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1. 发明授权

US08354498B2 CD4 mimic peptides and their uses 有权
标题翻译： CD4模拟肽及其用途
公开(公告)号：US08354498B2
公开(公告)日：2013-01-15
申请号：US12304485
申请日：2007-05-09
申请人： Loïc Martin , François Stricher , Anne Descours , Laurence Morellato , Mireille Sauvage-Vita , Fabio Vita , Elena Vita
发明人： Claudio Vita , Loïc Martin , François Stricher , Anne Descours , Laurence Morellato
IPC分类号： C07K14/73
CPC分类号： C07K14/70514
摘要： An isolated peptide comprising the sequence (I): TPA-Asn-Leu-His-Phe-Cys-Gln-Leu-Xaaa-Cys-Lys-Ser-Leu-Gly-Leu-Leu-Gly-Arg-Cys-Xaab-Xaac-Xaad-Xaae-Cys-Ala-Cys-Val-NH2, wherein: TPA represents thiopropionic acid; Xaaa represents Arg, Lys; Xaab represents Ala, Arg; Xaac represents a D-amino acid; Xaad represents Thr, Ser, Asn; Xaae represents phenylalanine or a phenylalanine derivative having the structure (II), where A is absent or represents S, O, NH or CH2, B is absent or represents a C1 to C6 branched or straight-chain alkyl, and R represents a C3 to C6 alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, cycloheterocyloalkenyl, aryl, or heteroaryl, and the use of the peptide for manufacturing anti-HIV therapeutic or vaccine compositions are disclosed herein.
摘要翻译：包含序列（I）的分离的肽：TPA-Asn-Leu-His-Phe-Cys-Gln-Leu-Xaaa-Cys-Lys-Ser-Leu-Gly-Leu-Leu-Gly-Arg-Cys-Xaab- Xaac-Xaad-Xaae-Cys-Ala-Cys-Val-NH 2，其中：TPA代表硫代丙酸; Xaaa代表Arg，Lys; Xaab代表Ala，Arg; Xaac代表D-氨基酸; Xaad代表Thr，Ser，Asn; Xaae表示苯丙氨酸或具有结构（II）的苯丙氨酸衍生物，其中A不存在或表示S，O，NH或CH 2，B不存在或表示C1至C6支链或直链烷基，R表示C3至 C6烷基，杂烷基，环烷基，杂环烷基，环烯基，环庚烯基，芳基或杂芳基，并且本文公开了用于制备抗HIV治疗剂或疫苗组合物的肽的用途。

2. 发明授权

US09321849B2 Uranium-chelating peptides and uses thereof 有权
标题翻译：铀螯合肽及其用途
公开(公告)号：US09321849B2
公开(公告)日：2016-04-26
申请号：US12979787
申请日：2010-12-28
申请人： Claudio Vita , Mireille Sauvage-Vita , Fabio Vita , Elena Vita , Loïc Le Clainche , Véronique Monjardet
发明人： Claudio Vita , Loïc Le Clainche , Véronique Monjardet
IPC分类号： A61K38/16 , C07K14/00 , C01G43/00 , C07K19/00 , C07K14/47 , A61K38/00
CPC分类号： C07K19/00 , A61K38/00 , C07K14/4728 , C07K2319/00 , G01N2333/4727
摘要： The invention concerns uranium-chelating peptides as well as their uses for decontaminating soils and water, and for detecting and treating people contaminated by uranium. Said peptides have a helix-loop-helix type structure comprising the sequence of a calmodulin loop including at least one mutation of neutral residues selected from the group consisting of S, T, C, H, Y, N and Q, of one, two or three residues of at least one of the four calmodulin calcium binding sites: site I: residues selected among D20, D22 and D24 residues; site II: residues selected among D56, D58 and N60 residues; site III: residues selected among D93, D95 and N97 residues; site IV: residues selected among D129, D131 and D133 residues; said positions being indicated with reference to the human calmodulin sequence.
摘要翻译：本发明涉及铀螯合肽以及其用于净化土壤和水的用途，以及用于检测和处理被铀污染的人。所述肽具有螺旋 - 环 - 螺旋型结构，其包含钙调蛋白环的序列，包括至少一个选自S，T，C，H，Y，N和Q的中性残基的突变，其中一个，两个或四个钙调蛋白钙结合位点中的至少一个的三个残基：位点I：选自D20，D22和D24残基的残基; 位点II：选自D56，D58和N60残基的残基; 位点III：选自D93，D95和N97残基的残基; 位点IV：选自D129，D131和D133残基的残基; 所述位置参照人钙调蛋白序列来指示。

3. 发明申请

US20110093964A1 URANIUM-CHELATING PEPTIDES AND USES THEREOF 有权
标题翻译：尿TING TING P。。。。。。。。。。。。。。。
公开(公告)号：US20110093964A1
公开(公告)日：2011-04-21
申请号：US12979787
申请日：2010-12-28
申请人： Claudio Vita , Mireille Sauvage-Vita , Fabio Vita , Elena Vita , Loïc Le Clainche , Véronique Monjardet
发明人： Claudio Vita , Mireille Sauvage-Vita , Fabio Vita , Elena Vita , Loïc Le Clainche , Véronique Monjardet
IPC分类号： B09C1/10 , C07K2/00 , C07K14/435 , C07K19/00 , G01N33/20 , G01N33/50 , C07H21/00 , C12N15/63 , C12N5/10 , C12N1/00 , A01K67/00 , A01H5/00 , C12Q1/02 , C07K16/18 , C02F1/62 , C02F3/32 , G21F9/06 , B09C1/00
CPC分类号： C07K19/00 , A61K38/00 , C07K14/4728 , C07K2319/00 , G01N2333/4727
摘要： The invention concerns uranium-chelating peptides as well as their uses for decontaminating soils and water, and for detecting and treating people contaminated by uranium. Said peptides have a helix-loop-helix type structure comprising the sequence of a calmodulin loop including at least one mutation of neutral residues selected from the group consisting of S, T, C, H, Y, N and Q, of one, two or three residues of at least one of the four calmodulin calcium binding sites: site I: residues selected among D20, D22 and D24 residues; site II: residues selected among D56, D58 and N60 residues; site III: residues selected among D93, D95 and N97 residues; site IV: residues selected among D129, D131 and D133 residues; said positions being indicated with reference to the human calmodulin sequence.
摘要翻译：本发明涉及铀螯合肽及其用于净化土壤和水的用途，以及用于检测和处理被铀污染的人。所述肽具有螺旋 - 环 - 螺旋型结构，其包含钙调蛋白环的序列，包括至少一个选自S，T，C，H，Y，N和Q的中性残基的突变，其中一个，两个或四个钙调蛋白钙结合位点中的至少一个的三个残基：位点I：选自D20，D22和D24残基的残基; 位点II：选自D56，D58和N60残基的残基; 位点III：选自D93，D95和N97残基的残基; 位点IV：选自D129，D131和D133残基的残基; 所述位置参照人钙调蛋白序列来指示。

4. 发明授权

US07888311B2 Uranium-chelating peptides and uses thereof 有权
标题翻译：铀螯合肽及其用途
公开(公告)号：US07888311B2
公开(公告)日：2011-02-15
申请号：US10562323
申请日：2004-07-01
申请人： Claudio Vita , Mireille Sauvage-Vita, legal representative , Fabio Vita, legal representative , Elena Vita, legal representative , Loïc Le Clainche , Véronique Monjardet
发明人： Claudio Vita , Loïc Le Clainche , Véronique Monjardet
IPC分类号： A61K38/00 , A61K31/555 , A01N55/02
CPC分类号： C07K19/00 , A61K38/00 , C07K14/4728 , C07K2319/00 , G01N2333/4727
摘要： The invention concerns uranium-chelating peptides as well as their uses for decontaminating soils and water, and for detecting and treating people contaminated by uranium. Said peptides have a helix-loop-helix type structure comprising the sequence of a calmodulin loop including at least one mutation of neutral residues selected from the group consisting of S, T, C, H, Y, N and Q, of one, two or three residues of at least one of the four calmodulin calcium binding sites: site I: residues selected among D20, D22 and D24 residues; site II: residues selected among D56, D58 and N60 residues; site III: residues selected among D93, D95 and N97 residues; site IV: residues selected among D129, D131 and D133 residues; said positions being indicated with reference to the human calmodulin sequence.
摘要翻译：本发明涉及铀螯合肽及其用于净化土壤和水的用途，以及用于检测和处理被铀污染的人。所述肽具有螺旋 - 环 - 螺旋型结构，其包含钙调蛋白环的序列，包括至少一个选自S，T，C，H，Y，N和Q的中性残基的突变，其中一个，两个或四个钙调蛋白钙结合位点中的至少一个的三个残基：位点I：选自D20，D22和D24残基的残基; 位点II：选自D56，D58和N60残基的残基; 位点III：选自D93，D95和N97残基的残基; 位点IV：选自D129，D131和D133残基的残基; 所述位置参照人钙调蛋白序列来指示。

5. 发明申请

US20090285798A1 CD4 MIMIC PEPTIDES AND THEIR USES 有权
标题翻译： CD4 MIMIC PEPTIDES及其用途
公开(公告)号：US20090285798A1
公开(公告)日：2009-11-19
申请号：US12304485
申请日：2007-05-09
申请人： Claudio Vita , Mireille Sauvage-Vita , Fabio Vita , Elena Vita , Loïc Martin , Francois Stricher , Anne Descours , Laurence Morellato
发明人： Claudio Vita , Mireille Sauvage-Vita , Fabio Vita , Elena Vita , Loïc Martin , Francois Stricher , Anne Descours , Laurence Morellato
IPC分类号： A61K39/395 , C07K14/00 , A61K38/16 , A61P31/18
CPC分类号： C07K14/70514
摘要： An isolated peptide comprising the sequence (I): TPA-Asn-Leu-His-Phe-Cys-Gln-Leu-Xaaa-Cys-Lys-Ser-Leu-Gly-Leu-Leu-Gly-Arg-Cys-Xaab-Xaac-Xaad-Xaae-Cys-Ala-Cys-Val-NH2, wherein: TPA represents thiopropionic acid; Xaaa represents Arg, Lys; Xaab represents Ala, Arg; Xaac represents a D-amino acid; Xaad represents Thr, Ser, Asn; Xaae represents phenylalanine or a phenylalanine derivative having the structure (II), where A is absent or represents S, O, NH or CH2, B is absent or represents a C1 to C6 branched or straight-chain alkyl, and R represents a C3 to C6 alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, cycloheterocyloalkenyl, aryl, or heteroaryl, and the use of the peptide for manufacturing anti-HIV therapeutic or vaccine compositions are disclosed herein.
摘要翻译：包含序列（I）的分离的肽：TPA-Asn-Leu-His-Phe-Cys-Gln-Leu-Xaaa-Cys-Lys-Ser-Leu-Gly-Leu-Leu-Gly-Arg-Cys-Xaab- Xaac-Xaad-Xaae-Cys-Ala-Cys-Val-NH 2，其中：TPA代表硫代丙酸; Xaaa代表Arg，Lys; Xaab代表Ala，Arg; Xaac代表D-氨基酸; Xaad代表Thr，Ser，Asn; Xaae表示苯丙氨酸或具有结构（II）的苯丙氨酸衍生物，其中A不存在或表示S，O，NH或CH 2，B不存在或表示C1至C6支链或直链烷基，R表示C3至 C6烷基，杂烷基，环烷基，杂环烷基，环烯基，环庚烯基，芳基或杂芳基，并且本文公开了用于制备抗HIV治疗剂或疫苗组合物的肽的用途。

6. 发明申请

US20100015056A1 Uranium-chelating peptides and uses thereof 有权
标题翻译：铀螯合肽及其用途
公开(公告)号：US20100015056A1
公开(公告)日：2010-01-21
申请号：US10562323
申请日：2004-07-01
申请人： Claudio Vita , Mireille Sauvage-Vita , Fabio Vita , Elena Vita , Loïc Le Clainche , Véronique Monjardet
发明人： Claudio Vita , Mireille Sauvage-Vita , Fabio Vita , Elena Vita , Loïc Le Clainche , Véronique Monjardet
IPC分类号： C07K14/435 , C07K19/00 , C07H21/00 , C12N15/63 , C12N5/10 , A01K67/00 , A01H5/00 , C12Q1/02 , A61K49/00 , C07K16/00 , A62D3/02 , G21F9/00 , C02F1/68
CPC分类号： C07K19/00 , A61K38/00 , C07K14/4728 , C07K2319/00 , G01N2333/4727
摘要： The invention concerns uranium-chelating peptides as well as their uses for decontaminating soils and water, and for detecting and treating people contaminated by uranium. Said peptides have a helix-loop-helix type structure comprising the sequence of a calmodulin loop including at least one mutation of neutral residues selected from the group consisting of S, T, C, H, Y, N and Q, of one, two or three residues of at least one of the four calmodulin calcium binding sites: site I: residues selected among D20, D22 and D24 residues; site II: residues selected among D56, D58 and N60 residues; site III: residues selected among D93, D95 and N97 residues; site IV: residues selected among D129, D131 and D133 residues; said positions being indicated with reference to the human calmodulin sequence.
摘要翻译：本发明涉及铀螯合肽及其用于净化土壤和水的用途，以及用于检测和处理被铀污染的人。所述肽具有螺旋 - 环 - 螺旋型结构，其包含钙调蛋白环的序列，包括至少一个选自S，T，C，H，Y，N和Q的中性残基的突变，其中一个，两个或四个钙调蛋白钙结合位点中的至少一个的三个残基：位点I：选自D20，D22和D24残基的残基; 位点II：选自D56，D58和N60残基的残基; 位点III：选自D93，D95和N97残基的残基; 位点IV：选自D129，D131和D133残基的残基; 所述位置参照人钙调蛋白序列来指示。

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