专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20150168407A1 ENZYME DETECTION DEVICE 审中-公开
标题翻译：酶检测装置
公开(公告)号：US20150168407A1
公开(公告)日：2015-06-18
申请号：US14395777
申请日：2013-04-22
申请人： Mologic Limited
发明人： Paul Davis , Gita Parekh
IPC分类号： G01N33/573
CPC分类号： G01N33/573 , G01N2333/96419 , G01N2333/96494
摘要： The present invention relates to an enzyme detection device for use in the detection of enzyme activity in a test sample. The invention also relates to indicator molecules for use in the detection of enzyme activity, particularly enzyme cleavage activity, in a test sample, and to methods for detecting the presence of enzyme activity.
摘要翻译：本发明涉及用于检测试验样品中酶活性的酶检测装置。本发明还涉及用于检测测试样品中的酶活性，特别是酶裂解活性的指示剂分子以及用于检测酶活性存在的方法。

2. 发明申请

US20160195534A1 Enzyme Detection Device 审中-公开
标题翻译：酶检测装置
公开(公告)号：US20160195534A1
公开(公告)日：2016-07-07
申请号：US14987314
申请日：2016-01-04
申请人： Mologic Limited
发明人： Paul Davis
IPC分类号： G01N33/573
CPC分类号： G01N33/573 , C12Q1/37 , G01N33/54386 , G01N33/558
摘要： An enzyme detection device (1) for detecting the presence, in a sample, of an enzyme capable of modifying a provided substrate (10). The device (1) comprises a substrate which has a modification region (14) that is sensitive to modification by the enzyme from an unmodified state to a modified state. The device (1) further comprises a substrate recognition molecule (16) which binds the modification region (14) in either the modified or the unmodified state. The modification region 14 of the substrate is preferentially bound by the substrate recognition molecule (16) as compared with the enzyme when mixed. The device further comprises a detectable label (18) coupled to the substrate recognition molecule (17).
摘要翻译：一种用于检测样品中能够修饰所提供的底物（10）的酶的酶检测装置（1）。装置（1）包括具有对酶的修饰敏感的修饰区域（14）的衬底，其从未修饰状态改变为修饰状态。装置（1）还包括在改性或未修饰状态下结合修饰区（14）的底物识别分子（16）。与混合时的酶相比，底物的修饰区域14优先与底物识别分子（16）结合。该装置还包括耦合到基底识别分子（17）的可检测标记（18）。

3. 发明申请

US20150160219A1 ENZYME DETECTION DEVICE 审中-公开
标题翻译：酶检测装置
公开(公告)号：US20150160219A1
公开(公告)日：2015-06-11
申请号：US14395775
申请日：2013-04-22
申请人： Mologic Limited
发明人： Paul Davis , Gita Parekh
IPC分类号： G01N33/573 , G01N33/58
CPC分类号： G01N33/573 , C12Q1/37 , G01N33/543 , G01N33/581 , G01N2333/948 , G01N2333/96494 , G01N2333/966
摘要： The present invention relates to an enzyme detection device for detecting or measuring the presence in a test sample of the activity of an enzyme capable of cleaving a substrate. The invention also relates to methods for detecting enzyme activity, in particular the presence in a test sample of an enzyme capable of cleaving a substrate, and methods for determining the level or amount of such an enzyme in a test sample.
摘要翻译：本发明涉及一种酶检测装置，用于检测或测量试验样品中能够切割底物的酶活性的存在。本发明还涉及用于检测酶活性的方法，特别是在能够切割底物的酶的测试样品中的存在，以及测定样品中这种酶的水平或量的方法。

4. 发明申请

US20200378963A1 DETECTION OF CLEAVAGE ACTIVITY OF AN ENZYME 审中-公开
公开(公告)号：US20200378963A1
公开(公告)日：2020-12-03
申请号：US16909309
申请日：2020-06-23
申请人： Mologic Limited
发明人： Paul Davis , Gita Parekh , James Schouten
IPC分类号： G01N33/543 , G01N33/558 , C12Q1/37 , G01N33/573
摘要： The present invention relates to detecting cleavage activity of an enzyme. The various aspects of the invention include an enzyme detection device, kit, method and use for detecting or measuring the presence in a test sample of the activity of an enzyme capable of cleaving a substrate. The invention also relates to indicator and binding molecules useful for carrying out the invention. The enzyme substrate contains a hidden binding site which is only revealed upon cleavage by the enzyme.

5. 发明授权

US10197571B2 Enzyme detection device 有权
公开(公告)号：US10197571B2
公开(公告)日：2019-02-05
申请号：US14395775
申请日：2013-04-22
申请人： Mologic Limited
发明人： Paul Davis , Gita Parekh
IPC分类号： G01N33/50 , G01N33/573 , C12Q1/37 , G01N33/543 , G01N33/58
摘要： Described herein is an enzyme detection device for detecting or measuring the presence in a test sample of the activity of an enzyme capable of cleaving a substrate. Also provided are methods for detecting enzyme activity, in particular the presence in a test sample of an enzyme capable of cleaving a substrate, and methods for determining the level or amount of such an enzyme in a test sample.

6. 发明申请

US20170108511A1 Monitoring Inflammation Status 审中-公开
公开(公告)号：US20170108511A1
公开(公告)日：2017-04-20
申请号：US15122304
申请日：2015-03-02
申请人： Mologic Limited
发明人： Gita Parekh , Paul Davis
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/6863 , G01N2800/12 , G01N2800/7095
摘要： Methods for monitoring inflammation status of a subject comprise determining levels of at least one neutrophil activation marker, or at least three markers, in urine samples taken from the subject at multiple time points, wherein increased levels of the at least one neutrophil activation marker, or at least one of the markers, in a urine sample are indicative of or predictive of an exacerbation of inflammation and/or wherein decreased levels of the at least one neutrophil activation marker, or at least one of the markers, in a urine sample following an increase are indicative or predictive of recovery from, or successful treatment of, an exacerbation of inflammation. Corresponding systems, test kits and computer programs are provided.

7. 发明申请

US20160257988A1 Indicator Molecules For Use In Detecting Enzyme Cleavage Activity 审中-公开
标题翻译：指示剂分子用于检测酶裂解活性
公开(公告)号：US20160257988A1
公开(公告)日：2016-09-08
申请号：US15031608
申请日：2014-10-23
申请人： Mologic Limited
发明人： Paul Davis , Gita Parekh
IPC分类号： C12Q1/37 , G01N21/64 , G01N21/77
CPC分类号： C12Q1/37 , G01N21/6428 , G01N21/77 , G01N33/542 , G01N2021/6432
摘要： The present invention relates to indicator molecules containing multiple cleavage sites for use in detecting enzyme cleavage activity. The invention also relates to various applications of these indicator molecules, for example in enzyme detection devices, particularly although not exclusively, devices for use in the detection of enzyme activity in a test sample. The invention also relates to using the indicator molecules in methods for detecting the presence of enzyme activity in a test sample.
摘要翻译：本发明涉及包含用于检测酶裂解活性的多个切割位点的指示剂分子。本发明还涉及这些指示剂分子的各种应用，例如酶检测装置，特别是但不排他地用于检测试样中酶活性的装置。本发明还涉及在测试样品中用于检测酶活性存在的方法中使用指示剂分子。

8. 发明申请

US20150152471A1 PROTEASE DETECTION 有权
标题翻译： PROTEASE检测
公开(公告)号：US20150152471A1
公开(公告)日：2015-06-04
申请号：US14553182
申请日：2014-11-25
申请人： Mologic Limited
发明人： James A. Schouten
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , B01L3/5055 , B01L2300/0809 , C07K5/0808 , C07K7/06 , G01N33/583
摘要： A polypeptide comprising a chromogenic amino acid. The chromogenic amino acid is flanked by at least one amino acid to the N and C termini thereof. The amine group of the chromogenic amino acid has a pKa of less than 5. The chromogenic amino acid is capable of reacting with a conjugated aldehyde. The polypeptide comprises a target sequence for a target protease which is capable of cleaving the peptide bond comprising the amino group of the chromogenic amino acid.
摘要翻译：包含显色氨基酸的多肽。发色氨基酸的侧面是与其N和C末端的至少一个氨基酸。显色氨基酸的胺基的pKa小于5.发色氨基酸能够与共轭醛反应。多肽包含靶蛋白酶的靶序列，其能够切割包含显色氨基酸的氨基的肽键。

9. 发明申请

US20190154704A1 DETECTING SEPSIS 审中-公开
公开(公告)号：US20190154704A1
公开(公告)日：2019-05-23
申请号：US16087909
申请日：2017-03-24
申请人： Mologic Limited
发明人： Paul Davis , Gita Parekh , Chris Dunston
IPC分类号： G01N33/68
摘要： A method for predicting sepsis or diagnosing systemic inflammatory response syndrome (SIRS) and/or sepsis in a subject comprises determining levels of at least three markers selected from CCL23, A1AT, CRP, sICAM, PLA2, IL-6, procalcitonin, MMP8, TNFalpha, AcPGP, enzymatic MMP activity, TIMP1, sRAGE and desmosine in a sample taken from the subject. The combined levels of the at least three markers are used to predict or diagnose SIRS and/or sepsis. The methods may be performed on a subject with SIRS and which is used to identify an infection in the subject. A preferred panel of markers includes CCL23, A1AT, sICAM, sICAM/VCAM-1 and CRP. Corresponding products, methods of treatment and medical uses are provided.

10. 发明申请

US20170276633A1 DETERMINING GLUCOSE CONTENT OF A SAMPLE 审中-公开
公开(公告)号：US20170276633A1
公开(公告)日：2017-09-28
申请号：US15512287
申请日：2015-09-21
申请人： Mologic Limited
发明人： Andrew John Austin , Paul James Davis
IPC分类号： G01N27/327 , G01N33/66
CPC分类号： G01N27/3277 , G01N33/66
摘要： Non-enzymatic approaches to measuring glucose are based on the direct oxidation of glucose using unmodified copper metal electrodes. A potential is applied to a copper measurement/working electrode, which potential is monitored by a separate reference electrode and the current within the system is balanced with a counter electrode. The presence of the ionized glucose in the sample can then be determined electrochemically. Disclosed herein are methods, devices, and test systems which utilise this novel approach.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式