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    • 4. 发明授权
    • Optimized high-speed magnetic resonance imaging method and system using hyperpolarized noble gases
    • 优化的高速磁共振成像方法和使用超极化惰性气体的系统
    • US07174200B2
    • 2007-02-06
    • US10474571
    • 2002-04-12
    • Michael SalernoJohn P. Mugler, IIIJames R. Brookeman
    • Michael SalernoJohn P. Mugler, IIIJames R. Brookeman
    • B61B5/05
    • G01R33/5601G01R33/56341
    • A system and method for using hyperpolarized noble gases together with an appropriately designed and optimized magnetic resonance imaging pulse sequence to rapidly acquire static or dynamic magnetic resonance images. The strong magnetic resonance signal from hyperpolarized gases, combined with the present magnetic resonance imaging technique, presents the opportunity for the imaging of gases with both high spatial and high temporal resolution. One potential application for such a method is the direct, dynamic visualization of gas flow, which would be extremely useful for characterizing a variety of fluid systems. In the medical field, one such system of substantial importance is the lung. The system and method provides for visualizing regional ventilatory patterns throughout the respiratory cycle with high temporal and high spatial resolution. The low sensitivity to susceptibility artifacts permits good image quality to be obtained in various orientations. Depending on the application, temporal resolution can be traded for anatomical coverage. Such application of dynamic imaging of the lung using hyperpolarized gases will provide unique information on the physiology and pathophysiology of the lung, and has the potential for many clinically-relevant applications.
    • 一种使用超极化惰性气体与适当设计和优化的磁共振成像脉冲序列的系统和方法,以快速获取静态或动态磁共振图像。 来自超极化气体的强磁共振信号与目前的磁共振成像技术相结合,为高空间和高时间分辨率的气体成像提供了机会。 这种方法的一个潜在应用是气流的直接,动态可视化,这对于表征各种流体系统是非常有用的。 在医疗领域,一个这样重要的体系是肺。 该系统和方法提供了在整个呼吸周期中具有高时空和高空间分辨率的可视化区域通气模式。 对敏感性伪影的低灵敏度允许在各种取向中获得良好的图像质量。 根据应用,时间分辨率可以交换用于解剖学覆盖。 使用超极化气体对肺的动态成像的这种应用将提供关于肺的生理学和病理生理学的独特信息,并且具有许多临床相关应用的潜力。