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1. 发明授权

US11512326B2 Small angiotensin peptide expression system in mammalian cells 有权
公开(公告)号：US11512326B2
公开(公告)日：2022-11-29
申请号：US13321104
申请日：2010-05-26
申请人： Qiuhong Li , William W. Hauswirth , Alfred S. Lewin
发明人： Qiuhong Li , William W. Hauswirth , Alfred S. Lewin
IPC分类号： C12N15/86 , A61K48/00 , C12P21/02 , C07K7/14 , A61K38/00
摘要： The present invention is directed to a delivery vector for transferring a small peptide coding sequence to a cell for expression of the small peptide coding sequence within the cell. The delivery vector comprises a secretory signal sequence; a sequence encoding a carrier protein operatively associated with the secretory signal sequence; a sequence encoding a cleavage site operatively associated with the sequence encoding a carrier protein; and a sequence encoding a small peptide operatively associated with the sequence encoding a cleavage site.

2. 发明申请

US20150164701A1 Method of Applying Bulk Glue for Nursing Pad Base Film to Four Corners of Sanitary Product Nursing Pad Base Film and Device Therefor 有权
标题翻译：卫生用品护垫基片及其装置四角护理垫基底胶的方法
公开(公告)号：US20150164701A1
公开(公告)日：2015-06-18
申请号：US14349399
申请日：2012-08-16
申请人： Qiuhong Li
发明人： Qiuhong Li
IPC分类号： A61F13/15 , B32B37/00 , B32B38/00 , B32B37/12 , B32B37/26
CPC分类号： A61F13/15804 , A61F2013/1591 , B32B37/0046 , B32B37/0053 , B32B37/1292 , B32B37/26 , B32B38/0004 , B32B38/1858 , B32B2037/1215 , B32B2037/268 , B32B2555/00 , D21H23/22 , D21H27/001 , Y10T156/1062 , Y10T156/1077 , Y10T156/1097 , Y10T156/133
摘要： The invention discloses a method for applying large areas of glue used for a bottom film of an absorbent pad at the four corners of the bottom film of the absorbent pad of a health care article, comprising the following processes and steps: (a) gluing and conveying a release paper; (b) cutting the glued release paper; and (c) transferring an adhesive glue piece of the release paper. The invention also relates to a device for achieving the method for applying large areas of glue used for the bottom film of the absorbent pad at the four corners of the bottom film of the absorbent pad of the health care article. As to a glue piece applied on the bottom film of the absorbent pad of the invention, its peeling force may reach 20 N or more than 20 N; the width of the lump glue applied on the bottom film of the absorbent pad may reach 60 mm-450 mm; its length may reach 120 mm-1000 mm; and the normal production speed of the improved machine of the absorbent pad may reach 120-180 m/minute. The invention facilitates the absorbent pad not to be moved, draped and folded when in use and meets the market requirements of the industrialized production of the absorbent pad with large areas of glue.
摘要翻译：本发明公开了一种在医疗用品的吸收垫的底膜的四个角落处应用用于吸收垫的底膜的大面积胶水的方法，包括以下工序和步骤：（a）胶合和输送脱模纸; （b）切割粘合的隔离纸; 和（c）转印离型纸的粘合胶片。本发明还涉及一种用于实现在医疗用品的吸收垫的底部膜的四个角处应用用于吸收垫的底部膜的大面积胶水的方法的装置。对于施加在本发明的吸收垫的底膜上的胶片，其剥离力可以达到20N或大于20N; 应用在吸收垫的底膜上的块状胶的宽度可以达到60mm-450mm; 其长度可达120mm-1000mm; 吸收垫的改进机器的正常生产速度可以达到120-180m /分钟。本发明有利于吸收垫在使用时不被移动，展开和折叠，并且满足具有大面积粘合剂的吸收垫的工业化生产的市场需求。

3. 发明申请

US20120157513A1 Small Peptide Expression System in Mammalian Cells 审中-公开
标题翻译：哺乳动物细胞中的小肽表达系统
公开(公告)号：US20120157513A1
公开(公告)日：2012-06-21
申请号：US13321104
申请日：2010-05-26
申请人： Qiuhong Li , William W. Hauswirth , Alfred S. Lewin
发明人： Qiuhong Li , William W. Hauswirth , Alfred S. Lewin
IPC分类号： A61K31/7088 , C12P21/00 , A61P3/10 , A61P9/12 , A61P13/12 , C12N15/85 , A61P9/00
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C07K7/14 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C07K2319/60 , C12N2750/14143 , C12P21/02
摘要： The present invention is directed to a delivery vector for transferring a small peptide coding sequence to a cell for expression of the small peptide coding sequence within the cell. The delivery vector comprises a secretory signal sequence; a sequence encoding a carrier protein operatively associated with the secretory signal sequence; a sequence encoding a cleavage site operatively associated with the sequence encoding a carrier protein; and a sequence encoding a small peptide operatively associated with the sequence encoding a cleavage site.
摘要翻译：本发明涉及用于将小肽编码序列转移到细胞内用于在细胞内表达小肽编码序列的递送载体。递送向量包括分泌信号序列; 编码与分泌信号序列可操作地相关联的载体蛋白的序列; 编码与编码载体蛋白的序列可操作地相关联的切割位点的序列; 以及编码与编码切割位点的序列可操作地相关联的小肽的序列。

4. 发明授权

US09248057B2 Method of applying bulk glue for nursing pad base film to four corners of sanitary product nursing pad base film and device therefor 有权
标题翻译：将护理垫基膜的胶料用于卫生产品护理垫基膜的四个角落的方法及其装置
公开(公告)号：US09248057B2
公开(公告)日：2016-02-02
申请号：US14349399
申请日：2012-08-16
申请人： Qiuhong Li
发明人： Qiuhong Li
IPC分类号： B32B37/12 , B32B38/04 , A61F13/15 , D21H23/22 , D21H27/00 , B32B37/26 , B32B37/00 , B32B38/00 , B32B38/18
CPC分类号： A61F13/15804 , A61F2013/1591 , B32B37/0046 , B32B37/0053 , B32B37/1292 , B32B37/26 , B32B38/0004 , B32B38/1858 , B32B2037/1215 , B32B2037/268 , B32B2555/00 , D21H23/22 , D21H27/001 , Y10T156/1062 , Y10T156/1077 , Y10T156/1097 , Y10T156/133
摘要： A method and a device for applying large areas of glue used for a bottom film of an absorbent pad at the four corners of the bottom film of the absorbent pad of a health care article is described. The processes includes (a) gluing and conveying a release paper; (b) cutting the glued release paper; and (c) transferring the glue from the release paper to the absorbent pad.
摘要翻译：描述了用于在保健用品的吸收垫的底部膜的四个角处应用用于吸收垫的底部薄膜的大面积胶水的方法和装置。这些方法包括（a）粘合和输送剥离纸; （b）切割粘合的隔离纸; 和（c）将胶从脱模纸转移到吸收垫。

5. 发明申请

US20230132355A2 DELIVERY OF CARD PROTEIN AS THERAPY FOR OCCULAR INFLAMMATION 有权
公开(公告)号：US20230132355A2
公开(公告)日：2023-04-27
申请号：US17204627
申请日：2021-03-17
申请人： Cristhian J. Ildefonso , Alfred S. Lewin , Qiuhong Li
发明人： Cristhian J. Ildefonso , Alfred S. Lewin , Qiuhong Li
IPC分类号： C07K14/47 , A61K48/00 , A61K9/00
摘要： The present invention provides methods and compositions for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, ocular neovascularization, or ocular inflammation. In an exemplary embodiment, a method is disclosed that involves administering an expression vector that delivers a secretable and cell penetrating CARD to a subject in need of treatment or prevention of age-related macular degeneration or another condition involving macular degeneration or ocular neovascularization.

6. 发明授权

US10182948B2 Method and device for making absorbent cores used in disposable hygiene pad 有权
公开(公告)号：US10182948B2
公开(公告)日：2019-01-22
申请号：US14357156
申请日：2012-08-16
申请人： Qiuhong Li
发明人： Qiuhong Li
IPC分类号： A61F13/15 , A61F13/535 , A61F13/536 , A61F13/53
摘要： The invention relates to a method and a device for making absorbent cores used in disposable hygiene pads, the method or device comprising three steps: (A) suctioning of wood pulp fibers mixed with super absorbent polymers into a net structure on a base tissue to form an absorbent core; (B) compressing and embossing absorbent material; and (C) shaping of the absorbent core. The method of the current invention can be used for making different kinds of absorbent pad products. While increasing the tear strength of the product, the method realizes and simplifies the process of making both the absorbent material and the hygiene pad utilizing the absorbent material on the same manufacturing line, and reduces the cost of making the absorbent pads. The absorbent core made by applying the method of the current invention has a new structure formed by super absorbent polymers and wood pulp fibers, wherein the structure enables the super absorbent polymers to be evenly distributed in between the wood pulp fibers. Through the compressing and embossing process, the super absorbent polymers are prevented from sliding or piling together in the absorbent core, which increases the liquid-absorbing capacity of the hygiene pad products.

7. 发明申请

US20140308483A1 METHOD AND DEVICE FOR MAKING ABSORBENT CORES USED IN DISPOSABLE HYGIENE PADS 审中-公开
标题翻译：用于制造在可弃置的卫生巾中使用的吸收胶的方法和装置
公开(公告)号：US20140308483A1
公开(公告)日：2014-10-16
申请号：US14357156
申请日：2012-08-16
申请人： Qiuhong Li
发明人： Qiuhong Li
IPC分类号： A61F13/15 , A61F13/535
CPC分类号： A61F13/15658 , A61F13/15626 , A61F13/1565 , A61F13/535 , A61F13/536 , A61F2013/530124 , Y10T156/1051 , Y10T428/2457
摘要： The invention relates to a method and a device for making absorbent cores used in disposable hygiene pads, the method or device comprising three steps: (A) suctioning of wood pulp fibers mixed with super absorbent polymers into a net structure on a base tissue to form an absorbent core; (B) compressing and embossing absorbent material; and (C) shaping of the absorbent core. The method of the current invention can be used for making different kinds of absorbent pad products. While increasing the tear strength of the product, the method realizes and simplifies the process of making both the absorbent material and the hygiene pad utilizing the absorbent material on the same manufacturing line, and reduces the cost of making the absorbent pads. The absorbent core made by applying the method of the current invention has a new structure formed by super absorbent polymers and wood pulp fibers, wherein the structure enables the super absorbent polymers to be evenly distributed in between the wood pulp fibers. Through the compressing and embossing process, the super absorbent polymers are prevented from sliding or piling together in the absorbent core, which increases the liquid-absorbing capacity of the hygiene pad products.
摘要翻译：本发明涉及用于一次性卫生垫中使用的吸收芯的方法和装置，该方法或装置包括三个步骤：（A）将与超级吸收性聚合物混合的木浆纤维抽吸到基底组织上的网状结构中以形成吸收芯; （B）压缩和压花吸收材料; 和（C）吸湿芯的成型。本发明的方法可用于制造不同种类的吸收垫产品。在提高产品的撕裂强度的同时，该方法实现并简化了使用吸收材料在同一生产线上制造吸收材料和卫生垫两者的过程，并且降低了制造吸收垫的成本。通过应用本发明的方法制造的吸收芯具有由超吸收聚合物和木浆纤维形成的新结构，其中该结构使得高吸水性聚合物能够均匀地分布在木浆纤维之间。通过压缩和压花处理，防止了超吸收性聚合物在吸收芯中滑动或堆积在一起，这增加了卫生垫产品的吸液能力。

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