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    • 4. 发明授权
    • Data entry systems
    • 数据录入系统
    • US08290538B2
    • 2012-10-16
    • US13036987
    • 2011-02-28
    • Francis John CallaghanPaul Marshall DoranGary Douglas Robb
    • Francis John CallaghanPaul Marshall DoranGary Douglas Robb
    • H04B1/38
    • H04M1/0202G06K7/10772G06K7/10881G06K17/0022G06Q30/0643H04B1/18
    • A data entry system includes a hand held data entry unit having a reading sensor for sensing commands and/or data, rewritable storage for storing information relating to selectable items, a controller (a microprocessor or other processing circuitry) and a display screen for displaying a user readable representation of the commands and/or stored information for a selected item, and a telecommunication interface for the telephonic transmission of information relating to a selected item or items from the storage to a remote processing center and for the telephonic information relating to selectable items from the remote processing center to the storage. Preferably a telecommunications interface is provided in the hand held unit for cellular or other wireless telephony systems. The hand held unit can be configured to combine the data entry functions with those of audio telephony.
    • 数据输入系统包括具有用于感测命令和/或数据的读取传感器的手持数据输入单元,用于存储与可选择项目相关的信息的可重写存储器,控制器(微处理器或其他处理电路)以及显示屏幕 用于所选项目的命令和/或存储信息的用户可读表示,以及用于电话传输与从所述存储器到远程处理中心的所选项目或项目有关的信息的电信接口以及与可选项目有关的电话信息 从远程处理中心到存储。 优选地,在用于蜂窝或其他无线电话系统的手持单元中提供电信接口。 手持单元可以配置为将数据输入功能与音频电话的功能相结合。
    • 7. 发明申请
    • Method and system for implementing power reduction algorithms in a night vision system power system
    • 在夜视系统电源系统中实现功率降低算法的方法和系统
    • US20080001084A1
    • 2008-01-03
    • US11259463
    • 2005-10-26
    • Paul MarshallCraig Boucher
    • Paul MarshallCraig Boucher
    • H02J7/00
    • H04N5/33G02B23/12H04N5/23241
    • A night vision system comprising a power system having a low voltage unit coupled to a high voltage unit. The low voltage unit includes a low voltage controller and a low voltage table correlating step values to pulse widths, the low voltage controller obtaining a desired pulse width and accessing the table to obtain a step value. The low voltage unit transmits the step value to the high voltage unit using a pulse count modulation format. The high voltage unit includes an opto-isolator for receiving the step value from the low voltage controller and a high voltage controller demodulating the step value. In response to the step value, the high voltage controller accesses a high voltage table correlating step values to pulse width to obtain a pulse width, the high voltage controller generating a control pulse in response to the pulse width.
    • 一种夜视系统,包括具有耦合到高压单元的低电压单元的电力系统。 低电压单元包括低电压控制器和低电压表将步长值与脉冲宽度相关联,低电压控制器获得期望的脉冲宽度并访问表以获得步进值。 低电压单元使用脉冲计数调制格式将步进值发送到高电压单元。 高电压单元包括用于从低电压控制器接收步长值的光隔离器和解调台阶值的高压控制器。 响应于步进值,高电压控制器访问将​​步进值与脉冲宽度相关联的高电压表,以获得脉冲宽度,高电压控制器响应于脉冲宽度产生控制脉冲。
    • 9. 发明授权
    • Hand held telecommunications and data entry device
    • 手持通信和数据录入设备
    • US07139591B2
    • 2006-11-21
    • US10869215
    • 2004-06-15
    • Francis John CallaghanPaul Marshall DoranGary Douglas Robb
    • Francis John CallaghanPaul Marshall DoranGary Douglas Robb
    • H04B1/38
    • H04M1/0202G06K7/10772G06K7/10881G06K17/0022G06Q30/0643H04B1/18
    • A data entry system includes a hand held data entry unit having a reading sensor for sensing commands and/or data, rewritable storage for storing information relating to selectable items, a controller (a microprocessor or other processing circuitry) and a display screen for displaying a user readable representation of the commands and/or stored information for a selected item, and a telecommunication interface for the telephonic transmission of information relating to a selected item or items from the storage to a remote processing center and for the telephonic information relating to selectable items from the remote processing center to the storage. Preferably a telecommunications interface is provided in the hand held unit for cellular or other wireless telephony systems. The hand held unit can be configured to combine the data entry functions with those of audio telephony.
    • 数据输入系统包括具有用于感测命令和/或数据的读取传感器的手持数据输入单元,用于存储与可选择项目相关的信息的可重写存储器,控制器(微处理器或其他处理电路)以及显示屏幕 用于所选项目的命令和/或存储信息的用户可读表示,以及用于电话传输与从所述存储器到远程处理中心的所选项目或项目有关的信息的电信接口以及与可选项目有关的电话信息 从远程处理中心到存储。 优选地,在用于蜂窝或其他无线电话系统的手持单元中提供电信接口。 手持单元可以配置为将数据输入功能与音频电话的功能相结合。
    • 10. 发明申请
    • Stabilized proteins
    • US20050123530A1
    • 2005-06-09
    • US11043731
    • 2005-01-26
    • Christopher MarshallAlexander HoffmanJoseph ErricoPaul Marshall
    • Christopher MarshallAlexander HoffmanJoseph ErricoPaul Marshall
    • C07K16/00C12N9/00C12N9/20C12N9/54C12N9/96A61K38/46A61K39/395
    • C07K16/00C07K2317/56C12N9/00C12N9/20C12N9/54C12N9/96
    • The invention described herein comprises methods for stabilizing polypeptides and polypeptide complexes, and the polypeptides and polypeptide complexes stabilized using the methods. To achieve stabilization, a cross-link reaction is controlled such that polypeptides and polypeptide complexes maintain their original functionality. In one embodiment, the invention provides a method for the identification of amino acid residues which, when cross-linked, are least disruptive to the structure and function of the polypeptide or polypeptide complex. In another embodiment, the invention provides a method for mutagenesis of identified residues to further control the cross-link reaction. Polypeptides and polypeptide complexes so stabilized can be utilized under a wide variety of physiological and non-physiological conditions. Further, the cross-link methodology disclosed herein may preclude the need for addition of exogenous structures to engineered proteins and complexes, such as peptide linkers that could be immunogenic and/or significantly decrease efficacy. In another embodiment, the invention provides a method for statistical analysis of databases of structural and/or sequence information available for polypeptides and polypeptide complexes to be stabilized. The statistical analysis identifies suitable residue pairs which are least likely to be disruptive of structure and function when cross-linked. Further, in a polypeptide chain or chains to be cross-linked, potentially undesirable reactive side-chains may be masked and protected, or altered using site-directed mutagenesis, e.g., to introduce a maximally conservative point mutation that will not support the cross-link reaction. The cross-link reaction conditions may also be adjusted to prevent undesired cross-links or other undesired side-effects. At residues identified as desirable positions for cross-linking, reactive side-chains may be introduced by site-directed mutagenesis, and the cross-link reaction is carried out using the conditions identified above.