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1. 发明授权

US06626959B1 Automatic formatting of pivot table reports within a spreadsheet 有权
标题翻译：在电子表格中自动格式化数据透视表报表
公开(公告)号：US06626959B1
公开(公告)日：2003-09-30
申请号：US09332958
申请日：1999-06-14
申请人： Wesner P. Moise , Thomas P. Conlon , Michelle Lee Thompson
发明人： Wesner P. Moise , Thomas P. Conlon , Michelle Lee Thompson
IPC分类号： G06F1500
CPC分类号： G06F17/246
摘要： Automatically formatting a spreadsheet pivot table using one of a plurality of predefined formats that include banded report formats and tabular report formats. The pivot table is reformatted automatically, based on a user selection of a predefined banded table or tabular format. Alternatively, the format of an original pivot table or a reformatted pivot table may be changed based on user choices made from a plurality of formatting dialogs. The automatically and modified formats include field emphasis, positioning of group totals, and insertion of blank lines. The predefined formats include a variety of different font styles, colors, backgrounds and borders. A reformatted pivot table has an enhanced appearance, while maintaining the full-functionality associated with a spreadsheet pivot table. The underlying format of a reformatted pivot table is maintained, allowing a user to move, add, or delete fields and add or remove calculated data without altering the overall format of the reformatted pivot table.
摘要翻译：使用包含带状报告格式和表格报告格式的多种预定格式之一自动格式化电子表格数据透视表。基于用户选择预定义的带状表或表格格式，自动重新格式化数据透视表。或者，可以基于从多个格式化对话中进行的用户选择来改变原始枢轴表或重新格式化的枢轴表的格式。自动和修改的格式包括字段强调，组总计的定位和空行的插入。预定义的格式包括各种不同的字体样式，颜色，背景和边框。重新格式化的数据透视表具有增强的外观，同时保持与电子表格数据透视表相关联的全部功能。维护重新格式化的数据透视表的基本格式，允许用户移动，添加或删除字段，并添加或删除计算的数据，而不会更改重新格式化的数据透视表的整体格式。

2. 发明申请

US20110178093A1 TETRASUBSTITUTED PYRIDAZINES HEDGEHOG PATHWAY ANTAGONISTS 失效
标题翻译：四甲基磷酰胆碱（HEDGEHOG PATHWAY ANTAGONISTS）
公开(公告)号：US20110178093A1
公开(公告)日：2011-07-21
申请号：US13122225
申请日：2009-11-09
申请人： Jolie Anne Bastian , Julia Marie Clay , Takako Wilson (nee Takakuwa) , Michelle Lee Thompson , Daniel Jon Sall , Philip Arthur Hipskind
发明人： Jolie Anne Bastian , Julia Marie Clay , Takako Wilson (nee Takakuwa) , Michelle Lee Thompson , Daniel Jon Sall , Philip Arthur Hipskind
IPC分类号： A61K31/501 , C07D403/04 , A61P35/00
CPC分类号： C07D403/04
摘要： The present invention provides novel tetrasubstituted pyridazine hedgehog pathway antagonists useful in the treatment of cancer.
摘要翻译：本发明提供可用于治疗癌症的新型四取代哒嗪猬草素途径拮抗剂。

3. 发明授权

US07625932B2 Pyrrole and pyrazole derivatives as potentiators of glutamate receptors 失效
标题翻译：吡咯和吡唑衍生物作为谷氨酸受体的增效剂
公开(公告)号：US07625932B2
公开(公告)日：2009-12-01
申请号：US10570985
申请日：2004-08-27
申请人： Pamela Ann Albaugh , Esteban Dominguez-Manzanares , Jian Eric Hong , William Joseph Hornback , Delu Jiang , Paul Leslie Ornstein , Michelle Lee Thompson , Eric George Tromiczak , Zhipei Wu , Hamideh Zarrinmayeh , Dennis Michael Zimmerman , Ana Maria Castano Mansanet , Larry Gene Huffman , William David Miller
发明人： Pamela Ann Albaugh , Esteban Dominguez-Manzanares , Jian Eric Hong , William Joseph Hornback , Delu Jiang , Paul Leslie Ornstein , Michelle Lee Thompson , Eric George Tromiczak , Zhipei Wu , Hamideh Zarrinmayeh , Dennis Michael Zimmerman , Ana Maria Castano Mansanet , Larry Gene Huffman , William David Miller
IPC分类号： A61K31/675 , A61K31/433 , C07D417/02 , C07D413/02
CPC分类号： C07D207/34 , C07D207/36 , C07D231/14 , C07D401/10 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/10 , C07D409/10 , C07D409/12 , C07D413/10 , C07D417/10
摘要： The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression. The compounds act as potentiators on glutamate receptors, in particular AMPA and the GluR family.
摘要翻译：本发明涉及式（I）的吡咯和吡唑化合物及其药学上可接受的盐，并且还涉及它们在治疗精神分裂症，与精神分裂症相关的认知缺陷，阿尔茨海默病，阿尔茨海默氏型痴呆，轻度认知障碍或萧条。这些化合物作为谷氨酸受体，特别是AMPA和GluR家族的增效剂。

4. 发明申请

US20110263602A1 TETRASUBSTITUTED PYRIDAZINE HEDGEHOG PATHWAY ANTAGONISTS 失效
标题翻译：四唑基吡啶恶嗪路线拮抗剂
公开(公告)号：US20110263602A1
公开(公告)日：2011-10-27
申请号：US13122216
申请日：2009-11-05
申请人： Jolie Anne Bastian , Julia Marie Clay , Jeffrey Daniel Cohen , Philip Arthur Hipskind , Karen Lynn Lobb , Daniel Jon Sall , Michelle Lee Thompson , Takako Wilson (nee Takakuwa)
发明人： Jolie Anne Bastian , Julia Marie Clay , Jeffrey Daniel Cohen , Philip Arthur Hipskind , Karen Lynn Lobb , Daniel Jon Sall , Michelle Lee Thompson , Takako Wilson (nee Takakuwa)
IPC分类号： A61K31/5377 , A61P35/00 , C07D413/14 , C07D401/04 , C07D401/14 , A61K31/501
CPC分类号： C07D401/04 , C07D401/14 , C07D417/14
摘要： The present invention provides novel tetrasubstituted pyridine hedgehog pathway antagonists of the following formula I (I) or a pharmaceutically acceptable salt thereof, wherein: X is C—R1 or N; R1 is hydrogen, fluoro or cyano; R2 is formula II (II), piperidinyl, or gem di-F-substituted cyclohexyl; R3 is methyl or trifluoromethyl; R4 is pyrrolidinyl, morpholinyl or pyridyl, amino or dimethylamino; R5 is trifluoromethyl or methylsulfonyl; R6 is hydrogen or methyl; and R7, R8, R9, R10 and R11 are independently hydrogen fluoro, cyano, chloro, methyl, trifluoromethyl, trifluoromethoxy or methylsulfonyl, provided that at least two of R7, R8, R9, R10 and R11 are hydrogen useful in the treatment of cancer.
摘要翻译：本发明提供下式I（I）的新型四取代吡啶hedgehog途径拮抗剂或其药学上可接受的盐，其中：X为C-R 1或N; R1是氢，氟或氰基; R2是式II（II），哌啶基或gem二-F取代的环己基; R3是甲基或三氟甲基; R4是吡咯烷基，吗啉基或吡啶基，氨基或二甲基氨基; R5是三氟甲基或甲基磺酰基; R6是氢或甲基; 并且R 7，R 8，R 9，R 10和R 11中的至少两个是可用于治疗癌症的氢，并且R 7，R 8，R 9，R 10和R 11独立地为氢，氰基，氯，甲基，三氟甲基，三氟甲氧基或甲基磺酰基。

5. 发明授权

US08507490B2 Tetrasubstituted pyridazine hedgehog pathway antagonists 失效
标题翻译：四取代的哒嗪刺猬通路拮抗剂
公开(公告)号：US08507490B2
公开(公告)日：2013-08-13
申请号：US13122216
申请日：2009-11-05
申请人： Jolie Anne Bastian , Julia Marie Clay , Jeffrey Daniel Cohen , Philip Arthur Hipskind , Karen Lynn Lobb , Daniel Jon Sall , Michelle Lee Thompson , Takako Wilson (nee Takakuwa)
发明人： Jolie Anne Bastian , Julia Marie Clay , Jeffrey Daniel Cohen , Philip Arthur Hipskind , Karen Lynn Lobb , Daniel Jon Sall , Michelle Lee Thompson , Takako Wilson (nee Takakuwa)
IPC分类号： C07D401/14 , A61K31/501 , A61P35/00
CPC分类号： C07D401/04 , C07D401/14 , C07D417/14
摘要： The present invention provides novel tetrasubstituted pyridine hedgehog pathway antagonists of the following formula I (I) or a pharmaceutically acceptable salt thereof, wherein: X is C—R1 or N; R1 is hydrogen, fluoro or cyano; R2 is formula II (II), piperidinyl, or gem di-F-substituted cyclohexyl; R3 is methyl or trifluoromethyl; R4 is pyrrolidinyl, morpholinyl or pyridyl, amino or dimethylamino; R5 is trifluoromethyl or methylsulfonyl; R6 is hydrogen or methyl; and R7, R8, R9, R10 and R11 are independently hydrogen fluoro, cyano, chloro, methyl, trifluoromethyl, trifluoromethoxy or methylsulfonyl, provided that at least two of R7, R8, R9, R10 and R11 are hydrogen useful in the treatment of cancer.
摘要翻译：本发明提供下式I（I）的新型四取代吡啶hedgehog途径拮抗剂或其药学上可接受的盐，其中：X为C-R 1或N; R1是氢，氟或氰基; R2是式II（II），哌啶基或gem二-F取代的环己基; R3是甲基或三氟甲基; R4是吡咯烷基，吗啉基或吡啶基，氨基或二甲基氨基; R5是三氟甲基或甲基磺酰基; R6是氢或甲基; 并且R 7，R 8，R 9，R 10和R 11中的至少两个是可用于治疗癌症的氢，并且R 7，R 8，R 9，R 10和R 11独立地为氢，氰基，氯，甲基，三氟甲基，三氟甲氧基或甲基磺酰基。

6. 发明授权

US08445493B2 Tetrasubstituted pyridazines hedgehog pathway antagonists 失效
标题翻译：四氮杂哒嗪类刺猬通路拮抗剂
公开(公告)号：US08445493B2
公开(公告)日：2013-05-21
申请号：US13122225
申请日：2009-11-09
申请人： Jolie Anne Bastian , Julia Marie Clay , Takako Wilson (nee Takakuwa) , Michelle Lee Thompson , Daniel Jon Sall , Philip Arthur Hipskind
发明人： Jolie Anne Bastian , Julia Marie Clay , Takako Wilson (nee Takakuwa) , Michelle Lee Thompson , Daniel Jon Sall , Philip Arthur Hipskind
IPC分类号： C07D401/04 , A61K31/501 , A61P35/00
CPC分类号： C07D403/04
摘要： The present invention provides novel tetrasubstituted pyridazine hedgehog pathway antagonists useful in the treatment of cancer.
摘要翻译：本发明提供可用于治疗癌症的新型四取代哒嗪猬草素途径拮抗剂。

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