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1. 发明申请

US20100041756A1 METHOD OF MODULATING B CELL FUNCTIONING 审中-公开
标题翻译：调节B细胞功能的方法
公开(公告)号：US20100041756A1
公开(公告)日：2010-02-18
申请号：US11719511
申请日：2005-11-17
申请人： Michael Lionel Selley , Julia Jane Inglis , Richard Owen Williams
发明人： Michael Lionel Selley , Julia Jane Inglis , Richard Owen Williams
IPC分类号： A61K31/195 , A61P37/00
CPC分类号： A61K31/196 , A61K31/198 , A61K31/44 , A61K31/4402 , A61K31/47
摘要： The present invention relates generally to a method of modulating cellular functioning. More particularly, the present invention relates to a method of modulating B cell functioning, for example B cell proliferation, utilising an IDO-mediated tryptophan metabolite as herein defined (particular examples of such IDO-mediated tryptophan metabolites include 3-hydroxykynurenic acid, 3-hydroxyanthranilic acid, picolinic acid, quinolinic acid and tranilast). The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate B cell functioning such as antibody production, autoimmune conditions and B cell proliferation and neoplasias. In a related aspect, the present invention is directed to a method of therapeutically and/or prophylactically treating rheumatoid arthritis via the administration of the above-mentioned compounds.
摘要翻译：本发明一般涉及调节细胞功能的方法。更具体地说，本发明涉及利用如本文定义的IDO介导的色氨酸代谢物来调节B细胞功能（例如B细胞增殖）的方法（这种IDO介导的色氨酸代谢物的具体实例包括3-羟基犬尿酸，3- 羟基邻氨基苯甲酸，吡啶甲酸，喹啉酸和曲尼司特）。本发明的方法尤其可用于治疗和/或预防以异常，不需要或其他不适当的B细胞功能为特征的病症，例如抗体产生，自身免疫病症和B细胞增殖和肿瘤。在相关方面，本发明涉及通过施用上述化合物治疗和/或预防性地治疗类风湿性关节炎的方法。

2. 发明申请

US20090197957A1 Methods and compositions for the treatment of pain 审中-公开
标题翻译：治疗疼痛的方法和组合物
公开(公告)号：US20090197957A1
公开(公告)日：2009-08-06
申请号：US11914442
申请日：2006-05-16
申请人： Michael Lionel Selley , Richard Owen Williams , Julia Jane Inglis
发明人： Michael Lionel Selley , Richard Owen Williams , Julia Jane Inglis
IPC分类号： A61K31/196 , C07C229/48 , A61P31/18
CPC分类号： A61K31/196
摘要： The present invention relates generally to the area of pain management and more particularly, to a method of analgesia and agents useful for same. More particularly, the present invention relates to a method of analgesia utilising a compound of formula (I). The method of the present invention is useful, inter alia, in the therapeutic or prophylactic treatment of pain, including acute pain, chronic non-malignant pain and chronic malignant pain. Also provided are compounds for use in the method of the invention.
摘要翻译：本发明一般涉及疼痛管理的领域，更具体地，涉及一种镇痛方法和可用于其的药剂。更具体地说，本发明涉及利用式（I）化合物的止痛方法。本发明的方法尤其可用于治疗或预防性治疗疼痛，包括急性疼痛，慢性非恶性疼痛和慢性恶性疼痛。还提供了用于本发明方法的化合物。

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