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1. 发明授权

US6008342A DNA encoding eimeria antigen 失效
标题翻译：编码艾美球虫抗原的DNA
公开(公告)号：US6008342A
公开(公告)日：1999-12-28
申请号：US770035
申请日：1996-12-19
申请人： Mary-Helen Binger , Luis Pasamontes
发明人： Mary-Helen Binger , Luis Pasamontes
IPC分类号： A61K39/00 , C07K14/455 , C07H21/04 , A61K39/012 , C12N1/20 , C12P21/04
CPC分类号： C07K14/455 , A61K39/00 , C12N2799/023 , C12N2799/028
摘要： The invention provides an immunogenic polypeptide having the amino acid sequenceM A K S M L S G I V F A G L V A A A A A - S S A N S A A N V S V L E S G P A V Q E - V P A R T V T A R L A K P L L L L S A L - A A T L A A A F L V L Q C F N I I S S N - N Q Q T S V R R L A A G G A C G D E E D - A D E G T S Q Q A S R R R R K P D T P A - A D K Y D F V G G T P V S V T E P N V D - E V L I Q I R N K Q I F L K N P W T G Q - E E Q V L V L E R Q S E E P I L I V A R - T R Q T L E G Y L G S Q A L A Q D G K T - A K E E K V E G G K T H R R Y K V K S S - D P G Y G F P Y T T V L D G V P V G T D - E D G Y V V E V L M K T G P H G G V D M - M T S T A S Q G K F C G V L M D D G K G - N L V D G Q G R K I T A V I G M L T Q P - D T E F R S G P G D D E D D E (SEQ ID NO:1) and fragments thereof,which polypeptides are capable of inducing an immune response against Eimeria parasites, and the DNA encoding such polypeptides, as well as recombinant vectors and recombinant viruses containing the said DNA or fragments thereof and transformed microorganisms containing such vectors and viruses and coccidiosis vaccines comprising such polypeptides.
摘要翻译：本发明提供了具有氨基酸序列的免疫原性多肽 - MAKSMLSGIVFAGLVAAAAA - - SSANSAANVSVLESGPAVQE - - VPARTVTARLAKPLLLLSAL - - AATLAAAFLVLQCFNIISSN - - NQQTSVRRLAAGGACGDEED - - ADEGTSQQASRRRRKPDTPA - - ADKYDFVGGTPVSVTEPNVD - - EVLIQIRNKQIFLKNPWTGQ - - EEQVLVLERQSEEPILIVAR - - TRQTLEGYLGSQALAQDGKT - - AKEEKVEGGKTHRRYKVKSS - - DPGYGFPYTTVLDGVPVGTD - - EDGYVVEVLMKTGPHGGVDM - - MTSTASQGKFCGVLMDDGKG - - NLVDGQGRKITAVIGMLTQP - - DTEFRSGPGDDEDDE（SEQ ID NO：1）及其片段，其能够诱导针对艾美虫寄生虫的免疫应答，以及编码这些多肽的DNA，以及重组载体和重组病毒将所述DNA或其片段和含有这样的载体和病毒的转化微生物以及包含这种多肽的球虫病疫苗。

2. 发明授权

US5688513A Coccidiosis vaccines 失效
标题翻译：球虫病疫苗
公开(公告)号：US5688513A
公开(公告)日：1997-11-18
申请号：US257392
申请日：1994-06-09
申请人： Mary-Helen Binger , Luis Pasamontes
发明人： Mary-Helen Binger , Luis Pasamontes
IPC分类号： A61K39/00 , A61K39/002 , A61K39/012 , A61P33/02 , C07K5/04 , C07K5/08 , C07K7/06 , C07K7/08 , C07K14/455 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/30 , C12P21/02 , C12R1/91 , C07K14/00
CPC分类号： C07K14/455 , A61K39/00
摘要： The invention provides an immunogenic polypeptide having the amino acid sequence ##STR1## and fragments thereof, which polypeptides are capable of inducing an immune response against Eimeria parasites, and the DNA encoding such polypeptides, as well as recombinant vectors and recombinant viruses containing the said DNA or fragments thereof and transformed microorganisms containing such vectors and viruses and coccidiosis vaccines comprising such polypeptides.
摘要翻译：本发明提供了具有氨基酸序列MAKSMLSGIVFAGLVAAAAA SSANSAANVSVLESGPAVQE VPARTVTARLAKPLLLLSAL AATLAAAFLVLQCFNIISSN NQQTSVRRLAAGGACGDEED ADEGTSQQASRRRRKPDTPA ADKYDFVGGTPVSVTEPNVD EVLIQIRNKQIFLKNPWTGQ EEQVLVLERQSEEPILIVAR TRQTLEGYLGSQALAQDGKT AKEEKVEGGKTHRRYKVKSS DPGYG免疫原性多肽

3. 发明授权

US5661015A Recombinant coccidiosis vaccines 失效
标题翻译：重组球虫病疫苗
公开(公告)号：US5661015A
公开(公告)日：1997-08-26
申请号：US812349
申请日：1991-12-20
申请人： Mary-Helen Binger , Richard Anthony Chizzonite , Richard Allen Kramer , Peter Thomas Lomedico , Stephen J. McAndrew , Werner Altenburger
发明人： Mary-Helen Binger , Richard Anthony Chizzonite , Richard Allen Kramer , Peter Thomas Lomedico , Stephen J. McAndrew , Werner Altenburger
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/012 , A61P33/02 , A61P37/00 , A61P37/02 , C07K1/22 , C07K14/00 , C07K14/195 , C07K14/44 , C07K14/455 , C07K16/00 , C07K16/12 , C07K16/20 , C12N1/21 , C12N5/10 , C12N15/02 , C12N15/30 , C12N15/863 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91 , C12N15/00
CPC分类号： C12N15/86 , C07K14/455 , C07K16/20 , A61K2039/51 , A61K39/00 , C12N2710/24143
摘要： This invention provides DNA sequences coding for Eimeria surface antigens, recombinant vectors containing such DNA sequences, transformed microorganisms containing such vectors, and methods for producing the antigens using the transformed microorganisms. Methods are also provided for protecting poultry against coccidiosis using the Eimeria surface antigens. The surface antigens can be administered for such protection either as purified proteins or in the form of DNA encoding the proteins in a suitable viral vector such as vaccinia virus.
摘要翻译：本发明提供编码艾美球虫表面抗原的DNA序列，含有此类DNA序列的重组载体，含有该载体的转化微生物，以及使用转化的微生物产生抗原的方法。还提供了使用艾美球虫表面抗原来保护家禽免于球虫病的方法。表面抗原可以作为纯化的蛋白质或以合适的病毒载体如牛痘病毒编码蛋白质的DNA的形式进行这种保护。

4. 发明授权

US5403581A Coccidiosis vaccines 失效
标题翻译：球虫病疫苗
公开(公告)号：US5403581A
公开(公告)日：1995-04-04
申请号：US729099
申请日：1991-07-12
申请人： Mary-Helen Binger , Luis Pasamontes
发明人： Mary-Helen Binger , Luis Pasamontes
IPC分类号： A61K39/00 , A61K39/002 , A61K39/012 , A61P33/02 , C07K5/04 , C07K5/08 , C07K7/06 , C07K7/08 , C07K14/455 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/30 , C12P21/02 , C12R1/91 , C12N1/21 , C12P21/00 , C07K13/00
CPC分类号： C07K14/455 , A61K39/00
摘要： The invention provides an immunogenic polypeptide having the amino acid sequence ##STR1## which polypeptides are capable of inducing an immune response against Eimeria parasites, and the DNA encoding such polypeptides, as well as recombinant vectors and recombinant viruses containing the said DNA and transformed microorganisms containing such vectors and viruses and coccidiosis vaccines comprising such polypeptides.
摘要翻译：本发明提供了具有氨基酸序列MAKSMLSGIVFAGLVAAAAA SSANSAANVSVLESGPAVQE VPARTVTARLAKPLLLLSAL AATLAAAFLVLQCFNIISSN NQQTSVRRLAAGGACGDEED ADEGTSQQASRRRRKPDTPA ADKYDFVGGTPVSVTEPNVD EVLIQIRNKQIFLKNPWTGQ EEQVLVLERQSEEPILIVAR TRQTLEGYLGSQALAQD GKT AKEEKVEGGKTHRRYKVKSS DPGYGFPYTTVLDGVPVGTD EDGYVVEVLMKTGPHGGVDM MTSTASQGKFCGVLMDDGKG NLVDGQGRKITAVIGMLTQP DTEFRSGPGDDEDDE免疫原性多肽（SEQ ID NO：1），其多肽能够诱导针对艾美球虫寄生虫的免疫应答的，并且编码这种多肽的DNA，以及含有所述DNA的重组载体和重组病毒以及含有这种载体和病毒的转化微生物以及包含这种多肽的球虫病疫苗。

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