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    • 2. 发明申请
    • Heterocyclic Sulfonamide Derivatives As Inhibitors Of Factor Xa
    • 杂环磺酰胺衍生物作为因子Xa的抑制剂
    • US20080221063A1
    • 2008-09-11
    • US11994847
    • 2006-07-05
    • Christer AlstermarkKjell AnderssonUlf FahlanderKenneth Granberg
    • Christer AlstermarkKjell AnderssonUlf FahlanderKenneth Granberg
    • A61K31/715C07D403/14A61K31/501
    • C07D401/14
    • The invention relates to heterocyclic derivatives of formula (I), Chemical formula should be inserted here. Please see paper copy wherein R1 is hydrogen or C1-3alkyl; R2 is selected from hydroxy, C1-5alkyl, carboxy, cyano, tetrazolyl, N—C1-5alkyltetrazolyl, oxazolyl, C1-5oxazolyl, isoxazolyl, C1-5 isoxazolyl, hydroxyC1-5alkyl, carboxy C1-5alkyl, C1-5alkoxyoxo C1-5alkyl, carbamoyl, C1-5alkylcarbamoyl, di(C1-5alkyl)carbamoyl, C1-5alkylcarbamoyl C1-4alkyl, hydroxy C1-5alkylcarbamoyl, C1-5alkoxy C1-5alkylcarbamoyl; —C1-5alkyl-Y1, —COOCHR17R18 and —CONR17R18; and R3 is hydrogen or halogen; or a pharmaceutically acceptable salt thereof, said compounds possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the compounds, to their use, to pharmaceutical compositions comprising them, to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect, and to combinations comprising them.
    • 本发明涉及式(I)的杂环衍生物,其中应插入化学式。 请参见其中R 1是氢或C 1-3烷基的纸副本; R 2选自羟基,C 1-5烷基,羧基,氰基,四唑基,NC 1-5烷基四唑基,恶唑基, 1〜5个恶唑基,异恶唑基,C 1〜5个异恶唑基,羟基C 1-5烷基,羧基C 1-5 烷基,C 1-5烷氧基氧基C 1-5烷基,氨基甲酰基,C 1-5烷基氨基甲酰基,二(C 1) -5个烷基)氨基甲酰基,C 1-5烷基氨基甲酰基C 1-4烷基,羟基C 1-5烷基氨基甲酰基,C 1-5烷氧基C 1-5烷基氨基甲酰基; -C 1-5烷基-Y 1,-COOCHR 17 R 18和-CONR 17 R< 18>; R 3是氢或卤素; 或其药学上可接受的盐,所述化合物具有抗血栓形成和抗凝血性质,因此可用于治疗人或动物的方法。 本发明还涉及制备化合物,其用途,包含它们的药物组合物在制备用于产生抗血栓形成或抗凝血作用的药物中的用途,以及包含它们的组合的方法。
    • 7. 发明授权
    • Jointing system
    • 接合系统
    • US6029416A
    • 2000-02-29
    • US875270
    • 1997-07-18
    • Kjell Andersson
    • Kjell Andersson
    • E04F15/02E04B1/61E04F15/04E04B5/00
    • E04B1/6133E04F15/04E04F2201/08Y10T403/7016
    • In a system for jointing together of adjacent pieces of flooring material by means of grooves (3) and tongues (4), at least one of the opposing surfaces on the tongues (4) and the grooves (3) of the pieces display flocked surface portions (10-13). The flocked surface portions (10-13) extend along the tongues (4) and/or the grooves (3) and cover substantially their entire length. The fiber length (9) of the flocked surface portions (10-13) exceeds the difference between the width of the grooves (3) and the thickness of the tongues (4).
    • PCT No.PCT / SE96 / 01537第 371日期1997年7月18日 102(e)日期1997年7月18日PCT 1995年12月19日PCT PCT。 第WO96 / 23942号公报 日期:1996年8月8日在通过槽(3)和舌片(4)将邻接的地板材料块接合在一起的系统中,舌部(4)和沟槽(3)中的至少一个相对表面 片展示植绒表面部分(10-13)。 植绒表面部分(10-13)沿着舌片(4)和/或凹槽(3)延伸并且基本上覆盖其整个长度。 植绒表面部分(10-13)的纤维长度(9)超过槽(3)的宽度和舌部(4)的厚度之差。