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1. 发明申请

US20130243732A1 ABROGATING PROINFLAMMATORY CYTOKINE PRODUCTION DURING ONCOLYTIC REOVIRUS THERAPY 审中-公开
标题翻译：肿瘤性溃疡治疗期间抗肿瘤细胞因子生产的研究
公开(公告)号：US20130243732A1
公开(公告)日：2013-09-19
申请号：US13898771
申请日：2013-05-21
申请人： Matthew C. Coffey , Bradley G. Thompson , Hardev Pandha
发明人： Matthew C. Coffey , Bradley G. Thompson , Hardev Pandha
IPC分类号： A61K35/76 , A61K31/282 , A61K33/24
CPC分类号： A61K35/765 , A61K31/282 , A61K31/555 , A61K33/24 , C12N2720/12032 , A61K2300/00
摘要： Provided herein are methods for treating a proliferative disorder in a subject comprising administering to the subject one or more reoviruses and one or more agents that modulate expression or activity of pro-inflammatory cytokines. For example, the agents may inhibit expression or activity of pro-inflammatory cytokines.
摘要翻译：本文提供了治疗受试者中增殖性病症的方法，包括向受试者施用一种或多种呼肠孤病毒和一种或多种调节促炎细胞因子的表达或活性的试剂。例如，该试剂可抑制促炎细胞因子的表达或活性。

2. 发明授权

US08512712B2 Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions 有权
公开(公告)号：US08512712B2
公开(公告)日：2013-08-20
申请号：US13408478
申请日：2012-02-29
申请人： Donald Morris , Bradley G. Thompson , Matthew C. Coffey
发明人： Donald Morris , Bradley G. Thompson , Matthew C. Coffey
IPC分类号： A61K35/14 , A61K38/16 , A61K39/12 , A61K39/38 , A61K39/385 , A61K49/00 , C12N5/00 , C12N5/02 , C12N5/08 , C12N5/10 , C07K14/00 , C07K16/00
CPC分类号： C12N5/0093 , A61K35/28 , A61K35/765 , A61K48/00 , A61L2/00 , C12N5/0693 , C12N7/00 , C12N15/86 , C12N2720/12032 , C12N2720/12211 , C12N2720/12232 , C12N2720/12243 , Y10T436/25
摘要： Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.

3. 发明授权

US08491884B2 Virus clearance of neoplastic cells from mixed cellular compositions 有权
标题翻译：来自混合细胞组合物的肿瘤细胞的病毒清除
公开(公告)号：US08491884B2
公开(公告)日：2013-07-23
申请号：US13080856
申请日：2011-04-06
申请人： Donald Morris , Bradley G. Thompson , Matthew C. Coffey
发明人： Donald Morris , Bradley G. Thompson , Matthew C. Coffey
IPC分类号： A61K51/00 , A61K48/00
CPC分类号： C12N5/0634 , A61K35/28 , A61K35/761 , A61K35/768 , C12N2720/12032
摘要： The present invention relates to a method for removing neoplastic cells from a mixed cellular composition, which is outside of a living organism, by using a virus which selectively infect and kill neoplastic cell. A variety of viruses can be used in this method to remove neoplastic cells for different purposes, for example, to purge hematopoietic stem cells prior to transplantation. Also provided are compositions prepared according to this method, and kits comprising a combination of viruses which are useful in this invention.
摘要翻译：本发明涉及通过使用选择性感染和杀死肿瘤细胞的病毒，从活体外部的混合细胞组合物中去除肿瘤细胞的方法。在该方法中可以使用各种病毒以除去不同目的的肿瘤细胞，例如在移植前清除造血干细胞。还提供了根据该方法制备的组合物，以及包含可用于本发明的病毒组合的试剂盒。

4. 发明申请

US20120141426A1 Reovirus for the Treatment of Cellular Proliferative Disorders 有权
标题翻译：呼肠孤病毒治疗细胞增生性疾病
公开(公告)号：US20120141426A1
公开(公告)日：2012-06-07
申请号：US13287399
申请日：2011-11-02
申请人： Patrick W.K. Lee , James Strong , Matthew C. Coffey
发明人： Patrick W.K. Lee , James Strong , Matthew C. Coffey
IPC分类号： A61K35/76 , A61P35/00
CPC分类号： A61K9/0019 , A61K35/765 , C12N2720/12032 , C12N2720/12232
摘要： Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts ras-mediated proliferating cells. Proliferative disorders include but are not limited to neoplasms. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, serotype 1 (e.g., strain Lang), serotype 2 (e.g., strain Jones), serotype 3 (e.g., strain Dearing or strain Abney), as well as other serotypes or strains of reovirus can be used. Combinations of more than one type and/or strain of reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.
摘要翻译：公开了通过向Ras介导的增殖性病症施用呼肠孤病毒来治疗增殖性疾病的方法。施用呼肠孤病毒使其最终直接接触ras介导的增殖细胞。增生性疾病包括但不限于赘生物。可以使用人呼肠病毒，非人哺乳动物呼肠病毒和/或禽呼肠孤病毒。如果呼肠孤病毒是人呼肠病毒，则可以使用血清型1（例如，菌株Lang），血清型2（例如菌株琼斯），血清型3（例如，菌株Dearing或菌株Abney）以及呼肠孤病毒的其它血清型或菌株。可以使用多于一种类型和/或菌株的呼肠病病毒的组合，以及来自不同动物种类的呼肠弧病毒。可以治疗实体肿瘤或造血赘生物。

5. 发明申请

US20110243890A1 Sensitization of Chemotherapeutic Agent Resistant Neoplastic Cells With a Virus 审中-公开
标题翻译：具有病毒的耐化学药物抗肿瘤细胞的致敏作用
公开(公告)号：US20110243890A1
公开(公告)日：2011-10-06
申请号：US13109631
申请日：2011-05-17
申请人： Matthew C. Coffey , Bradley G. Thompson
发明人： Matthew C. Coffey , Bradley G. Thompson
IPC分类号： A61K38/21 , C12N5/09 , A61K35/76 , A61P35/00 , A61P35/02 , A61P35/04
CPC分类号： A61K33/24 , A61K35/765 , A61K45/06 , C12N2720/12232 , A61K2300/00
摘要： The present invention relates to a method of increasing the sensitivity of neoplastic cells to chemotherapeutic agents by using a virus, a method of treating proliferative disorders with a virus and chemotherapeutic agents, and a method for preventing a neoplasm from developing drug resistance to chemotherapeutic agents. The virus is preferably a reovirus.
摘要翻译：本发明涉及通过使用病毒增加肿瘤细胞对化学治疗剂的敏感性的方法，使用病毒和化学治疗剂治疗增殖性病症的方法以及预防肿瘤对化疗药物的耐药性的方法。病毒优选为呼肠孤病毒。

6. 发明申请

US20110200565A1 VIRUS CLEARANCE OF NEOPLASTIC CELLS FROM MIXED CELLULAR COMPOSITIONS 有权
标题翻译：来自混合细胞组成的神经细胞的病毒清除
公开(公告)号：US20110200565A1
公开(公告)日：2011-08-18
申请号：US13080856
申请日：2011-04-06
申请人： Donald MORRIS , Bradley G. THOMPSON , Matthew C. COFFEY
发明人： Donald MORRIS , Bradley G. THOMPSON , Matthew C. COFFEY
IPC分类号： A61K35/12 , C12N5/09 , A61P35/00
CPC分类号： C12N5/0634 , A61K35/28 , A61K35/761 , A61K35/768 , C12N2720/12032
摘要： The present invention relates to a method for removing neoplastic cells from a mixed cellular composition, which is outside of a living organism, by using a virus which selectively infect and kill neoplastic cell. A variety of viruses can be used in this method to remove neoplastic cells for different purposes, for example, to purge hematopoietic stem cells prior to transplantation. Also provided are compositions prepared according to this method, and kits comprising a combination of viruses which are useful in this invention.
摘要翻译：本发明涉及通过使用选择性感染和杀死肿瘤细胞的病毒，从活体外部的混合细胞组合物中去除肿瘤细胞的方法。在该方法中可以使用各种病毒以除去不同目的的肿瘤细胞，例如在移植前清除造血干细胞。还提供了根据该方法制备的组合物，以及包含可用于本发明的病毒组合的试剂盒。

7. 发明授权

US07901921B2 Viral purification methods 有权
标题翻译：病毒纯化方法
公开(公告)号：US07901921B2
公开(公告)日：2011-03-08
申请号：US11255800
申请日：2005-10-20
申请人： Matthew C. Coffey
发明人： Matthew C. Coffey
IPC分类号： C12N7/02 , A61K39/15
CPC分类号： C12N7/00 , A61K35/13 , C12N2720/12051
摘要： The present invention is directed to an improved method of purifying virus, particularly reovirus. Infectious virus can be extracted from a cell culture with a detergent to produce high titers of virus, and the virus can then be purified by simple steps such as filtration and column chromatography. Viruses and compositions comprising the viruses prepared according to the present invention are also provided.
摘要翻译：本发明涉及一种纯化病毒，特别是呼肠弧病毒的改进方法。可以用洗涤剂从细胞培养物中提取传染病毒以产生高滴度的病毒，然后可以通过简单的步骤如过滤和柱层析纯化病毒。还提供了包含根据本发明制备的病毒的病毒和组合物。

8. 发明授权

US07803385B2 Reoviruses having modified sequences 有权
标题翻译：具有修饰序列的呼肠病毒
公开(公告)号：US07803385B2
公开(公告)日：2010-09-28
申请号：US12046095
申请日：2008-03-11
申请人： Matthew C. Coffey
发明人： Matthew C. Coffey
IPC分类号： A61K48/00 , C12N7/00
CPC分类号： A61K45/06 , A61K35/13 , A61K35/765 , C07K14/005 , C12N7/00 , C12N2720/12221 , C12N2720/12222
摘要： The invention provides for modified reovirus nucleic acid sequences and modified reovirus polypeptide sequences as well as reoviruses containing such modified nucleic acid or polypeptide sequences. The invention also provides for pharmaceutical compositions that include reoviruses having a modified sequence as well as methods of making and using such reoviruses.
摘要翻译：本发明提供了修饰的呼肠孤病毒核酸序列和修饰的呼肠孤病毒多肽序列以及含有这种修饰的核酸或多肽序列的呼肠病毒。本发明还提供了包含具有修饰序列的呼肠病毒的药物组合物以及制备和使用这些呼肠孤病毒的方法。

9. 发明授权

US07763252B2 Methods for the treatment of cellular proliferative disorders 有权
标题翻译：治疗细胞增殖性疾病的方法
公开(公告)号：US07763252B2
公开(公告)日：2010-07-27
申请号：US11807908
申请日：2007-05-30
申请人： Matthew C. Coffey
发明人： Matthew C. Coffey
IPC分类号： A61K39/395 , C12Q1/02 , A61P43/00
CPC分类号： G01N33/6872 , A61K35/765 , A61K45/06 , C12N2720/12232 , C12Q1/485 , G01N33/57407 , G01N33/57415 , G01N33/57496 , G01N2333/135 , G01N2333/14 , A61K2300/00
摘要： The present invention relates to methods of identifying the susceptibility of cells to reovirus infection by measuring constitutive ras-MAP signaling. The invention also pertains to methods using reovirus for the treatment of cellular proliferative disorders, and particularly cellular proliferative disorders wherein the proliferating cells exhibit constitutive MAPK phosphorylation, in mammals. In particular, the methods provide for reovirus treatment of mammals to treat proliferative disorders which include breast tumors, a subset of tumors in which mutation of the ras gene is not believed to play a significant role.
摘要翻译：本发明涉及通过测量组成型ras-MAP信号来鉴定细胞对呼肠孤病毒感染的易感性的方法。本发明还涉及使用呼肠孤病毒治疗细胞增殖性疾病的方法，特别是哺乳动物中增殖细胞表现出组成型MAPK磷酸化的细胞增殖性疾病。特别地，所述方法提供了呼肠孤病毒治疗哺乳动物以治疗增殖性疾病，包括乳腺肿瘤，其中ras基因的突变不被认为起重要作用的肿瘤的子集。

10. 发明申请

US20080292594A1 MUTANT REOVIRUSES AND METHODS OF MAKING AND USING 审中-公开
标题翻译：突变体病毒及其制备和使用方法
公开(公告)号：US20080292594A1
公开(公告)日：2008-11-27
申请号：US12124522
申请日：2008-05-21
申请人： Matthew C. Coffey , Bradley G. Thompson
发明人： Matthew C. Coffey , Bradley G. Thompson
IPC分类号： A61K35/76 , C12N7/00 , C07K14/00 , A61P43/00 , C12N15/74
CPC分类号： C12N7/00 , A61K35/13 , A61K2035/11 , C07K14/005 , C12N2720/12021 , C12N2720/12022
摘要： Provided herein is a mutant reovirus (e.g., a genetically-engineered ISVP). Compositions including mutant reoviruses and methods of using such mutant reoviruses are also provided.
摘要翻译：本文提供突变型呼肠孤病毒（例如，遗传工程ISVP）。还提供了包括突变型呼肠病毒的组合物和使用这种突变型呼肠孤病毒的方法。

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