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1. 发明公开

US20230158267A1 COMPOSITIONS FOR IMPROVING MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME (ME/CFS) AND/OR FIBROMYALGIA (FM) AND/OR INHIBITING WORSENING OF SYMPTOMS 审中-公开
公开(公告)号：US20230158267A1
公开(公告)日：2023-05-25
申请号：US17940817
申请日：2022-09-08
申请人： MiZ Company Limited
发明人： Fumitake SATOH , Yoshiyasu TAKEFUJI , Takashi YAMAMURA , Bunpei SATO , Shin-ichi HIRANO , Yusuke ICHIAKWA
IPC分类号： A61M16/10 , A61M15/00 , A61M15/08
CPC分类号： A61M16/10 , A61M15/0005 , A61M15/08
摘要： Described is a composition for ameliorating symptoms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and/or fibromyalgia (FM) that has few side effects and can be easily produced. Specifically, described is a composition for ameliorating at least one symptom of fatigue, headache, body pain, impaired thinking, impaired concentration, and/or impaired activity level associated with these symptoms caused by ME/CFS and/or FM in a patient, including a hydrogen gas-containing gas as an active ingredient. Also, described herein is a method for ameliorating symptoms such as fatigue, headache, body pain, impaired thinking, impaired concentration, and/or impaired activity levels associated with these symptoms caused by ME/CFS and/or FM in a patient with ME/CFS and/or FM, including administering the composition to the patient.

2. 发明申请

US20210275576A1 MOLECULAR HYDROGEN-CONTAINING COMPOSITION FOR PREVENTION AND/OR IMPROVEMENT OF GENETIC DISORDER 有权
公开(公告)号：US20210275576A1
公开(公告)日：2021-09-09
申请号：US17189973
申请日：2021-03-02
申请人： MiZ Company Limited
发明人： Fumitake SATOH , Bunpei SATO , Yusuke ICHIKAWA , Shinichi HIRANO , Ryosuke KUROKAWA
IPC分类号： A61K33/00 , A61K9/00 , A61P25/24 , A61P25/28
摘要： The present invention provides a composition for prevention and/or improvement of a genetic disorder. More specifically, the present invention provides a composition for prevention and/or improvement of a genetic disorder and a symptom associated with the genetic disorder in a subject, comprising molecular hydrogen as an active ingredient.

3. 发明申请

US20210213049A1 METHOD AND MOLECULAR HYDROGEN-CONTAINING COMPOSITION FOR PROMOTION OF POSTOPERATIVE RECOVERY 有权
公开(公告)号：US20210213049A1
公开(公告)日：2021-07-15
申请号：US17147692
申请日：2021-01-13
申请人： MiZ Company Limited
发明人： Fumitake SATOH , Hideyuki SASAKI , Ryosuke KUROKAWA , Shinichi HIRANO , Yusuke ICHIKAWA
IPC分类号： A61K33/00 , A61K45/06 , A61P43/00
摘要： The present invention provides a method or a composition for promotion of improvement of postoperative recovery. More specifically, the present invention provides a composition for promotion of recovery from or improvement of surgical invasion and/or a symptom associated with a surgery in a subject undergoing the surgery, comprising molecular hydrogen as an active ingredient, and a method for promotion of recovery from or improvement of surgical invasion and/or a symptom associated with a surgery in a subject undergoing the surgery, comprising administering a composition comprising molecular hydrogen as an active ingredient to the subject.

4. 发明申请

US20200368272A1 COMPOSITION FOR AMELIORATING POST-CEREBRAL STROKE SEQUELA 审中-公开
公开(公告)号：US20200368272A1
公开(公告)日：2020-11-26
申请号：US16849057
申请日：2020-04-15
申请人： MiZ Company Limited
发明人： Fumitake Satoh , Shinichi Hirano , Yusuke Ichikawa
IPC分类号： A61K33/00 , A61K47/02 , A61P25/04
摘要： This application provides a composition for ameliorating a post-cerebral stroke sequela in a human, comprising molecular hydrogen as an active ingredient, and a method for ameliorating a post-cerebral stroke sequela, comprising administering the composition to a human having a post-cerebral stroke sequela.

5. 发明申请

US20180297842A1 METHOD OF GENERATING HYDROGEN-CONTAINING LIQUID 审中-公开
公开(公告)号：US20180297842A1
公开(公告)日：2018-10-18
申请号：US15787052
申请日：2017-10-18
申请人： MiZ Company Limited
发明人： Ryousuke KUROKAWA
IPC分类号： C01B3/08 , C01B3/06 , A61K33/00
摘要： A method is provided, comprising: preparing a hydrogen generating agent (14) that reacts with water to generate hydrogen gas, a first container (11) that encloses a liquid (16) applicable to a living organism and has hydrogen gas permeability, and a second container (12) that has hydrogen gas permeability equal to or lower than the hydrogen permeability of the first container; storing the first container and the hydrogen generating agent in the second container and sealing the second container with no water except moisture in air; maintaining the second container storing the first container and the hydrogen generating agent in a frozen state from when the second container is sealed until when the liquid is used; upon use of the liquid, placing the second container storing the first container and the hydrogen generating agent in an unfreezing atmosphere so that the hydrogen generating agent reacts with water in the second container to generate hydrogen gas in the second container, the water in the second container including water vapor resulting from vaporization of water contained in the liquid stored in the first container and permeation of the water vapor through the first container into the second container and/or the moisture in air in the second container; and allowing the hydrogen gas generated in the second container to pass through the first container so that hydrogen molecules are contained in the liquid stored in the first container.

6. 发明申请

US20170327958A1 METHOD OF OBTAINING HYDROGEN CONCENTRATION IN HYDROGEN-CONTAINING LIQUID AND GENERATOR FOR HYDROGEN-CONTAINING LIQUID 审中-公开
公开(公告)号：US20170327958A1
公开(公告)日：2017-11-16
申请号：US15591602
申请日：2017-05-10
申请人： MiZ Company Limited
发明人： Ryousuke KUROKAWA , Fumitake SATOH
IPC分类号： C25B1/04 , C25B15/02
CPC分类号： C25B1/04 , C25B15/02 , Y02E60/366
摘要： The generator comprises: a hydrogen supply source (2) configured to continuously supply a hydrogen-containing gas; a liquid supply source (3) configured to continuously supply a liquid; a dissolving unit (4) configured to dissolve the hydrogen-containing gas in the liquid; a memory (5) configured to store preliminarily-obtained relational information among a flow rate, water pressure, and hydrogen concentration of the hydrogen-containing liquid passing through the dissolving unit; a flow rate detector (52) configured to detect the flow rate of the hydrogen-containing liquid; a water pressure detector (51) configured to detect the water pressure of the hydrogen-containing liquid; and a calculator (5) configured to obtain the hydrogen concentration on the basis of the detected flow rate and water pressure and the relational information.

7. 发明授权

US11529367B2 Radiation damage protective agent 有权
公开(公告)号：US11529367B2
公开(公告)日：2022-12-20
申请号：US16465567
申请日：2017-12-26
申请人： MiZ Company Limited , Incorporated Medical Institution YUKOKAI
发明人： Yukimasa Aoki , Shinichi Hirano , Bunpei Sato , Ryosuke Kurokawa
IPC分类号： A61K33/00 , A61P39/06 , A61K9/00 , A61P7/00 , A61G10/02 , A61H33/14 , A61M16/12 , A61N5/10 , A61P35/00
摘要： The present application provides a radiation damage protecting agent comprising hydrogen gas as an active ingredient at a concentration of 18.5% by volume or less, for treating or alleviating, in a hyperbaric capsule under a pressure higher than standard atmospheric pressure, radiation damage in a human patient who has been exposed to radiation or who has received or receives radiotherapy, and a hyperbaric capsule for administering a hydrogen gas-containing therapeutic agent such as the radiation damage protecting agent to a patient including a human.

8. 发明申请

US20220280558A1 MOLECULAR HYDROGEN-CONTAINING COMPOSITION FOR PREVENTING OR IMPROVING OSTEOPOROSIS 有权
公开(公告)号：US20220280558A1
公开(公告)日：2022-09-08
申请号：US17686135
申请日：2022-03-03
申请人： MiZ Company Limited
发明人： Fumitake SATOH , Yusuke ICHIKAWA , Bunpei SATO , Shinichi HIRANO , Hatuko NAGASAKI
IPC分类号： A61K33/00 , A61K9/00 , A61P19/10
摘要： The present invention provides a composition for preventing or improving human osteoporosis, comprising molecular hydrogen as an active ingredient. More specifically, the present invention provides a composition for preventing or improving human osteoporosis, wherein the human osteoporosis is primary osteoporosis and/or secondary osteoporosis.

9. 发明申请

US20200230170A1 HYDROGEN-CONTAINING COMPOSITION 审中-公开
公开(公告)号：US20200230170A1
公开(公告)日：2020-07-23
申请号：US16644432
申请日：2018-09-14
申请人： Jason Madison MILLER , MiZ Company Limited
发明人： Yasushi SATOH , Shinichi HIRANO , Bunpei SATO , Ryosuke KUROKAWA , Jason Madison MILLER
IPC分类号： A61K33/00 , A61K9/00
摘要： An object of the present invention is to provide means for treating post-traumatic stress disorder or a blast-induced traumatic brain injury-protective agent. The present invention provides a pharmaceutical composition containing hydrogen as an active ingredient, used for treating post-traumatic stress disorder or protecting against blast-induced traumatic brain injury.

10. 发明申请

US20200000843A1 COMPOSITION FOR IMPROVEMENT OR PREVENTION OF PARKINSONIAN SYNDROME 审中-公开
公开(公告)号：US20200000843A1
公开(公告)日：2020-01-02
申请号：US16456099
申请日：2019-06-28
申请人： MiZ Company Limited
发明人： Fumitake Satoh , Shinichi Hirano , Ryosuke Kurokawa , Yi-Da Hsieh , Masatsugu Saito , Yusuke Ichikawa , Takeshirou Takekoshi
IPC分类号： A61K33/00 , A61P25/16 , A61P25/14 , A61K9/00
摘要： The present application provides: a composition for improving or preventing symptoms of human Parkinson's disease, multiple system atrophy or progressive supranuclear palsy, for example symptoms including at least tremors and/or forward-bending posture, or gait disorder, the composition including a hydrogen gas-containing gas as an effective ingredient; and a method for improving or preventing symptoms of Parkinson's disease, multiple system atrophy or progressive supranuclear palsy, which method comprises administering the composition to a human patient.

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