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    • 2. 发明授权
    • Blood pressure monitoring with improved noise rejection
    • 血压监测,改善噪声抑制
    • US5873836A
    • 1999-02-23
    • US890402
    • 1997-07-09
    • Alan R. KahnDennis E. BahrKurt W. Allen
    • Alan R. KahnDennis E. BahrKurt W. Allen
    • A61B5/022A61B5/00
    • A61B5/02208A61B5/02141A61B5/7214
    • A method and apparatus is provided for distinguishing blood pressure sounds from noise in an automatic blood pressure monitoring system using the information contained in two microphone signals. Two microphones are placed on a patient along an axis of an artery to pick up blood pressure sounds. Pressure is applied to the artery such that the artery opens and closes during each heart cycle, the opening snap of the artery producing a blood pressure sound. The two microphone signals are sampled, filtered, and multiplied together to produce a microphone signal product. The microphone signal product is wave width filtered to remove therefrom portions of the signal having a wave width which is less than a selected minimum wave width value. A blood pressure sound is indicated as being detected when an amplitude of this wave width filtered microphone signal product exceeds a noise signal threshold level. The microphone signal product is also wave width filtered to remove therefrom portions of the signal having a wave width which is greater than a selected maximum wave width value. The amplitude of the resulting noise amplitude signal is used to adjust dynamically the noise signal threshold level in response to changing noise conditions. The detection of blood pressure sounds at a range of applied pressure levels is used to determine the systolic and diastolic blood pressure levels of the patient.
    • 提供了一种使用包含在两个麦克风信号中的信息在自动血压监测系统中区分血压声和噪声的方法和装置。 沿着动脉轴将两个麦克风放置在患者身上以拾取血压声音。 对动脉施加压力,使得动脉在每个心脏周期期间打开和关闭,动脉的开口卡扣产生血压声音。 两个麦克风信号被采样,滤波和相乘在一起以产生麦克风信号产物。 麦克风信号乘积被波宽滤波以从其中移除具有小于所选择的最小波宽值的波宽的信号的部分。 当该波长滤波的麦克风信号乘积的幅度超过噪声信号阈值电平时,表示检测到血压声。 麦克风信号乘积也被波宽滤波以从其去除具有大于所选最大波宽值的波宽的信号的部分。 所得到的噪声幅度信号的振幅用于响应于变化的噪声条件动态地调整噪声信号阈值电平。 使用在施加的压力水平范围内检测血压声音来确定患者的收缩压和舒张压水平。
    • 3. 发明授权
    • Method and apparatus for detecting blood pressure by blood pressure
sounds in the presence of significant noise
    • 在存在显着噪音的情况下通过血压声检测血压的方法和装置
    • US5680868A
    • 1997-10-28
    • US665286
    • 1996-06-17
    • Alan R. KahnDennis E. BahrKurt W. Allen
    • Alan R. KahnDennis E. BahrKurt W. Allen
    • A61B7/04A61B5/00
    • A61B5/021A61B5/02208A61B7/045
    • A method and apparatus is provided for detecting blood pressure sounds produced by the opening snap of an artery in a patient in the presence of significant noise using the phase information contained in two microphone signals. The two microphones are placed on a patient along the axis of an artery with their centers separated by a distance such that blood pressure sounds picked up by the microphones will be out of phase. Pressure is applied to the artery such that the artery opens and closes during each heart cycle, the opening snap of the artery producing blood pressure sounds. The two microphone signals are filtered, preferably using band pass filters having pass bands corresponding to the frequency of the blood pressure sounds. The filtered microphone signals are sampled and multiplied together or convolved in the frequency domain to generate a microphone signal product. If the microphone signal product is negative, the detection of a valid blood pressure signal for that sampling time is indicated. In an alternative embodiment, the slope of the two microphone signals at the sample time is also determined. A valid blood pressure signal is indicated when the microphone signal product is negative and either the two microphone signal slopes have inverse signs or are both less than a selected slope threshold. A selected number of consecutive valid blood pressure signal detections indicates the detection of a blood pressure sound. The detection of blood pressure sounds at a range of cuff pressures is used to determine the systolic and diastolic blood pressure levels of the patient.
    • 提供一种方法和装置,用于使用包含在两个麦克风信号中的相位信息,在存在有效噪声的情况下检测由患者的动脉的开口卡扣产生的血压声音。 两个麦克风沿着动脉轴放置在患者身上,其中心分开一段距离,使得由麦克风拾取的血压声音将异相。 对动脉施加压力,使得动脉在每个心脏周期期间打开和关闭,动脉的开口卡扣产生血压声音。 两个麦克风信号被滤波,优选地使用具有对应于血压声音的频率的通带的带通滤波器。 滤波的麦克风信号被采样并相乘在一起或卷积在频域中以产生麦克风信号乘积。 如果麦克风信号产物为负,则指示该采样时间的有效血压信号的检测。 在替代实施例中,也确定了在采样时间的两个麦克风信号的斜率。 当麦克风信号产物为负并且两个麦克风信号斜率具有反符号或都小于选择的斜率阈值时,指示有效的血压信号。 选择数量的连续有效的血压信号检测指示检测血压声音。 使用袖带压力范围内的血压声音的检测来确定患者的收缩压和舒张压水平。
    • 4. 发明授权
    • Coherent pattern identification in non-stationary periodic data and
blood pressure measurement using same
    • 非平稳周期数据中的相干模式识别和使用相同模式的血压测量
    • US5772600A
    • 1998-06-30
    • US665362
    • 1996-06-17
    • Alan R. KahnDennis E. BahrKurt W. Allen
    • Alan R. KahnDennis E. BahrKurt W. Allen
    • A61B5/0225A61B5/0285A61B5/02
    • A61B5/02208A61B5/0225A61B5/0285
    • A method and apparatus for automatically recognizing meaningful patterns in non-stationary periodic data is provided. The invention may be used in making measurements of physiological phenomena, such as arterial blood pressure, wherein data of interest is undergoing small changes in timing and magnitude in succeeding cycles, and wherein noise artifacts are detected along with the data of interest. Data points of interest are identified by grouping all received data points into family groups of multi-dimensional data points wherein each data point in the family group has dimensional values similar to at least one other data point in the family. The present invention may preferably be employed for the determination of a patient's systolic and diastolic blood pressure levels. For this application, the data points include a time dimension value corresponding to the delay time between an ECG signal and the detection of a potential blood pressure sound by a microphone placed in an inflatable cuff on the arm of a patient, and a magnitude dimension value corresponding to the cuff pressure at the time of the potential blood pressure sound detection. Data points are collected for a series of cuff pressures ranging from above the systolic blood pressure level of the patient to below the diastolic blood pressure level of the patient. The highest and lowest pressures of data points in the family containing the largest number of data points are used to derive the systolic and diastolic blood pressure levels of the patient, respectively.
    • 提供了一种在非平稳周期数据中自动识别有意义的模式的方法和装置。 本发明可以用于测量生理现象,例如动脉血压,其中感兴趣的数据在随后的周期中的时间和量值经历小的变化,并且其中检测到噪声伪像以及感兴趣的数据。 通过将所有接收到的数据点分组成多维数据点的族组来识别感兴趣的数据点,其中家庭组中的每个数据点具有与家族中的至少一个其他数据点相似的尺寸值。 本发明可优选用于确定患者的收缩压和舒张压水平。 对于该应用,数据点包括对应于ECG信号与放置在患者的手臂上的可充气袖带中的麦克风的潜在血压声音的延迟时间之间的时间维度值,以及幅度尺寸值 对应于潜在血压声音检测时的袖带压力。 收集数据点,用于从患者的收缩压水平高于患者的舒张压水平以下的一系列袖带压。 使用包含最多数据点的家庭中数据点的最高和最低压力分别用于导出患者的收缩压和舒张压水平。