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1. 发明授权

US09248219B2 Medical devices having bioerodable layers for the release of therapeutic agents 有权
公开(公告)号：US09248219B2
公开(公告)日：2016-02-02
申请号：US11900980
申请日：2007-09-14
申请人： Jeffrey S. Lindquist , Peter G. Edelman
发明人： Jeffrey S. Lindquist , Peter G. Edelman
IPC分类号： A61F2/06 , A61L31/16 , A61L31/10 , A61L31/14 , A61L29/14 , A61L27/50 , A61F2/30 , A61L33/00
CPC分类号： A61L31/148 , A61F2002/30062 , A61L27/502 , A61L29/141 , A61L31/10 , A61L31/141 , A61L31/16 , A61L33/0052 , A61L2300/204 , A61L2300/604 , A61L2420/08 , C08L67/04
摘要： According to an aspect of the present invention, medical devices are provided which comprise: (a) a substrate and (b) bioerodable polymeric layer over the substrate that contains (i) one or more biodegradable polymers, (ii) one or more therapeutic agents, and (iii) one or more plasticizers.

2. 发明授权

US08535705B2 Biocompatible polymers and hydrogels and methods of use 有权
标题翻译：生物相容性聚合物和水凝胶及其使用方法
公开(公告)号：US08535705B2
公开(公告)日：2013-09-17
申请号：US11985588
申请日：2007-11-16
申请人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Peter G. Edelman
发明人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Peter G. Edelman
IPC分类号： A61F2/00
CPC分类号： A61K9/0024 , A61K31/74 , A61K47/34 , A61K47/46 , A61L27/18 , A61L27/50 , A61L27/52 , A61L27/58 , A61L31/06 , A61L31/145 , A61L31/148 , C08G63/08 , C08G63/912
摘要： Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants.
摘要翻译：公开了生物相容的交联聚合物及其制备和使用的方法，其中生物相容的交联聚合物由具有能够原位反应和交联的亲电子基团和亲核基团的水溶性前体形成。制备生物相容的交联聚合物可生物降解或不生物降解的方法与控制降解速率的方法一样。交联反应可以在器官或组织上或身体外的原位进行。用于这种生物相容性交联聚合物及其前体的应用包括药物的受控递送，术后粘连的预防，医疗装置如血管移植物，伤口敷料和手术密封剂的涂覆。

3. 发明申请

US20090076595A1 Medical devices having bioerodable layers for the release of therapeutic agents 有权
标题翻译：具有用于释放治疗剂的生物侵蚀层的医疗装置
公开(公告)号：US20090076595A1
公开(公告)日：2009-03-19
申请号：US11900980
申请日：2007-09-14
申请人： Jeffrey S. Lindquist , Peter G. Edelman
发明人： Jeffrey S. Lindquist , Peter G. Edelman
IPC分类号： A61F2/82 , A61F2/00 , A61K47/30
CPC分类号： A61L31/148 , A61F2002/30062 , A61L27/502 , A61L29/141 , A61L31/10 , A61L31/141 , A61L31/16 , A61L33/0052 , A61L2300/204 , A61L2300/604 , A61L2420/08 , C08L67/04
摘要： According to an aspect of the present invention, medical devices are provided which comprise: (a) a substrate and (b) bioerodable polymeric layer over the substrate that contains (i) one or more biodegradable polymers, (ii) one or more therapeutic agents, and (iii) one or more plasticizers.
摘要翻译：根据本发明的一个方面，提供了医疗装置，其包括：（a）基底和（b）在基底上的可生物侵蚀的聚合物层，其包含（i）一种或多种可生物降解的聚合物，（ii）一种或多种治疗剂，和（iii）一种或多种增塑剂。

4. 发明申请

US20080260802A1 Biocompatible hydrogels made with small molecule precursors 有权
标题翻译：用小分子前体制备的生物相容性水凝胶
公开(公告)号：US20080260802A1
公开(公告)日：2008-10-23
申请号：US12156085
申请日：2008-05-29
申请人： Amarpreet S. Sawhney , Steven Bennett , Peter G. Edelman
发明人： Amarpreet S. Sawhney , Steven Bennett , Peter G. Edelman
IPC分类号： A61L27/58 , A61L27/52
CPC分类号： A61K47/42 , A61K9/0014 , A61K9/0019 , A61L27/52 , A61L27/58 , A61L31/145 , A61L31/148 , C07K14/75 , C08L89/00 , C08L2666/02
摘要： Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable, or not, are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers. Embodiments that include hydrogels having isolated hydrolytically degradable esters are set forth. Embodiments including the use of low molecular weight amines to make degradable hydrogels are also set forth.
摘要翻译：公开了生物相容的交联聚合物及其制备和使用的方法，其中生物相容的交联聚合物由具有能够原位反应和交联的亲电子和亲核官能团的水溶性前体形成。制备生物相容的交联聚合物可生物降解的方法也可以提供，以及用于控制降解速率的方法。交联反应可以在器官或组织上或身体外的原位进行。用于这种生物相容性交联聚合物及其前体的应用包括药物的受控递送，术后粘连的预防，医疗装置如血管移植物，伤口敷料和手术密封剂的涂覆。可交联剂可以与交联聚合物一起包含。阐述包括具有分离的水解可降解酯的水凝胶的实施方案。还阐述了包括使用低分子量胺来制备可降解水凝胶的实施方案。

5. 发明授权

US07009034B2 Biocompatible crosslinked polymers 有权
公开(公告)号：US07009034B2
公开(公告)日：2006-03-07
申请号：US10010715
申请日：2001-11-09
申请人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Peter G. Edelman
发明人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Peter G. Edelman
IPC分类号： C09F15/00 , C07K1/00 , C08G63/48 , A61K47/30
CPC分类号： A61K47/34 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K31/74 , A61K47/42 , A61L24/106 , A61L27/18 , A61L27/50 , A61L31/06 , C07K14/75 , C08G63/08 , C08G63/912 , C08L89/00 , G06K7/10831 , G06K2207/1016 , C08L2666/02
摘要： Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers.

6. 发明授权

US06703047B2 Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use 有权
标题翻译：脱水水凝胶前体，组织粘附组合物和使用方法
公开(公告)号：US06703047B2
公开(公告)日：2004-03-09
申请号：US09776120
申请日：2001-02-02
申请人： Amarpreet S. Sawhney , Peter G. Edelman
发明人： Amarpreet S. Sawhney , Peter G. Edelman
IPC分类号： A61K914
CPC分类号： A61K9/0075 , A61K9/7023 , A61K47/34
摘要： Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize naturally-occurring body fluids as an aqueous environment that initiates transformation, which causes dissolution and nearly simultaneous crosslinking of the precursors, thus forming an insoluble hydrogel implant. The dehydrated precursor-based hydrogels may be used as sealants for fluid leaks from tissue, as adherent drug delivery depots, as means for augmenting and/or supporting tissue, and as means for serving a variety of other useful medical and surgical purposes.
摘要翻译：提供了使用基本上干燥的前体形成组织粘附水凝胶的组合物和方法。脱水前体在原位治疗之前被预混合，并且利用天然存在的体液作为引发转化的水性环境，其导致前体的溶解和几乎同时的交联，从而形成不溶性水凝胶注入物。脱水的基于前体的水凝胶可以用作来自组织的流体泄漏的密封剂，作为粘附药物递送贮库，作为用于增强和/或支持组织的手段，以及用于服务于各种其它有用的医学和外科用途的手段。

7. 发明授权

US5616222A Electrochemical sensors paste 失效
标题翻译：电化学传感器糊
公开(公告)号：US5616222A
公开(公告)日：1997-04-01
申请号：US508271
申请日：1995-09-15
申请人： Thomas C. Maley , Paul A. D'Orazio , Peter G. Edelman , John A. Zalenski
发明人： Thomas C. Maley , Paul A. D'Orazio , Peter G. Edelman , John A. Zalenski
IPC分类号： G01N27/28 , C08L1/00 , C08L1/12 , C12Q1/00 , G01N27/30 , G01N27/327 , G01N27/40 , G01N27/416 , G01N33/483 , G01N37/00 , C25B11/12
CPC分类号： C12Q1/006 , C12Q1/001 , Y10S435/817 , Y10T29/49117 , Y10T29/49204 , Y10T29/53261 , Y10T29/53265
摘要： A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.
摘要翻译：一种固态多用途电化学传感器，其具有非导电衬底，工作电极和覆盖工作电极的半透膜。工作电极包括粘附到基板的一部分的导电材料。导电材料的第一部分被电绝缘介电涂层覆盖，导电材料的第二部分被活性层覆盖。活性层包括催化活性量的由镀铂碳粉末颗粒载带的酶，其分布在整个活性层上。提供了一种用于结合传感器的传感器封装。

8. 发明授权

US5503719A Extended use planar sensors 失效
公开(公告)号：US5503719A
公开(公告)日：1996-04-02
申请号：US209081
申请日：1994-03-09
申请人： Joseph S. Foos , Peter G. Edelman , James E. Flaherty , Joseph Berger
发明人： Joseph S. Foos , Peter G. Edelman , James E. Flaherty , Joseph Berger
IPC分类号： G01N27/404 , B01D63/00 , C08F20/12 , C08F20/44 , C08F220/14 , G01N27/40 , G01N27/407 , G01N27/416 , G01N27/48 , G01N27/49 , G01N33/49 , G01N27/26
CPC分类号： C08F220/14 , G01N27/404 , G01N33/4925 , Y10T29/49117 , Y10T29/5313 , Y10T29/5317 , Y10T29/532 , Y10T29/53204
摘要： A planar, solid-state electrochemical oxygen sensor having a substrate, conductive strips deposited on the substrate, and a dielectric layer insulating portions of the conductive strips except those portions which define a working electrode and at least one second electrode. The working electrode may be defined by an open printed region of the dielectric, or by a needle-punched or laser-burned hole or opening in the dielectric which exposes a small region of one of the conductive strips. A solid electrolyte contacting the electrodes is covered by a semipermeable membrane which may comprise an acrylonitrile butadiene copolymer or an acrylate-based copolymer. A sample chamber is defined by the membrane, a cover member, and a gasket therebetween, and has a volume of from about 1 to about 2 .mu.l. The gasket is formulated from the highly cross-linked polymerization product of epichlorohydrin. All sensor components are selected such that a sensor operable for at least 2 days under normal conditions is produced.

9. 发明授权

US5401376A Electrochemical sensors 失效
标题翻译：电化学传感器
公开(公告)号：US5401376A
公开(公告)日：1995-03-28
申请号：US212662
申请日：1994-03-11
申请人： Joseph S. Foos , Peter G. Edelman , James E. Flaherty , Joseph Berger
发明人： Joseph S. Foos , Peter G. Edelman , James E. Flaherty , Joseph Berger
IPC分类号： G01N27/404 , B01D63/00 , C08F20/12 , C08F20/44 , C08F220/14 , G01N27/40 , G01N27/407 , G01N27/416 , G01N27/48 , G01N27/49 , G01N33/49 , G01N25/26
CPC分类号： C08F220/14 , G01N27/404 , G01N33/4925 , Y10T29/49117 , Y10T29/5313 , Y10T29/5317 , Y10T29/532 , Y10T29/53204
摘要： An electrochemical sensor having a substrate, conductive strips deposited on the substrate, and a layer insulating portions of the conductive strips except those portions which define a working electrode and at least one second electrode. A solid electrolyte contacting the electrodes is covered by a semipermeable membrane which may comprise an acrylonitrile butadiene copolymer or an acrylate-based copolymer. A sample chamber is defined by the membrane, a cover member, and a gasket therebetween, and has a volume of from about 1 to about 2 .mu.L. The gasket is formulated from the highly cross-linked polymerization product of epichlorohydrin. All sensor components are selected such that a sensor operable for at least 2 days under normal conditions is produced.
摘要翻译：具有衬底的电化学传感器，沉积在衬底上的导电条以及除了限定工作电极和至少一个第二电极的部分之外的导电条的层绝缘部分。与电极接触的固体电解质被半透膜覆盖，该膜可包含丙烯腈丁二烯共聚物或基于丙烯酸酯的共聚物。样品室由膜，盖构件和垫圈之间限定，并且具有约1至约2μL的体积。垫圈由表氯醇的高度交联的聚合产物配制。选择所有传感器部件，使得在正常条件下可操作至少2天的传感器被产生。

10. 发明授权

US4334000A Cyanine and diane dye mixture provides near I. R. sensitive, charge transport layer, electrophotographic photoconductive element 失效
标题翻译： Cyanine和diane染料混合物提供了靠近I.R敏感的电荷传输层，电子照相感光元件
公开(公告)号：US4334000A
公开(公告)日：1982-06-08
申请号：US218389
申请日：1980-12-19
申请人： Mike S. H. Chang , John T. Donoghue , Peter G. Edelman
发明人： Mike S. H. Chang , John T. Donoghue , Peter G. Edelman
IPC分类号： G03G5/047 , G03G5/06 , G03G5/14
CPC分类号： G03G5/047 , G03G5/067 , G03G5/0674 , G03G5/0679 , Y10S430/10
摘要： Dual layer organic photoconductive elements which are stable, have good negative charge acceptance and are sensitive over a broad range of the spectrum, including near the infrared band, and the process for preparing same. The charge-generating layer comprises a mixture of a charge-generating diane dye, such as Chlorodiane Blue, and a cyanine dye as a near-infrared sensitizer.
摘要翻译：双层有机光电导元件是稳定的，具有良好的负电荷接受性，并且在宽范围的光谱范围内，包括靠近红外波段的光敏元件及其制备方法。电荷产生层包括产生电荷的二烷基染料如Chlorodiane Blue和作为近红外敏化剂的花青染料的混合物。

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