专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07119203B2 Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors 失效
标题翻译：哌啶基和哌嗪基 - 磺酰基甲基异羟肟酸及其作为蛋白酶抑制剂的用途
公开(公告)号：US07119203B2
公开(公告)日：2006-10-10
申请号：US10618288
申请日：2003-04-25
申请人： Thomas E. Barta , Daniel P. Becker , Louis J. Bedell , Terri L. Boehm , David L. Brown , Jeffery N. Carroll , Yiyuan Chen , Yvette M. Fobian , John N. Freskos , Alan F. Gasiecki , Margaret L. Grapperhaus , Robert M. Heintz , Susan L. Hockerman , Darren J. Kassab , Ish K. Khanna , Stephen A. Kolodziej , Mark A. Massa , Joseph J. McDonald , Brent V. Mischke , Deborah A. Mischke , Patrick B. Mullins , Mark A. Nagy , Monica B. Norton , Joseph G. Rico , Michelle A. Schmidt , Nathan W. Stehle , John J. Talley , William F. Vernier , Clara I. Villamil , Lijuan J. Wang , Thomas A. Wynn
发明人： Thomas E. Barta , Daniel P. Becker , Louis J. Bedell , Terri L. Boehm , David L. Brown , Jeffery N. Carroll , Yiyuan Chen , Yvette M. Fobian , John N. Freskos , Alan F. Gasiecki , Margaret L. Grapperhaus , Robert M. Heintz , Susan L. Hockerman , Darren J. Kassab , Ish K. Khanna , Stephen A. Kolodziej , Mark A. Massa , Joseph J. McDonald , Brent V. Mischke , Deborah A. Mischke , Patrick B. Mullins , Mark A. Nagy , Monica B. Norton , Joseph G. Rico , Michelle A. Schmidt , Nathan W. Stehle , John J. Talley , William F. Vernier , Clara I. Villamil , Lijuan J. Wang , Thomas A. Wynn
IPC分类号： C07D405/14 , C07D405/12 , A61K31/496
CPC分类号： C07D213/74 , C07D211/66 , C07D211/96 , C07D309/08 , C07D335/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D411/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. Such hydroxamic acids generally correspond in structure to the following formula: (wherein A1, A2, Y, E1, E2, E3, and Rx are as defined in this specification), and further include salts of such compounds. This invention also is directed to compositions of such hydroxamic acids, intermediates for the syntheses of such hydroxamic acids, methods for making such hydroxamic acids, and methods for treating conditions (particularly pathological conditions) associated with MMP activity and/or aggrecanase activity.
摘要翻译：本发明一般涉及蛋白酶（也称为“蛋白酶”）抑制剂，尤其涉及哌啶基和哌嗪基 - 磺酰基甲基异羟肟酸，其特别是抑制基质金属蛋白酶（也称为“基质金属蛋白酶”或“MMP “）活性和/或蛋白聚糖蛋白聚糖酶活性。这样的异羟肟酸通常在结构上对应于下式：（其中A 1，A 2，Y，E 1， 2，E 3和R x如本说明书中所定义），并且还包括这些化合物的盐。本发明还涉及这种异羟肟酸的组合物，用于合成这种异羟肟酸的中间体，制备这种异羟肟酸的方法，以及用于治疗与MMP活性和/或蛋白聚糖蛋白聚糖酶活性相关的病症（特别是病理状态）的方法。

2. 发明申请

US20130029987A1 SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 有权
公开(公告)号：US20130029987A1
公开(公告)日：2013-01-31
申请号：US13451574
申请日：2012-04-20
申请人： Brydon L. Bennett , Jan Elsner , Paul Erdman , Robert Hilgraf , Laurie Ann LeBrun , Meg McCarrick , Mehran F. Moghaddam , Mark A. Nagy , Stephen Norris , David A. Paisner , Marianne Sloss , William J. Romanow , Yoshitaka Satoh , Jayashree Tikhe , Won Hyung Yoon , Mercedes Delgado
发明人： Brydon L. Bennett , Jan Elsner , Paul Erdman , Robert Hilgraf , Laurie Ann LeBrun , Meg McCarrick , Mehran F. Moghaddam , Mark A. Nagy , Stephen Norris , David A. Paisner , Marianne Sloss , William J. Romanow , Yoshitaka Satoh , Jayashree Tikhe , Won Hyung Yoon , Mercedes Delgado
IPC分类号： A61K31/505 , C07D405/12 , C07D401/12 , A61K31/506 , C07D405/14 , C12N5/071 , C07D413/12 , A61K31/5377 , A61P1/16 , A61P3/10 , A61P3/00 , C07D239/48 , C07D403/12
CPC分类号： C07D239/48 , A61K31/505 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： Provided herein are Diaminopyrimidine Compounds having the following structures: wherein R1, R2, R3, and R4 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidine Compound, and methods for treating or preventing liver fibrotic disorders or a condition treatable or preventable by inhibition of a JNK pathway.

3. 发明授权

US5049039A Radial piston and cylinder compressed gas motor 失效
标题翻译：径向活塞和气缸压缩气体马达
公开(公告)号：US5049039A
公开(公告)日：1991-09-17
申请号：US443757
申请日：1989-11-30
申请人： Donald E. Knoth , James W. Bradbury , Mark A. Nagy
发明人： Donald E. Knoth , James W. Bradbury , Mark A. Nagy
IPC分类号： F01B1/06 , F01B17/02 , F02B75/18 , F02B75/22 , F03C1/053 , F03C1/36 , F03C1/38
CPC分类号： F03C1/0444 , F01B1/062 , F01B17/02 , F02B75/22 , F03C1/0438 , F03C1/053 , F02B2075/184
摘要： A radial piston and cylinder compressed gas motor is disclosed which is particularly suited for use where economical power sources are required. The motor includes a cylinder block having a plurality of radially extending cylinders open at their outer ends to radially extending passages and having exhaust ports open when associated pistons are adjacent their bottom dead center positions. Such passages extend to a valve system provided on the crank of the motor which functions to supply compressed gas to selected cylinders while connecting other cylinders together so that gas is exhausted from cylinders containing extending pistons to open exhaust ports in other cylinders. This minimizes back pressure to resist motor operation. The crank is formed of two generally cylindrical members and can be produced without eccentric machining or grinding operations. A simple cylindrical head gasket, which is compressed against the periphery of the cylinder block, closes the cylinders and is held in place by a shrink-fitted ring. Peripherally extending inclined slots are formed in the cylinder wall for exhausting gas from the motor into a circular manifold chamber through which the gas is exhausted from the motor. The manifold chamber is provided with enlarged portions adjacent to each exhaust port which reduce exhaust noise. Some embodiments provide motors without master piston rods. Such embodiments provide wrist plates connected to offset piston rods to provide improved starting and running torque.
摘要翻译：公开了一种径向活塞和气缸压缩气体电动机，其特别适用于需要经济电源的场合。马达包括一个气缸体，其具有多个径向延伸的气缸，在其外端开放到径向延伸通道，并且当相关的活塞邻近其下止点位置时，排气口打开。这种通道延伸到设置在马达的曲柄上的阀系统，其功能是将压缩气体供应到选定的气缸，同时将其它气缸连接在一起，使得气体从包含延伸活塞的气缸排出到其它气缸中的排气口。这最大限度地减少了抵抗电机运行的背压。曲柄由两个通常为圆柱形的构件形成，并且可以在没有偏心加工或研磨操作的情况下制造。一个简单的圆柱形头垫片被压靠在气缸体的周边上，使气缸闭合，并通过一个收缩环保持在适当位置。在气缸壁中形成有外围延伸的倾斜槽，用于将气体从电动机排出到圆形歧管室中，气体通过该歧管室从电动机排出。歧管室设置有与每个排气口相邻的放大部分，其减少排气噪声。一些实施例提供没有主活塞杆的电动机。这样的实施例提供连接到偏移活塞杆的腕板，以提供改进的启动和运行扭矩。

4. 发明授权

US09139534B2 Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith 有权
标题翻译：取代的二氨基甲酰胺和二氨基腈嘧啶，其组合物及其处理方法
公开(公告)号：US09139534B2
公开(公告)日：2015-09-22
申请号：US13451574
申请日：2012-04-20
申请人： Brydon L. Bennett , Jan Elsner , Paul Erdman , Robert Hilgraf , Laurie Ann LeBrun , Meg McCarrick , Mehran F. Moghaddam , Mark A. Nagy , Stephen Norris , David A. Paisner , Marianne Sloss , William J. Romanow , Yoshitaka Satoh , Jayashree Tikhe , Won Hyung Yoon , Mercedes Delgado
发明人： Brydon L. Bennett , Jan Elsner , Paul Erdman , Robert Hilgraf , Laurie Ann LeBrun , Meg McCarrick , Mehran F. Moghaddam , Mark A. Nagy , Stephen Norris , David A. Paisner , Marianne Sloss , William J. Romanow , Yoshitaka Satoh , Jayashree Tikhe , Won Hyung Yoon , Mercedes Delgado
IPC分类号： C07D239/48 , A61K31/505 , C07D401/12 , C07D409/12 , C07D403/12 , C07D401/04 , C07D405/12
CPC分类号： C07D239/48 , A61K31/505 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： Provided herein are Diaminopyrimidine Compounds having the following structures: wherein R1, R2, R3, and R4 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidine Compound, and methods for treating or preventing liver fibrotic disorders or a condition treatable or preventable by inhibition of a JNK pathway.
摘要翻译：本文提供具有以下结构的二氨基嘧啶化合物：其中R1，R2，R3和R4如本文所定义，包含有效量的二氨基嘧啶化合物的组合物，以及用于治疗或预防肝纤维化疾病的方法或可治疗或可预防的病症抑制JNK通路。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式