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1. 发明申请

US20150015253A1 AUTOMATED IMAGE ANALYSIS FOR MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：自动图像分析用于磁共振成像
公开(公告)号：US20150015253A1
公开(公告)日：2015-01-15
申请号：US14248998
申请日：2014-04-09
申请人： Susumu Mori , Michael I. Miller , Jiangyang Zhang , Kenichi Oishi
发明人： Susumu Mori , Michael I. Miller , Jiangyang Zhang , Kenichi Oishi
IPC分类号： G01R33/56
CPC分类号： G01R33/56 , G01R33/5608 , G01R33/56341 , G06T7/0012 , G06T7/11 , G06T7/30 , G06T2207/10088 , G06T2207/30016
摘要： A magnetic resonance imaging (MRI) system, comprising: a magnetic resonance imaging scanner configured to generate a plurality of signals for forming at least one magnetic resonance image of a soft tissue region from a subject under observation, wherein the at least one magnetic resonance image provides at least one integrating feature to facilitate automatic segmentation; a signal processing system in communication with the magnetic resonance imaging scanner to receive the plurality of signals; and a data storage unit in communication with the signal processing system, wherein the data storage unit contains at least one template corresponding to the soft tissue region, wherein the signal processing system is adapted to process the plurality of signals received from the magnetic resonance imaging scanner to automatically perform segmentation for the soft tissue region of the subject under observation by utilizing the at least one template and the at least one integrating feature.
摘要翻译：一种磁共振成像（MRI）系统，包括：磁共振成像扫描器，被配置为产生用于从观察对象形成软组织区域的至少一个磁共振图像的多个信号，其中所述至少一个磁共振图像提供至少一个积分特征以促进自动分割; 信号处理系统，与所述磁共振成像扫描器通信以接收所述多个信号; 以及与所述信号处理系统通信的数据存储单元，其中所述数据存储单元包含与所述软组织区域对应的至少一个模板，其中所述信号处理系统适于处理从所述磁共振成像扫描器接收的所述多个信号通过利用所述至少一个模板和所述至少一个积分特征来自动执行观察对象的软组织区域的分割。

2. 发明授权

US08838201B2 Atlas-based analysis for image-based anatomic and functional data of organism 有权
标题翻译：基于图像的生物体解剖学和功能数据分析
公开(公告)号：US08838201B2
公开(公告)日：2014-09-16
申请号：US13703859
申请日：2011-06-22
申请人： Susumu Mori , Andreia V. Faria , Michael I. Miller , Kenichi Oishi
发明人： Susumu Mori , Andreia V. Faria , Michael I. Miller , Kenichi Oishi
IPC分类号： A61B5/05 , G06T7/00 , A61B6/00 , A61B5/055 , G06K9/20 , G01R33/56 , A61B6/03
CPC分类号： G06K9/2054 , A61B5/055 , A61B6/03 , A61B6/5217 , G01R33/5608 , G06T7/11 , G06T7/149 , G06T2207/10072 , G06T2207/20128 , G06T2207/30016
摘要： A non-invasive imaging system, including an imaging scanner suitable to generate an imaging signal from a tissue region of a subject under observation, the tissue region having at least one anatomical substructure and more than one constituent tissue type; a signal processing system in communication with the imaging scanner to receive the imaging signal from the imaging scanner; and a data storage unit in communication with the signal processing system, wherein the data storage unit is configured to store a parcellation atlas comprising spatial information of the at least one substructure in the tissue region, wherein the signal processing system is adapted to: reconstruct an image of the tissue region based on the imaging signal; parcellate, based on the parcellation atlas, the at least one anatomical substructure in the image; segment the more than one constituent tissue types in the image; and automatically identify, in the image, a portion of the at least one anatomical substructure that correspond to one of the more than one constituent tissue type.
摘要翻译：一种非侵入性成像系统，包括适于从观察对象的组织区域产生成像信号的成像扫描器，所述组织区域具有至少一个解剖学亚结构和多于一种构成组织类型; 与成像扫描仪通信的信号处理系统，以从成像扫描仪接收成像信号; 以及与所述信号处理系统通信的数据存储单元，其中所述数据存储单元被配置为存储包括所述组织区域中的所述至少一个子结构的空间信息的分割图集，其中所述信号处理系统适于：重构基于成像信号的组织区域的图像; 基于分割图谱分析图像中的至少一个解剖学亚结构; 在图像中分割多个组成组织类型; 并且在所述图像中自动识别所述至少一个解剖学亚结构的对应于多于一种构成组织类型之一的部分。

3. 发明申请

US20140181754A1 SYSTEM FOR A THREE-DIMENSIONAL INTERFACE AND DATABASE 审中-公开
标题翻译：三维接口和数据库系统
公开(公告)号：US20140181754A1
公开(公告)日：2014-06-26
申请号：US14129552
申请日：2012-06-28
申请人： Susumu Mori , Michael I. Miller
发明人： Susumu Mori , Michael I. Miller
IPC分类号： G06F3/0484 , G06F3/0481
CPC分类号： G06F3/04842 , G06F3/04815 , G06F16/444 , G06F16/48 , G06T19/00 , G06T2210/41 , G16H50/50
摘要： An embodiment in accordance with the present invention provides a system and method for a three-dimensional interface for interacting with a database. The three-dimensional interface can include an interactive three-dimensional atlas depicting an element of anatomy, machine, device, or other object. Given the three-dimensional nature of the atlas, a user can zoom in on particular areas to view them with more specificity. Different structural points of the anatomy are labeled with names or coordinates, such that the user can select one of the structural points and search a database for information related to that specific structural point. The user can also use specific keywords to search with respect to the specific structural point selected. The three-dimensional interface and atlas are displayed to the user on a computing device that can either house the database within its memory or alternately communicate with the database over a network.
摘要翻译：根据本发明的实施例提供了一种用于与数据库进行交互的三维界面的系统和方法。三维界面可以包括描绘解剖结构，机器，装置或其他对象的元件的交互式三维图集。鉴于地图集的三维性质，用户可以放大特定区域以更具体地查看它们。解剖结构的不同结构点用名称或坐标标记，使得用户可以选择结构点之一并搜索数据库以获得与该特定结构点相关的信息。用户还可以使用特定关键词来搜索所选择的特定结构点。三维界面和图集在计算设备上显示给用户，该计算设备可以将数据库存储在其存储器内，或者通过网络交替地与数据库通信。

4. 发明申请

US20130223716A1 IMAGE SEARCH ENGINE 有权
标题翻译：图像搜索引擎
公开(公告)号：US20130223716A1
公开(公告)日：2013-08-29
申请号：US13824853
申请日：2011-10-25
申请人： Susumu Mori , Michael I. Miller , Kenichi Oishi , Andreia V. Faria
发明人： Susumu Mori , Michael I. Miller , Kenichi Oishi , Andreia V. Faria
IPC分类号： G06T7/00
CPC分类号： G06T7/0014 , A61B5/0013 , A61B5/055 , A61B6/032 , A61B6/501 , A61B6/56 , A61B8/56 , A61B8/565 , G06F17/30247 , G06F19/00 , G06F19/321 , G16H50/70
摘要： An embodiment of the current invention includes a non-invasive imaging system, comprising: an imaging scanner suitable to generate an image representing a tissue region of a subject under observation, the tissue region having at least one substructure and the image comprising a plurality of image voxels; a signal processing system in communication with the imaging scanner to receive the imaging signal from the imaging scanner; and a data storage unit in communication with the signal processing system, wherein the data storage unit is configured to store: an atlas comprising spatial information of the at least one substructure in the tissue region, and a database comprising a plurality of pre-stored medical images representing the tissue region, and wherein the signal processing system is adapted to: identify, based on the atlas and for each of the at least one substructure, a corresponding portion of image voxels in the image; provide a computed quantification of the corresponding portion of image voxels for each of the at least one substructure of the tissue region by performing spatial filtering on the image; and search the database to provide at least one selected medical image from the plurality of pre-stored medical images, the at least one selected medical image having a corresponding quantification that is substantially similar to the computed quantification.
摘要翻译：本发明的一个实施例包括一种非侵入性成像系统，包括：成像扫描仪，其适于产生表示观察对象的组织区域的图像，所述组织区域具有至少一个子结构，并且所述图像包括多个图像体素与成像扫描仪通信的信号处理系统，以从成像扫描仪接收成像信号; 以及与所述信号处理系统通信的数据存储单元，其中所述数据存储单元被配置为存储：包括所述组织区域中的所述至少一个子结构的空间信息的图集，以及包括多个预先存储的医疗表示组织区域的图像，并且其中所述信号处理系统适于：基于所述图集并且针对所述至少一个子结构中的每一个识别所述图像中的图像体素的相应部分; 通过对图像执行空间滤波来提供组织区域的至少一个子结构中的每一个的图像体素的相应部分的计算定量; 并且搜索所述数据库以从所述多个预先存储的医学图像中提供至少一个所选择的医学图像，所述至少一个所选择的医学图像具有与所计算的定量基本相似的相应量化。

5. 发明申请

US20100284595A1 AUTOMATED IMAGE ANALYSIS FOR MAGNETIC RESONANCE IMAGING 有权
标题翻译：自动图像分析用于磁共振成像
公开(公告)号：US20100284595A1
公开(公告)日：2010-11-11
申请号：US12747816
申请日：2009-02-02
申请人： Susumu Mori , Michael I. Miller , Jiangyang Zhang , Kenichi Oishi
发明人： Susumu Mori , Michael I. Miller , Jiangyang Zhang , Kenichi Oishi
IPC分类号： G06K9/00 , A61B5/055
CPC分类号： G01R33/56 , G01R33/5608 , G01R33/56341 , G06T7/0012 , G06T7/11 , G06T7/30 , G06T2207/10088 , G06T2207/30016
摘要： A magnetic resonance imaging (MRI) system, comprising: a magnetic resonance imaging scanner configured to generate a plurality of signals for forming at least one magnetic resonance image of a soft tissue region from a subject under observation, wherein the at least one magnetic resonance image provides at least one integrating feature to facilitate automatic segmentation; a signal processing system in communication with the magnetic resonance imaging scanner to receive the plurality of signals; and a data storage unit in communication with the signal processing system, wherein the data storage unit contains at least one template corresponding to the soft tissue region, wherein the signal processing system is adapted to process the plurality of signals received from the magnetic resonance imaging scanner to automatically perform segmentation for the soft tissue region of the subject under observation by utilizing the at least one template and the at least one integrating feature.
摘要翻译：一种磁共振成像（MRI）系统，包括：磁共振成像扫描器，被配置为产生用于从观察对象形成软组织区域的至少一个磁共振图像的多个信号，其中所述至少一个磁共振图像提供至少一个积分特征以促进自动分割; 信号处理系统，与所述磁共振成像扫描器通信以接收所述多个信号; 以及与所述信号处理系统通信的数据存储单元，其中所述数据存储单元包含与所述软组织区域相对应的至少一个模板，其中所述信号处理系统适于处理从所述磁共振成像扫描器接收的所述多个信号通过利用所述至少一个模板和所述至少一个积分特征来自动执行观察对象的软组织区域的分割。

6. 发明授权

US11294547B2 Query-based three-dimensional atlas for accessing image-related data 有权
公开(公告)号：US11294547B2
公开(公告)日：2022-04-05
申请号：US14129552
申请日：2012-06-28
申请人： Susumu Mori , Michael I. Miller
发明人： Susumu Mori , Michael I. Miller
IPC分类号： G06F3/0484 , G06F3/0481 , G06F16/48 , G16H50/50 , G06F3/04842 , G06F3/04815 , G06T19/00 , G06F16/44 , G16Z99/00
摘要： An embodiment in accordance with the present invention provides a system and method for a three-dimensional interface for interacting with a database. The three-dimensional interface can include an interactive three-dimensional atlas depicting an element of anatomy, machine, device, or other object. Given the three-dimensional nature of the atlas, a user can zoom in on particular areas to view them with more specificity. Different structural points of the anatomy are labeled with names or coordinates, such that the user can select one of the structural points and search a database for information related to that specific structural point. The user can also use specific keywords to search with respect to the specific structural point selected. The three-dimensional interface and atlas are displayed to the user on a computing device that can either house the database within its memory or alternately communicate with the database over a network.

7. 发明授权

US09730615B2 Automated surface-based anatomical analysis based on atlas-based segmentation of medical imaging 有权
公开(公告)号：US09730615B2
公开(公告)日：2017-08-15
申请号：US12999866
申请日：2009-07-07
申请人： Michael I. Miller , Susumu Mori , Anqi Qiu
发明人： Michael I. Miller , Susumu Mori , Anqi Qiu
IPC分类号： A61B5/00 , A61B5/103 , A61B6/03 , G06T7/00 , G06T7/46 , A61B6/00
CPC分类号： A61B5/103 , A61B6/037 , A61B6/501 , G06T7/0012 , G06T7/46 , G06T2207/10072 , G06T2207/20068 , G06T2207/20128 , G06T2207/30096
摘要： A non-invasive imaging system, including: a non-invasive imaging scanner; a signal processing unit in communication with the imaging scanner to receive an imaging signal from a subject under observation; and a data storage unit in communication with the signal processing unit, wherein the data storage unit stores template data corresponding to a tissue region of the subject, and wherein the signal processing unit is adapted to generate a surface map to encode a property of a subvolume of the tissue region using the template data.

8. 发明授权

US08731256B2 Automated image analysis for magnetic resonance imaging 有权
标题翻译：磁共振成像自动图像分析
公开(公告)号：US08731256B2
公开(公告)日：2014-05-20
申请号：US12747816
申请日：2009-02-02
申请人： Susumu Mori , Michael I. Miller , Jiangyang Zhang , Kenichi Oishi
发明人： Susumu Mori , Michael I. Miller , Jiangyang Zhang , Kenichi Oishi
IPC分类号： G06K9/00 , G06T7/00
CPC分类号： G01R33/56 , G01R33/5608 , G01R33/56341 , G06T7/0012 , G06T7/11 , G06T7/30 , G06T2207/10088 , G06T2207/30016
摘要： A magnetic resonance imaging (MRI) system, comprising: a magnetic resonance imaging scanner configured to generate a plurality of signals for forming at least one magnetic resonance image of a soft tissue region from a subject under observation, wherein the at least one magnetic resonance image provides at least one integrating feature to facilitate automatic segmentation; a signal processing system in communication with the magnetic resonance imaging scanner to receive the plurality of signals; and a data storage unit in communication with the signal processing system, wherein the data storage unit contains at least one template corresponding to the soft tissue region, wherein the signal processing system is adapted to process the plurality of signals received from the magnetic resonance imaging scanner to automatically perform segmentation for the soft tissue region of the subject under observation by utilizing the at least one template and the at least one integrating feature.
摘要翻译：一种磁共振成像（MRI）系统，包括：磁共振成像扫描器，被配置为产生用于从观察对象形成软组织区域的至少一个磁共振图像的多个信号，其中所述至少一个磁共振图像提供至少一个积分特征以促进自动分割; 信号处理系统，与所述磁共振成像扫描器通信以接收所述多个信号; 以及与所述信号处理系统通信的数据存储单元，其中所述数据存储单元包含与所述软组织区域对应的至少一个模板，其中所述信号处理系统适于处理从所述磁共振成像扫描器接收的所述多个信号通过利用所述至少一个模板和所述至少一个积分特征来自动执行观察对象的软组织区域的分割。

9. 发明申请

US20110274330A1 AUTOMATED CHARACTERIZATION OF TIME-DEPENDENT TISSUE CHANGE 有权
标题翻译：时间依赖组织变化的自动表征
公开(公告)号：US20110274330A1
公开(公告)日：2011-11-10
申请号：US13075408
申请日：2011-03-30
申请人： Susumu Mori , Michael I. Miller
发明人： Susumu Mori , Michael I. Miller
IPC分类号： G06K9/00
CPC分类号： G06T7/0016 , A61B5/055 , A61B6/032 , A61B6/037 , A61B6/486 , A61B6/50 , A61B6/5235 , A61B8/085 , A61B8/5246 , A61B2576/00 , G06T2207/10072 , G06T2207/30064
摘要： A non-invasive medical imaging system includes: an imaging scanner capable of generating an imaging signal from a subject under observation inside the imaging scanner; a signal processing system in communication with the imaging scanner, and a data storage unit in communication with the signal processing system, wherein the data storage unit is suitable for storing a first image corresponding to a tissue region of the subject, wherein the signal processing system is capable of generating a second image encoding the tissue region of the subject by performing a reconstruction based on the imaging signal, the imaging signal acquired at a later time than the first image; wherein the signal processing system is constructed to receive the imaging signal from the imaging scanner and the first image from the data storage unit respectively, wherein the signal processing system is adapted to provide a registered first image by registering the first image to the second image via a transformation in a space of diffeomorphism, wherein the signal processing system is further adapted to compute a difference image between the second image and the registered first image; and wherein the signal processing system is further adapted to output the difference image.
摘要翻译：非侵入性医学成像系统包括：成像扫描仪，其能够在成像扫描仪内部从观察对象产生成像信号; 与成像扫描器通信的信号处理系统和与信号处理系统通信的数据存储单元，其中数据存储单元适于存储对应于被摄体的组织区域的第一图像，其中信号处理系统能够通过基于成像信号，在比第一图像稍后时间获取的成像信号进行重建来产生编码对象的组织区域的第二图像; 其中所述信号处理系统被构造成分别从所述成像扫描仪和所述数据存储单元接收所述成像信号，其中所述信号处理系统适于通过将所述第一图像注册到所述第二图像来提供登记的第一图像，所述第一图像经由在变形空间中的变换，其中所述信号处理系统还适于计算所述第二图像和所述注册的第一图像之间的差分图像; 并且其中所述信号处理系统还适于输出所述差分图像。

10. 发明申请

US20110103672A1 ADVANCED COST FUNCTIONS FOR IMAGE REGISTRATION FOR AUTOMATED IMAGE ANALYSIS: MULTI-CHANNEL, HYPERTEMPLATE AND ATLAS WITH BUILT-IN VARIABILITY 有权
标题翻译：用于自动图像分析的图像注册的高级成本函数：具有内置变异性的多通道，高通滤波器和ATLAS
公开(公告)号：US20110103672A1
公开(公告)日：2011-05-05
申请号：US12999721
申请日：2009-07-07
申请人： Michael I. Miller , Susumu Mori , Anqi Qiu , Jiangyang Zhang , Can Ceritoglu
发明人： Michael I. Miller , Susumu Mori , Anqi Qiu , Jiangyang Zhang , Can Ceritoglu
IPC分类号： G06K9/00 , G01R33/20 , G01N23/00 , G01T1/164
CPC分类号： A61B6/563 , A61B5/055 , A61B6/032 , A61B6/501 , A61B6/5235 , G06F19/00 , G06K9/6206 , G06K9/6215 , G06K9/6255 , G16H50/70
摘要： A non-invasive imaging system, comprising: an imaging scanner; a signal processing system in communication with the imaging scanner to receive an imaging signal from the imaging scanner; and a data storage unit in communication with the signal processing system, wherein the data storage unit stores template data corresponding to a tissue region of a subject under observation, wherein the signal processing system is adapted to compute, using the imaging signal and the template data, refined template data corresponding to the tissue region, and wherein the refined template data incorporates subpopulation variability information associated with the tissue region such that the signal processing system provides an image of the tissue region in which a substructure is automatically identified taking into account the subpopulation variability information.
摘要翻译：一种非侵入性成像系统，包括：成像扫描仪; 与成像扫描仪通信的信号处理系统，以从成像扫描器接收成像信号; 以及与所述信号处理系统通信的数据存储单元，其中所述数据存储单元存储对应于被观察对象的组织区域的模板数据，其中所述信号处理系统适于使用所述成像信号和所述模板数据对应于所述组织区域的精细模板数据，并且其中所述精制模板数据包含与所述组织区域相关联的亚群体变异性信息，使得所述信号处理系统提供所述组织区域的图像，其中在考虑到亚群的情况下自动识别子结构变异性信息。

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