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1. 发明授权

US06716834B2 Thiochromane derivatives and their use as thrombin inhibitors 失效
标题翻译：硫代色满衍生物及其作为凝血酶抑制剂的用途
公开(公告)号：US06716834B2
公开(公告)日：2004-04-06
申请号：US10276150
申请日：2002-11-12
申请人： Kjell Andersson , Tord Inghardt , Olle Karlsson , Marcel Linschoten , Jan-Erik Nyström , Gunnel Sundén
发明人： Kjell Andersson , Tord Inghardt , Olle Karlsson , Marcel Linschoten , Jan-Erik Nyström , Gunnel Sundén
IPC分类号： A61K31395
CPC分类号： C07D409/06 , C07D413/14
摘要： There is provided compounds of formulae I and IA wherein Y, R1, R2, R3, D1 and D2 have meanings given in the description which are useful as, or as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
摘要翻译：提供式I和IA的化合物，其中Y，R 1，R 2，R 3，D 1和D 2具有在本说明书中给出的含义，或作为，胰蛋白酶样蛋白酶如凝血酶的竞争性抑制剂，特别是在需要抑制凝血酶（例如血栓形成）或作为抗凝剂的条件的治疗中。

2. 发明授权

US06337394B2 Compounds 失效
标题翻译：化合物
公开(公告)号：US06337394B2
公开(公告)日：2002-01-08
申请号：US09214143
申请日：1998-12-29
申请人： Olle Karlsson , Marcel Linschoten , Jan-Erik Nyström
发明人： Olle Karlsson , Marcel Linschoten , Jan-Erik Nyström
IPC分类号： A01N6100
CPC分类号： C07D207/16 , A61K38/00
摘要： There is provided compounds of formula I, wherein R1, R2, R3, Rx, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
摘要翻译：提供式I化合物，其中R1，R2，R3，Rx，Y，n和B具有在描述中给出的含义，其可用作胰蛋白酶样蛋白酶（例如凝血酶）的竞争性抑制剂，特别是在治疗中需要抑制凝血酶的条件（如血栓形成）或作为抗凝剂。

3. 发明授权

US4138277A Method and apparatus for producing metal blanks, in particular steel slabs, which at least in a predetermined surface area have substantially no defects 失效
标题翻译：至少在预定表面积中基本上没有缺陷的用于生产金属坯料，特别是钢坯的方法和设备
公开(公告)号：US4138277A
公开(公告)日：1979-02-06
申请号：US677078
申请日：1976-04-15
申请人： Per-Olle Karlsson
发明人： Per-Olle Karlsson
IPC分类号： B24B27/033 , B23D36/00 , B23K7/06 , G01N27/20 , G01N27/90
CPC分类号： G01N27/9093
摘要： Method and apparatus for producing metal blanks, in particular steel slabs, which at least in a predetermined surface area have substantially no defects such as cracks, seams, bubbles, scabs, or the like, at least the surface portion to be made free of defects being systematically and substantially completely scanned by means of at least one inspecting device which detects such defects at and closely beneath the surface as regards location and depth and a working means being controlled by means of the recorded defects, which by scarfing, grinding, milling, planing and/or another cutting machine and/or local material melt deposition and/or material replacement or the like removes the defects detected, the defects being recorded with their depth for surface sub-areas whose width transversely of the working means is sustantially equal or less than the smallest working width of the working means and the working depth of the working means being controlled in accordance with the maximum defect depth recorded for the particular surface sub-area to be worked, wherein defects which occur within a surface sub-areas in a defect accumulation exceeding a predetermined defect minimum number and/or defects having a longitudinal extent whose direction deviates appreciably from the rolling direction are especially marked and/or taken into account with a weight changed with respect to a single defect in the determination of the maximum defect depth.
摘要翻译：至少在预定表面积中至少具有缺陷，例如裂纹，接缝，气泡，疤痕等的金属坯料，特别是钢板坯的制造方法和装置，至少要形成缺陷的表面部分通过至少一个检查装置系统地和基本上完全地扫描，该检查装置在位置和深度方面检测和紧密地在表面下方的这种缺陷，并且通过记录的缺陷来控制工作装置，其通过烧结，研磨，铣削，刨削和/或另一种切割机和/或局部材料熔体沉积和/或材料替换等去除所检测的缺陷，其工作装置横向宽度的表面子区域的深度被记录的缺陷维持在相等或小于工作装置的最小工作宽度，并且工作装置的工作深度根据最大失败进行控制记录特定表面子区域的ct深度，其中在超过预定缺陷最小数量的缺陷累积的表面子区域内发生的缺陷和/或具有方向从滚动方向明显偏离的纵向范围的缺陷在确定最大缺陷深度时相对于单个缺陷改变的重量被特别标记和/或考虑。

4. 发明授权

US4041379A Apparatus for testing metal blanks utilizing at least one inspecting head moved along the surface thereof 失效
标题翻译：用于利用沿其表面移动的至少一个检查头测试金属坯料的装置
公开(公告)号：US4041379A
公开(公告)日：1977-08-09
申请号：US591938
申请日：1975-06-30
申请人： Per-Olle Karlsson
发明人： Per-Olle Karlsson
IPC分类号： G01N19/08 , G01N27/87 , G01N27/90 , G01R33/12
CPC分类号： G01N27/9093
摘要： Apparatus for non-destructive testing of metal blanks, in particular steel slabs, flat steel, billets or blooms, for defects such as cracks, seams, cavities, bubbles or the like disposed at or near the surface comprising one or more inspecting heads movable relatively to the surface of the test objects and provided with inspecting means for detecting such defects, said inspecting heads being held by means of pressure and tension members which are carried by a common support arm and transmit the pressure and tension forces substantially separately from each other so as to be individually movable up and down perpendicularly to the slab surface and constrained to move in the travelling direction in engagement with the slab surface.
摘要翻译：用于金属坯料，特别是钢板，扁钢，坯料或花纹的非破坏性测试的装置，用于设置在表面或附近的缺陷，例如裂缝，接缝，空腔，气泡等，包括可相对移动的一个或多个检查头检测对象的表面并具有用于检测这些缺陷的检查装置，所述检查头通过压力和张力构件保持，所述压力和张力构件由共同的支撑臂承载并且将压力和张力基本上彼此分开地传递到可以单独地上下垂直于板坯表面移动，并被限制为在与板坯表面接合的行进方向上移动。

5. 发明申请

US20070249578A1 New amidino derivatives and their use as thrombin inhibitors 审中-公开
标题翻译：新的脒基衍生物及其作为凝血酶抑制剂的用途
公开(公告)号：US20070249578A1
公开(公告)日：2007-10-25
申请号：US11808122
申请日：2007-06-06
申请人： Tord Inghardt , Olle Karlsson , Marcel Linschoten , Jan-Erik Nystrom
发明人： Tord Inghardt , Olle Karlsson , Marcel Linschoten , Jan-Erik Nystrom
IPC分类号： A61K31/397 , A61K31/4427 , A61K31/497 , A61K31/53 , C07D205/04 , C07D237/02 , C07D239/02 , C07D241/02 , C07D251/02 , C07D253/04 , C07D253/06 , C07D257/02 , C07D401/12
CPC分类号： C07D205/04 , C07D207/16 , C07D405/06
摘要： There is provided compounds of formula I wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
摘要翻译：提供式I化合物，其中R 1，R x，Y，R y，n和B具有在描述中给出的含义可用作胰蛋白酶样蛋白酶（例如凝血酶）的竞争性抑制剂，特别是用于治疗需要凝血酶抑制（例如血栓形成）或作为抗凝剂的条件。

6. 发明授权

US06750243B1 Amidino derivatives and their use as thrombin inhibitors 失效
标题翻译：脒衍生物及其作为凝血酶抑制剂的用途
公开(公告)号：US06750243B1
公开(公告)日：2004-06-15
申请号：US09509032
申请日：2000-03-21
申请人： Tord Inghardt , Olle Karlsson , Marcel Linschoten , Jan-Erik Nyström
发明人： Tord Inghardt , Olle Karlsson , Marcel Linschoten , Jan-Erik Nyström
IPC分类号： A61K314025
CPC分类号： C07D205/04 , C07D207/16 , C07D405/06
摘要： There is provided compounds of formula I wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
摘要翻译：提供了式I化合物，其中R 1，R X，Y，R y，n和B具有在描述中给出的含义，其可用作胰蛋白酶样蛋白酶如凝血酶的竞争性抑制剂，特别是在治疗需要凝血酶抑制（例如血栓形成）或作为抗凝剂的条件。

7. 发明授权

US06576657B2 Amidino derivatives and their use as thrombin inhibitors 失效
标题翻译：脒衍生物及其作为凝血酶抑制剂的用途
公开(公告)号：US06576657B2
公开(公告)日：2003-06-10
申请号：US09844428
申请日：2001-04-30
申请人： Olle Karlsson , Marcel Linschoten , Jan-Erik Nyström
发明人： Olle Karlsson , Marcel Linschoten , Jan-Erik Nyström
IPC分类号： C07D20716
CPC分类号： C07D405/06 , C07D205/04
摘要： There is provided compounds of formula I, wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
摘要翻译：提供式I化合物，其中R1，Rx，Y，Ry，n和B具有在描述中给出的含义，其可用作胰蛋白酶样蛋白酶如凝血酶的竞争性抑制剂，特别是在治疗条件需要抑制凝血酶（如血栓形成）或作为抗凝剂。

8. 发明授权

US06265397B1 Amidino derivatives and their use as thrombin inhibitors 失效
标题翻译：脒衍生物及其作为凝血酶抑制剂的用途
公开(公告)号：US06265397B1
公开(公告)日：2001-07-24
申请号：US09091994
申请日：1998-06-26
申请人： Olle Karlsson , Marcel Linschoten , Jan-Erik Nyström
发明人： Olle Karlsson , Marcel Linschoten , Jan-Erik Nyström
IPC分类号： C07D20504
CPC分类号： C07D405/06 , C07D205/04
摘要： There is provided compounds of formula I, wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
摘要翻译：提供式I化合物，其中R1，Rx，Y，Ry，n和B具有在描述中给出的含义，其可用作胰蛋白酶样蛋白酶如凝血酶的竞争性抑制剂，特别是在治疗条件需要抑制凝血酶（如血栓形成）或作为抗凝剂。

9. 发明授权

US07241757B2 Amidino derivatives and their use as thrombin inhibitors 失效
标题翻译：脒衍生物及其作为凝血酶抑制剂的用途
公开(公告)号：US07241757B2
公开(公告)日：2007-07-10
申请号：US10815954
申请日：2004-04-02
申请人： Tord Inghardt , Olle Karlsson , Marcel Linschoten , Jan-Erik Nyström
发明人： Tord Inghardt , Olle Karlsson , Marcel Linschoten , Jan-Erik Nyström
IPC分类号： A61K31/397 , A61K31/445 , C07D207/00
CPC分类号： C07D205/04 , C07D207/16 , C07D405/06
摘要： There is provided compounds of formula I wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
摘要翻译：提供式I化合物，其中R 1，R x，Y，R y，n和B具有在描述中给出的含义可用作胰蛋白酶样蛋白酶（例如凝血酶）的竞争性抑制剂，特别是用于治疗需要凝血酶抑制（例如血栓形成）或作为抗凝剂的条件。

10. 发明授权

US4280094A Test plate method and an arrangement for testing the serviceability and for setting and calibrating a test apparatus for the non-destructive electrical or magnetic testing of metallic blanks 失效
标题翻译：测试板方法和用于测试适用性的设置和用于设置和校准用于金属坯料的非破坏性电或磁测试的测试装置
公开(公告)号：US4280094A
公开(公告)日：1981-07-21
申请号：US969274
申请日：1978-12-14
申请人： Per-Olle Karlsson
发明人： Per-Olle Karlsson
IPC分类号： G01N27/00 , G01N27/20 , G01N27/82 , G01N27/90 , G01R35/00 , G01R33/00
CPC分类号： G01N27/9086 , G01N27/20
摘要： A method and arrangement for testing the serviceability and for setting and calibrating a test apparatus for the non-destructive electrical and/or magnetic testing of metallic blanks, particularly steel slabs, for defects, such as surface or below-surface cracks, laps, shrinkholes, blowholes or the like, comprising inspecting means capable of detecting defects such as these and mounted for displacement relative to the surface of the blank to be tested, test plate simulating a defective metallic blank being brought up to the test apparatus in a position in which they are in substantial alignment with the surface of the blank to be tested, the inspecting means of the test apparatus being tested by the test plates for working order and calibrated.
摘要翻译：用于测试适用性以及用于设置和校准用于金属坯料，特别是钢板的非破坏性电和/或磁性测试的测试装置的方法和装置，用于缺陷，例如表面或表面下裂纹，圈，收缩孔，气孔等，包括检测装置，其能够检测这些缺陷并相对于要测试的坯料的表面进行位移安装，该模板将模拟有缺陷的金属坯料模拟到测试装置上，它们与要测试的坯件的表面大致对准，测试装置的检查装置由测试板进行测试以进行工作和校准。

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