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1. 发明授权

US11717410B2 Implantable tissue repair devices 有权
公开(公告)号：US11717410B2
公开(公告)日：2023-08-08
申请号：US16615357
申请日：2018-05-22
申请人： ORTHOX LIMITED
发明人： Robert Alan Walker , Ben Armstrong , Nicholas James Vavasour Skaer
IPC分类号： A61F2/30 , A61L27/52
CPC分类号： A61F2/30756 , A61F2/30749 , A61F2/30965 , A61L27/52 , A61F2002/30062 , A61F2002/3092 , A61F2002/30461 , A61F2002/30878 , A61F2002/30957
摘要： An implantable tissue repair device containing a body having a biocompatible hydrogel and a plurality of tissue anchoring elements projecting from the body, where the anchoring elements are integrally formed with the body and have the same biocompatible hydrogel as the body, and the anchoring elements, in use, are arranged to enter apertures in a tissue and anchor the device to the tissue.

2. 发明申请

US20200069430A1 IMPLANTABLE TISSUE REPAIR DEVICES AND METHODS FOR MANUFACTURING THE SAME 审中-公开
公开(公告)号：US20200069430A1
公开(公告)日：2020-03-05
申请号：US16614598
申请日：2018-05-22
申请人： ORTHOX LIMITED
发明人： Robert ALAN WALKER , Ben ARMSTRONG , Nicholas James Vavasour SKAER
IPC分类号： A61F2/30
摘要： An implantable tissue repair device containing a body having a biocompatible hydrogel and a rigid support at least partly located within the body or device, or connected to the body or device.

3. 发明申请

US20140277452A1 IMPLANTABLE REPAIR DEVICE 有权
标题翻译：可植入维修设备
公开(公告)号：US20140277452A1
公开(公告)日：2014-09-18
申请号：US14351952
申请日：2012-10-18
申请人： ORTHOX LIMITED
发明人： Nicholas Skaer
IPC分类号： A61F2/30
CPC分类号： A61F2/30756 , A61F2002/30757 , A61L27/227 , A61L27/56 , A61L2430/06
摘要： An implantable repair device for the repair, augmentation or replacement of tissue, uses silk fibroin and has a smooth surface and a porous surface. The smooth surface has a measured Sa value of less than approximately 0.1 μm when using Atomic Force Microscopy when samples of the repair device are fully hydrated by imaging through fluid in peak force tapping mode. A method of preparing such an implantable repair device includes preparing a gel from a fibroin solution in a mould, preparing a material by subjecting the gel to one or more steps of freezing and thawing the gel, and creating at least a porous surface on the device, wherein a portion of the mould is adapted to provide at least one smooth surface.
摘要翻译：用于修复，增加或更换组织的植入式修复装置使用丝素蛋白，并具有光滑的表面和多孔表面。当使用原子力显微镜时，光滑表面具有小于约0.1μm的测量值，当修补装置的样品通过在峰值强力攻丝模式下通过流体成像而完全水合时。制备这种可植入修复装置的方法包括从模具中的丝心蛋白溶液制备凝胶，通过使凝胶进行一个或多个步骤来冻结和解冻凝胶，并在该装置上产生至少多孔表面来制备材料，其中所述模具的一部分适于提供至少一个光滑表面。

4. 发明申请

US20200155322A1 IMPLANTABLE TISSUE REPAIR DEVICES AND METHODS FOR MANUFACTURING THE SAME 审中-公开
公开(公告)号：US20200155322A1
公开(公告)日：2020-05-21
申请号：US16615357
申请日：2018-05-22
申请人： ORTHOX LIMITED
发明人： ROBERT Alan WALKER , Ben ARMSTRONG , Nicholas James Vavasour SKAER
IPC分类号： A61F2/30 , A61F2/44 , A61L27/52 , A61L27/26
摘要： An implantable tissue repair device containing a body having a biocompatible hydrogel and a plurality of tissue anchoring elements projecting from the body, where the anchoring elements are integrally formed with the body and have the same biocompatible hydrogel as the body, and the anchoring elements, in use, are arranged to enter apertures in a tissue and anchor the device to the tissue.

5. 发明申请

US20200205986A1 IMPLANTABLE TISSUE REPAIR DEVICES AND METHODS FOR MANUFACTURING THE SAME 审中-公开
公开(公告)号：US20200205986A1
公开(公告)日：2020-07-02
申请号：US16615731
申请日：2018-05-18
申请人： ORTHOX LIMITED
发明人： Nicholas James Vavasour SKAER , Robert Alan WALKER
IPC分类号： A61F2/30 , A61F2/38 , A61F2/44
摘要： An implantable tissue repair device for the repair, replacement or augmentation of a tissue, the device having a biocompatible solvated structural material, where at least part of the structural material is in a compressed and/or dried state.

6. 发明授权

US09943412B2 Implantable repair device 有权
公开(公告)号：US09943412B2
公开(公告)日：2018-04-17
申请号：US14351952
申请日：2012-10-18
申请人： ORTHOX LIMITED
发明人： Nicholas Skaer
IPC分类号： A61L27/56 , A61F2/30 , A61L27/22
CPC分类号： A61F2/30756 , A61F2002/30757 , A61L27/227 , A61L27/56 , A61L2430/06
摘要： An implantable repair device for the repair, augmentation or replacement of tissue, uses silk fibroin and has a smooth surface and a porous surface. The smooth surface has a measured Sa value of less than approximately 0.1 μm when using Atomic Force Microscopy when samples of the repair device are fully hydrated by imaging through fluid in peak force tapping mode. A method of preparing such an implantable repair device includes preparing a gel from a fibroin solution in a mold, preparing a material by subjecting the gel to one or more steps of freezing and thawing the gel, and creating at least a porous surface on the device, wherein a portion of the mold is adapted to provide at least one smooth surface.

7. 发明申请

US20160228604A1 METHOD FOR THE MANUFACTURE OF AN IMPLANTABLE CARTILAGINOUS TISSUE REPAIR DEVICE 审中-公开
标题翻译：可植入性组织修复装置的制造方法
公开(公告)号：US20160228604A1
公开(公告)日：2016-08-11
申请号：US14955081
申请日：2015-12-01
申请人： Orthox Limited
发明人： Stephan MANN , David Philip KNIGHT , Nicholas James Vavasour SKAER , Caroline BERTRAM , Richard O.C. OREFFO , Helmtrud I. ROACH , Andrew Michael COLLINS
IPC分类号： A61L27/22 , A61L27/58 , B29C70/30 , B29C44/12 , B29C44/34 , B29C70/22 , A61L27/52 , A61L27/46
CPC分类号： A61L27/227 , A61F2/30756 , A61F2/3872 , A61F2/442 , A61F2002/30062 , A61F2002/30075 , A61F2002/30766 , A61F2002/3092 , A61F2002/4495 , A61F2210/0004 , A61F2210/0061 , A61L27/46 , A61L27/48 , A61L27/52 , A61L27/56 , A61L27/58 , A61L2430/06 , B29C44/1276 , B29C44/3419 , B29C70/222 , B29C70/30 , B29K2105/041 , B29K2105/0809 , B29K2311/10
摘要： A cartilaginous tissue repair device with a biocompatible, bioresorbable three-dimensional silk or other fibre lay and a biocompatible, bioresorbable substantially porous silk-based or other hydrogel partially or substantially filling the interstices of the fibre lay; with or without an integral means of firmly anchoring the device to a patient's hone.
摘要翻译：具有生物相容性，生物可再吸收的三维丝或其它纤维布的软骨组织修复装置和部分或基本上填充纤维布的间隙的生物相容的，生物可再吸收的基本上多孔的丝基或其它水凝胶; 具有或不具有将装置牢固地固定在患者的磨牙上的整体手段。

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