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1. 发明申请

US20080051388A1 Novel Compounds That Inhibit Factor Xa Activity 审中-公开
标题翻译：抑制因子Xa活性的新型化合物
公开(公告)号：US20080051388A1
公开(公告)日：2008-02-28
申请号：US11632291
申请日：2005-07-19
申请人： Thilo Fuchs , Robert Eckl
发明人： Thilo Fuchs , Robert Eckl
IPC分类号： A61K31/445 , A61K31/541 , A61K31/55 , A61P7/02 , C07D243/08 , C07D405/02 , C07D417/02
CPC分类号： C07H15/203
摘要： The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts, solvates, hydrates or pharmaceutically acceptable formulations thereof. Those compounds can be used in inhibiting factor Xa and in the prevention and/or treatment of thrombolytic conditions.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，水合物或其药学上可接受的制剂。那些化合物可用于抑制因子Xa和预防和/或治疗溶栓症状。

2. 发明授权

US07102034B2 Process for preparing sulfonated arylphosphines 失效
标题翻译：制备磺化芳基膦的方法
公开(公告)号：US07102034B2
公开(公告)日：2006-09-05
申请号：US11007399
申请日：2004-12-08
申请人： Michael Riedel , Ernst Wiebus , Carl D Frohning , Wilfried Fenske , Florian Rampf , Jurgen Herwig , Helmut Bahrmann , Klaus Bergrath , Wolfgang Zgorzel-Ski , Robert Eckl , Hans Bohnen , Richard Fischer , Kurt Schalapski , Wolfgang Greb
发明人： Michael Riedel , Ernst Wiebus , Carl D Frohning , Wilfried Fenske , Florian Rampf , Jurgen Herwig , Helmut Bahrmann , Klaus Bergrath , Wolfgang Zgorzel-Ski , Robert Eckl , Hans Bohnen , Richard Fischer , Kurt Schalapski , Wolfgang Greb
IPC分类号： C07C45/00
CPC分类号： B01J31/2404 , B01J31/2409 , B01J31/28 , B01J2231/321 , B01J2531/822 , B01J2531/96 , C07C45/50 , C07F9/5022 , C07F9/5054 , C07F9/5095 , C07C47/02
摘要： A process for preparing sulfonated arylphosphines by reaction of arylphosphines with oleum, wherein, after reaction of the arylphosphines with oleum, the sulfonation mixture is firstly diluted with water, an inert gas stream is then passed through the diluted sulfonation mixture until SO2 is no longer liberated from the diluted sulfonation mixture and the latter is then worked up further in a customary manner and its use.
摘要翻译：通过芳基膦与发烟硫酸的反应制备磺化芳基膦的方法，其中在芳基膦与发烟硫酸反应之后，首先用水稀释磺化混合物，然后使惰性气体流通过稀释的磺化混合物直到SO 2 不再从稀释磺化混合物中释放出来，而后者则以常规方式进一步处理及其用途。

3. 发明授权

US5706636A Envelope-stuffing device 失效
标题翻译：信封装置
公开(公告)号：US5706636A
公开(公告)日：1998-01-13
申请号：US646253
申请日：1996-05-10
申请人： Robert Eckl
发明人： Robert Eckl
IPC分类号： B43M3/04 , B65B43/26
CPC分类号： B43M3/045
摘要： The present invention pertains to the object of substantially increasing the performance of an envelope-stuffing machine. While EP-A-0 504 114 discloses the use of rotating elements for opening the envelopes and for grasping the envelope flaps for this purpose, the present invention suggests that the opening and grasping of the envelopes (20) be performed in one conveying plane (13), and the introduction of the envelope contents (21) be performed in a conveying plane (12) arranged offset in relation thereto at another level, and that a link chain (10) with a plurality of spreading members (9) be provided between them, which is movable at right angles to the conveying planes (12, 13) and keeps the envelopes (20) picked up by the spreading members (9) ready at another point for the introduction of the envelope contents (21) and discharges them.
摘要翻译： PCT No.PCT / EP94 / 03519 371日期：1996年5月10日 102（e）日期1996年5月10日PCT 1994年10月26日PCT公布。 WO95 / 13197 PCT出版物日期：1995年5月18日本发明涉及显着增加包络填充机性能的目的。虽然EP-A-0 504 114公开了为了这个目的而使用旋转元件来打开信封并且为了抓住信封襟翼，本发明提出，在一个输送平面（20）中执行信封（20）的打开和抓握 13），并且在另一个层面上在相对于其偏移设置的输送平面（12）中执行信封内容（21）的引入，并且提供具有多个扩展构件（9）的链节（10）在它们之间，其可以与输送平面（12,13）成直角地移动，并且保持由扩展构件（9）拾取的信封（20）准备在另一个位置用于引入信封内容物（21）并将其放电他们。

4. 发明授权

US06864387B2 Process for preparing sulfonated arylphosphines 有权
标题翻译：制备磺化芳基膦的方法
公开(公告)号：US06864387B2
公开(公告)日：2005-03-08
申请号：US10413014
申请日：2003-04-14
申请人： Michael Riedel , Ernst Wiebus , Carl D Frohning , Wilfried Fenske , Florian Rampf , Jurgen Herwig , Helmut Bahrmann , Klaus Bergrath , Wolfgang Zgorzel-Ski , Robert Eckl , Hans Bohnen , Richard Fischer , Kurt Schalapski , Wolfgang Greb
发明人： Michael Riedel , Ernst Wiebus , Carl D Frohning , Wilfried Fenske , Florian Rampf , Jurgen Herwig , Helmut Bahrmann , Klaus Bergrath , Wolfgang Zgorzel-Ski , Robert Eckl , Hans Bohnen , Richard Fischer , Kurt Schalapski , Wolfgang Greb
IPC分类号： B01J31/24 , B01J31/28 , C07C45/50 , C07F9/50 , C07C304/00
CPC分类号： B01J31/2404 , B01J31/2409 , B01J31/28 , B01J2231/321 , B01J2531/822 , B01J2531/96 , C07C45/50 , C07F9/5022 , C07F9/5054 , C07F9/5095 , C07C47/02
摘要： A process for preparing solutions of sulfonated arylphosphines comprising reacting arylphosphines with oleum, diluting the sulfonation mixture with water, extracting the diluted sulfonation mixture with a solution of a water-insoluble organic solvent, reacting the organic phase with a solution of an inorganic base in water, adjusting the resulting aqueous solutin of sulfonated arylphosphines to a pH of up to 3 by addition of an acid, and passing an inert gas stream through the aqueous solution comprising sulfonated arylphosphines until sulfur is no longer liberated from the aqueous solution of sulfonated arylphosphines.
摘要翻译：一种制备磺化芳基膦溶液的方法，包括使芳基膦与发烟硫酸反应，用水稀释磺化混合物，用水不溶性有机溶剂的溶液萃取稀释的磺化混合物，将有机相与无机碱溶于水通过加入酸将所得的磺化芳基膦的水溶液调节至最高达3的pH，并使惰性气体流通过包含磺化芳基膦的水溶液，直到硫从磺化芳基膦的水溶液中不再释放出来。

5. 发明授权

US09527002B2 Method and apparatus for the low-temperature fractionation of a fluid mixture 有权
$Method and apparatus for the low-temperature fractionation of a fluid mixture$
标题翻译：流体混合物的低温分馏方法和装置
公开(公告)号：US09527002B2
公开(公告)日：2016-12-27
申请号：US14240565
申请日：2012-08-02
申请人： Horst Rudiger , Robert Eckl , Christoph Windmeier , Alexander Beimler , Yonggui Yu
发明人： Horst Rudiger , Robert Eckl , Christoph Windmeier , Alexander Beimler , Yonggui Yu
IPC分类号： F25J3/00 , B01D1/00 , B01D3/32 , F25J3/04
CPC分类号： B01D1/0023 , B01D3/322 , F25J3/04745 , F25J3/04751 , F25J2200/40 , F25J2250/00 , F25J2290/44
摘要： The method and the apparatus are used for the low-temperature fractionation of a fluid mixture. The fluid mixture is introduced into a separation column. At least a portion of the sump liquid from the separation column is introduced into a sump evaporator and at least partly evaporated there. At least a portion of the vapor produced in the sump evaporator is led back into a lower section of the separation column. A top product is removed at the top of the separation column, and a sump product is removed from the sump of the separation column or from the sump evaporator. The sump evaporator is operated by means of inductive heating.
摘要翻译：该方法和装置用于流体混合物的低温分馏。将流体混合物引入分离塔。来自分离塔的至少一部分贮槽液体被引入到贮槽蒸发器中并且至少部分地在那里蒸发。在贮槽蒸发器中产生的蒸汽的至少一部分被引回到分离塔的下部。在分离塔的顶部除去顶部产物，并且从分离塔的贮槽或从贮槽蒸发器除去贮槽产物。贮槽蒸发器通过感应加热操作。

6. 发明申请

US20060084614A1 Novel factor viia inhibiting compounds 审中-公开
标题翻译：新型因子viia抑制化合物
公开(公告)号：US20060084614A1
公开(公告)日：2006-04-20
申请号：US10541347
申请日：2004-01-05
申请人： Robert Eckl , Lutz Weber , Christian Oefner
发明人： Robert Eckl , Lutz Weber , Christian Oefner
IPC分类号： A61K31/704 , C07H17/00
CPC分类号： C07H15/203 , A61K31/7034
摘要： The present invention relates to new compounds of formula (I): These compounds are very effective factor VIIa inhibitors and are therefore of interest in the treatment and/or prevention of thromboses, stroke, heart attack, inflammation, arteriosclerosis and tumour conditions.
摘要翻译：本发明涉及式（I）的新化合物：这些化合物是非常有效的因子VIIa抑制剂，因此对治疗和/或预防血栓形成，中风，心脏病发作，炎症，动脉硬化和肿瘤状况感兴趣。

7. 发明申请

US20050171377A1 Process for preparing sulfonated arylphosphines 失效
标题翻译：制备磺化芳基膦的方法
公开(公告)号：US20050171377A1
公开(公告)日：2005-08-04
申请号：US11007399
申请日：2004-12-08
申请人： Michael Riedel , Ernst Wiebus , Carl Frohning , Wilfried Fenske , Florian Rampf , Jurgen Herwig , Helmut Bahrmann , Klaus Bergrath , Wolfgang Zgorzel-Ski , Robert Eckl , Hans Bohnen , Richard Fischer , Kurt Schalapski , Wolfgang Greb
发明人： Michael Riedel , Ernst Wiebus , Carl Frohning , Wilfried Fenske , Florian Rampf , Jurgen Herwig , Helmut Bahrmann , Klaus Bergrath , Wolfgang Zgorzel-Ski , Robert Eckl , Hans Bohnen , Richard Fischer , Kurt Schalapski , Wolfgang Greb
IPC分类号： B01J31/24 , B01J31/28 , C07C45/50 , C07F9/50 , C07F9/02
CPC分类号： B01J31/2404 , B01J31/2409 , B01J31/28 , B01J2231/321 , B01J2531/822 , B01J2531/96 , C07C45/50 , C07F9/5022 , C07F9/5054 , C07F9/5095 , C07C47/02
摘要： A process for preparing sulfonated arylphosphines by reaction of arylphosphines with oleum, wherein, after reaction of the arylphosphines with oleum, the sulfonation mixture is firstly diluted with water, an inert gas stream is then passed through the diluted sulfonation mixture until SO2 is no longer liberated from the diluted sulfonation mixture and the latter is then worked up further in a customary manner and its use.
摘要翻译：通过芳基膦与发烟硫酸的反应制备磺化芳基膦的方法，其中在芳基膦与发烟硫酸反应之后，首先用水稀释磺化混合物，然后使惰性气体流通过稀释的磺化混合物直到SO 2 不再从稀释磺化混合物中释放出来，而后者则以常规方式进一步处理及其用途。

8. 发明授权

US4042235A Method of an apparatus for unstacking a pile of sheets 失效
标题翻译：用于拆卸一堆纸的装置的方法
公开(公告)号：US4042235A
公开(公告)日：1977-08-16
申请号：US606206
申请日：1975-08-20
申请人： Rudolf Wanner , Robert Eckl
发明人： Rudolf Wanner , Robert Eckl
IPC分类号： B65H3/10 , B65H3/34 , G01N33/52 , B65H3/08
CPC分类号： G01N33/521 , B65H3/10 , B65H3/34 , B65H2701/1916
摘要： A pile of sheets arranged vertically next to one another is gently urged against a rigid metal plate that can be reciprocated back and forth very rapidly so as to pull the end sheet off the pile by suction and to return to rest against the pile of sheets before they have followed this reciprocation motion to the same extent as the end sheet. Once the plate pulls rapidly away from the end of the pile, pulling the end sheet with it, this end sheet is engaged by a suction roller and pulled laterally off the pile.
摘要翻译：将一堆彼此垂直排列的片材轻轻地推靠在刚性金属板上，该刚性金属板可以非常快速地来回往复运动，以便通过抽吸将端片从该桩上拉出，并在靠前的一堆片材上返回休息他们已经按照这种往复运动与最终单相同。一旦板从桩的端部迅速拉开，用其拉动端板，该端板通过抽吸辊接合并从桩侧向拉出。

9. 发明授权

US07256194B2 Compounds that inhibit factor Xa activity 失效
标题翻译：抑制因子Xa活性的化合物
公开(公告)号：US07256194B2
公开(公告)日：2007-08-14
申请号：US10468975
申请日：2002-02-22
申请人： Sven Nerdinger , Thilo Fuchs , Katrin Illgen , Robert Eckl
发明人： Sven Nerdinger , Thilo Fuchs , Katrin Illgen , Robert Eckl
IPC分类号： C07D241/04 , C07D209/44 , A61K31/4965 , A61K43/38
CPC分类号： C07D295/185 , C07D209/16
摘要： The present invention relates to compounds of the Formula or a pharmaceutically acceptable salt, solvate, hydrate or formulation thereof. These compounds can be used for the inhibition of Factor Xa and for the treatment and/or prevention of diseases that are mediated by Factor Xa activity.
摘要翻译：本发明涉及式的化合物或其药学上可接受的盐，溶剂合物，水合物或制剂。这些化合物可用于抑制因子Xa，以及用于治疗和/或预防由因子Xa活性介导的疾病。

10. 发明申请

US20060276669A1 Process for preparing sulfonated arylphosphines 审中-公开
标题翻译：制备磺化芳基膦的方法
公开(公告)号：US20060276669A1
公开(公告)日：2006-12-07
申请号：US11480178
申请日：2006-06-30
申请人： Michael Riedel , Ernst Wiebus , Carl Frohning , Wilfried Fenske , Florian Rampf , Jurgen Herwig , Helmut Bahrmann , Klaus Bergrath , Wolfgang Zgorzel-Ski , Robert Eckl , Hans Bohnen , Richard Fischer , Kurt Schalapski , Wolfgang Greb
发明人： Michael Riedel , Ernst Wiebus , Carl Frohning , Wilfried Fenske , Florian Rampf , Jurgen Herwig , Helmut Bahrmann , Klaus Bergrath , Wolfgang Zgorzel-Ski , Robert Eckl , Hans Bohnen , Richard Fischer , Kurt Schalapski , Wolfgang Greb
IPC分类号： C07F9/02 , C07C45/90
CPC分类号： B01J31/2404 , B01J31/2409 , B01J31/28 , B01J2231/321 , B01J2531/822 , B01J2531/96 , C07C45/50 , C07F9/5022 , C07F9/5054 , C07F9/5095 , C07C47/02
摘要： An aqueous catalyst solution comprising rhodium and an aqueous solution comprising sulfonated arylphosphines by reacting arylphosphines with oleum to form a sulfonation mixture, diluting the sulfonation mixture with water, extracting the diluted sulfonation mixture with a solution of a water-insoluble amine in a water-insoluble organic solvent, reacting the resulting water-immiscible organic phase with a solution of an inorganic base in water, adjusting the resulting aqueous solution of sulfonated arylphosphines of pH of up to 3 by addition of an acid, and passing an inert gas stream through the aqueous solution comprising sulfonated arylphosphines until sulfur dioxide is no longer liberated from the aqueous solution of sulfonated arylphosphines.
摘要翻译：包含铑的水溶液和包含磺化芳基膦的水溶液，通过使芳基膦与发烟硫酸反应形成磺化混合物，用水稀释磺化混合物，用水不溶性胺在水不溶性的溶液中萃取稀释的磺化混合物有机溶剂，使得到的与水不混溶的有机相与无机碱在水中的溶液反应，通过加入酸调节得到的pH为3的磺化芳基膦水溶液，并将惰性气流通过水溶液包含磺化芳基膦的溶液，直到二氧化硫不再从磺化芳基膦的水溶液中释放出来。

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