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1. 发明授权

US08470776B2 Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof 有权
标题翻译：异恶唑及其衍生物与细胞结合分子的结合物，新型二唑衍生物，制造方法及其用途
公开(公告)号：US08470776B2
公开(公告)日：2013-06-25
申请号：US12728050
申请日：2010-03-19
申请人： Eckhard Guenther , Olaf Schaefer , Michael Teifel , Klaus Paulini
发明人： Eckhard Guenther , Olaf Schaefer , Michael Teifel , Klaus Paulini
IPC分类号： A61K31/42 , A61K38/24 , A61K38/31
CPC分类号： C12P17/188 , C07D498/18 , C07D498/22 , C07K7/23 , C07K14/6555
摘要： The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.
摘要翻译：本发明提供了disorazole及其衍生物与细胞结合分子如肽，蛋白质，激素，血液蛋白和抗体的缀合物。本发明还提供了新的二唑衍生物和制备这种缀合物和二唑衍生物的方法。这些化合物可以用作治疗哺乳动物的生理和/或病理生理状况的药物，特别是用于治疗各种肿瘤。

2. 发明授权

US07858826B2 Process for producing 6-dimethylaminomethyl-phenyl-cyclohexane-1,3-diols 失效
标题翻译： 6-二甲基氨基甲基 - 苯基 - 环己烷-1,3-二醇的制备方法
公开(公告)号：US07858826B2
公开(公告)日：2010-12-28
申请号：US12394727
申请日：2009-02-27
申请人： Wolfgang Hell , Oswald Zimmer , Markus Kegel , Olaf Schaefer , Felix Spindler , Anita Schnyder , Urs Siegrist , Detlef Heller , Hans-Joachim Drexler
发明人： Wolfgang Hell , Oswald Zimmer , Markus Kegel , Olaf Schaefer , Felix Spindler , Anita Schnyder , Urs Siegrist , Detlef Heller , Hans-Joachim Drexler
IPC分类号： C07C215/42
CPC分类号： C07C213/00 , C07B2200/07 , C07C2601/14 , C07C215/64 , C07C217/74
摘要： A process for producing 6-dimethylaminomethyl-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-1,3-diols from 6-dimethylaminomethyl-1-hydroxy-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-3-ones by catalytic hydrogenation in the presence of heterogeneous or homogeneous catalysts, or by using metal hydrides.
摘要翻译：由6-二甲基氨基甲基-1-羟基-1-（3-羟基 - 或3-甲基-1-羟基-1-（3-羟基 - C1-C4烷氧基苯基） - 环己烷-3-酮，通过催化氢化在非均相或均相催化剂存在下，或通过使用金属氢化物。

3. 发明申请

US20100323963A1 CONJUGATES OF DISORAZOLES AND THEIR DERIVATIVES WITH CELL-BINDING MOLECULES, NOVEL DISORAZOLE DERIVATIVES, PROCESSES OF MANUFACTURING AND USES THEREOF 审中-公开
标题翻译：异恶唑及其衍生物与细胞结合分子的结合，新型异唑衍生物，制造方法及其用途
公开(公告)号：US20100323963A1
公开(公告)日：2010-12-23
申请号：US12728075
申请日：2010-03-19
申请人： Eckhard GUENTHER , Olaf Schaefer , Michael Teifel , Klaus Paulini
发明人： Eckhard GUENTHER , Olaf Schaefer , Michael Teifel , Klaus Paulini
IPC分类号： A61K38/09 , C07D498/22 , C07D498/16 , C07K7/23 , C07K14/655 , A61K31/424 , A61K38/31 , A61P35/00 , A61P35/02
CPC分类号： C12P17/188 , C07D498/18 , C07D498/22 , C07K7/23 , C07K14/6555
摘要： The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.
摘要翻译：本发明提供了disorazole及其衍生物与细胞结合分子如肽，蛋白质，激素，血液蛋白和抗体的缀合物。本发明还提供了新的二唑衍生物和制备这种缀合物和二唑衍生物的方法。这些化合物可以用作治疗哺乳动物的生理和/或病理生理状况的药物，特别是用于治疗各种肿瘤。

4. 发明申请

US20090227813A1 Process for Producing 6-Dimethylaminomethyl-phenyl-cyclohexane-1,3-diols 失效
标题翻译：制备6-二甲基氨基甲基 - 苯基 - 环己烷-1,3-二醇的方法
公开(公告)号：US20090227813A1
公开(公告)日：2009-09-10
申请号：US12394727
申请日：2009-02-27
申请人： Wolfgang Hell , Oswald Zimmer , Markus Kegel , Olaf Schaefer , Felix Spindler , Anita Schnyder , Urs Siegrist , Detlef Heller , Hans-Joachim Drexler
发明人： Wolfgang Hell , Oswald Zimmer , Markus Kegel , Olaf Schaefer , Felix Spindler , Anita Schnyder , Urs Siegrist , Detlef Heller , Hans-Joachim Drexler
IPC分类号： C07C215/44
CPC分类号： C07C213/00 , C07B2200/07 , C07C2601/14 , C07C215/64 , C07C217/74
摘要： A process for producing 6-dimethylaminomethyl-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-1,3-diols from 6-dimethylaminomethyl-1-hydroxy-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-3-ones by catalytic hydrogenation in the presence of heterogeneous or homogeneous catalysts, or by using metal hydrides.
摘要翻译：由6-二甲基氨基甲基-1-羟基-1-（3-羟基 - 或3-甲基-1-羟基-1-（3-羟基 - C1-C4烷氧基苯基） - 环己烷-3-酮，通过催化氢化在非均相或均相催化剂存在下，或通过使用金属氢化物。

5. 发明申请

US20100317580A1 CONJUGATES OF DISORAZOLES AND THEIR DERIVATIVES WITH CELL-BINDING MOLECULES, NOVEL DISORAZOLE DERIVATIVES, PROCESSES OF MANUFACTURING AND USES THEREOF 有权
公开(公告)号：US20100317580A1
公开(公告)日：2010-12-16
申请号：US12728050
申请日：2010-03-19
申请人： Eckhard GUENTHER , Olaf Schaefer , Michael Teifel , Klaus Paulini
发明人： Eckhard GUENTHER , Olaf Schaefer , Michael Teifel , Klaus Paulini
IPC分类号： A61K38/09 , A61K31/424 , A61K38/31 , A61P35/00 , A61P35/02
CPC分类号： C12P17/188 , C07D498/18 , C07D498/22 , C07K7/23 , C07K14/6555
摘要： The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.

6. 发明申请

US20080090758A1 CONJUGATES OF DISORAZOLES AND THEIR DERIVATIVES WITH CELL-BINDING MOLECULES, NOVEL DISORAZOLE DERIVATIVES, PROCESSES OF MANUFACTURING AND USES THEREOF 失效
标题翻译：异恶唑及其衍生物与细胞结合分子的结合，新型异唑衍生物，制造方法及其用途
公开(公告)号：US20080090758A1
公开(公告)日：2008-04-17
申请号：US11850747
申请日：2007-09-06
申请人： Eckhard Guenther , Olaf Schaefer , Michael Teifel , Klaus Paulini
发明人： Eckhard Guenther , Olaf Schaefer , Michael Teifel , Klaus Paulini
IPC分类号： A61K38/00 , A61P35/00 , C07K16/00
CPC分类号： C12P17/188 , C07D498/18 , C07D498/22 , C07K7/23 , C07K14/6555
摘要： The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.
摘要翻译：本发明提供了disorazole及其衍生物与细胞结合分子如肽，蛋白质，激素，血液蛋白和抗体的缀合物。本发明还提供了新的二唑衍生物和制备这种缀合物和二唑衍生物的方法。这些化合物可以用作治疗哺乳动物的生理和/或病理生理状况的药物，特别是用于治疗各种肿瘤。

7. 发明申请

US20070276032A1 Use of 8-Prenylnaringenin for Hormone Replacement Therapy 审中-公开
标题翻译：使用8-Prenylnaringenin进行激素替代治疗
公开(公告)号：US20070276032A1
公开(公告)日：2007-11-29
申请号：US10575391
申请日：2004-10-06
申请人： Michael Huempel , Wolf-Dieter Schleuning , Olaf Schaefer , Paivi Isaksson , Rolf Bohlmann
发明人： Michael Huempel , Wolf-Dieter Schleuning , Olaf Schaefer , Paivi Isaksson , Rolf Bohlmann
IPC分类号： A61K31/352 , A61P5/30 , C07D311/30
CPC分类号： C07D311/32 , A61K31/35
摘要： The invention provides a production method for the phytoestrogen 8-Prenylnaringenin, the preparation produced by this method and the use of 8-Prenylnaringenin for the production of a medicament for the prevention and treatment of hormone-dependent osteoporosis and of peri- and postmenopausal symptoms in women.
摘要翻译：本发明提供了植物雌激素8-芘基栀子苷的制备方法，该方法制备的制剂以及8-芘基栀子腺苷在制备用于预防和治疗激素依赖性骨质疏松症和绝经后和绝经后症状的药物中的用途妇女

8. 发明授权

US6010240A Capsule holder for rotary mixing device 失效
公开(公告)号：US6010240A
公开(公告)日：2000-01-04
申请号：US61909
申请日：1998-04-17
申请人： Olaf Schaefer , Werner Lissner
发明人： Olaf Schaefer , Werner Lissner
IPC分类号： A61C5/06 , B01F9/22 , B01F11/00 , B01F15/00
CPC分类号： B01F11/0008 , B01F15/00746 , Y10S366/602
摘要： A capsule holder for retaining a mixing capsule on a rotary mixing device includes a carrier plate 10, an actuator disk 11 rotatable relative to the plate, and two retaining arms 12, 13 for clamping the capsule from opposite sides, the retaining arms having driving pins 22 engaging spiral cam slots 26 of the actuator disk 11. By rotating the actuator disk 11, the retaining arms 12, 13 are moved away from, or toward, each other. The thus constituted gearing is self-locking in one direction of force transmission so that centrifugal forces exerted on the retaining arms 12, 13 during rotation cannot move the arms apart. On the other hand, the retaining arms 12, 13 are opened with little effort by rotating the actuator disk 11.

9. 发明授权

US07741277B2 Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof 失效
标题翻译：异恶唑及其衍生物与细胞结合分子的结合物，新型二唑衍生物，制造方法及其用途
公开(公告)号：US07741277B2
公开(公告)日：2010-06-22
申请号：US11850747
申请日：2007-09-06
申请人： Eckhard Guenther , Olaf Schaefer , Michael Teifel , Klaus Paulini
发明人： Eckhard Guenther , Olaf Schaefer , Michael Teifel , Klaus Paulini
IPC分类号： A61K38/00
CPC分类号： C12P17/188 , C07D498/18 , C07D498/22 , C07K7/23 , C07K14/6555
摘要： The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.
摘要翻译：本发明提供了disorazole及其衍生物与细胞结合分子如肽，蛋白质，激素，血液蛋白和抗体的缀合物。本发明还提供了新的二唑衍生物和制备这种缀合物和二唑衍生物的方法。这些化合物可以用作治疗哺乳动物的生理和/或病理生理状况的药物，特别是用于治疗各种肿瘤。

10. 发明授权

US6152593A Capsule holder for rotary mixing device 有权
标题翻译：用于旋转混合装置的胶囊支架
公开(公告)号：US6152593A
公开(公告)日：2000-11-28
申请号：US369849
申请日：1999-08-09
申请人： Olaf Schaefer , Werner Lissner
发明人： Olaf Schaefer , Werner Lissner
IPC分类号： A61C5/06 , B01F9/22 , B01F11/00 , B01F15/00
CPC分类号： B01F11/0008 , B01F15/00746 , Y10S366/602
摘要： A capsule holder for retaining a mixing capsule on a rotary mixing device includes a carrier plate 10, an actuator disk 11 rotatable relative to the plate, and two retaining arms 12, 13 for clamping the capsule from opposite sides, the retaining arms having driving pins 22 engaging spiral cam slots 26 of the actuator disk 11. By rotating the actuator disk 11, the retaining arms 12, 13 are moved away from, or toward, each other. The thus constituted gearing is self-locking in one direction of force transmission so that centrifugal forces exerted on the retaining arms 12, 13 during rotation cannot move the arms apart. On the other hand, the retaining arms 12, 13 are opened with little effort by rotating the actuator disk 11.
摘要翻译：用于将混合胶囊保持在旋转混合装置上的胶囊保持器包括载体板10，可相对于板旋转的致动器盘11和用于从相对侧夹紧胶囊的两个保持臂12,13，保持臂具有驱动销 22接合致动器盘11的螺旋形凸轮槽26.通过旋转致动器盘11，保持臂12,13彼此移动或朝向彼此移动。这样构成的传动装置在力传递的一个方向上是自锁的，使得在旋转期间施加在保持臂12,13上的离心力不能使臂分开。另一方面，通过使致动器盘11旋转，保持臂12,13以很小的努力被打开。

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