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1. 发明申请

US20180169444A1 Method and Apparatus for Ultrasonic Mediation of Drug Delivery Using Microbubbles 审中-公开
公开(公告)号：US20180169444A1
公开(公告)日：2018-06-21
申请号：US15847217
申请日：2017-12-19
申请人： Michalakis Averkiou , Edward Lam Shang Leen
发明人： Michalakis Averkiou , Edward Lam Shang Leen
IPC分类号： A61N7/02 , A61M37/00
CPC分类号： A61N7/02 , A61B8/085 , A61B8/46 , A61B34/30 , A61B2090/065 , A61B2090/378 , A61M37/0092 , A61N7/00 , A61N2007/0039 , A61N2007/0078 , A61N2007/0095
摘要： An ultrasonic therapy system delivers ultrasonic therapy energy to a therapy site in the body which is infused with microbubbles. A system without an image guidance capability has an array transducer which delivers therapy energy, a therapy transducer driver which causes the array transducer to deliver therapeutic energy, a control for controlling the intensity of the therapeutic energy, and a display of the sonotherapy signal strength of the energy and the concentration of microbubbles at the therapy site. A system with ultrasonic imaging capability will display an ultrasound image for therapeutic guidance and a measure of the microbubble concentration. The method of the present invention is performed as an adjunct to a standard drug therapy or other treatment regimen, following such treatment with an infusion of ultrasound and delivery of ultrasound therapy energy.

2. 发明申请

US20080234580A1 Ultrasonic Imaging of Perfusion and Blood Flow with Harmonic Contrast Agents 审中-公开
标题翻译：超声波成像灌注和血流与谐波对比剂
公开(公告)号：US20080234580A1
公开(公告)日：2008-09-25
申请号：US10597532
申请日：2005-01-31
申请人： Matthew Bruce , Jeffrey E. Powers , David Hope Simpson , Michalakis Averkiou
发明人： Matthew Bruce , Jeffrey E. Powers , David Hope Simpson , Michalakis Averkiou
IPC分类号： A61B8/00 , A61B8/14
CPC分类号： A61B8/481 , A61B8/06 , A61B8/08 , A61B8/13 , A61B8/463 , A61B8/488
摘要： An ultrasonic diagnostic imaging method and system produce diagnostic contrast images depicting both tissue perfusion and flow velocity in larger vessels by utilizing both linear and nonlinear imaging techniques. A sequence of echoes from differently modulated transmit pulses is received and processed in different ways to detect nonlinear signals from microbubble-perfused tissue and Doppler blood flow in larger vessels. The Doppler flow signals may be either linear or nonlinear or a mixture of both. A decision circuit classifies the detected signals for display pixels in a perfusion and/or flow and/or tissue image. Separate perfusion and flow images can be simultaneously displayed or an image of both perfusion and flow can be displayed.
摘要翻译：超声诊断成像方法和系统通过利用线性和非线性成像技术产生描绘组织灌注和较大血管中流速的诊断对比图像。来自不同调制的发射脉冲的一系列回波以不同的方式被接收和处理，以检测来自微泡灌注组织的非线性信号和较大血管中的多普勒血流。多普勒流信号可以是线性的或非线性的，或两者的混合。判定电路将检测到的信号分类为灌注和/或流动和/或组织图像中的显示像素。可以同时显示单独的灌注和流动图像，或者可以显示灌注和流动的图像。

3. 发明申请

US20080228075A1 Combination Imaging and Therapy Transducer With Therapy Transducer Amplifier 有权
标题翻译：组合成像和治疗传感器与治疗传感器放大器
公开(公告)号：US20080228075A1
公开(公告)日：2008-09-18
申请号：US12064309
申请日：2006-08-25
申请人： John Fraser , Jeffry E. Powers , Michalakis Averkiou
发明人： John Fraser , Jeffry E. Powers , Michalakis Averkiou
IPC分类号： A61B8/00
CPC分类号： A61B17/22004 , A61B8/0833 , A61B8/14 , A61B8/4405 , A61B8/481 , A61B17/2256 , A61B2017/22028 , A61B2090/378 , G01S15/8918 , G01S15/8977
摘要： A combined ultrasound imaging and therapy transducer (10) includes a linear array of imaging transducer elements (14). First and second linear arrays of therapy transducer elements (18, 20) extend longitudinally along respective first and second sides of the imaging transducer elements and are canted inwardly toward each other. The imaging and therapy transducer is used with an ultrasound imaging system to locate clots in a region of interest. After the region of interest has been perfused with a microbubble contrast agent, the therapy transducer elements are driven by an amplifier located in the transducer to dissolve the clot. The use of the imaging transducer elements and the therapy transducer elements can be interleaved so that the therapy can be conditioned on an ultrasound image showing substantial destruction of the contrast agent microbubbles, re-perfusion of microbubbles in the region of interest, or the continued presence of the clot.
摘要翻译：组合的超声成像和治疗换能器（10）包括成像换能器元件（14）的线性阵列。治疗换能器元件（18,20）的第一和第二线性阵列沿着成像换能器元件的相应的第一和第二侧纵向延伸并且向内朝向彼此倾斜。成像和治疗传感器与超声成像系统一起使用以定位感兴趣区域中的凝块。在用微泡造影剂灌注感兴趣区域之后，治疗换能器元件由位于换能器中的放大器驱动以溶解凝块。可以使用成像换能器元件和治疗换能器元件进行交织，使得治疗可以对超声图像进行调节，该超声图像显示造影剂微泡的显着破坏，感兴趣区域中微泡的再次灌注，或持续存在的凝块。

4. 发明授权

US06540684B2 Ultrasonic perfusion measurement using contrast agents 有权
公开(公告)号：US06540684B2
公开(公告)日：2003-04-01
申请号：US10007287
申请日：2001-11-08
申请人： Michalakis Averkiou , Matthew Bruce , Jeffry E. Powers
发明人： Michalakis Averkiou , Matthew Bruce , Jeffry E. Powers
IPC分类号： A61B806
CPC分类号： A61B8/481 , A61B5/0456 , A61B5/7239 , A61B8/06 , A61B8/08 , A61B8/13 , A61B8/463 , A61B8/483 , A61B8/488 , A61B8/543 , A61K49/223 , G01S7/52026 , G01S7/52038 , G01S7/52039 , G01S7/52041 , G01S15/8959 , G01S15/8963 , G01S15/8993
摘要： Apparatus and methods are disclosed for the detection and imaging of ultrasonic contrast agents. Ultrasonic apparatus is provided for coherent imaging of ultrasonic contrast agents, and for detecting harmonic contrast agents. The inventive apparatus includes a dual display for simultaneously viewing a real time image which displays the location of the contrast agent and a triggered contrast image. Methods of contrast agent detection and imaging include the measurement of perfusion rate characteristics, multizone contrast imaging, multifrequency contrast imaging, tissue perfusion display, and high PRF contrast image artifact elimination.

5. 发明授权

US06315729B1 Ultrasonic diagnostic imaging with contrast agents 有权
标题翻译：超声波诊断成像与造影剂
公开(公告)号：US06315729B1
公开(公告)日：2001-11-13
申请号：US09188650
申请日：1998-11-09
申请人： Michalakis Averkiou , Matthew Bruce , Jeffry E. Powers
发明人： Michalakis Averkiou , Matthew Bruce , Jeffry E. Powers
IPC分类号： A61B800
CPC分类号： A61B8/481 , A61B5/0456 , A61B5/7239 , A61B8/06 , A61B8/08 , A61B8/13 , A61B8/463 , A61B8/483 , A61B8/488 , A61B8/543 , A61K49/223 , G01S7/52026 , G01S7/52038 , G01S7/52039 , G01S7/52041 , G01S15/8959 , G01S15/8963 , G01S15/8993
摘要： Apparatus and methods are disclosed for the detection and imaging of ultrasonic contrast agents. Ultrasonic apparatus is provided for coherent imaging of ultrasonic contrast agents, and for detecting harmonic contrast agents. The inventive apparatus includes a dual display for simultaneously viewing a real time image which displays the location of the contrast agent and a triggered contrast image. Methods of contrast agent detection and imaging include the measurement of perfusion rate characteristics, multizone contrast imaging, multifrequency contrast imaging, tissue perfusion display, and high PRF contrast image artifact elimination.
摘要翻译：公开了用于超声造影剂的检测和成像的装置和方法。提供超声波设备用于超声造影剂的相干成像，以及用于检测谐波造影剂。本发明的装置包括双显示器，用于同时观看显示造影剂的位置的实时图像和触发的对比度图像。造影剂检测和成像的方法包括灌注速率特征，多区域造影成像，多频对比成像，组织灌注显示和高PRF对比度图像伪像消除的测量。

6. 发明授权

US06171246B2 Realtime ultrasonic imaging of perfusion using ultrasonic contrast agents 失效
标题翻译：使用超声造影剂实时灌注超声成像
公开(公告)号：US06171246B2
公开(公告)日：2001-01-09
申请号：US09302063
申请日：1999-04-29
申请人： Michalakis Averkiou , Jeffry E. Powers , Matthew Bruce , Danny M. Skyba
发明人： Michalakis Averkiou , Jeffry E. Powers , Matthew Bruce , Danny M. Skyba
IPC分类号： A61B814
CPC分类号： A61B8/481 , A61B8/543 , G01S7/52038 , G01S7/52039 , G01S15/8981
摘要： Perfusion of tissue such as the myocardium by a microbubble contrast agent is imaged in realtime by a multiple pulse technique which uses low power transmit pulses which are sufficient to elicit a harmonic response from the microbubbles but are not high enough in power to cause substantial destruction to the microbubbles. In a preferred embodiment the realtime microbubble image sequence is displayed in color, overlaid with a grayscale image of the surrounding tissue in the region being imaged.
摘要翻译：通过微泡造影剂对诸如心肌的组织灌注通过多脉冲技术实时成像，所述多脉冲技术使用足以引起来自微泡的谐波响应的低功率发射脉冲，但是不足以引起大量破坏微泡。在优选实施例中，实时微泡图像序列以彩色显示，并与被成像区域中的周围组织的灰度图像重叠。

7. 再颁专利

USRE44708E1 Ultrasonic diagnostic imaging with blended tissue harmonic signals 有权
标题翻译：超声波诊断成像与混合组织谐波信号
公开(公告)号：USRE44708E1
公开(公告)日：2014-01-14
申请号：US11713118
申请日：2007-02-28
申请人： David N. Roundhill , Michalakis Averkiou , Jeffrey E. Powers
发明人： David N. Roundhill , Michalakis Averkiou , Jeffrey E. Powers
IPC分类号： A61B8/14
CPC分类号： G01S7/52038 , A61B8/08 , A61B8/14 , A61B8/463 , A61B8/488 , G01S7/52026 , G01S7/52033 , G01S7/52036 , G01S7/52046 , G01S7/5206 , G01S7/52074 , G01S7/52077 , G01S15/895 , G01S15/8979 , G01S15/8993
摘要： An ultrasonic diagnostic imaging system and method are described which produce tissue harmonic images containing both fundamental and harmonic frequency components. Such a blended image takes advantage of the performance possible with the two types of ultrasonic echo information and can advantageously reduce near field clutter while improving signal to noise performance in the far field of the image.
摘要翻译：描述了产生包含基波和谐波频率分量的组织谐波图像的超声波诊断成像系统和方法。这种混合图像利用两种类型的超声波回波信息来利用可能的性能，并且可以有利地减少近场杂波，同时提高图像的远场中的信噪比性能。

8. 发明授权

US08012092B2 Method of using a combination imaging and therapy transducer to dissolve blood clots 有权
标题翻译：使用组合成像和治疗传感器来溶解血块的方法
公开(公告)号：US08012092B2
公开(公告)日：2011-09-06
申请号：US12065343
申请日：2006-08-25
申请人： Jeffry E. Powers , John Fraser , Michalakis Averkiou
发明人： Jeffry E. Powers , John Fraser , Michalakis Averkiou
IPC分类号： A61B8/14 , A61B7/00
CPC分类号： A61N7/02 , A61B8/0833 , A61B8/14 , A61B8/4405 , A61B8/481 , A61B2017/22008 , A61B2090/378 , A61N2007/0078
摘要： A combined ultrasound imaging and therapy transducer includes a linear array of imaging transducer elements. First and second linear arrays of therapy transducer elements extend longitudinally along respective first and second sides of the imaging transducer elements and are canted inwardly toward each other. The imaging and therapy transducer is used with an ultrasound imaging system to locate clots in a region of interest. After the region of interest has been perfused with a microbubble contrast agent, the therapy transducer elements are driven by an amplifier located in the transducer to dissolve the clot. The use of the imaging transducer elements and the therapy transducer elements can be interleaved so that the therapy can be conditioned on an ultrasound image showing substantial destruction of the contrast agent microbubbles, re-perfusion of microbubbles in the region of interest, or the continued presence of the clot.
摘要翻译：组合的超声成像和治疗换能器包括成像换能器元件的线性阵列。治疗换能器元件的第一和第二线性阵列沿着成像换能器元件的相应第一和第二侧纵向延伸并且向内朝向彼此倾斜。成像和治疗传感器与超声成像系统一起使用以定位感兴趣区域中的凝块。在用微泡造影剂灌注感兴趣区域之后，治疗换能器元件由位于换能器中的放大器驱动以溶解凝块。可以使用成像换能器元件和治疗换能器元件进行交织，使得治疗可以对超声图像进行调节，该超声图像显示造影剂微泡的显着破坏，感兴趣区域中微泡的再次灌注，或持续存在的凝块。

9. 发明申请

US20100298710A1 THERAPY ASSESSMENT WITH ULTRASOUND CONTRAST AGENTS 有权
标题翻译：超声波对比剂的治疗评估
公开(公告)号：US20100298710A1
公开(公告)日：2010-11-25
申请号：US12864262
申请日：2009-01-23
申请人： Michalakis Averkiou , Marios Lampaskis , Konstantina Kyriakopoulou
发明人： Michalakis Averkiou , Marios Lampaskis , Konstantina Kyriakopoulou
IPC分类号： A61B8/14
CPC分类号： G06T7/0012 , A61B8/0833 , A61B8/481 , A61B8/543 , G06T2200/04 , G06T2207/10016 , G06T2207/10132 , G06T2207/20104 , G06T2207/30096
摘要： An ultrasonic imaging apparatus and method are described for monitoring the progress of therapy for pathology such as lesions, tumors, and metastases by means of contrast agent imaging. A sequence of images are acquired as a bolus of contrast agent infuses the tissue containing the pathology. A contrast wash-in time parameter is calculated for both the tumor and normal tissue, and a ratio is calculated of the two wash-in time parameters (called WITR) which removes the effects of variations in the procedure from one therapy monitoring session to another. A difference curve of the time-intensity curves of the pathology and normal tissue is also produced, which is similarly immune to procedural variations. The motional effects of respiration can be taken into account by detecting the position of a landmark such as the diaphragm in each of the images of the sequence and discarding from processing those which exhibit a change in the position of the landmark relative to the probe.
摘要翻译：描述了超声成像装置和方法，用于通过造影剂成像来监测病理学如病变，肿瘤和转移的治疗进展。当大量造影剂注入包含病理学的组织时，获取图像序列。计算肿瘤和正常组织的对比洗涤时间参数，并计算两次洗脱时间参数（称为WITR）的比例，其消除了从一个治疗监测期到另一个治疗监测期的变化的影响。还产生了病理学和正常组织的时间 - 强度曲线的差异曲线，其类似地不受程序变化的影响。可以通过在序列的每个图像中检测诸如隔膜之类的标记的位置来消除呼吸的运动效应，并且从处理那些表现出相对于探针的地标相对位置变化的那些的位置而被考虑。

10. 发明申请

US20100298706A1 RESPIRATORY-GATED THERAPY ASSESSMENT WITH ULTRASONIC CONTRAST AGENTS 有权
标题翻译：超声对照药物的呼吸治疗治疗评估
公开(公告)号：US20100298706A1
公开(公告)日：2010-11-25
申请号：US12864273
申请日：2009-01-23
申请人： Michalakis Averkiou , Marios Lampaskis , Konstantina Kyriakopoulou
发明人： Michalakis Averkiou , Marios Lampaskis , Konstantina Kyriakopoulou
IPC分类号： A61B8/14
CPC分类号： G06T7/0012 , A61B8/0833 , A61B8/481 , A61B8/543 , G06T2200/04 , G06T2207/10016 , G06T2207/10132 , G06T2207/20104 , G06T2207/30096
摘要： An ultrasonic imaging apparatus and method are described for monitoring the progress of therapy for pathology such as lesions, tumors, and metastases by means of contrast agent imaging. A sequence of images are acquired as a bolus of contrast agent infuses the tissue containing the pathology. A contrast wash-in time parameter is calculated for both the tumor and normal tissue, and a ratio is calculated of the two wash-in time parameters (called WITR) which removes the effects of variations in the procedure from one therapy monitoring session to another. A difference curve of the time-intensity curves of the pathology and normal tissue is also produced, which is similarly immune to procedural variations. The motional effects of respiration can be taken into account by detecting the position of a landmark such as the diaphragm in each of the images of the sequence and discarding from processing those which exhibit a change in the position of the landmark relative to the probe.
摘要翻译：描述了超声成像装置和方法，用于通过造影剂成像来监测病理学如病变，肿瘤和转移的治疗进展。当大量造影剂注入包含病理学的组织时，获取图像序列。计算肿瘤和正常组织的对比洗涤时间参数，并计算两次洗脱时间参数（称为WITR）的比例，其消除了从一个治疗监测期到另一个治疗监测期的变化的影响。还产生了病理学和正常组织的时间 - 强度曲线的差异曲线，其类似地不受程序变化的影响。可以通过在序列的每个图像中检测诸如隔膜之类的标记的位置来消除呼吸的运动效应，并且从处理那些表现出相对于探针的地标相对位置变化的位置而被忽略。

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