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1. 发明申请

US20050071344A1 Dynamic generation of XML schema for backend driven data validation 有权
标题翻译：动态生成用于后端驱动数据验证的XML模式
公开(公告)号：US20050071344A1
公开(公告)日：2005-03-31
申请号：US10674974
申请日：2003-09-30
申请人： Yen-Fu Chen , John Dunsmoir , Mark Feinberg , Abhay Pradhan , Hari Shankar
发明人： Yen-Fu Chen , John Dunsmoir , Mark Feinberg , Abhay Pradhan , Hari Shankar
IPC分类号： G06F17/30 , G06F7/00
CPC分类号： G06F17/30917
摘要： The present invention comprises a Schema Generation Program (SGP) and Schema Update Program (SUP). The SGP creates an initial XML Schema and copies the database into a hashtable. At the occurrence of a query interval, the SGP compares the database to the hashtable. If the database is identical to the hashtable, then the SGP resets the query interval and repeats the comparison. If the database and the hashtable are not identical, then the SGP deletes the old hashtable, stores a copy of the database as a new hashtable, and creates a new XML Schema. The XML Schema is stored in the web server so that a registered party may access the XML Schema and check the validity of a group of data before sending the data to the web server as a proposed addition to the database. The SUP notifies registered parties of updates to the XML Schema.
摘要翻译：本发明包括模式生成程序（SGP）和模式更新程序（SUP）。 SGP创建一个初始XML模式，并将数据库复制到散列表中。在查询间隔发生时，SGP将数据库与哈希表进行比较。如果数据库与哈希表相同，则SGP重置查询间隔并重复比较。如果数据库和散列表不相同，则SGP将删除旧的散列表，将数据库的副本存储为新的散列表，并创建新的XML模式。 XML模式存储在Web服务器中，以便注册的方可以访问XML模式，并在将数据发送到Web服务器之前检查一组数据的有效性，作为数据库的建议添加。 SUP通知注册方对XML模式的更新。

2. 发明申请

US20050066026A1 Method of displaying real-time service level performance, breach, and guaranteed uniformity with automatic alerts and proactive rebating for utility computing environment 失效
标题翻译：显示实时服务级别性能，违规和保证均匀性的方法，用于实用计算环境的自动警报和主动返回
公开(公告)号：US20050066026A1
公开(公告)日：2005-03-24
申请号：US10666796
申请日：2003-09-18
申请人： Yen-Fu Chen , John Dunsmoir , Mark Feinberg , Abhay Pradhan , Hari Shankar
发明人： Yen-Fu Chen , John Dunsmoir , Mark Feinberg , Abhay Pradhan , Hari Shankar
IPC分类号： G06Q50/00 , G06F15/16 , G06Q30/00 , G06Q99/00 , H04L12/14 , H04L12/24 , H04L12/26 , G06F15/173
CPC分类号： G06Q30/0601 , H04L12/14 , H04L12/1496 , H04L41/06 , H04L41/22 , H04L41/5003 , H04L41/5009 , H04L41/5016 , H04L41/5029 , H04L41/5032 , H04L43/00 , H04L43/067 , H04L43/0811 , H04L43/0852 , H04L43/0888 , H04L43/16
摘要： The present invention provides a method, apparatus, and computer program product for displaying real-time service level performance, breach, and guaranteed uniformity with automatic alerts and proactive rebating for a utility computing environment. Service level agreement parameters, based on a service level agreement between a customer and a service provider, are used to identify discrepancies in a promised service level for the utility computing environment. A real-time view of a current service level and the promised service level for the customer are displayed. When a discrepancy between the promised service level and the current service level occurs, a rebate is generated for the customer. Alerts identifying the discrepancy and its root cause are provided to the customer and the service provider for the discrepancy. Alerts may also be provided prior to the occurrence of the discrepancy so that an action may be performed to eliminate the potential discrepancy.
摘要翻译：本发明提供了一种方法，装置和计算机程序产品，用于显示实时服务水平的性能，违反和保证的统一性，并为实用计算环境提供自动警报和主动回扣。根据客户和服务提供商之间的服务级别协议，服务级别协议参数用于识别应用程序计算环境的承诺服务级别中的差异。显示当前服务级别和客户承诺的服务级别的实时视图。当承诺服务水平与当前服务水平出现差异时，会为客户生成回扣。识别差异的警报及其根本原因被提供给客户和服务提供商的差异。警报也可以在发生差异之前提供，以便可以执行动作以消除潜在的差异。

3. 发明申请

US20090263830A1 VISUALIZATION AND QUANTITIATION OF CELLULAR CYTOTOXICITY USING CELL-PERMEABLE FLUOROGENIC PROTEASE SUBSTRATES AND CASPASE ACTIVITY INDICATOR MARKERS 审中-公开
标题翻译：使用细胞渗透性荧光素酶基质和CASPASE活性指示剂的细胞生物学活性的可视化和定量
公开(公告)号：US20090263830A1
公开(公告)日：2009-10-22
申请号：US12396736
申请日：2009-03-03
申请人： BEVERLY PACKARD , MARTIN J. BROWN , MARK FEINBERG , LUZHENG LIU , GUIDO SILVESTRI , ANN CHAHROUDI , AKIRA KOMORIYA
发明人： BEVERLY PACKARD , MARTIN J. BROWN , MARK FEINBERG , LUZHENG LIU , GUIDO SILVESTRI , ANN CHAHROUDI , AKIRA KOMORIYA
IPC分类号： G01N33/53 , C12Q1/37 , C12Q1/02
CPC分类号： C12Q1/37 , G01N33/505 , G01N33/573
摘要： This invention provides a non-radioactive assay to monitor and quantify the target-cell killing activities mediated by cytotoxic T lymphocytes (CTLs). This assay is predicated on the discovery that apoptosis pathway activation and, in particular, caspase activity, provides a measure of cytotoxic effector cell activity. In one embodiment, measurement of CTL-induced caspase activation in target cells is achieved through detection of the specific cleavage of fluorogenic caspase substrates. This assay reliably detects antigen-specific CTL killing of target cells, and provides a more sensitive, more informative and safer alternative to the standard 51Cr-release assay most often used to quantify CTL responses. The assay can be used to study CTL-mediated killing of primary host target cells of different cell lineages, and enables the study of antigen-specific cellular immune responses in real time at the single-cell level. As such, the assay can provide a valuable tool for studies of infectious disease pathogenesis and development of new vaccines and immunotherapies.
摘要翻译：本发明提供了用于监测和定量由细胞毒性T淋巴细胞（CTL）介导的靶细胞杀伤活性的非放射性测定。该测定基于发现细胞凋亡途径激活，特别是胱天蛋白酶活性提供细胞毒效应细胞活性的量度的发现。在一个实施方案中，通过检测荧光半胱天冬酶底物的特异性切割来实现靶细胞中CTL诱导的半胱天冬酶激活的测量。该测定可靠地检测靶细胞的抗原特异性CTL杀伤，并且提供了更常用于定量CTL反应的标准51Cr释放测定法更灵敏，更有信息和更安全的替代方法。该测定法可用于研究CTL介导的不同细胞系主要宿主靶细胞的杀伤作用，并能够在单细胞水平实时研究抗原特异性细胞免疫应答。因此，该测定可以为感染性疾病发病机理的研究和新疫苗和免疫疗法的开发提供有价值的工具。

4. 发明授权

US5965124A Replication-competent recombinant viral vaccines and method of producing same 失效
标题翻译：具有复制能力的重组病毒疫苗及其生产方法
公开(公告)号：US5965124A
公开(公告)日：1999-10-12
申请号：US381637
申请日：1995-01-31
申请人： Mark Feinberg , Raul Andino , Carolyn Louise Weeks-Levy , Patricia Anne Reilly
发明人： Mark Feinberg , Raul Andino , Carolyn Louise Weeks-Levy , Patricia Anne Reilly
IPC分类号： A61K39/00 , C07K14/02 , C07K14/035 , C07K14/105 , C07K14/11 , C07K14/14 , C07K14/235 , C07K14/28 , C12N15/86 , A01N63/00
CPC分类号： C07K14/005 , C07K14/235 , C07K14/28 , C12N15/86 , A61K39/00 , C07K2319/00 , C12N2710/16622 , C12N2720/12322 , C12N2730/10122 , C12N2760/16122 , C12N2770/32622
摘要： Replication-competent recombinant viruses, particularly replication-competent recombinant polioviruses, which include (1) exogenous nucleic acid sequences which encode an exogenous polypeptide and (2) a nucleic acid sequence which encodes an artificial proteolytic cleavage site for a viral or cellular protease which proteolytically processes (cleaves) the precursor protein produced by the parent virus and uses therefor. The recombinant precursor is cleaved into the usual array of constituent proteins, freeing the exogenous polypeptide. Replication-competent recombinant viruses are useful as vaccines against bacterial, viral, fungal and yeast infections, parasitic diseases, cancer and allergies.
摘要翻译：具有复制能力的重组病毒，特别是具有复制能力的重组体脊髓灰质炎病毒，其包括（1）编码外源多肽的外源核酸序列和（2）编码蛋白水解的病毒或细胞蛋白酶的人工蛋白水解切割位点的核酸序列过程（切割）母体病毒产生的前体蛋白并用于其。将重组前体切割成通常的组成蛋白阵列，释放外源多肽。可复制的重组病毒可用作抗细菌，病毒，真菌和酵母菌感染，寄生虫病，癌症和过敏的疫苗。

5. 发明申请

US20070275010A1 Mva Vaccines 审中-公开
标题翻译： Mva疫苗
公开(公告)号：US20070275010A1
公开(公告)日：2007-11-29
申请号：US10572229
申请日：2004-09-20
申请人： Mark Feinberg , David Garber
发明人： Mark Feinberg , David Garber
IPC分类号： A61K39/12 , A61P31/12 , A61P31/18 , C12N15/63 , C12N15/86 , C12N5/10 , C12N7/00
CPC分类号： C12N15/86 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N2710/24143 , C12N2740/16043 , C12N2740/16122 , C12N2740/16234
摘要： Recombinant modified vaccinia Ankara vectors are provided having a null mutation in a gene necessary for replication of the recombinant modified vaccinia Ankara virus and at least one heterologous antigen. The disclosed vectors optionally encode at least one pro-apoptotic factor, at least one anti-apoptotic factor, at least one immunomodulator, and combinations thereof. Cells complementing the null mutation the disclosed vectors are also provided.
摘要翻译：提供了重组修饰的牛痘安卡拉载体，其在重组修饰的痘苗病毒安卡拉病毒和至少一种异源抗原的复制所必需的基因中具有无效突变。所公开的载体任选地编码至少一种促凋亡因子，至少一种抗凋亡因子，至少一种免疫调节剂及其组合。还提供补充所公开载体的无效突变的细胞。

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