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1. 发明授权

US07214353B2 Peptide or protein-capturing surfaces for high throughput MALDI mass spectrometry 失效
标题翻译：用于高通量MALDI质谱的肽或蛋白质捕获表面
公开(公告)号：US07214353B2
公开(公告)日：2007-05-08
申请号：US10232346
申请日：2002-08-30
申请人： Bernice I. Feuer , Jinlin Peng , Ma Sha
发明人： Bernice I. Feuer , Jinlin Peng , Ma Sha
IPC分类号： B01D11/02
CPC分类号： B82Y30/00 , G01N33/54353 , G01N33/545 , Y10T436/24
摘要： Methods and compositions useful for capturing proteins or peptides from a sample mixture and analyzing the captured proteins or peptides via high throughput electrospray ionization (ESI) or matrix-assisted laser desorption/ionization mass spectrometry (HT MALDI MS) are provided. The methods and compositions are useful in large scale, simultaneous analyses of proteins and peptides present in a cell(s), tissue(s), or biological fluid(s).
摘要翻译：提供了用于从样品混合物中捕获蛋白质或肽的方法和组合物，并通过高通量电喷雾电离（ESI）或基质辅助激光解吸/电离质谱（HT MALDI MS）分析捕获的蛋白质或肽。所述方法和组合物可用于大量，同时分析存在于细胞，组织或生物流体中的蛋白质和肽。

2. 发明授权

US07112241B2 Protein crystallography hanging drop multiwell plate 有权
标题翻译：蛋白质晶体悬滴多孔板
公开(公告)号：US07112241B2
公开(公告)日：2006-09-26
申请号：US10694692
申请日：2003-10-27
申请人： Ma Sha
发明人： Ma Sha
IPC分类号： C30B7/14
CPC分类号： C30B7/00 , C30B29/58 , Y10T117/1012
摘要： The present invention includes a microplate for performing crystallography studies. In particular, the microplate has a frame that includes a plurality of wells formed therein. Each well includes a first well and a second well. The first well includes a relatively large reservoir capable of receiving a reagent solution. The second well includes a relatively small reservoir having a substantially concaved form capable of receiving a protein solution and a reagent solution. The second well is suspended above the first well such that space on the plate is conserved and to enable protein crystal growth utilizing a hanging drop vapor diffusion crystallization process.
摘要翻译：本发明包括用于进行晶体学研究的微孔板。特别地，微板具有包括形成在其中的多个阱的框架。每个井都包括第一口井和第二口井。第一阱包括能够接收试剂溶液的相对较大的储存器。第二阱包括具有能够接收蛋白质溶液和试剂溶液的基本上凹陷形状的相对较小的储存器。第二个阱悬浮在第一个阱的上方，使得板上的空间被保存并且利用悬滴蒸气扩散结晶过程来实现蛋白质晶体生长。

3. 发明授权

US06913732B2 Microplate for performing crystallography studies and methods for making and using such microplates 有权
标题翻译：用于进行晶体学研究的微孔板以及制造和使用这种微孔板的方法
公开(公告)号：US06913732B2
公开(公告)日：2005-07-05
申请号：US09811999
申请日：2001-03-19
申请人： Ma Sha , Kathy Youngbear
发明人： Ma Sha , Kathy Youngbear
IPC分类号： B01L3/00 , B29C45/00 , B29C45/26 , C07K1/36 , C30B7/00
CPC分类号： C07K1/36 , B01L3/5025 , B29C45/00 , B29C45/2628 , C30B7/00 , C30B29/58 , Y10T117/1024
摘要： The present invention includes a microplate for performing crystallography studies and methods for making and using such microplates. In particular, the microplate has a frame which includes a plurality of wells formed therein. Each well includes a first well and a second well. The first well includes a relatively small reservoir having a substantially concaved form capable of receiving a protein solution and a reagent solution. The second well includes a relatively large reservoir capable of receiving a reagent solution that has a higher concentration than the reagent solution within the first well, wherein the protein solution and the reagent solution within the first well interact with the reagent solution within the second well via a vapor diffusion process which enables the formation of protein crystals within the first well. The microplate may be sized so that it can be handled by a robotic handling system and/or a liquid handling system.
摘要翻译：本发明包括用于进行晶体学研究的微孔板和用于制造和使用这种微孔板的方法。特别地，微孔板具有包括形成在其中的多个阱的框架。每个井都包括第一口井和第二口井。第一阱包括具有能够接收蛋白质溶液和试剂溶液的基本上凹陷形状的相对小的储存器。第二阱包括能够接收具有比第一阱内的试剂溶液更高的浓度的试剂溶液的相对大的储存器，其中第一阱内的蛋白质溶液和试剂溶液与第二孔内的试剂溶液相互作用通过能够在第一井内形成蛋白质晶体的蒸气扩散过程。微孔板的尺寸可以由机器人处理系统和/或液体处理系统来处理。

4. 发明申请

US20070224688A1 Peptide or protein-capturing surfaces for high throughput MALDI mass spectrometry 审中-公开
公开(公告)号：US20070224688A1
公开(公告)日：2007-09-27
申请号：US11717259
申请日：2007-03-13
申请人： Bernice Feuer , Jinlin Peng , Ma Sha
发明人： Bernice Feuer , Jinlin Peng , Ma Sha
IPC分类号： G01N33/48
CPC分类号： B82Y30/00 , G01N33/54353 , G01N33/545 , Y10T436/24
摘要： Methods and compositions useful for capturing proteins or peptides from a sample mixture and analyzing the captured proteins or peptides via high throughput electrospray ionization (ESI) or matrix-assisted laser desorption/ionization mass spectrometry (HT MALDI MS) are provided. The methods and compositions are useful in large scale, simultaneous analyses of proteins and peptides present in a cell(s), tissue(s), or biological fluid(s).

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