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1. 发明授权

US11634738B2 Use of marine algae for co-producing alkenones, alkenone derivatives, and co-products 有权
公开(公告)号：US11634738B2
公开(公告)日：2023-04-25
申请号：US17388298
申请日：2021-07-29
申请人： Woods Hole Oceanographic Institution , Western Washington University , Marine Biological Laboratory
发明人： Christopher M. Reddy , Gregory W. O'Neil , Scott R. Lindell
IPC分类号： C12P7/64 , C12P7/26 , C07D303/32 , C12N1/12 , C10L1/185 , C10L1/19 , C10L1/18 , C12P7/649 , C11C3/00 , C07C49/00
摘要： A method comprising a series of selective extraction techniques for the parallel production of biodiesel and isolation of several valuable co-products including an alkenone hydrocarbon mixture of the kerosene/jet fuel range (primarily C10-, C12-, and C17-hydrocarbons) and fucoxanthin, a high-valued carotenoid, from the marine alkenone-producing microalgae Isochrysis.

2. 发明授权

US09970034B2 Use of marine algae for co-producing alkenones, alkenone derivatives, and co-products 有权
公开(公告)号：US09970034B2
公开(公告)日：2018-05-15
申请号：US14599460
申请日：2015-01-17
申请人： Woods Hole Oceanographic Institution , Western Washington University , Marine Biological Laboratory
发明人： Christopher M. Reddy , Gregory W. O'Neil , Scott R. Lindell
IPC分类号： C12N1/26 , C12N1/12 , C12P7/64 , C12P7/26 , C07D303/32
CPC分类号： C12P7/649 , C07D303/32 , C12N1/12 , C12P7/26 , Y02E50/13
摘要： A method comprising a series of selective extraction techniques for the parallel production of biodiesel and isolation of several valuable co-products including an alkenone hydrocarbon mixture of the kerosene/jet fuel range (primarily C10-, C12-, and C17-hydrocarbons) and fucoxanthin, a high-valued carotenoid, from the marine alkenone-producing microalgae Isochrysis.

3. 发明申请

US20040173472A1 SELF-REFERENCING ENZYME-BASED MICROSENSOR AND METHOD OF USE 失效
标题翻译：基于酶的基于酶的微型传感器及其使用方法
公开(公告)号：US20040173472A1
公开(公告)日：2004-09-09
申请号：US09966581
申请日：2001-09-28
申请人： Marine Biological Laboratory
发明人： Sung-Kwon Jung , Richard H. Sanger , Peter J.S. Smith , John R. Pepperell
IPC分类号： G01N027/26 , G01N027/327
CPC分类号： C12Q1/001
摘要： A micron-scale self-referencing microsensor is disclosed which uses an enzyme-based electrode to measure the flux of an electrochemically inactive analyte such as glucose. The electrode oscillates between at least two positions. In the presence of the analyte, the enzyme generates a species detectable by the electrode.
摘要翻译：公开了一种微米级自参照微传感器，其使用酶基电极来测量电化学惰性分析物如葡萄糖的通量。电极在至少两个位置之间振荡。在分析物的存在下，酶产生可被电极检测的物质。

4. 发明授权

US10918657B2 Treatment of spinal cord injury or traumatic brain injury by inhibition of synuclein protein aggregation 有权
公开(公告)号：US10918657B2
公开(公告)日：2021-02-16
申请号：US14536176
申请日：2014-11-07
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , THE MARINE BIOLOGICAL LABORATORY , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： Jennifer R. Morgan , Gal Bitan , David J. Busch
IPC分类号： A61K31/7088 , A61K31/6615 , A61K31/663 , A61K31/255 , A61K31/194 , C12N15/113 , A61K45/06
摘要： Methods for the treatment of spinal cord injury or traumatic brain injury are provided. In certain embodiments, the methods include the use of a molecular tweezers and/or nucleobase oligomer capable of inhibiting the accumulation or aggregation of one or more amyloidogenic proteins and/or synuclein proteins. Examples of treatments that may inhibit accumulation or aggregation of one or more amyloidogenic proteins and/or synuclein proteins include treatment with a synuclein antisense nucleobase oligomer or treatment with the molecular tweezers CLR01. These treatments may improve outcomes of spinal cord surgery or traumatic brain injury, including, without limitation, neuronal survival, neuronal regeneration, and recovery of neuronal functions.

5. 发明申请

US20140171608A1 USE OF MARINE ALGAE FOR PRODUCING POLYMERS 审中-公开
标题翻译：用于生产聚合物的海藻的使用
公开(公告)号：US20140171608A1
公开(公告)日：2014-06-19
申请号：US14187929
申请日：2014-02-24
申请人： Marine Biological Laboratory , WOODS HOLE OCEANOGRAPHIC INSTITUTION
发明人： Scott R. Lindell , Christopher M. Reddy
IPC分类号： C12P7/64 , C08F116/36
CPC分类号： C08F216/36 , C12N1/12 , C12P7/26 , C12P7/649 , Y02E50/13
摘要： In certain aspects, the disclosure provides methods for producing polymers from alkenone-producing algae, such as algae species of the Isochrysis family.
摘要翻译：在某些方面，本公开提供了从产生烯酮的藻类（例如等sis sis族的藻类）生产聚合物的方法。

6. 发明申请

US20030167283A1 Managing taxonomic information 有权
标题翻译：管理分类信息
公开(公告)号：US20030167283A1
公开(公告)日：2003-09-04
申请号：US10087621
申请日：2002-03-01
申请人： Marine Biological Laboratory
发明人： David Pratt Remsen , Catherine N. Norton
IPC分类号： G06F007/00
CPC分类号： G06F17/30882
摘要： In a management of taxonomic information, a name that specifies an organism is identified. Based on the name and a database of organism names or classifications, another name that specifies the organism and that represents a link between pieces of biological identification information in the database, or a classification for the organism, is determined. Based on the other name or the classification, information associated with the organism is identified.
摘要翻译：在分类信息管理中，确定了一个指定有机体的名称。基于有机体名称或分类的名称和数据库，确定指定生物体的另一个名称，其表示数据库中的生物识别信息之间的链接或生物体的分类。根据其他名称或分类，确定与生物相关的信息。

7. 发明授权

US09739734B2 Methods and systems of detecting exocytosis of a target molecule from a population of cells 有权
公开(公告)号：US09739734B2
公开(公告)日：2017-08-22
申请号：US14889568
申请日：2014-05-12
申请人： THE MARINE BIOLOGICAL LABORATORY
发明人： Mark Alan Messerli , Emma Heart , Munan Xu , Shanta Menon Messerli
IPC分类号： A61K35/39 , G01N27/02 , G01N33/50 , G01N33/483
CPC分类号： G01N27/026 , A61K35/39 , G01N33/4833 , G01N33/5005
摘要： A method of detecting exocytosis of a target molecule from a population of cells derived from a human subject, includes applying first and second electrical signals, each having a respective frequency, across the population of cells. Each of the first and second electrical signals being either an alternating current or an alternating voltage. The method includes measuring a first voltage change if the first electrical signal is an alternating current or measuring a first current change if the first electrical signal is an alternating voltage, and measuring a second voltage change if the second electrical signal is an alternating current or measuring a second current change if the second electrical signal is an alternating voltage. The method includes determining an electrical impedance of the population of cells, a change in that impedance indicating an amount of the target molecule released from the population of cells.

8. 发明申请

US20190161777A1 USE OF MARINE ALGAE FOR CO-PRODUCING ALKENONES, ALKENONE DERIVATIVES, AND CO-PRODUCTS 审中-公开
公开(公告)号：US20190161777A1
公开(公告)日：2019-05-30
申请号：US16259339
申请日：2019-01-28
申请人： WOODS HOLE OCEANOGRAPHIC INSTITUTION , WESTERN WASHINGTON UNIVERSITY , MARINE BIOLOGICAL LABORATORY
发明人： CHRISTOPHER M. REDDY , GREGORY W. O'NEIL , SCOTT R. LINDELL
IPC分类号： C12P7/64 , C12N1/12 , C07D303/32 , C12P7/26
摘要： A method comprising a series of selective extraction techniques for the parallel production of biodiesel and isolation of several valuable co-products including an alkenone hydrocarbon mixture of the kerosene/jet fuel range (primarily C10-, C12-, and C17-hydrocarbons) and fucoxanthin, a high-valued carotenoid, from the marine alkenone-producing microalgae Isochrysis.

9. 发明申请

US20040125373A1 Enhancing polarized light microscopy 失效
标题翻译：增强偏振光显微镜
公开(公告)号：US20040125373A1
公开(公告)日：2004-07-01
申请号：US10435929
申请日：2003-05-12
申请人： Marine Biological Laboratory
发明人： Rudolf Oldenbourg , Mykhailo Shribak , Clifford C. Hoyt , Peter Torok
IPC分类号： G01J004/00
CPC分类号： G02B21/0092 , G02B21/0004
摘要： A microscope system for determining optical properties of a specimen includes a source of polarized light, a detector for detecting the intensity of light incident thereon, an optical path extending from the source to the detector, a condenser for providing light from the source to the specimen, an objective for receiving light from the specimen, a support for mounting the specimen, a sectored variable retarder mounted in the optical path, and a polarized light analyzer mounted in the path between the sectored variable retarder and the detector. The variable retarder has a multiple sectors. Each sector is individually addressable by a control signal that affects the light retardation characteristics of the sector.
摘要翻译：用于确定样品的光学特性的显微镜系统包括偏振光源，用于检测入射到其上的光的强度的检测器，从光源延伸到检测器的光路，用于将光从源提供到样品的冷凝器，用于接收来自试样的光的目的，用于安装试样的支撑体，安装在光路中的分段可变延迟器，以及安装在切线可变延迟器和检测器之间的路径中的偏振光分析器。可变延迟器具有多个扇区。每个扇区可以通过影响扇区的光延迟特性的控制信号单独寻址。

10. 发明申请

US20210355512A1 USE OF MARINE ALGAE FOR CO-PRODUCING ALKENONES, ALKENONE DERIVATIVES, AND CO-PRODUCTS 有权
公开(公告)号：US20210355512A1
公开(公告)日：2021-11-18
申请号：US17388298
申请日：2021-07-29
申请人： Woods Hole Oceanographic Institution , Western Washington University , Marine Biological Laboratory
发明人： CHRISTOPHER M. REDDY , GREGORY W. O'NEIL , SCOTT R. LINDELL
IPC分类号： C12P7/64 , C12P7/26 , C07D303/32 , C12N1/12 , C10L1/185 , C10L1/19 , C10L1/18
摘要： A method comprising a series of selective extraction techniques for the parallel production of biodiesel and isolation of several valuable co-products including an alkenone hydrocarbon mixture of the kerosene/jet fuel range (primarily C10-, C12-, and C17-hydrocarbons) and fucoxanthin, a high-valued carotenoid, from the marine alkenone-producing microalgae Isochrysis.

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