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1. 发明授权

US4839290A Process for producing cytotoxic T-cells and compositions produced by said process 失效
标题翻译：用于生产细胞毒性T细胞的方法和由所述方法制备的组合物
公开(公告)号：US4839290A
公开(公告)日：1989-06-13
申请号：US96259
申请日：1987-09-08
申请人： Takeji Kaieda , Kimimasa Yamada , Naokuni Yamawaki
发明人： Takeji Kaieda , Kimimasa Yamada , Naokuni Yamawaki
IPC分类号： A61K35/14 , A61K39/00 , C12N5/02
CPC分类号： A61K39/0011 , A61K2039/5158
摘要： A method of inducing antitumor immunocytes which is simple in operation and suitable for inducing antitumor immunocytes having not only excellent cytotoxic activity against tumor cells but also high safety, which method comprises contacting leucocytes with an insoluble, antitumor immunocyte-inducing material capable of linking with T cells, said antitumor immunocyte-inducing material comprising an insoluble carrier and a ligand linked therewith. The induced antitumor immunocytes can be simply separated in substantially ligand-free form from the insoluble, antitumor immunocyte-inducing material. The obtained antitumor immunocytes have not only excellent cytotoxic activity against tumor cells but also high safety.
摘要翻译：一种诱导抗肿瘤免疫细胞的方法，其操作简单，适用于诱导不仅对肿瘤细胞具有优异细胞毒性活性的抗肿瘤免疫细胞，而且安全性高，该方法包括使白细胞与能够与T连接的不溶性抗肿瘤免疫细胞诱导材料接触细胞，所述抗肿瘤免疫细胞诱导材料包含不溶性载体和与其连接的配体。诱导的抗肿瘤免疫细胞可以简单地从基本上不含配体的形式从不溶性的抗肿瘤免疫细胞诱导材料中分离出来。获得的抗肿瘤免疫细胞不仅对肿瘤细胞具有优异的细胞毒活性，而且具有高度的安全性。

2. 发明授权

US4627915A Absorbent of autoantibody and immune complexes, adsorbing device and blood purifying apparatus comprising the same 失效
标题翻译：自身抗体和免疫复合物的吸收剂，包含其的吸附装置和血液净化装置
公开(公告)号：US4627915A
公开(公告)日：1986-12-09
申请号：US592631
申请日：1984-03-23
申请人： Toru Kuroda , Naokuni Yamawaki
发明人： Toru Kuroda , Naokuni Yamawaki
IPC分类号： A61M1/36 , B01D15/08 , B01J20/28 , B01J20/32 , B01D15/00
CPC分类号： A61M1/3679 , B01D15/08 , B01D15/3804 , B01J20/321 , B01J20/3219 , B01J20/3246 , B01J20/3248 , B01J20/3251 , B01J20/3285
摘要： An adsorbent for adsorbing thereonto an autoantibody and/or immune complexes from a body fluid. The adsorbent comprises a surface, a hydrophobic member and a negative charge-producing member. The negative charge-producing member is adapted to produce such an effective number of negative charges in a body fluid that the ratio of: ##EQU1## is greater than 1. The adsorbent is excellent in selectively and efficiently adsorbing an autoantibody and/or immune complexes while little adsorbing useful substances from the body fluid. The adsorbent may be used in an adsorbing device comprising a vessel having a fluid inlet and a fluid outlet with the adsorbent contained in the vessel. The adsorbing device may be used in a blood purifying apparatus for adsorbing and removing an autoantibody and/or immune complexes from blood plasma, which apparatus comprises a blood circulation passage provided with a plasma separating means and a blood-plasma mixing means, and a plasma recycle passage connected to the blood circulation passage and adapted to introduce plasma, separated by the plasma separating means and purified by a plasma purifying means comprised of the above-mentioned adsorbing device and disposed in the plasma recycle passage, into the mixing device.
摘要翻译：一种吸附剂，用于在体液上吸附其自身抗体和/或免疫复合物。吸附剂包括表面，疏水性构件和负电荷产生构件。负电荷产生构件适于在体积流体中产生如此有效数量的负电荷，其比例大于1.吸附剂选择性且有效地吸附自身抗体和/或免疫复合物同时从体液吸附有用物质少。吸附剂可用于吸附装置，该吸附装置包括具有流体入口的容器和具有容纳在容器中的吸附剂的流体出口。吸附装置可以用于血液净化装置，用于从血浆中吸附和去除自身抗体和/或免疫复合物，该装置包括设置有血浆分离装置和血浆混合装置的血液循环通道，以及血浆循环通道连接到血液循环通道并适于引入等离子体，由等离子体分离装置分离，并通过由上述吸附装置构成的等离子体净化装置进行净化，并设置在等离子体循环通道中，进入混合装置。

3. 发明授权

US4430229A Immune adsorbent and adsorbing device 失效
标题翻译：免疫吸附剂和吸附装置
公开(公告)号：US4430229A
公开(公告)日：1984-02-07
申请号：US378924
申请日：1982-05-17
申请人： Naokuni Yamawaki , Katsunori Horikoshi
发明人： Naokuni Yamawaki , Katsunori Horikoshi
IPC分类号： A61M1/36 , B01J20/32 , B01D15/00
CPC分类号： A61M1/3679 , B01J20/321 , B01J20/3255
摘要： An immune adsorbent for autoantibodies and/or immune complexes is provided which is comprised of a water-insoluble carrier and at least one low-molecular-weight substance containing a purine base or pyrimidine base as a constituent element, which is fixed to said carrier. The immune adsorbent is usually used in an adsorption apparatus comprising a vessel having fluid inlet and outlet openings and having packed therein said immune adsorbent.
摘要翻译：提供了一种用于自身抗体和/或免疫复合物的免疫吸附剂，其由水不溶性载体和至少一种含有作为组成元素的嘌呤碱基或嘧啶碱基的低分子量物质固定在所述载体上。免疫吸附剂通常用于包括具有流体入口和出口开口的容器的吸附装置中并且在其中填充有所述免疫吸附剂。

4. 发明授权

US4240376A Method for keeping aquatic animals alive over long periods of time 失效
标题翻译：保持水生动物长期存活的方法
公开(公告)号：US4240376A
公开(公告)日：1980-12-23
申请号：US969132
申请日：1978-12-13
申请人： Naoya Kominami , Hirokazu Fukumi , Naokuni Yamawaki , Junji Nomura
发明人： Naoya Kominami , Hirokazu Fukumi , Naokuni Yamawaki , Junji Nomura
IPC分类号： A01K63/02 , A01K61/00 , A01K63/00 , A01K63/04 , C02F1/72
CPC分类号： A01K63/00
摘要： Aquatic animals can be kept in a living condition over a long period of time, without feeding them, by placing the aquatic animals, at a large density of more than 200 kg/m.sup.3 in environmental water; maintaining the temperature of the environmental water in a lowest possible range in which it is possible for the aquatic animals to exist; controlling the concentrations of ammonia compounds, water-soluble organic compounds and carbonic acid radical in the environmental water so that their levels do not exceed 20 ppm, 150 ppm and 1,000 ppm, respectively; and regulating the concentration of molecular oxygen dissolved in the environmental water so that it is 3 ppm or more.
摘要翻译：水生动物可以长时间保持在生活状态，不用喂养，在环境水中以大于200kg / m3的密度放置水生动物; 将环境水的温度保持在水生动物可能存在的最低可能范围内; 控制环境水中氨化合物，水溶性有机化合物和碳酸根的浓度，使其水平分别不超过20ppm，150ppm和1,000ppm; 并调节溶解在环境水中的分子氧的浓度，使其为3ppm以上。

5. 发明授权

US5665233A Filter apparatus for selectively removing leukocytes 失效
标题翻译：用于选择性除去白细胞的过滤装置
公开(公告)号：US5665233A
公开(公告)日：1997-09-09
申请号：US531700
申请日：1995-09-21
申请人： Tatsuya Fukuda , Takao Nishimura , Naokuni Yamawaki
发明人： Tatsuya Fukuda , Takao Nishimura , Naokuni Yamawaki
IPC分类号： A61M1/36 , B01D39/16 , B01D29/00 , B01D29/05
CPC分类号： B01D39/1692 , A61M1/3633 , B01D39/1623 , B01D39/1676 , A61M2202/0439
摘要： Disclosed is a filter material for selectively removing leukocytes from a leukocyte-containing suspension, which comprises a porous element having an average pore diameter of 1 to 25 .mu.m and a total pore volume of 0.40 to 0.95 ml/ml of the porous element, and wherein the sum of respective pore volumes of pores of the porous element which have a pore diameter of 1 to 30 .mu.m is 90% or more, based on said total pore volume. Also disclosed is a filter apparatus for selectively removing leukocyte from a leukocyte-containing suspension which is packed with the above-mentioned filter material. By virtue of the filter material, the filter apparatus not only can remove leukocytes from a leukocyte-containing suspension at a leukocyte removal efficiency as excellent as 10.sup.-4 or less in terms of a leukocyte residual ratio without suffering from a pressure loss increase, but also can be rendered compact.
摘要翻译：公开了一种用于从含白细胞的悬浮液中选择性除去白细胞的过滤材料，其包含平均孔径为1〜25μm，多孔元素的总孔体积为0.40〜0.95ml / ml的多孔元素，以及其特征在于，孔径为1〜30μm的多孔质元素的孔的孔体积的总和为总孔体积的90％以上。还公开了一种用于从含有上述过滤材料的含白细胞的悬浮液中选择性除去白细胞的过滤装置。由于过滤器材料，过滤装置不仅可以白细胞去除效率从含白细胞的悬浮液中除去白细胞，白细胞残留率优于10-4或更低，而不会造成压力损失增加，但是也可以使其紧凑。

6. 发明授权

US5478470A Filter material for selectively removing leukocytes 失效
标题翻译：用于选择性去除白细胞的过滤材料
公开(公告)号：US5478470A
公开(公告)日：1995-12-26
申请号：US353335
申请日：1994-12-05
申请人： Tatsuya Fukuda , Takao Nishimura , Naokuni Yamawaki
发明人： Tatsuya Fukuda , Takao Nishimura , Naokuni Yamawaki
IPC分类号： A61M1/36 , B01D39/16 , B01D39/00 , B01D39/08
CPC分类号： B01D39/1692 , A61M1/3633 , B01D39/1623 , B01D39/1676 , A61M2202/0439
摘要： Disclosed is a filter material for selectively removing leukocytes from a leukocyte-containing suspension, which comprises a porous element having an average pore diameter of 1 to 25 .mu.m and a total pore volume of 0.40 to 0.95 ml/ml of the porous element, and wherein the sum of respective pore volumes of pores of the porous element which have a pore diameter of 1 to 30 .mu.m is 90% or more, based on said total pore volume. Also disclosed is a filter apparatus for selectively removing leukocyte from a leukocyte-containing suspension which is packed with the above-mentioned filter material. By virtue of the filter material, the filter apparatus not only can remove leukocytes from a leukocyte-containing suspension at a leukocyte removal efficiency as excellent as 10.sup.-4 or less in terms of a leukocyte residual ratio without suffering from a pressure loss increase, but also can be rendered compact.
摘要翻译：公开了一种用于从含白细胞的悬浮液中选择性除去白细胞的过滤材料，其包含平均孔径为1〜25μm，多孔元素的总孔体积为0.40〜0.95ml / ml的多孔元素，以及其特征在于，孔径为1〜30μm的多孔质元素的孔的孔体积的总和为总孔体积的90％以上。还公开了一种用于从含有上述过滤材料的含白细胞的悬浮液中选择性除去白细胞的过滤装置。由于过滤器材料，过滤装置不仅可以白细胞去除效率从含白细胞的悬浮液中除去白细胞，白细胞残留率优于10-4或更低，而不会造成压力损失增加，但是也可以使其紧凑。

7. 发明授权

US5051185A Absorbent of .beta..sub.2 -microglobulin 失效
标题翻译： β2-微球蛋白的吸收
公开(公告)号：US5051185A
公开(公告)日：1991-09-24
申请号：US512629
申请日：1990-04-19
申请人： Hiroyuki Watanabe , Tadashi Yokoyama , Naokuni Yamawaki
发明人： Hiroyuki Watanabe , Tadashi Yokoyama , Naokuni Yamawaki
IPC分类号： A61M1/36 , B01J20/32
CPC分类号： A61M1/3679 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/28004 , B01J20/28016 , B01J20/28023 , B01J20/28033 , B01J20/28059 , B01J20/28078 , B01J20/3092 , B01J20/321 , B01J20/3219 , B01J20/3255 , B01J20/3274 , B01J20/3289 , A61M2202/0421 , B01J2220/58 , G03C2001/0471 , Y10S210/905 , Y10S530/813 , Y10S530/815
摘要： An adsorbent for .beta..sub.2 -microglobulin is disclosed, which comprises a water-insoluble carrier having supported thereon, as a ligand, at least one electrolyte selected from the group consisting of a polyamino acid, a polysaccharide, a synthetic high polymer, collagen having an isoelectric point of 9.5 or more, and gelatin having an isoelectric point of 6.5 or more, wherein said electrolyte has a molecular weight not less than 1,000 and an X value of more than 2.0, wherein X is a relationship regarding the skeleton structure of said electrolyte and is the sum of A and B, wherein A represents (the number of carbon atoms of the skeleton structure)-(the number of hydrophilic groups)/(the number of hydrophilic groups); and B represents .vertline.(the number of cationic groups)-(the number of anionic groups).vertline./(the number of hydrophilic groups). The adsorbent exhibits adsorptivity for .beta..sub.2 -microglobulin at high efficiency and high selectivity.

8. 发明授权

US4576927A Porous adsorbent for adsorbing low density lipoproteins 失效
标题翻译：用于吸附低密度脂蛋白的多孔吸附剂
公开(公告)号：US4576927A
公开(公告)日：1986-03-18
申请号：US668795
申请日：1984-11-06
申请人： Toru Kuroda , Naokuni Yamawaki
发明人： Toru Kuroda , Naokuni Yamawaki
IPC分类号： B01J20/32 , B01J20/22
CPC分类号： B01J20/3278 , B01J20/3204 , B01J20/3219 , B01J20/3257 , B01J20/327
摘要： An adsorbent for adsorbing low density lipoproteins, which comprises a surface and, linked with the surface, at least one member selected from a silanol group and a synthetic polyanion member having a molecular weight of 600 or more, and has pores of diameters widely distributed in a specific range. The adsorbent has a high adsorbing capacity for low density lipoproteins and is useful for purifying and regenerating a body fluid with high selectivity for low density lipoproteins.
摘要翻译：一种用于吸附低密度脂蛋白的吸附剂，其包括表面并与表面连接至少一种选自硅烷醇基和分子量为600以上的合成聚阴离子构件的成员，并且具有广泛分布在其中的直径的孔一个特定的范围。吸附剂对低密度脂蛋白具有高吸附能力，可用于对低密度脂蛋白的高选择性的体液的纯化和再生。

9. 发明授权

US4202291A Method for keeping aquatic animals alive over long period of time 失效
标题翻译：长期保存水生动物的方法
公开(公告)号：US4202291A
公开(公告)日：1980-05-13
申请号：US802338
申请日：1977-06-01
申请人： Naoya Kominami , Hirokazu Fukumi , Naokuni Yamawaki , Junji Nomura
发明人： Naoya Kominami , Hirokazu Fukumi , Naokuni Yamawaki , Junji Nomura
IPC分类号： A01K63/02 , A01K61/00 , A01K63/00 , A01K63/04 , C02F1/72
CPC分类号： A01K63/00
摘要： Aquatic animals can be kept in living condition over a long period of time by placing the aquatic animals in environmental water in a large density of more than 200 kg/m.sup.3 ; maintaining the temperature of the environmental water at a lowest possible level in which it is possible for the aquatic animals to exist; controlling the concentrations of ammonia compounds, water-soluble organic compounds and carbonic acid radical in the environmental water so that their levels do not exceed 20 ppm, 150 ppm and 1,000 ppm, respectively; and regulating the concentration of molecular oxygen dissolved in the environmental water so that it is 3 ppm or more.
摘要翻译：水生动物可以长时间保持在生活状态，将水生动物放置在200公斤/立方米以上的环境水中; 将环境水的温度保持在水生动物可能存在的最低水平; 控制环境水中氨化合物，水溶性有机化合物和碳酸根的浓度，使其水平分别不超过20ppm，150ppm和1,000ppm; 并调节溶解在环境水中的分子氧的浓度，使其为3ppm以上。

10. 发明授权

US4182267A Apparatus for keeping aquatic animals alive over long period of time 失效
标题翻译：保持水生动物长时间活着的装置
公开(公告)号：US4182267A
公开(公告)日：1980-01-08
申请号：US803339
申请日：1977-06-03
申请人： Naoya Kominami , Hirokazu Fukumi , Naokuni Yamawaki , Junji Nomura , Hiroshi Kayamori
发明人： Naoya Kominami , Hirokazu Fukumi , Naokuni Yamawaki , Junji Nomura , Hiroshi Kayamori
IPC分类号： A01K63/02 , A01K63/00 , C02F1/72
CPC分类号： A01K63/00
摘要： Aquatic animals can be kept alive over a long period of time by utilizing the apparatus of the present invention comprising:a water tank for containing aquatic animals and environmental water, which tank has an inside volume large enough to contain the aquatic animals in an amount greater than 200 kg per m.sup.3 of the environmental water;a control path for containing a portion of the environmental water, which control path is located outside the water tank and is connected to the water tank through a windraw pipe and a return pipe line, while containing therein the following means:(1) means for controlling the temperature of the environmental water in the control path so that the temperature is maintained at a level as low as it is possible for the aquatic animals to exist,(2) means for bringing the environmental water in the control path into contact with air,(3) means for eliminating ammonia compounds from the environmental water, and(4) means for eliminating water-soluble organic compounds from the environmental water, and;a pump for recycling the environmental water through the water tank, the withdraw pipe line, the control path and the return pipe line.
摘要翻译：通过利用本发明的装置，水生动物可以长时间保存，包括：用于容纳水生动物和环境水的水箱，该罐具有足够大的内部容积以容纳更多的水生动物每立方米环保用水200公斤以上; 用于容纳环境水的一部分的控制路径，该控制路径位于水箱外部，并且通过制冰管和回流管线连接到水箱，同时容纳以下装置：（1）用于控制控制路径中的环境水的温度，使得温度保持在水生动物可能存在的水平上，（2）使控制路径中的环境水与空气接触的装置，（3）从环境水中除去氨化合物的手段，（4）从环境水中除去水溶性有机化合物的手段; 一个用于通过水箱回收环境水的泵，抽出管线，控制路径和回流管线。

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