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1. 发明申请

US20110105436A1 HETEROARYL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE IN CANCER TREATMENT 审中-公开
标题翻译： HETEROARYL化合物，组合物和使用癌症治疗方法
公开(公告)号：US20110105436A1
公开(公告)日：2011-05-05
申请号：US12921767
申请日：2009-03-10
申请人： Sandra Turcotte , Denise A. Chan , Patrick D. Sutphin , Amato J. Giaccia , Michael P. Hay , William A. Denny , Muriel Marie Bonnet
发明人： Sandra Turcotte , Denise A. Chan , Patrick D. Sutphin , Amato J. Giaccia , Michael P. Hay , William A. Denny , Muriel Marie Bonnet
IPC分类号： A61K31/675 , C07D417/04 , C07F9/6558 , C07D417/14 , C07D413/14 , C07D413/04 , C07D401/04 , A61K31/4439 , A61K31/5377 , A61K31/4709 , A61K31/496 , A61P35/00
CPC分类号： C07D417/04 , C07D401/04
摘要： Provided herein are novel heteroaryl compounds, compositions comprising the compounds, and methods of treatment or prevention comprising administration of the compounds. The compounds are effective in the targeting of cells defective in the von Hippel-Lindau gene and in inducing autophagic cell death. The methods are directed to treating or preventing diseases such as cancer, and in particular cancers resulting from von Hippel-Lindau disease. The compounds of the invention may be administered in combination with another therapeutic agent.
摘要翻译：本文提供了新颖的杂芳基化合物，包含该化合物的组合物，以及治疗或预防方法，包括施用化合物。这些化合物在靶向von Hippel-Lindau基因中缺陷的细胞和诱导自噬细胞死亡中是有效的。该方法涉及治疗或预防诸如癌症的疾病，特别是由冯·希波尔 - 林多病引起的癌症。本发明的化合物可以与另一种治疗剂组合施用。

2. 发明授权

US4078614A Fire extinguisher 失效
标题翻译：灭火器
公开(公告)号：US4078614A
公开(公告)日：1978-03-14
申请号：US671170
申请日：1976-03-29
申请人： George P. Hay
发明人： George P. Hay
IPC分类号： A62C13/64 , A62C37/50 , A62C37/06
CPC分类号： A62C37/50 , A62C13/64
摘要： A fire extinguisher includes a pressure vessel containing an extinguishing agent and pressurized gas and a valve remotely operated by a manual control at the outlet end of the delivery hose for controlling the discharge of the extinguishing agent from the pressure vessel to the delivery hose. This discharge control valve is opened and closed by a pneumatic cylinder operated by pressurized gas from a valve pneumatically operated by a manually actuated valve mounted near the outlet end of the delivery hose. For purging the hose of accumulated dry chemical, a second valve is positioned in the discharge conduit between the discharge control valve and the hose and is arranged to open and close simultaneously with the main discharge valve responsive to actuation of the valve at the outlet end of the discharge hose; a second manually actuated valve is provided to permit the second valve in the discharge conduit to be opened even though the main discharge valve is closed, and there is a gas pressure line from the pressure vessel to the discharge conduit between the main discharge control valve and the second control valve therein whereby gas pressure from the vessel is introduced into the discharge conduit when the main valve therein is closed to purge the discharge hose of dry chemical therein and to fluidize dry chemical in the discharge conduit when the main valve is open. The system also includes a three-way manually actuated vent valve in the line connecting the pressure vessel to the pressure gauge whereby prior to testing pressure the pressure gauge can be exhausted and sticking eliminated, so as to assure an accurate pressure reading at any time.
摘要翻译：灭火器包括容纳灭火剂和加压气体的压力容器和通过在输送软管的出口端通过手动控制远程操作的阀，用于控制灭火剂从压力容器排放到输送软管。该排放控制阀由气动缸打开和关闭，该气缸由加压气体从由安装在输送软管出口端附近的手动致动阀气动操作的阀门操作。为了清除积聚的干燥化学品的软管，第二阀定位在排放控制阀和软管之间的排放管道中，并且被布置成与主排出阀同时打开和关闭，响应于阀的出口端处的阀的致动排放软管; 设置第二手动致动阀以允许排放管道中的第二阀打开，即使主排气阀关闭，并且存在从压力容器到主排出控制阀和排出管之间的排出管道的气体压力线其中的第二控制阀，当其中的主阀关闭时，来自容器的气体压力被引入排放管道，以在主阀打开时清除干燥化学品的排出软管并使排出管道中的干燥化学品流化。该系统还包括将压力容器连接到压力计的管路中的三通手动致动排气阀，由此在测试压力之前，压力计可以被排出并粘附消除，以便在任何时间确保精确的压力读数。

3. 发明申请

US20060041175A1 Method and system for hydrogen evolution and storage 有权
标题翻译：氢气演化和储存的方法和系统
公开(公告)号：US20060041175A1
公开(公告)日：2006-02-23
申请号：US11152525
申请日：2005-06-10
申请人： David Thorn , William Tumas , P. Hay , Daniel Schwarz , Thomas Cameron
发明人： David Thorn , William Tumas , P. Hay , Daniel Schwarz , Thomas Cameron
IPC分类号： C07C19/08
CPC分类号： C07D235/06 , C07D235/18
摘要： A method and system for storing and evolving hydrogen employ chemical compounds that can be hydrogenated to store hydrogen and dehydrogenated to evolve hydrogen. A catalyst lowers the energy required for storing and evolving hydrogen. The method and system can provide hydrogen for devices that consume hydrogen as fuel.
摘要翻译：用于储存和演化氢的方法和系统使用可被氢化以储存氢并脱氢以释放氢的化合物。催化剂降低储存和放出氢气所需的能量。该方法和系统可以为消耗氢气作为燃料的装置提供氢气。

4. 发明授权

US745035A Harvesting-machine. 失效
公开(公告)号：US745035A
公开(公告)日：1903-11-24
申请号：US1903155835
申请日：1903-05-06
申请人： GEORGE H STARKE , SOREN P HAY , BRAMMER JAMES H
发明人： BRAMMER JAMES H
CPC分类号： A01D43/06

5. 发明授权

US3949812A Fire extinguishing system 失效
标题翻译：消防系统
公开(公告)号：US3949812A
公开(公告)日：1976-04-13
申请号：US523124
申请日：1974-11-12
申请人： George P. Hay
发明人： George P. Hay
IPC分类号： A62C35/62 , A62C37/21 , A62C37/06
CPC分类号： A62C35/62 , A62C37/21
摘要： A fire extinguishing system includes a container of extinguishing agent and a valve for controlling the discharge of the extinguishing agent. The discharge control valve is opened and closed by a pneumatic cylinder operated by pressurized gas through a solenoid-actuated directional control valve. The solenoid of the directional control valve is coupled with a pneumatic timing relay actuated by a temperature sensor. With this arrangement, a pre-determined amount of extinghishing agent is discharged from the container and delivered to the hazard area and then the discharge shut-off. The discharge cycle is repeated, if necessary, until the fire is extinguished. The system is then automatically reset and ready to deliver further extinguishing agent on demand. The system also includes manual or automatic means for purging the delivery line downstream of the discharge control valve.

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