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1. 发明授权

US09095506B2 Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof 有权
标题翻译：可生物降解的α-2激动剂聚合物植入物及其治疗用途
公开(公告)号：US09095506B2
公开(公告)日：2015-08-04
申请号：US12272548
申请日：2008-11-17
申请人： Lon T. Spada , Alazar N. Ghebremeskel , Michael R. Robinson
发明人： Lon T. Spada , Alazar N. Ghebremeskel , Michael R. Robinson
IPC分类号： A61K9/00 , A61K31/498 , A61K47/34
CPC分类号： A61K9/0051 , A61K31/498 , A61K47/34
摘要： Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants can be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, including reduction of an elevated intraocular pressure.
摘要翻译：生物相容性眼内植入物包括α-2肾上腺素能受体激动剂和与α-2肾上腺素能受体激动剂相关的聚合物，以促进α-2肾上腺素能受体激动剂延长一段时间的眼睛释放。 α-2肾上腺素能受体激动剂可以与可生物降解的聚合物基质例如两种可生物降解的聚合物的基质相关联。植入物可以放置在眼睛中以治疗一种或多种眼部病症，例如眼睛血管病变或青光眼，包括降低眼内压升高。

2. 发明授权

US08846073B2 Low temperature processes for making cyclic lipid implants for intraocular use 有权
标题翻译：制备环状脂质植入物用于眼内使用的低温过程
公开(公告)号：US08846073B2
公开(公告)日：2014-09-30
申请号：US11612928
申请日：2006-12-19
申请人： Lon T. Spada , James N. Chang , Michelle Luu
发明人： Lon T. Spada , James N. Chang , Michelle Luu
IPC分类号： A61F2/00 , A61K31/165 , A61K9/00 , A61K31/557 , A61K9/14
CPC分类号： A61K9/146 , A61K9/0051 , A61K9/141 , A61K31/165 , A61K31/557 , A61K31/5575 , A61K47/10 , A61K47/34
摘要： Biocompatible implants comprising a cyclic lipid therapeutic agent are made using a low temperature melt extrusion process. The implants are suitable for intraocular use to treat an ocular condition.
摘要翻译：使用低温熔融挤出方法制备包含环状脂质治疗剂的生物相容性植入物。植入物适用于眼内用于治疗眼部病症。

3. 发明授权

US08771722B2 Methods of treating ocular disease using steroid-containing sustained release intraocular implants 有权
标题翻译：使用含类固醇的持续释放眼内植入物治疗眼部疾病的方法
公开(公告)号：US08771722B2
公开(公告)日：2014-07-08
申请号：US13356934
申请日：2012-01-24
申请人： Glenn T. Huang , Thierry Nivaggioli , Lon T. Spada , Hiroshi Sugimoto , Wendy M. Blanda , James N. Chang , Orest Olejnik
发明人： Glenn T. Huang , Thierry Nivaggioli , Lon T. Spada , Hiroshi Sugimoto , Wendy M. Blanda , James N. Chang , Orest Olejnik
IPC分类号： A61F2/14
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0024 , A61K9/0092 , A61K9/1647 , A61K9/204 , A61K31/5377 , A61K31/56 , A61K31/573 , A61K31/58 , A61K45/06 , A61K47/593 , A61L27/18 , A61L27/54 , A61L27/58 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/222 , A61L2300/436 , A61L2300/45 , A61L2300/604 , A61L2430/16 , A61K2300/00 , C08L67/04
摘要： Biocompatible intraocular implants include a steroid and an auxiliary agent, where the auxiliary agent is present in an amount sufficient to lessen the severity of at least one side effect compared to the use of an otherwise identical implant lacking said auxiliary agent. The steroid and the auxiliary agent may be present on the same intraocular implant or on different implants. The steroid and auxiliary agent may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants containing the steroid and an auxiliary agent may be placed in an eye to treat one or more ocular conditions while reducing the side effects otherwise accompanying steroid use.
摘要翻译：生物相容性眼内植入物包括类固醇和辅助剂，其中与使用缺乏所述辅助剂的其它相同的植入物相比，辅助剂的存在量足以减轻至少一种副作用的严重性。类固醇和辅助剂可以存在于相同的眼内植入物或不同的植入物上。类固醇和辅助剂可以与可生物降解的聚合物基质相结合，例如两种可生物降解的聚合物的基质。或者，类固醇可以与具有一个或多个开口有效以允许类固醇释放到外部环境中的聚合物涂层相关联。包含类固醇和辅助剂的植入物可以放置在眼睛中以治疗一种或多种眼部病症，同时减少否则伴随类固醇使用的副作用。

4. 发明授权

US08529927B2 Alpha-2 agonist polymeric drug delivery systems 有权
标题翻译： α-2激动剂聚合物药物递送系统
公开(公告)号：US08529927B2
公开(公告)日：2013-09-10
申请号：US11394765
申请日：2006-03-31
申请人： James N. Chang , Lon T. Spada , Wendy M. Blanda , Werhner C. Orilla , James A. Burke , Patrick M. Hughes
发明人： James N. Chang , Lon T. Spada , Wendy M. Blanda , Werhner C. Orilla , James A. Burke , Patrick M. Hughes
IPC分类号： A61K9/00 , A61K31/415 , A61K31/417 , A61K31/498 , A01N43/50
CPC分类号： A61K9/0051 , A61K31/498 , A61L27/18 , A61L27/26 , A61L27/54 , A61L27/58 , A61L2300/604 , A61L2430/16 , Y02A50/401 , C08L67/04
摘要： Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants can be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, including reduction of an elevated intraocular pressure.
摘要翻译：生物相容性眼内植入物包括α-2肾上腺素能受体激动剂和与α-2肾上腺素能受体激动剂相关的聚合物，以促进α-2肾上腺素能受体激动剂延长一段时间的眼睛释放。 α-2肾上腺素能受体激动剂可以与可生物降解的聚合物基质例如两种可生物降解的聚合物的基质相关联。植入物可以放置在眼睛中以治疗一种或多种眼部病症，例如眼睛血管病变或青光眼，包括降低眼内压升高。

5. 发明申请

US20120122821A1 STEROID-CONTAINING SUSTAINED RELEASE INTRAOCULAR IMPLANTS AND RELATED METHODS 有权
标题翻译： STEROID含有持续释放内分泌植入物及相关方法
公开(公告)号：US20120122821A1
公开(公告)日：2012-05-17
申请号：US13356934
申请日：2012-01-24
申请人： Glenn T. Huang , Thierry Nivaggioli , Lon T. Spada , Hiroshi Sugimoto , Wendy M. Blanda , James N. Chang , Orest Olejnik
发明人： Glenn T. Huang , Thierry Nivaggioli , Lon T. Spada , Hiroshi Sugimoto , Wendy M. Blanda , James N. Chang , Orest Olejnik
IPC分类号： A61K31/56 , A61K31/6615 , A61P29/00 , A61P27/06 , A61P25/00 , A61K31/573 , A61P27/02
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0024 , A61K9/0092 , A61K9/1647 , A61K9/204 , A61K31/5377 , A61K31/56 , A61K31/573 , A61K31/58 , A61K45/06 , A61K47/593 , A61L27/18 , A61L27/54 , A61L27/58 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/222 , A61L2300/436 , A61L2300/45 , A61L2300/604 , A61L2430/16 , A61K2300/00 , C08L67/04
摘要： Biocompatible intraocular implants include a steroid and an auxiliary agent, where the auxiliary agent is present in an amount sufficient to lessen the severity of at least one side effect compared to the use of an otherwise identical implant lacking said auxiliary agent. The steroid and the auxiliary agent may be present on the same intraocular implant or on different implants. The steroid and auxiliary agent may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants containing the steroid and an auxiliary agent may be placed in an eye to treat one or more ocular conditions while reducing the side effects otherwise accompanying steroid use.
摘要翻译：生物相容性眼内植入物包括类固醇和辅助剂，其中与使用缺乏所述辅助剂的其它相同的植入物相比，辅助剂的存在量足以减轻至少一种副作用的严重性。类固醇和辅助剂可以存在于相同的眼内植入物或不同的植入物上。类固醇和辅助剂可以与可生物降解的聚合物基质相结合，例如两种可生物降解的聚合物的基质。或者，类固醇可以与具有一个或多个开口有效以允许类固醇释放到外部环境中的聚合物涂层相关联。包含类固醇和辅助剂的植入物可以放置在眼睛中以治疗一种或多种眼部病症，同时减少否则伴随类固醇使用的副作用。

6. 发明申请

US20110263611A1 Kinase Inhibitors 有权
标题翻译：激酶抑制剂
公开(公告)号：US20110263611A1
公开(公告)日：2011-10-27
申请号：US13178277
申请日：2011-07-07
申请人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. Devries , Jeffrey L. Edelman , Julie A. Wurster
发明人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. Devries , Jeffrey L. Edelman , Julie A. Wurster
IPC分类号： A61K31/496 , A61P27/06 , A61K31/5377 , A61P27/02
CPC分类号： C07D213/82 , A61K9/0051 , A61K31/44 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K47/34 , C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D413/06 , C07D417/06 , Y02A50/401
摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.
摘要翻译：本发明涉及药物递送系统，其包括眼部植入物，其包括能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子，所述聚合物用于控制聚合物，改变，调节和/或缓慢释放治疗组分到其中放置所述复合物的眼睛的环境中。

7. 发明申请

US20100247606A1 INTRAOCULAR SUSTAINED RELEASE DRUG DELIVERY SYSTEMS AND METHODS FOR TREATING OCULAR CONDITIONS 审中-公开
标题翻译：内镜持续释放药物输送系统及治疗眼睛病症的方法
公开(公告)号：US20100247606A1
公开(公告)日：2010-09-30
申请号：US12411250
申请日：2009-03-25
申请人： Michael R. ROBINSON , James A. Burke , Hui Liu , Werhner C. Orilla , Lon T. Spada , Scott Whitcup , Alazar N. Ghebremskel , Patrick M. Hughes , Kun Xu , Marianne M. Do
发明人： Michael R. ROBINSON , James A. Burke , Hui Liu , Werhner C. Orilla , Lon T. Spada , Scott Whitcup , Alazar N. Ghebremskel , Patrick M. Hughes , Kun Xu , Marianne M. Do
IPC分类号： A61F2/00 , A61K31/215 , A61K31/165 , A61K9/14 , A61K31/4025 , A61K31/426 , A61K31/415 , A61K31/42
CPC分类号： A61K31/557 , A61K9/0051 , A61K9/1647 , A61K9/70 , A61K31/00 , A61K31/5575
摘要： Biocompatible, bioerodible sustained release implants and microspheres for intracameral or anterior vitreal placement include an anti-hypertensive agent and a biodegradable polymer effective to treat an ocular hypertensive condition (such as glaucoma) by relapsing therapeutic amount of the anti-hypertensive agent over a period of time between 10 days and 1 year.
摘要翻译：生物相容性，生物可蚀性缓释植入物和用于乳房内或玻璃体前置放置的微球包括抗高血压剂和可生物降解的聚合物，其通过在一段时间内复发治疗量的抗高血压药物而有效治疗眼高血压病症（如青光眼）时间在10天到1年之间。

8. 发明授权

US06293037B1 Pressure-sensitive adhesives and self-adhesive postage stamps made therewith 失效
标题翻译：压敏粘合剂和自粘邮票
公开(公告)号：US06293037B1
公开(公告)日：2001-09-25
申请号：US09319295
申请日：1999-09-22
申请人： Lon T. Spada , Carol A. Koch , Kathleen M. Alpaugh
发明人： Lon T. Spada , Carol A. Koch , Kathleen M. Alpaugh
IPC分类号： G09F310
CPC分类号： C09J133/08 , C08F220/18 , C09J4/00 , Y10T428/31797 , Y10T428/31895 , Y10T428/31917
摘要： Acrylic, self-adhesive postage stamps are provided and include a flexible facestock bearing an acrylic pressure-sensitive adhesive (PSA), protected by a release liner. The acrylic PSA is a tackified or inherently tacky polymer formed from a plurality of monomers comprising, based on the total weight of monomeric composition, essentially of (i) 9 to 40% isobornyl acrylate and (ii) 50 to 91% of one or more alkyl acrylates.
摘要翻译：提供丙烯酸，自粘邮票，并且包括一个由释放衬垫保护的丙烯酸压敏粘合剂（PSA）的柔性面材。丙烯酸PSA是由多个单体形成的增粘或固有的粘性聚合物，其包含基于单体组合物的总重量，基本上由（i）9至40％的丙烯酸异冰片酯和（ii）50至91％的一种或多种丙烯酸烷基酯。

9. 发明授权

US5122567A Pressure sensitive adhesives of acetoacetoxy-alkyl acrylate polymers 失效
标题翻译：乙酰乙酰氧基 - 丙烯酸烷基酯聚合物的压敏粘合剂
公开(公告)号：US5122567A
公开(公告)日：1992-06-16
申请号：US728820
申请日：1991-07-08
申请人： Lon T. Spada , Joseph J. Wilczynski
发明人： Lon T. Spada , Joseph J. Wilczynski
IPC分类号： C08F220/12 , C09J7/02 , C09J157/04
CPC分类号： C09J157/04 , C08F220/12 , C09J7/021 , C09J7/0217 , Y10S526/931
摘要： There are disclosed normally tacky, pressure-sensitive adhesive compositions comprising one or more normally tacky polymers having a T.sub.g of about 0.degree. C. or less and containing pendant functional groups attached to the backbone and having the formula: ##STR1## in which R.sub.1 is a divalent organic radical at least 3 atoms in length, and X is organoacyl or cyano, the polymers preferably also being normally tacky when cured. Such polymers have markedly improved cohesive strength (shear holding value) with little or no detriment to adhesive tack or adhesion (peel resistance), and these improvements are realized without the necessity of incorporating cross-linking monomers such as N-methylolamides or other cross-linking agents. Pressure-sensitive adhesive, water-based emulsions containing such polymers and pressure-sensitive adhesive articles comprising a substrate having at least a portion of one surface thereof coated with the adhesive compositions are also disclosed. In a preferred embodiment, the adhesive compositions further include a polyacid component for further improving cohesive strength, particularly at acidic pH.
摘要翻译：公开了通常具有粘性的压敏粘合剂组合物，其包含一种或多种具有约0℃或更低的Tg的通常具有粘性的聚合物，并且含有连接于骨架上的侧链官能团并具有下式：其中R 1为长度为至少3个原子的二价有机基团，X是有机酰基或氰基，聚合物优选在固化时通常是发粘的。这些聚合物显着地提高了粘合强度（剪切保持值），很少或没有损害粘合剂粘着性或粘合性（抗剥离性），并且实现了这些改进，而不需要引入交联单体如N-甲基丙烯酰胺或其它交联剂，连接剂。还公开了压敏粘合剂，含有这种聚合物的水性乳液和压敏粘合剂制品，其包含具有涂覆有粘合剂组合物的至少一部分表面的基材。在优选的实施方案中，粘合剂组合物还包括用于进一步提高内聚强度的多酸组分，特别是在酸性pH下。

10. 发明授权

US08147865B2 Steroid-containing sustained release intraocular implants and related methods 有权
标题翻译：类固醇持续释放眼内植入物及相关方法
公开(公告)号：US08147865B2
公开(公告)日：2012-04-03
申请号：US11474149
申请日：2006-06-23
申请人： Glenn T. Huang , Thierry Nivaggioli , Lon T. Spada , Hiroshi Sugimoto , Wendy M. Blanda , James N. Chang , Orest Olejnik
发明人： Glenn T. Huang , Thierry Nivaggioli , Lon T. Spada , Hiroshi Sugimoto , Wendy M. Blanda , James N. Chang , Orest Olejnik
IPC分类号： A61F2/14
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0024 , A61K9/0092 , A61K9/1647 , A61K9/204 , A61K31/5377 , A61K31/56 , A61K31/573 , A61K31/58 , A61K45/06 , A61K47/593 , A61L27/18 , A61L27/54 , A61L27/58 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/222 , A61L2300/436 , A61L2300/45 , A61L2300/604 , A61L2430/16 , A61K2300/00 , C08L67/04
摘要： Biocompatible intraocular implants include a steroid and an auxiliary agent, where the auxiliary agent is present in an amount sufficient to lessen the severity of at least one side effect compared to the use of an otherwise identical implant lacking said auxiliary agent. The steroid and the auxiliary agent may be present on the same intraocular implant or on different implants. The steroid and auxiliary agent may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants containing the steroid and an auxiliary agent may be placed in an eye to treat one or more ocular conditions while reducing the side effects otherwise accompanying steroid use.
摘要翻译：生物相容性眼内植入物包括类固醇和辅助剂，其中与使用缺乏所述辅助剂的其它相同的植入物相比，辅助剂的存在量足以减轻至少一种副作用的严重性。类固醇和辅助剂可以存在于相同的眼内植入物或不同的植入物上。类固醇和辅助剂可以与可生物降解的聚合物基质相结合，例如两种可生物降解的聚合物的基质。或者，类固醇可以与具有一个或多个开口有效以允许类固醇释放到外部环境中的聚合物涂层相关联。包含类固醇和辅助剂的植入物可以放置在眼睛中以治疗一种或多种眼部病症，同时减少否则伴随类固醇使用的副作用。

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