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1. 发明授权

US07368264B2 SLC1A1 marker for anxiety disorder 有权
标题翻译： SLC1A1焦虑症标志物
公开(公告)号：US07368264B2
公开(公告)日：2008-05-06
申请号：US11591244
申请日：2006-10-31
申请人： Paul Daniel Arnold , Margaret A. Richter , James Lowery Kennedy
发明人： Paul Daniel Arnold , Margaret A. Richter , James Lowery Kennedy
IPC分类号： C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention provides methods for diagnosing or identifying susceptibility of a subject to an anxiety or mood disorder. One method involves testing a sample obtained from the subject for the presence of a polymorphism in Intron 10 of the SLC1A1 gene. The presence of allele G or allele A of the A/G polymorphism rs301434 indicates that the patient is susceptible to an anxiety disorder. An alternate method involves testing a sample obtained from the subject for the presence of a polymorphism in the 3′ untranslated region of the SLC1A1 gene. The presence of allele C of C/G polymorphism rs3087879 indicates that the patient is susceptible to an anxiety disorder. Furthermore, a method is provided that involves testing a sample obtained from the subject for the presence of a haplotype in the SLC1A1 gene, wherein the combined presence allele G of the A/G polymorphism rs301434 and allele C of C/G polymorphism rs3087879 indicates that the patient is susceptible to a mood disorder.
摘要翻译：本发明提供用于诊断或鉴定受试者对焦虑或情绪障碍的易感性的方法。一种方法包括测试从受试者获得的样品在SLC1A1基因的内含子10中存在多态性。 A / G多态性rs301434等位基因G或等位基因A的存在表明患者易患焦虑症。一种替代方法包括测试从受试者获得的样品在SLC1A1基因的3'非翻译区中存在多态性。 C / G多态性rs3087879等位基因C的存在表明患者易患焦虑症。此外，提供了一种方法，其包括测试从受试者获得的样品中SLC1A1基因中单体型的存在，其中A / G多态性rs301434的组合存在等位基因G和C / G多态性rs3087879的等位基因C表明患者容易发生心境障碍。

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