is provided to adjustably deflect the diaphragm and includes a catch mechanism to allow adjustment of the fluid outlet pressures and also retain the device at a desired value. An indicator arrangement may be provided to visually indicate the fluid outlet pressure.
    • 用于调节来自阀体的流体的出口压力的可变装置包括压力感测室,该压力感测室具有由响应腔室中的压力的​​弹性自恢复隔膜形成的壁。 连接到隔膜的阀元件控制流入腔室。 室中增加的压力降低了进入室的流量,并且减小的压力增加了流量,从而从腔室流出的流体保持在期望的压力。 出口压力通过使膜片沿打开阀的方向偏转来调节,同时允许连接到阀构件的隔膜的一部分保持对腔室中的压力的​​响应。 提供调节盖以可调节地偏转隔膜并且包括捕获机构以允许调节流体出口压力并且还将装置保持在期望值。 可以提供指示器布置以在视觉上指示流体出口压力。
    • 6. 发明授权
    • Anti-microbial catheter
    • 抗微生物导管
    • US07547302B2
    • 2009-06-16
    • US11216534
    • 2005-08-31
    • James Dal PortoJose Castillo DeniegaRoger MassengaleLois Rake, legal representativeKevin ForrestMark Siminuk
    • Kenneth W. Rake
    • A61M25/00
    • A61L27/54A61L29/16A61L2300/104A61L2300/404A61M25/0045A61M25/0069A61M25/007A61M25/0071A61M2025/0056A61M2025/0057
    • A catheter having features configured to provide a substantially uniform flow rate of a fluid exiting the catheter and also exhibits anti-microbial properties. The uniform flow rate features may include one or more of a flow restricting membrane or flow restricting component within an infusion section of the catheter. In other arrangements, exit holes defining the infusion section of the catheter may be configured to provide the desired uniform flow rate over the length of the infusion section. Furthermore, the catheter also includes anti-microbial properties to inhibit the growth of microbes on or within the catheter and, preferably, to inhibit microbe growth in an anatomical region surrounding the catheter. The desired anti-microbial properties may be provided by an anti-microbial layer, anti-microbial materials dispersed within the material from which components of the catheters are constructed, or a combination of anti-microbial layers and embedded anti-microbial materials. In some arrangements, one or more portions of the catheter may be bio-absorbable.
    • 具有被配置为提供离开导管的流体的基本均匀流速并且还具有抗微生物性质的特征的导管。 均匀流速特征可以包括在导管的输注部分内的流动限制膜或流量限制部件中的一个或多个。 在其他布置中,限定导管的输注部分的出口孔可以被配置为在输注部分的长度上提供期望的均匀流速。 此外,导管还包括抗微生物性质以抑制导管上或导管内微生物的生长,并且优选地抑制导管周围解剖区域中的微生物生长。 所需的抗微生物性质可以通过抗微生物层,分散在构成导管的组分的材料中的抗微生物材料,或抗微生物层和嵌入的抗微生物材料的组合来提供。 在一些布置中,导管的一个或多个部分可以是生物可吸收的。
    • 8. 发明申请
    • Catheter for uniform delivery of medication
    • 导管统一服药
    • US20060149192A1
    • 2006-07-06
    • US11364767
    • 2006-02-28
    • Jose DeniegaRoger MassengaleKenneth Rake
    • Jose DeniegaRoger MassengaleKenneth Rake
    • A61M25/00
    • A61M25/0074A61M25/00A61M25/0023A61M25/0043A61M25/0068A61M25/0069A61M25/007A61M2025/0037A61M2025/0039A61M2025/0057A61M2025/0073
    • The present invention provides a catheter for the delivery of fluid medication across an anatomical region. In accordance with one embodiment, the catheter comprises an elongated tube with a plurality of exit holes along an infusion section of the catheter, and an elongated flexible porous member residing within the tube and forming an annular space between the tube and the member. In accordance with other embodiments, the catheter includes a tube having a plurality of exit holes in a side wall of the tube. The exit holes may combine to form a flow-restricting orifice of the catheter. In one particular embodiment, the catheter comprises a tube having elongated exit slots therein. In accordance with other embodiments, the catheter includes an elongated tubular member made of a porous membrane. In accordance with other embodiments, the catheter includes an elongated “weeping” tubular coil spring attached to an end of, or enclosed within, a tube.
    • 本发明提供一种用于在解剖区域上输送流体药物的导管。 根据一个实施例,导管包括细长管,其具有沿着导管的输注部分的多个出口孔,以及驻留在管内并在管与构件之间形成环形空间的细长柔性多孔构件。 根据其他实施例,导管包括管,其在管的侧壁中具有多个出口孔。 出口孔可以组合形成导管的限流孔。 在一个具体实施例中,导管包括其中具有细长出口槽的管。 根据其他实施例,导管包括由多孔膜制成的细长管状构件。 根据其他实施例,导管包括连接到管的端部或封闭在管内的细长的“哭泣”管状螺旋弹簧。