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1. 发明授权

US08812239B2 Method and system for real-time analysis of biosensor data 有权
标题翻译：生物传感器数据实时分析方法与系统
公开(公告)号：US08812239B2
公开(公告)日：2014-08-19
申请号：US11302844
申请日：2005-12-14
申请人： Elias Greenbaum , Miguel Rodriguez, Jr.
发明人： Elias Greenbaum , Miguel Rodriguez, Jr.
IPC分类号： G01N33/50 , G01N33/48 , G06F19/00
CPC分类号： G06F19/00 , C12Q1/02 , C12Q1/22 , G01N2333/405
摘要： A method of biosensor-based detection of toxins includes the steps of providing a fluid to be analyzed having a plurality of photosynthetic organisms therein, wherein chemical, biological or radiological agents alter a nominal photosynthetic activity of the photosynthetic organisms. At a first time a measured photosynthetic activity curve is obtained from the photosynthetic organisms. The measured curve is automatically compared to a reference photosynthetic activity curve to determine differences therebetween. The presence of the chemical, biological or radiological agents, or precursors thereof, are then identified if present in the fluid using the differences.
摘要翻译：一种基于生物传感器的毒素检测方法包括以下步骤：提供待分析的流体，其中具有多个光合生物，其中化学，生物或放射剂改变光合生物的标称光合活性。第一次从光合生物获得测量的光合活性曲线。测量曲线自动与参考光合活性曲线进行比较，以确定它们之间的差异。然后如果使用差异存在于流体中，则鉴定化学，生物或放射性物质或其前体的存在。

2. 发明申请

US20120238009A1 BIOSENSOR METHOD AND SYSTEM BASED ON FEATURE VECTOR EXTRACTION 有权
标题翻译：基于特征向量提取的生物传感器方法和系统
公开(公告)号：US20120238009A1
公开(公告)日：2012-09-20
申请号：US13431664
申请日：2012-03-27
申请人： Elias Greenbaum , Miguel Rodriguez, JR. , Hairong Qi , Xiaoling Wang
发明人： Elias Greenbaum , Miguel Rodriguez, JR. , Hairong Qi , Xiaoling Wang
IPC分类号： C12M1/34
CPC分类号： C12Q1/025
摘要： A system for biosensor-based detection of toxins includes providing at least one time-dependent control signal generated by a biosensor in a gas or liquid medium, and obtaining a time-dependent biosensor signal from the biosensor in the gas or liquid medium to be monitored or analyzed for the presence of one or more toxins selected from chemical, biological or radiological agents. The time-dependent biosensor signal is processed to obtain a plurality of feature vectors using at least one of amplitude statistics and a time-frequency analysis. At least one parameter relating to toxicity of the gas or liquid medium is then determined from the feature vectors based on reference to the control signal.
摘要翻译：用于基于生物传感器的毒素检测系统包括在气体或液体介质中提供由生物传感器产生的至少一个与时间有关的控制信号，并从待监测的气体或液体介质中的生物传感器获得时间依赖的生物传感器信号或分析一种或多种选自化学，生物或放射剂的毒素的存在。处理时间依赖的生物传感器信号以使用幅度统计和时间 - 频率分析中的至少一个来获得多个特征向量。然后，基于对控制信号的参考，从特征向量确定与气体或液体介质的毒性有关的至少一个参数。

3. 发明授权

US07258836B2 Freeze resistant buoy system 有权
标题翻译：防冻浮标系统
公开(公告)号：US07258836B2
公开(公告)日：2007-08-21
申请号：US10689261
申请日：2003-10-20
申请人： David E. Hill , Miguel Rodriguez, Jr. , Elias Greenbaum , James W. Klett
发明人： David E. Hill , Miguel Rodriguez, Jr. , Elias Greenbaum , James W. Klett
IPC分类号： G01N21/00
CPC分类号： B63B22/24 , B63B2035/4453
摘要： A freeze resistant buoy system includes a tail-tube buoy having a thermally insulated section disposed predominantly above a waterline, and a thermo-siphon disposed predominantly below the waterline.
摘要翻译：防冻浮标系统包括具有主要位于水线以上的绝热部分的尾管浮标和主要位于水线下方的热虹吸管。

4. 发明授权

US08476062B2 Biosensor method and system based on feature vector extraction 有权
标题翻译：基于特征向量提取的生物传感器方法和系统
公开(公告)号：US08476062B2
公开(公告)日：2013-07-02
申请号：US13431664
申请日：2012-03-27
申请人： Elias Greenbaum , Miguel Rodriguez, Jr. , Hairong Qi , Xiaoling Wang
发明人： Elias Greenbaum , Miguel Rodriguez, Jr. , Hairong Qi , Xiaoling Wang
IPC分类号： C12M1/00 , C12M1/34 , C12M3/00
CPC分类号： C12Q1/025
摘要： A system for biosensor-based detection of toxins includes providing at least one time-dependent control signal generated by a biosensor in a gas or liquid medium, and obtaining a time-dependent biosensor signal from the biosensor in the gas or liquid medium to be monitored or analyzed for the presence of one or more toxins selected from chemical, biological or radiological agents. The time-dependent biosensor signal is processed to obtain a plurality of feature vectors using at least one of amplitude statistics and a time-frequency analysis. At least one parameter relating to toxicity of the gas or liquid medium is then determined from the feature vectors based on reference to the control signal.
摘要翻译：用于基于生物传感器的毒素检测系统包括在气体或液体介质中提供由生物传感器产生的至少一个与时间有关的控制信号，并从待监测的气体或液体介质中的生物传感器获得时间依赖的生物传感器信号或分析一种或多种选自化学，生物或放射剂的毒素的存在。处理时间依赖的生物传感器信号以使用幅度统计和时间 - 频率分析中的至少一个来获得多个特征向量。然后，基于对控制信号的参考，从特征向量确定与气体或液体介质的毒性有关的至少一个参数。

5. 发明申请

US20120244572A1 METHOD AND APPARATUS FOR ENHANCED DETECTION OF TOXIC AGENTS 有权
标题翻译：增强毒性试剂检测方法和装置
公开(公告)号：US20120244572A1
公开(公告)日：2012-09-27
申请号：US13474183
申请日：2012-05-17
申请人： Elias GREENBAUM , Miguel RODRIGUEZ, JR. , Jie Jayne WU , Hairong Qi
发明人： Elias GREENBAUM , Miguel RODRIGUEZ, JR. , Jie Jayne WU , Hairong Qi
IPC分类号： G01N21/64
CPC分类号： C12Q1/025
摘要： A water quality analyzer for real-time detection according to the invention comprises a biased AC electro-osmosis (ACEO) cell for receiving a fluid to be analyzed having a plurality photosynthetic organisms therein, and concentrating the plurality photosynthetic organisms into at least one concentrated region. A photodetector is provided for obtaining a measured photosynthetic activity of the plurality of photosynthetic organisms in the concentrated region: wherein chemical, biological or radiological agents reduce a nominal photosynthetic activity of the photosynthetic organisms. An electronics package analyzes the measured photosynthetic activity to indicate a presence of the chemical, biological or radiological agents in the fluid.
摘要翻译：根据本发明的用于实时检测的水质分析器包括偏置AC电渗透（ACEO）电池，用于接收待分析的流体，其中具有多个光合生物，并将多个光合生物浓缩成至少一个集中区域。提供光电检测器用于获得在浓缩区域中的多个光合生物测量的光合活性：其中化学，生物或放射剂降低光合生物的标称光合活性。电子组件分析测量的光合活性以指示流体中化学，生物或放射性剂的存在。

6. 发明授权

US08546073B2 Method and apparatus for enhanced detection of toxic agents 有权
标题翻译：用于增强毒性剂检测的方法和装置
公开(公告)号：US08546073B2
公开(公告)日：2013-10-01
申请号：US13474183
申请日：2012-05-17
申请人： Elias Greenbaum , Miguel Rodriguez, Jr. , Jie Jayne Wu , Hairong Qi
发明人： Elias Greenbaum , Miguel Rodriguez, Jr. , Jie Jayne Wu , Hairong Qi
IPC分类号： C12N1/00 , C12Q1/00 , C12Q1/06 , C12Q1/24
CPC分类号： C12Q1/025
摘要： A biosensor based detection of toxins includes enhancing a fluorescence signal by concentrating a plurality of photosynthetic organisms in a fluid into a concentrated region using biased AC electro-osmosis. A measured photosynthetic activity of the photosynthetic organisms is obtained in the concentrated region, where chemical, biological or radiological agents reduce a nominal photosynthetic activity of the photosynthetic organisms. A presence of the chemical, biological and/or radiological agents or precursors thereof, is determined in the fluid based on the measured photosynthetic activity of the concentrated plurality of photosynthetic organisms. A lab-on-a-chip system is used for the concentrating step. The presence of agents is determined from feature vectors, obtained from processing a time dependent signal using amplitude statistics and/or time-frequency analysis, relative to a control signal. A linear discriminant method including support vector machine classification (SVM) is used to identify the agents.
摘要翻译：基于毒素检测的生物传感器包括通过使用偏压AC电渗析将多个光合生物在流体中浓缩成浓缩区域来增强荧光信号。在浓缩区域获得了光合生物测定的光合活性，其中化学，生物或放射剂降低光合生物的标称光合活性。基于浓缩的多个光合生物的测量的光合活性，在流体中确定化学，生物和/或放射性剂或其前体的存在。用于集中步骤的芯片实验室芯片系统。使用幅度统计和/或时间 - 频率分析从相对于控制信号处理与时间相关的信号获得的特征向量来确定代理的存在。使用支持向量机分类（SVM）的线性判别方法来识别代理。

7. 发明授权

US08158377B2 Biosensor method and system based on feature vector extraction 有权
标题翻译：基于特征向量提取的生物传感器方法和系统
公开(公告)号：US08158377B2
公开(公告)日：2012-04-17
申请号：US11216282
申请日：2005-08-31
申请人： Elias Greenbaum , Miguel Rodriguez, Jr. , Hairong Qi , Xiaoling Wang
发明人： Elias Greenbaum , Miguel Rodriguez, Jr. , Hairong Qi , Xiaoling Wang
IPC分类号： C02F3/34 , C12M1/00 , C12N1/00 , C12Q1/00 , C12Q1/02
CPC分类号： C12Q1/025
摘要： A method of biosensor-based detection of toxins comprises the steps of providing at least one time-dependent control signal generated by a biosensor in a gas or liquid medium, and obtaining a time-dependent biosensor signal from the biosensor in the gas or liquid medium to be monitored or analyzed for the presence of one or more toxins selected from chemical, biological or radiological agents. The time-dependent biosensor signal is processed to obtain a plurality of feature vectors using at least one of amplitude statistics and a time-frequency analysis. At least one parameter relating to toxicity of the gas or liquid medium is then determined from the feature vectors based on reference to the control signal.
摘要翻译：一种基于生物传感器的毒素检测方法包括以下步骤：在气体或液体介质中提供由生物传感器产生的至少一个时间依赖的控制信号，并从气体或液体介质中的生物传感器获得时间依赖的生物传感器信号被监测或分析一种或多种选自化学，生物或放射剂的毒素的存在。处理时间依赖的生物传感器信号以使用幅度统计和时间 - 频率分析中的至少一个来获得多个特征向量。然后，基于对控制信号的参考，从特征向量确定与气体或液体介质的毒性有关的至少一个参数。

8. 发明授权

US08198075B2 Method and apparatus for enhanced detection of toxic agents 有权
标题翻译：用于增强毒性剂检测的方法和装置
公开(公告)号：US08198075B2
公开(公告)日：2012-06-12
申请号：US11271643
申请日：2005-11-10
申请人： Elias Greenbaum , Miguel Rodriguez, Jr. , Jie Jayne Wu , Hairong Qi
发明人： Elias Greenbaum , Miguel Rodriguez, Jr. , Jie Jayne Wu , Hairong Qi
IPC分类号： C12M1/00 , C12M1/34 , C12M1/36 , C12M1/38 , C12M3/00 , C12N1/00
CPC分类号： C12Q1/025
摘要： A water quality analyzer for real-time detection according to the invention comprises a biased AC electro-osmosis (ACEO) cell for receiving a fluid to be analyzed having a plurality photosynthetic organisms therein, and concentrating the plurality photosynthetic organisms into at least one concentrated region. A photodetector is provided for obtaining a measured photosynthetic activity of the plurality of photosynthetic organisms in the concentrated region, wherein chemical, biological or radiological agents reduce a nominal photosynthetic activity of the photosynthetic organisms. An electronics package analyzes the measured photosynthetic activity to indicate a presence of the chemical, biological or radiological agents in the fluid.
摘要翻译：根据本发明的用于实时检测的水质分析器包括偏置AC电渗透（ACEO）电池，用于接收待分析的流体，其中具有多个光合生物，并将多个光合生物浓缩成至少一个集中区域。提供光电检测器用于获得在浓缩区域中的多个光合生物测量的光合活性，其中化学，生物或放射剂降低光合生物的标称光合活性。电子组件分析测量的光合活性以指示流体中化学，生物或放射性剂的存在。

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