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1. 发明授权

US10124114B2 Margin determination 有权
公开(公告)号：US10124114B2
公开(公告)日：2018-11-13
申请号：US12423228
申请日：2009-04-14
申请人： Raghu Raghavan , Martin Brady , Maria Inmaculada Rodriguez-Ponce
发明人： Raghu Raghavan , Martin Brady , Maria Inmaculada Rodriguez-Ponce
IPC分类号： A61B5/05 , A61M5/172 , A61B90/00 , A61B5/055 , A61M5/142 , G01R33/28 , G01R33/56 , A61B34/10
摘要： A method for identifying target regions in a tissue for local drug delivery, where functional and/or structural anatomical data such as edema and/or resection cavity is captured by an imaging system, and where the anatomical data is evaluated by segmentation techniques such as region-growing-based methods with computer assistance to determine a margin around a resection cavity and/or the volume of edema, the margin and/or the volume of edema being the target tissue for local drug delivery.

2. 发明授权

US08438180B2 Search and presentation engine 有权
标题翻译：搜索和演示引擎
公开(公告)号：US08438180B2
公开(公告)日：2013-05-07
申请号：US12694905
申请日：2010-01-27
申请人： Timothy Poston , Raghu Raghavan , Michael Fenton , David Poston
发明人： Timothy Poston , Raghu Raghavan , Michael Fenton , David Poston
IPC分类号： G06F17/30
CPC分类号： G06F17/30554 , G06F17/30424 , G06F17/3053 , G06F17/3087 , G06F17/30873 , Y10S707/956 , Y10S707/99931 , Y10S707/99933 , Y10S707/99943
摘要： A contents display and search system for navigating and searching and exploring a collection of objects includes a database of Attributes; each of the Attributes being associated with one or more objects, and a database of Kinds, each Kind being associated with one or more Attributes. When a user enters a search query including at least one Attribute, an object is tested to determine whether it has Attributes of the Kind corresponding to the Kind of the at least one specified Attribute before function testing is performed. Search and contents investigation results are presented in a hierarchical format in which Kinds and Attributes rather than objects, are displayed until the search or content type is further specified by selecting additional Kinds and/or Attributes such that the number of objects satisfying the specified search is below a threshold. User interaction modifies the hierarchical order of Kinds and Attributes in the display.
摘要翻译：用于导航和搜索和搜索对象集合的内容显示和搜索系统包括属性数据库; 每个属性与一个或多个对象相关联，以及一个种类的数据库，每个属性与一个或多个属性相关联。当用户输入包括至少一个属性的搜索查询时，测试对象以在执行功能测试之前确定其是否具有与所述至少一个指定属性的类型相对应的种类的属性。搜索和内容调查结果以分层格式呈现，其中显示种类和属性而不是对象，直到通过选择附加种类和/或属性进一步指定搜索或内容类型，使得满足指定搜索的对象的数量为低于门槛。用户交互在显示中修改种类和属性的层次顺序。

3. 发明授权

US08083720B2 Device and method for delivering therapeutic agents to an area of the body 有权
标题翻译：将治疗剂递送到身体区域的装置和方法
公开(公告)号：US08083720B2
公开(公告)日：2011-12-27
申请号：US12152280
申请日：2008-05-13
申请人： Matthew S. Solar , Chris Ross , Martin L. Brady , Raghu Raghavan
发明人： Matthew S. Solar , Chris Ross , Martin L. Brady , Raghu Raghavan
IPC分类号： A61M5/178
CPC分类号： A61B17/34 , A61B17/3478 , A61B2017/00247 , A61B2017/00331 , A61B2018/00392 , A61M37/00 , A61M37/0069
摘要： A device, system and method deliver an agent to a soft mass, such as an area of the body, and more specifically the brain. One aspect includes creation of one or more channels, tunnels or grooves in tissue using a relatively small diameter, minimally-invasive stylet and then removing the stylet prior to infusion. The stylet-created channels become paths of increased hydraulic conductivity, through which the infusate will tend to flow and produce a predictable infusion pattern. Infusate will be carried into these channels with relatively low resistance, and then infuse outward from these channels into the surrounding tissue. By carefully positioning these channels, one can control and modify the preferred paths and duration of distribution.
摘要翻译：装置，系统和方法将药剂递送到软质量体，例如身体的区域，更具体地是脑。一个方面包括使用相对较小直径的微创管心针产生组织中的一个或多个通道，隧道或凹槽，然后在输注之前去除探针。探针创造的通道成为增加水力传导性的途径，通过该途径，输注物将倾向于流动并产生可预测的输注模式。输液将以相对较低的阻力进入这些通道，然后从这些通道向外注入周围组织。通过仔细定位这些通道，可以控制和修改分配的首选路径和持续时间。

4. 发明授权

US07715902B2 Determining distribution for planning an infusion 有权
标题翻译：确定输液计划的分布情况
公开(公告)号：US07715902B2
公开(公告)日：2010-05-11
申请号：US10661827
申请日：2003-09-12
申请人： Andreas Hartlep , Christoph Pedain , Raghu Raghavan , Martin Brady
发明人： Andreas Hartlep , Christoph Pedain , Raghu Raghavan , Martin Brady
IPC分类号： A61B6/00
CPC分类号： A61M5/16836 , A61B5/055 , A61B5/4839 , A61B34/20 , A61B34/25 , A61B2034/2055 , A61B2034/2072 , A61B2034/252 , A61M5/16886 , A61M5/1723 , A61M2005/14292 , G01R33/5601 , G01R33/56341 , G06F19/00
摘要： A method for identifying advantageous and non-advantageous infusion regions in the tissue includes capturing at least one of (i) functional anatomical data and (ii) structural anatomical data. The captured anatomical data is evaluated with computer assistance. Based on the evaluating step, the method includes determining infusion distribution information, such as directional and velocity information.
摘要翻译：用于识别组织中有利和非有利的输注区域的方法包括捕获（i）功能解剖数据和（ii）结构解剖数据中的至少一个。所获取的解剖数据通过计算机辅助进行评估。基于评估步骤，该方法包括确定诸如方向和速度信息之类的输注分布信息。

5. 发明申请

US20090270790A1 Device, methods, and control for sonic guidance of molecules and other material utilizing time-reversal acoustics 有权
标题翻译：使用时间反转声学的分子和其他材料的声波引导的装置，方法和控制
公开(公告)号：US20090270790A1
公开(公告)日：2009-10-29
申请号：US12319311
申请日：2009-01-06
申请人： Raghu Raghavan
发明人： Raghu Raghavan
IPC分类号： A61M37/00
CPC分类号： A61M37/00 , A61B8/0816 , A61B8/445
摘要： Acoustic waves exhibit a a streaming force that pushes objects along the direction of sound propagation. Precise motions require well-focused beams. The technique of time-reversal acoustics (TRA) overcomes beam distortions introduced by propagation along irregular paths to focus sound without knowledge of the medium properties. TRA requires a small receiver to be placed at a point of desired focus. The invention disclosed refines TRA by introducing data matching schemes to extend the points of focus beyond the location points of the receivers. With as few as two receivers, a large region can be manipulated with well-focused acoustic beams and with no receiver at a desired point of focus. Applications are described in drug delivery in medicine; environmental fluid contaminant control; and in oil exploration, for retrieving oil stuck in underground pockets.
摘要翻译：声波表现出沿声音传播方向推动物体的流动力。精确的运动需要聚焦良好的光束。时间反射声学（TRA）的技术克服了通过不规则路径传播引起的波束失真，以聚焦声音而不知道介质属性。 TRA需要将小型接收器放置在所需焦点的位置。公开的发明通过引入数据匹配方案来提炼TRA，以将焦点扩展到接收器的位置点之外。使用少至两个接收器，可以使用良好聚焦的声束并且没有接收器在期望的焦点处操纵大的区域。药物中药物描述的应用; 环境流体污染物控制; 并在石油勘探中，用于检索卡在地下袋中的油。

6. 发明申请

US20090024181A1 TREATMENT SIMULATOR FOR BRAIN DISEASES AND METHOD OF USE THEREOF 有权
标题翻译：脑疾病治疗模拟器及其使用方法
公开(公告)号：US20090024181A1
公开(公告)日：2009-01-22
申请号：US12116765
申请日：2008-05-07
申请人： Raghu Raghavan , Stuart A. Grossman
发明人： Raghu Raghavan , Stuart A. Grossman
IPC分类号： A61N1/00 , A61B19/00 , A61B5/05 , G06G7/48
CPC分类号： A61B34/10 , A61B6/461 , A61B6/481 , A61B6/501 , A61B90/00 , A61B2034/101 , A61B2034/252 , A61N2005/1021 , G06F19/00 , G06F19/321 , G06T7/0012 , G06T2207/30016 , G16H50/50 , Y02A90/24 , Y02A90/26
摘要： A treatment simulator for providing information on physiological states and effects of treatment of neurological disease, comprising a computer, and an application configured to operate with the computer. The application is capable of: obtaining radiological imaging from the brain; obtaining anatomical information from the radiological imaging within a region of interest within the brain; constructing a physiological states model which assesses physiological states of the region of interest; locating sources of interstitial flow of particulate matter and obtaining fluid conductivities of paths of the interstitial flow utilizing the anatomical information and the physiological states model; and creating a flow model of the particulate matter which assesses velocities of flow and interstitial pressure variations utilizing the sources of interstitial flow and the fluid conductivities.
摘要翻译：一种用于提供关于神经系统疾病的治疗的生理状况和效果的信息的治疗模拟器，包括计算机以及被配置为与所述计算机一起操作的应用。该应用能够：从脑获得放射成像; 从大脑内感兴趣的区域内的放射成像获得解剖信息; 构建评估感兴趣区域的生理状态的生理状态模型; 利用解剖信息和生理状态模型确定颗粒物质的间质流的来源并获得间质流的路径的流体电导率; 并创建颗粒物质的流动模型，其使用间隙流和流体电导率来评估流动速率和间隙压力变化。

7. 发明申请

US20080200804A1 METHOD AND APPARATUS FOR INFUSING SUBSTANCES 有权
标题翻译：用于输送物质的方法和装置
公开(公告)号：US20080200804A1
公开(公告)日：2008-08-21
申请号：US11562262
申请日：2006-11-21
申请人： Andreas Hartlep , Christoph Pedain , Martin Brady , Raghu Raghavan
发明人： Andreas Hartlep , Christoph Pedain , Martin Brady , Raghu Raghavan
IPC分类号： A61B6/00 , A61M31/00
CPC分类号： A61M5/14 , A61M2005/14292 , A61M2210/0693 , G06F19/00 , G16H40/63 , G16H50/50
摘要： A method for determining a backflow of a substance along a track of a delivery device includes: a) obtaining parameters that influence the flow of the fluid or substance; b) acquiring information about delivery data; and c) computing the backflow along the delivery device using the information in steps a) and b).
摘要翻译：用于确定物质沿输送装置的轨道的回流的方法包括：a）获得影响流体或物质流动的参数; b）获取有关送货数据的信息; 以及c）使用步骤a）和b）中的信息来计算沿输送装置的回流。

8. 发明申请

US20070276340A1 Active delivery and flow redirection: novel devices and method of delivery of materials to patients 有权
标题翻译：主动输送和流向重定向：新型装置和向患者输送材料的方法
公开(公告)号：US20070276340A1
公开(公告)日：2007-11-29
申请号：US11434080
申请日：2006-05-15
申请人： David Poston , Raghu Raghavan , Martin Brady
发明人： David Poston , Raghu Raghavan , Martin Brady
IPC分类号： A61M5/32
CPC分类号： A61M25/0026 , A61B17/3401 , A61B17/3421 , A61B2017/3419 , A61F2/82 , A61F2002/826 , A61M25/0021 , A61M25/0068 , A61M25/0069 , A61M25/0074 , A61M2025/0042 , A61M2025/0096 , A61M2025/0681
摘要： A medical device for delivering material through tissue into a defined area of a patient may comprise: a material delivery element through which the material may flow out of a delivery end; the delivery end having an opening that can be inserted through a surface of the tissue; and a sealing system proximal to the delivery end that can extend away from the material delivery element along the surface of the tissue and apply pressure to the tissue after the material delivery element has been inserted through the surface of the tissue. A physical barrier may be provided on the material delivery device to reduce back flow loss of delivered material.
摘要翻译：用于将材料通过组织输送到患者的限定区域中的医疗装置可以包括：材料递送元件，材料可以通过该材料输送元件从输送端流出; 所述输送端具有能够穿过所述组织的表面插入的开口; 以及靠近输送端的密封系统，其可以沿着组织的表面远离材料输送元件延伸，并且在材料输送元件已经穿过组织的表面插入之后对组织施加压力。可以在材料输送装置上提供物理屏障以减少输送材料的回流损失。

9. 发明授权

US07231075B2 Method for dynamic characterization of density fields in a compound structure 有权
标题翻译：复合结构中密度场的动态表征方法
公开(公告)号：US07231075B2
公开(公告)日：2007-06-12
申请号：US11063662
申请日：2005-02-23
申请人： Raghu Raghavan , Timothy Poston , John Kucharczyk
发明人： Raghu Raghavan , Timothy Poston , John Kucharczyk
IPC分类号： G06K9/00
CPC分类号： G06F19/3481 , A61B5/055 , A61B6/03 , G06F19/00 , G06F19/3456 , G16H50/50
摘要： A method supplies a dynamic vector map of properties within a region or a unified suite of quantification functionality for property functions, such as density functions, conduction functions (e.g., thermal conduction, electrical conduction, atomic or subatomic mass conduction, macromolecular mass conduction), defined on, defined in or defining a three-dimensional space, which functions may optionally vary in time. At least two services assisting in the definition of the map or suite, even in a dynamic modality, are selected from: (a) computation of the volume of the region where the density lies above or below a specified threshold, or between two specified values; (b) computation of the integral of the density; (c) estimation of the rate of change of the density with respect to time, optionally restricted to a specified region; (d) estimation of the local or global failure of conservation represented by changes with time in the density; (e) estimation of the local or global rate at which material with a changing density is passing through a specified surface (e.g., boundary); and (f) separation of the density of a material with a changing density, given an implemented transport model, into “free” and “bound” densities.
摘要翻译：一种方法提供属性功能范围内的属性的动态向量图或属性函数的统一的量化功能，例如密度函数，传导函数（例如，热传导，导电，原子或亚原子质量传导，大分子质量传导）定义在，定义或定义三维空间，哪些功能可以可选地在时间上变化。即使在动态模式中，帮助定义地图或套件的至少两个服务可从以下选项中选择：（a）计算密度高于或低于指定阈值或两个指定值之间的区域的体积 ; （b）密度积分的计算; （c）可选地限制在特定区域内的密度相对于时间的变化率的估计; （d）以密度随时间变化而表示的地方或全球保护失效的估计; （e）估计具有变化密度的材料通过指定表面（例如边界）的局部或全局速率; （f）将已实施的运输模式，以密度变化的材料密度分离为“自由”和“限制”密度。

10. 发明申请

US20050267360A1 Visualization of procedural guidelines for a medical procedure 有权
标题翻译：可视化医疗程序的程序指南
公开(公告)号：US20050267360A1
公开(公告)日：2005-12-01
申请号：US11115093
申请日：2005-04-26
申请人： Rainer Birkenbach , Christoph Pedain , Andreas Hartlep , Raghu Raghavan , Martin Brady
发明人： Rainer Birkenbach , Christoph Pedain , Andreas Hartlep , Raghu Raghavan , Martin Brady
IPC分类号： A61B5/05 , A61B19/00
CPC分类号： A61B90/36 , A61B34/10 , A61B34/20 , A61B2034/107 , A61B2034/2055 , A61B2034/2068 , A61B2034/2072
摘要： The visualization of procedural guidelines for a medical procedure, in which a medical instrument is shown in an image representation of a body portion including an area in which a medical procedure is to be carried out, wherein, in the vicinity of the functional portion of the instrument, regions or locations are indicated which are of special relevance to the procedure according to established guidelines for said procedure.
摘要翻译：可视化的医疗程序的程序指南，其中医疗器械被显示在包括要执行医疗程序的区域的身体部位的图像表示中，其中在该功能部分的附近指示与所述程序的既定指导方针相关的手段，区域或位置。

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