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1. 发明授权

US10047549B2 Latch 有权
公开(公告)号：US10047549B2
公开(公告)日：2018-08-14
申请号：US14116096
申请日：2012-05-11
申请人： Robert Grant , Michael Block
发明人： Robert Grant , Michael Block
IPC分类号： E05C1/06 , E05C1/14 , E05B41/00 , E05B59/00 , E05B63/14 , E05C1/00 , E05C1/04 , E05B5/00 , B64D11/04
摘要： A latch includes a first locking bolt, where a first extended position of the first locking bolt defines a first locked condition and a first retracted position defines a first unlocked condition. The latch also includes a second locking bolt, where a second extended position of the second locking bolt defines a second locked condition and a second retracted position defines a second unlocked condition. A biasing member operatively connects to the first locking bolt to bias the first locking bolt in the first extended position. A lever pivotally connects to the housing and operatively connects to the first locking bolt such that movement of the lever from a closed position to an opened position causes at least the first locking bolt to move from the first extended position to the first retracted position. A locking indicator is provided in associated with the second locking bolt.

2. 发明申请

US20110039423A1 MULTI-PORT CONNECTOR SYSTEM 有权
标题翻译：多端口连接器系统
公开(公告)号：US20110039423A1
公开(公告)日：2011-02-17
申请号：US12541252
申请日：2009-08-14
申请人： FRANCIS J. BLASICK , DARON WALLACE , KEVIN E. WEIDNER , KEITH RICHARD FOLTZ , MICHAEL BLOCK , DAVID EVERTS
发明人： FRANCIS J. BLASICK , DARON WALLACE , KEVIN E. WEIDNER , KEITH RICHARD FOLTZ , MICHAEL BLOCK , DAVID EVERTS
IPC分类号： H01R12/00
CPC分类号： H01R24/50 , H01R12/585 , H01R12/724 , H01R13/112 , H01R43/16 , H01R2103/00
摘要： An electrical connector assembly includes a housing, a connector and a conductor. The housing extends from a mating interface to a back end along a longitudinal axis and from a top side to a mounting interface along a vertical axis. The connector is disposed at the mating interface and is configured to mate with a mating connector. The conductor extends from the electrical connector to the mounting interface to provide a conductive pathway between the mating connector and the circuit board. The conductor includes a mating portion oriented along the longitudinal axis and a mounting portion oriented along the vertical axis. One of the mating portion and the mounting portion includes a bifurcated end having opposing contact tips and the other of the mating portion and the mounting portion includes an interconnection end that is received between the contact tips to electrically couple the mating portion and the mounting portion.
摘要翻译：电连接器组件包括壳体，连接器和导体。壳体从纵向轴线的配合接口延伸到后端，并且沿着垂直轴线从顶侧延伸到安装界面。连接器设置在配合接口处并且被配置为与配合连接器配合。导体从电连接器延伸到安装界面，以在匹配连接器和电路板之间提供导电路径。导体包括沿着纵向轴线定向的配合部分和沿垂直轴线定向的安装部分。配合部分和安装部分之一包括具有相对的接触尖端的分叉端，并且配合部分和安装部分中的另一个包括接纳在接触尖端之间的互连端，以电耦合配合部分和安装部分。

3. 发明申请

US20050080106A1 Compounds effecting glucokinase 失效
标题翻译：影响葡萄糖激酶的化合物
公开(公告)号：US20050080106A1
公开(公告)日：2005-04-14
申请号：US10486496
申请日：2002-08-15
申请人： Scott Boyd , Peter Caulkett , Rodney Hargreaves , Suzanne Bowker , Roger James , Clifford Jones , Darren McKerrecher , Michael Block , Craig Johnstone
发明人： Scott Boyd , Peter Caulkett , Rodney Hargreaves , Suzanne Bowker , Roger James , Clifford Jones , Darren McKerrecher , Michael Block , Craig Johnstone
IPC分类号： A61K31/165 , A61K31/167 , A61K31/192 , A61K31/195 , A61K31/341 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/433 , A61K31/44 , A61K31/4402 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/445 , A61K31/454 , A61K31/455 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/50 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/5377 , A61P3/04 , A61P3/06 , A61P3/10 , A61P43/00 , C07D213/75 , C07D213/76 , C07D213/82 , C07D213/85 , C07D231/40 , C07D233/48 , C07D237/20 , C07D237/24 , C07D239/42 , C07D239/47 , C07D241/20 , C07D241/26 , C07D241/28 , C07D261/14 , C07D277/20 , C07D277/46 , C07D277/54 , C07D277/56 , C07D277/58 , C07D277/82 , C07D285/12 , C07D285/135 , C07D307/66 , C07D307/68 , C07D401/04 , C07D403/04 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
CPC分类号： C07D213/75 , A61K31/165 , A61K31/195 , A61K31/425 , A61K31/445 , C07D213/82 , C07D213/85 , C07D231/40 , C07D233/48 , C07D237/20 , C07D237/24 , C07D239/42 , C07D241/20 , C07D241/26 , C07D261/14 , C07D277/46 , C07D277/56 , C07D277/82 , C07D285/135 , C07D307/66 , C07D401/04 , C07D403/04 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).
摘要翻译：本发明涉及式（I）化合物或其盐，溶剂合物或前体药物的用途，其中R 1，R 2，R 3，n和m如说明书中所述，在制备用于治疗或预防通过葡萄糖激酶（GLK）介导的疾病状况的药物，例如2型糖尿病。本发明还涉及一组新的式（I）化合物和制备式（I）化合物的方法。

4. 发明授权

US09573911B2 Diphosphate mimetics and uses thereof 有权
标题翻译：二磷酸盐模拟物及其用途
公开(公告)号：US09573911B2
公开(公告)日：2017-02-21
申请号：US14131024
申请日：2012-07-06
申请人： Suzanne Walker Kahne , Jiaoyang Jiang , Michael Block Lazarus
发明人： Suzanne Walker Kahne , Jiaoyang Jiang , Michael Block Lazarus
IPC分类号： C07D263/58 , A61K45/06
CPC分类号： C07D263/58 , A61K45/06
摘要： The present invention provides compounds of Formulae (I)-(V), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. In one aspect, compounds of the present invention are useful as glycosyltransferase inhibitors, in particular, O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) inhibitors. In another aspect, compounds of the present invention are useful as kinase inhibitors, in particular, PLK1 inhibitors, GSK3P inhibitors, or MAPKAPK2 inhibitors. The present invention further provides methods of using the inventive compounds, e.g., as biological probes to study the inhibition of OGT and/or kinase activity and as therapeutics, e.g., for the treatment of OGT-associated and/or kinase-associated conditions.
摘要翻译：本发明提供式（I） - （V）的化合物，其药学上可接受的盐及其药物组合物。在一个方面，本发明的化合物可用作糖基转移酶抑制剂，特别是O-连接的N-乙酰葡糖胺（O-GlcNAc）转移酶（OGT）抑制剂。另一方面，本发明的化合物可用作激酶抑制剂，特别是PLK1抑制剂，GSK3P抑制剂或MAPKAPK2抑制剂。本发明进一步提供使用本发明化合物的方法，例如用作生物探针来研究OGT和/或激酶活性的抑制作为治疗剂，例如用于治疗OGT相关和/或激酶相关病症。

5. 发明申请

US20160036545A1 Measuring device and measuring method for start time synchronized signal generation 有权
标题翻译：用于启动时间同步信号产生的测量装置和测量方法
公开(公告)号：US20160036545A1
公开(公告)日：2016-02-04
申请号：US14814777
申请日：2015-07-31
申请人： Ralf Plaumann , Feng Xie , Thomas Lutz , Michael Block , Hailiang Jin
发明人： Ralf Plaumann , Feng Xie , Thomas Lutz , Michael Block , Hailiang Jin
IPC分类号： H04J3/14 , H04B17/00
CPC分类号： H04B17/0085 , G01R27/28 , H04L1/20 , H04L1/24
摘要： A measuring system comprises a timing unit and at least two signal generators. The signal generators are each configured to generate a measuring signal and to supply it to a device under test. The timing unit is configured to generate start time signals, which each indicate an allowed start time of the measuring signals. Said signal generators are configured to only start generating the measuring signals at least instances of start time signals.
摘要翻译：测量系统包括定时单元和至少两个信号发生器。信号发生器各自被配置为产生测量信号并将其提供给被测设备。定时单元被配置为产生起始时间信号，每个起始时间信号指示测量信号的允许的开始时间。所述信号发生器被配置为仅在开始时间信号的至少一些情况下开始产生测量信号。

6. 发明授权

US08757939B1 Drill bit jig 有权
标题翻译：钻头夹具
公开(公告)号：US08757939B1
公开(公告)日：2014-06-24
申请号：US12650987
申请日：2009-12-31
申请人： Michael Block
发明人： Michael Block
IPC分类号： B23B47/26
CPC分类号： B23B47/287 , B23B2247/12
摘要： A drill bit jig includes an elongate member, two jig securing elements and a rotatable drill bit guide. The elongate member is hollow so that one or more elongate drill bits may be stored therein. The drill bit guide includes a plurality of through holes where the axes of the through holes are parallel to the axis of the elongate member. Each of the plurality of through holes in the drill bit guide has a different diameter for accommodating drill bits of different thicknesses. The jig securing elements each include an L-shaped bolt and a door protecting material encasing one of the straight sections of the bolt.
摘要翻译：钻头夹具包括细长构件，两个夹具固定元件和可旋转的钻头引导件。细长构件是中空的，使得可以在其中存储一个或多个细长钻头。钻头引导件包括多个通孔，其中通孔的轴线平行于细长构件的轴线。钻头引导件中的多个通孔中的每一个具有不同的直径以容纳不同厚度的钻头。夹具固定元件各自包括L形螺栓和封闭螺栓的直段中的一个的门保护材料。

7. 发明申请

US20120108605A1 O-GLCNAC TRANSFERASE INHIBITORS AND USES THEREOF 有权
标题翻译： O-GLCNAC转移抑制剂及其用途
公开(公告)号：US20120108605A1
公开(公告)日：2012-05-03
申请号：US13375036
申请日：2010-06-01
申请人： Suzanne Walker Kahne , Michael Block Lazarus , Benjamin J. Gross
发明人： Suzanne Walker Kahne , Michael Block Lazarus , Benjamin J. Gross
IPC分类号： A61K31/496 , C07D401/12 , C07D409/14 , C07D215/36 , C07D417/12 , C07D405/14 , C07D405/12 , A61K31/4709 , A61K31/4725 , C12N5/071 , A61P25/00 , A61P35/00 , A61P3/10 , A61P29/00 , A61P37/00 , C07D401/14
CPC分类号： C07D417/12 , C07D215/36 , C07D401/12 , C07D405/12 , C07D409/14
摘要： The present invention provides inhibitors of O-GIcNAc transferase. Typically, the inhibitors are quinolinone-6-sulfonamides. The invention also provides pharmaceutical compositions thereof and methods for using the same in diabetes and complications thereof, neurodegenerative diseases, cancers, autoimmune diseases, and inflammatory diseases.
摘要翻译：本发明提供了O-GlcNAc转移酶的抑制剂。通常，抑制剂是喹啉酮-6-磺酰胺。本发明还提供了其药物组合物及其在糖尿病及其并发症，神经变性疾病，癌症，自身免疫性疾病和炎性疾病中的应用。

8. 发明申请

US20100090862A1 POINT-OF-USE ENERGY MONITORING AND MANAGEMENT 审中-公开
标题翻译：使用要点监测和管理
公开(公告)号：US20100090862A1
公开(公告)日：2010-04-15
申请号：US12554090
申请日：2009-09-04
申请人： Nicole M. Dubrow , Michael Block
发明人： Nicole M. Dubrow , Michael Block
IPC分类号： G08C19/16
CPC分类号： H04Q9/00 , H04Q2209/30 , H04Q2209/43 , H04Q2209/60
摘要： A system for monitoring and managing the energy consumption of designated devices or services obtains the point-of-use energy consumption of the designated devices or services and collects this consumption information in various formats as data. The collected data may be analyzed for peak load analysis and load shedding recommendations, among other analysis. The data may be displayed on a user interface to an energy consumer in various formats that permit the consumer to make decisions and take actions based on the displayed data or the analysis. The data may be displayed in real-time format so that the consumer may observe the instant energy consumption of a particular device. The consumer may also view a device's energy consumption to-date over a predetermined period of time. The consumer may also take an action through the system to reduce the consumer's overall energy consumption.
摘要翻译：用于监视和管理指定设备或服务的能量消耗的系统获得指定设备或服务的使用点能耗，并以数据形式收集各种格式的消费信息。收集的数据可以分析峰值负载分析和负载脱落建议，以及其他分析。数据可以以允许消费者基于显示的数据或分析作出决定并采取行动的各种格式的能量消费者的用户界面来显示。数据可以以实时格式显示，使得消费者可以观察特定设备的即时能量消耗。消费者还可以在预定时间段内查看设备的能量消耗。消费者也可以通过系统采取行动，以减少消费者的整体能源消耗。

9. 发明公开

US20230373014A1 CORING TOOL 审中-公开
公开(公告)号：US20230373014A1
公开(公告)日：2023-11-23
申请号：US18315588
申请日：2023-05-11
申请人： Michael Block
发明人： Michael Block
IPC分类号： B23B47/28
CPC分类号： B23B47/28 , B23B2247/06
摘要： A coring tool for coring doors is provided. The coring tool may include a tool body having a first end and an opposing second end and a clamp member coupled to the tool body adjacent the second end. The tool body and the clamp member are moveable toward and away from each other in response to operation of a clamp actuator. The coring tool may also include a head having guide bushings for inserting a bit through the guide bushings for coring a door. The head may be coupled adjacent the first end of the tool body and the head may be movable toward and away from the tool body to align the guide bushing with the door to be cored.

10. 发明申请

US20160263662A1 DRILL BIT JIG 审中-公开
标题翻译：钻头大
公开(公告)号：US20160263662A1
公开(公告)日：2016-09-15
申请号：US15162145
申请日：2016-05-23
申请人： Michael Block
发明人： Michael Block
IPC分类号： B23B47/28
CPC分类号： B23B47/287 , B23B47/28 , B23B2247/06 , B23B2247/12 , Y10T408/563 , Y10T408/567
摘要： A drill bit jig includes an elongate member, two jig securing elements and a drill bit guide. The drill bit guide includes a plurality of through holes where the axes of the through holes are parallel to the axis of the elongate member. Each of the plurality of through holes in the drill bit guide has a different diameter for accommodating drill bits of different thicknesses. The jig securing elements each include an L-shaped bolt and a door protecting material encasing one of the straight sections of the bolt. The drill bit jig also includes a core check to determine if a hole being drilled along the width of the door is straight.
摘要翻译：钻头夹具包括细长构件，两个夹具固定元件和钻头引导件。钻头引导件包括多个通孔，其中通孔的轴线平行于细长构件的轴线。钻头引导件中的多个通孔中的每一个具有不同的直径以容纳不同厚度的钻头。夹具固定元件各自包括L形螺栓和封闭螺栓的直线部分之一的门保护材料。钻头夹具还包括核心检查，以确定沿着门的宽度钻出的孔是否是直的。

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